Correlation between Cognitive Deficits and Glucose Hypometabolism in Mild Cognitive Impairment
Identifieur interne : 000768 ( Main/Exploration ); précédent : 000767; suivant : 000769Correlation between Cognitive Deficits and Glucose Hypometabolism in Mild Cognitive Impairment
Auteurs : Hiroko Nishi ; Nobukatsu Sawamoto ; Chihiro Namiki ; Hidefumi Yoshida ; Dinh Ha Duy Thuy ; Koichi Ishizu ; Kazuo Hashikawa ; Hidenao FukuyamaSource :
- Journal of Neuroimaging [ 1051-2284 ] ; 2010-01.
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Abstract
ABSTRACT: BACKGROUND: In patients with mild cognitive impairment (MCI), poor performances on delayed recall and executive function are risk factors of progression to dementia. The aim of the present study was to clarify neural correlates of these neuropsychological deficits. METHODS: Thirty patients with amnestic MCI and 15 control subjects underwent neuropsychological tests including three‐word delayed recall, visual delayed recall of Rey complex figure (RCF), and two‐relational reasoning of Raven's colored progressive matrices (RCPM) with a 18F‐fluorodeoxyglucose (FDG)‐position emission tomography (PET) measurement of resting state. We evaluated a relationship between performance of neuropsychological tests and regional cerebral glucose metabolism using voxel‐based analysis. RESULTS: Poor performance in three‐word delayed recall was related to glucose hypometabolism in the right medial temporal, right prefrontal, and left superior parietal cortices. The deficit in visual delayed recall of RCF correlated positively with hypometabolism in the bilateral posterior cingulate. The impairment in two‐relational reasoning was associated with hypometabolism in the right prefrontal cortex. CONCLUSIONS: The present findings suggest that hypometabolism in the right medial temporal cortex, right prefrontal cortex, left superior parietal cortex, and bilateral posterior cingulate reflects impairments in delayed recall while hypometabolism in the right prefrontal cortex mirrors deficits in executive function in MCI. J Neuroimaging 2010;20:29‐36.
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DOI: 10.1111/j.1552-6569.2008.00328.x
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uniqKey="Ishizu K" first="Koichi" last="Ishizu">Koichi Ishizu</name></author><author><name sortKey="Hashikawa, Kazuo" sort="Hashikawa, Kazuo" uniqKey="Hashikawa K" first="Kazuo" last="Hashikawa">Kazuo Hashikawa</name></author><author><name sortKey="Fukuyama, Hidenao" sort="Fukuyama, Hidenao" uniqKey="Fukuyama H" first="Hidenao" last="Fukuyama">Hidenao Fukuyama</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:36C08802014BB91B8FE20BB00128FE4C38943975</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1111/j.1552-6569.2008.00328.x</idno><idno type="url">https://api.istex.fr/document/36C08802014BB91B8FE20BB00128FE4C38943975/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002F79</idno><idno type="wicri:Area/Main/Curation">002B89</idno><idno type="wicri:Area/Main/Exploration">000768</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Correlation between Cognitive Deficits and Glucose Hypometabolism in Mild Cognitive Impairment</title><author><name sortKey="Nishi, Hiroko" sort="Nishi, Hiroko" uniqKey="Nishi H" first="Hiroko" last="Nishi">Hiroko Nishi</name><affiliation><wicri:noCountry code="subField">Japan (KI).</wicri:noCountry></affiliation></author><author><name sortKey="Sawamoto, Nobukatsu" sort="Sawamoto, Nobukatsu" uniqKey="Sawamoto N" first="Nobukatsu" last="Sawamoto">Nobukatsu Sawamoto</name><affiliation><wicri:noCountry code="subField">Japan (KI).</wicri:noCountry></affiliation></author><author><name sortKey="Namiki, Chihiro" sort="Namiki, Chihiro" uniqKey="Namiki C" first="Chihiro" last="Namiki">Chihiro Namiki</name><affiliation><wicri:noCountry code="subField">Japan (KI).</wicri:noCountry></affiliation></author><author><name sortKey="Yoshida, Hidefumi" sort="Yoshida, Hidefumi" uniqKey="Yoshida H" first="Hidefumi" last="Yoshida">Hidefumi Yoshida</name><affiliation><wicri:noCountry code="subField">Japan (KI).</wicri:noCountry></affiliation></author><author><name sortKey="Thuy, Dinh Ha Duy" sort="Thuy, Dinh Ha Duy" uniqKey="Thuy D" first="Dinh Ha Duy" last="Thuy">Dinh Ha Duy Thuy</name><affiliation><wicri:noCountry code="subField">Japan (KI).