Association between cognition and function in patients with Parkinson disease with and without dementia
Identifieur interne : 000805 ( Main/Exploration ); précédent : 000804; suivant : 000806Association between cognition and function in patients with Parkinson disease with and without dementia
Auteurs : Emily Rosenthal [États-Unis] ; Laura Brennan [États-Unis] ; Sharon Xie [États-Unis] ; Howard Hurtig [États-Unis] ; Joshua Milber [États-Unis] ; Daniel Weintraub [États-Unis] ; Jason Karlawish [États-Unis] ; Andrew Siderowf [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-07-15.
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Abstract
Patients with Parkinson's disease (PD) often have cognitive deficits from the time of diagnosis. Except in patients with dementia, the impact of cognitive symptoms on daily function is not well documented. This study had two objectives: (1) to determine the functional significance of cognitive deficits in nondemented patients with PD and (2) to assess the sensitivity of two measures of global cognitive abilities to identify individuals with impaired ADL function. One hundred eleven subjects with PD and a range of cognitive abilities were included. Of these, 20 were diagnosed with PDD. All subjects were assessed with the Mattis Dementia Rating Scale to two (DRS‐2) and the Mini‐Mental State Examination (MMSE). ADL function was reported by an informant using the Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory (ADCS‐ADL). The ability of the DRS‐2 and MMSE to capture the impact of cognitive impairment on ADL function was assessed in the entire cohort and in subsets of nondemented individuals. After adjustment for covariates, cognition as measured by the DRS‐2 was strongly related to ADL function in the entire cohort (partial correlation coefficient = 0.55, P < 0.001). The association remained strong when only nondemented subjects were included (r = 0.42, P < 0.001). The DRS‐2 was significantly more accurate than the MMSE, particularly for detecting milder degrees of ADL impairment (ROC area = 0.87 vs. 0.75, P = 0.0008). Cognition is associated with impairment in ADL function, even in nondemented patients with PD. However, sensitive cognitive assessment measures may be needed to identify these functionally relevant impairments. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23073
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Except in patients with dementia, the impact of cognitive symptoms on daily function is not well documented. This study had two objectives: (1) to determine the functional significance of cognitive deficits in nondemented patients with PD and (2) to assess the sensitivity of two measures of global cognitive abilities to identify individuals with impaired ADL function. One hundred eleven subjects with PD and a range of cognitive abilities were included. Of these, 20 were diagnosed with PDD. All subjects were assessed with the Mattis Dementia Rating Scale to two (DRS‐2) and the Mini‐Mental State Examination (MMSE). ADL function was reported by an informant using the Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory (ADCS‐ADL). The ability of the DRS‐2 and MMSE to capture the impact of cognitive impairment on ADL function was assessed in the entire cohort and in subsets of nondemented individuals. After adjustment for covariates, cognition as measured by the DRS‐2 was strongly related to ADL function in the entire cohort (partial correlation coefficient = 0.55, P < 0.001). The association remained strong when only nondemented subjects were included (r = 0.42, P < 0.001). The DRS‐2 was significantly more accurate than the MMSE, particularly for detecting milder degrees of ADL impairment (ROC area = 0.87 vs. 0.75, P = 0.0008). Cognition is associated with impairment in ADL function, even in nondemented patients with PD. However, sensitive cognitive assessment measures may be needed to identify these functionally relevant impairments. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Rosenthal, Emily" sort="Rosenthal, Emily" uniqKey="Rosenthal E" first="Emily" last="Rosenthal">Emily Rosenthal</name></region><name sortKey="Brennan, Laura" sort="Brennan, Laura" uniqKey="Brennan L" first="Laura" last="Brennan">Laura Brennan</name><name sortKey="Hurtig, Howard" sort="Hurtig, Howard" uniqKey="Hurtig H" first="Howard" last="Hurtig">Howard Hurtig</name><name sortKey="Karlawish, Jason" sort="Karlawish, Jason" uniqKey="Karlawish J" first="Jason" last="Karlawish">Jason Karlawish</name><name sortKey="Milber, Joshua" sort="Milber, Joshua" uniqKey="Milber J" first="Joshua" last="Milber">Joshua Milber</name><name sortKey="Siderowf, Andrew" sort="Siderowf, Andrew" uniqKey="Siderowf A" first="Andrew" last="Siderowf">Andrew Siderowf</name><name sortKey="Weintraub, Daniel" sort="Weintraub, Daniel" uniqKey="Weintraub D" first="Daniel" last="Weintraub">Daniel Weintraub</name><name sortKey="Weintraub, Daniel" sort="Weintraub, Daniel" uniqKey="Weintraub D" first="Daniel" last="Weintraub">Daniel Weintraub</name><name sortKey="Xie, Sharon" sort="Xie, Sharon" uniqKey="Xie S" first="Sharon" last="Xie">Sharon Xie</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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