Higher serum uric acid associated with decreased Parkinson's disease prevalence in a large community‐based survey
Identifieur interne : 000695 ( Main/Exploration ); précédent : 000694; suivant : 000696Higher serum uric acid associated with decreased Parkinson's disease prevalence in a large community‐based survey
Auteurs : Andrea Winquist [États-Unis] ; Kyle Steenland [États-Unis] ; Anoop Shankar [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-05-15.
English descriptors
Abstract
A large community‐based cross‐sectional survey provided an opportunity to evaluate a previously reported association between Parkinson's disease (PD) and low serum uric acid (UA) levels in this population. The association between a self‐reported PD diagnosis with treatment (n = 59) and serum UA level was examined using logistic and linear regression models, controlling for key covariates. In adjusted models, participants with UA levels at or above the median had a significantly lower odds of reporting PD with treatment compared with those with lower UA levels (OR 0.33, 95% CI 0.19–0.60, P = 0.0002). This association was observed for both men and women. The mean UA level among participants reporting PD with treatment was 0.78 mg/dl lower than the mean UA level among those not reporting PD (P ≤ 0.0001). These findings concur with several previous longitudinal studies that found an association between higher UA levels and decreased PD risk. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23070
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-05-15">2010-05-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="932">932</biblScope><biblScope unit="page" to="936">936</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">65FE60C80A7EB6F121035CB743F3C053D84C4910</idno><idno type="DOI">10.1002/mds.23070</idno><idno type="ArticleID">MDS23070</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cross‐sectional survey</term><term>uric acid</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A large community‐based cross‐sectional survey provided an opportunity to evaluate a previously reported association between Parkinson's disease (PD) and low serum uric acid (UA) levels in this population. The association between a self‐reported PD diagnosis with treatment (n = 59) and serum UA level was examined using logistic and linear regression models, controlling for key covariates. In adjusted models, participants with UA levels at or above the median had a significantly lower odds of reporting PD with treatment compared with those with lower UA levels (OR 0.33, 95% CI 0.19–0.60, P = 0.0002). This association was observed for both men and women. The mean UA level among participants reporting PD with treatment was 0.78 mg/dl lower than the mean UA level among those not reporting PD (P ≤ 0.0001). These findings concur with several previous longitudinal studies that found an association between higher UA levels and decreased PD risk. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Virginie-Occidentale</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Winquist, Andrea" sort="Winquist, Andrea" uniqKey="Winquist A" first="Andrea" last="Winquist">Andrea Winquist</name></region><name sortKey="Shankar, Anoop" sort="Shankar, Anoop" uniqKey="Shankar A" first="Anoop" last="Shankar">Anoop Shankar</name><name sortKey="Steenland, Kyle" sort="Steenland, Kyle" uniqKey="Steenland K" first="Kyle" last="Steenland">Kyle Steenland</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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