</wicri:noCountry></affiliation></author><author><name sortKey="Ishizu, Koichi" sort="Ishizu, Koichi" uniqKey="Ishizu K" first="Koichi" last="Ishizu">Koichi Ishizu</name><affiliation><wicri:noCountry code="subField">Japan (KI).</wicri:noCountry></affiliation></author><author><name sortKey="Hashikawa, Kazuo" sort="Hashikawa, Kazuo" uniqKey="Hashikawa K" first="Kazuo" last="Hashikawa">Kazuo Hashikawa</name><affiliation><wicri:noCountry code="subField">Japan (KI).</wicri:noCountry></affiliation></author><author><name sortKey="Fukuyama, Hidenao" sort="Fukuyama, Hidenao" uniqKey="Fukuyama H" first="Hidenao" last="Fukuyama">Hidenao Fukuyama</name><affiliation><wicri:noCountry code="subField">Japan (KI).</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neuroimaging</title><idno type="ISSN">1051-2284</idno><idno type="eISSN">1552-6569</idno><imprint><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2010-01">2010-01</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="29">29</biblScope><biblScope unit="page" to="36">36</biblScope></imprint><idno type="ISSN">1051-2284</idno></series><idno type="istex">36C08802014BB91B8FE20BB00128FE4C38943975</idno><idno type="DOI">10.1111/j.1552-6569.2008.00328.x</idno><idno type="ArticleID">JON328</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1051-2284</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dementia</term><term>episodic memory</term><term>executive function</term><term>mild cognitive impairment</term><term>positron emission tomography</term><term>psychology</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">ABSTRACT: BACKGROUND: In patients with mild cognitive impairment (MCI), poor performances on delayed recall and executive function are risk factors of progression to dementia. The aim of the present study was to clarify neural correlates of these neuropsychological deficits. METHODS: Thirty patients with amnestic MCI and 15 control subjects underwent neuropsychological tests including three‐word delayed recall, visual delayed recall of Rey complex figure (RCF), and two‐relational reasoning of Raven's colored progressive matrices (RCPM) with a 18F‐fluorodeoxyglucose (FDG)‐position emission tomography (PET) measurement of resting state. We evaluated a relationship between performance of neuropsychological tests and regional cerebral glucose metabolism using voxel‐based analysis. RESULTS: Poor performance in three‐word delayed recall was related to glucose hypometabolism in the right medial temporal, right prefrontal, and left superior parietal cortices. The deficit in visual delayed recall of RCF correlated positively with hypometabolism in the bilateral posterior cingulate. The impairment in two‐relational reasoning was associated with hypometabolism in the right prefrontal cortex. CONCLUSIONS: The present findings suggest that hypometabolism in the right medial temporal cortex, right prefrontal cortex, left superior parietal cortex, and bilateral posterior cingulate reflects impairments in delayed recall while hypometabolism in the right prefrontal cortex mirrors deficits in executive function in MCI. J Neuroimaging 2010;20:29‐36.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Fukuyama, Hidenao" sort="Fukuyama, Hidenao" uniqKey="Fukuyama H" first="Hidenao" last="Fukuyama">Hidenao Fukuyama</name><name sortKey="Hashikawa, Kazuo" sort="Hashikawa, Kazuo" uniqKey="Hashikawa K" first="Kazuo" last="Hashikawa">Kazuo Hashikawa</name><name sortKey="Ishizu, Koichi" sort="Ishizu, Koichi" uniqKey="Ishizu K" first="Koichi" last="Ishizu">Koichi Ishizu</name><name sortKey="Namiki, Chihiro" sort="Namiki, Chihiro" uniqKey="Namiki C" first="Chihiro" last="Namiki">Chihiro Namiki</name><name sortKey="Nishi, Hiroko" sort="Nishi, Hiroko" uniqKey="Nishi H" first="Hiroko" last="Nishi">Hiroko Nishi</name><name sortKey="Sawamoto, Nobukatsu" sort="Sawamoto, Nobukatsu" uniqKey="Sawamoto N" first="Nobukatsu" last="Sawamoto">Nobukatsu Sawamoto</name><name sortKey="Thuy, Dinh Ha Duy" sort="Thuy, Dinh Ha Duy" uniqKey="Thuy D" first="Dinh Ha Duy" last="Thuy">Dinh Ha Duy Thuy</name><name sortKey="Yoshida, Hidefumi" sort="Yoshida, Hidefumi" uniqKey="Yoshida H" first="Hidefumi" last="Yoshida">Hidefumi Yoshida</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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