Clues to how alpha‐synuclein damages neurons in Parkinson's disease
Identifieur interne : 000775 ( Main/Exploration ); précédent : 000774; suivant : 000776Clues to how alpha‐synuclein damages neurons in Parkinson's disease
Auteurs : David Sulzer [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010.
English descriptors
- KwdEn :
Abstract
Alpha‐synuclein (α‐syn) appears to normally regulate neurotransmitter release, possibly via calcium‐dependent binding and dissociation from lipid domains on secretory vesicles. The pathogenic effects of α‐syn leading to Parkinson's disease (PD) appear to result from alternate toxic effects on lipid membrane. A variety of findings indicate that overexpression of wild‐type α‐syn, pathogenic mutations of α‐syn, and dopamine‐modified‐α‐syn promote toxic interaction between α‐syn oligomers and lipids. These may disrupt transmembrane concentration gradients across secretory vesicles and other organelles and interfere with normal lysosomal or ubiqutin/proteasome mediated protein degradation or mitochondrial function. Additional causes of PD may interfere at other points with normal handling and degradation of α‐syn, providing a variety of entry points to a converging neurodegenerative path underlying the disease. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.22639
Affiliations:
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<front><div type="abstract" xml:lang="en">Alpha‐synuclein (α‐syn) appears to normally regulate neurotransmitter release, possibly via calcium‐dependent binding and dissociation from lipid domains on secretory vesicles. The pathogenic effects of α‐syn leading to Parkinson's disease (PD) appear to result from alternate toxic effects on lipid membrane. A variety of findings indicate that overexpression of wild‐type α‐syn, pathogenic mutations of α‐syn, and dopamine‐modified‐α‐syn promote toxic interaction between α‐syn oligomers and lipids. These may disrupt transmembrane concentration gradients across secretory vesicles and other organelles and interfere with normal lysosomal or ubiqutin/proteasome mediated protein degradation or mitochondrial function. Additional causes of PD may interfere at other points with normal handling and degradation of α‐syn, providing a variety of entry points to a converging neurodegenerative path underlying the disease. © 2010 Movement Disorder Society</div>
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