Plasma α‐synuclein in patients with Parkinson's disease with and without treatment
Identifieur interne : 000585 ( Main/Exploration ); précédent : 000584; suivant : 000586Plasma α‐synuclein in patients with Parkinson's disease with and without treatment
Auteurs : Raquel Duran [Espagne] ; Francisco J. Barrero [Espagne] ; Blas Morales [Espagne] ; Juan D. Luna [Espagne] ; Manuel Ramirez [Espagne] ; Francisco Vives [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-03-15.
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Abstract
Alpha‐synuclein (α‐syn) is an intracellular protein with a high tendency to aggregation. It is the major component of Lewy bodies and may play a key role in the pathogenesis of Parkinson's disease (PD). α‐Syn is also released by neurons and can be detected in biological fluids, such as plasma. The purpose of this study was to determine whether plasma α‐syn concentrations are elevated in newly diagnosed PD patients before treatment (nontreated PD group, ntPD; n = 53) and to compare them with concentrations in PD patients with at least 1 year of specific treatment (tPD; n = 42) and in healthy controls (n = 60). Plasma α‐syn concentrations in the ntPD and tPD groups were similar and significantly higher than in healthy controls. In conclusion, α‐syn was elevated early in the development of PD and specific PD treatment did not change plasma α‐syn levels. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.22928
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Luna</name></author><author><name sortKey="Ramirez, Manuel" sort="Ramirez, Manuel" uniqKey="Ramirez M" first="Manuel" last="Ramirez">Manuel Ramirez</name></author><author><name sortKey="Vives, Francisco" sort="Vives, Francisco" uniqKey="Vives F" first="Francisco" last="Vives">Francisco Vives</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E7B9AC7388B203AB6C94D7F8E9937FA02CE4E920</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.22928</idno><idno type="url">https://api.istex.fr/document/E7B9AC7388B203AB6C94D7F8E9937FA02CE4E920/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001E09</idno><idno type="wicri:Area/Main/Curation">001B23</idno><idno type="wicri:Area/Main/Exploration">000585</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Plasma α‐synuclein in patients with Parkinson's disease with and without treatment</title><author><name sortKey="Duran, Raquel" sort="Duran, Raquel" uniqKey="Duran R" first="Raquel" last="Duran">Raquel Duran</name><affiliation wicri:level="4"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Physiology and Institute of Neurosciences, Centro de Investigaciones Biomedicas (CIBM), University of Granada, Granada</wicri:regionArea><orgName type="university">Université de Grenade</orgName><placeName><settlement type="city">Grenade (Espagne)</settlement><region nuts="2" type="region">Andalousie</region></placeName></affiliation></author><author><name sortKey="Barrero, Francisco J" sort="Barrero, Francisco J" uniqKey="Barrero F" first="Francisco J." last="Barrero">Francisco J. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-03-15">2010-03-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="489">489</biblScope><biblScope unit="page" to="493">493</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">E7B9AC7388B203AB6C94D7F8E9937FA02CE4E920</idno><idno type="DOI">10.1002/mds.22928</idno><idno type="ArticleID">MDS22928</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>Parkinson's disease treatment</term><term>pathogenesis</term><term>plasma</term><term>α‐synuclein</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Alpha‐synuclein (α‐syn) is an intracellular protein with a high tendency to aggregation. It is the major component of Lewy bodies and may play a key role in the pathogenesis of Parkinson's disease (PD). α‐Syn is also released by neurons and can be detected in biological fluids, such as plasma. The purpose of this study was to determine whether plasma α‐syn concentrations are elevated in newly diagnosed PD patients before treatment (nontreated PD group, ntPD; n = 53) and to compare them with concentrations in PD patients with at least 1 year of specific treatment (tPD; n = 42) and in healthy controls (n = 60). Plasma α‐syn concentrations in the ntPD and tPD groups were similar and significantly higher than in healthy controls. In conclusion, α‐syn was elevated early in the development of PD and specific PD treatment did not change plasma α‐syn levels. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Andalousie</li></region><settlement><li>Grenade (Espagne)</li></settlement><orgName><li>Université de Grenade</li></orgName></list><tree><country name="Espagne"><region name="Andalousie"><name sortKey="Duran, Raquel" sort="Duran, Raquel" uniqKey="Duran R" first="Raquel" last="Duran">Raquel Duran</name></region><name sortKey="Barrero, Francisco J" sort="Barrero, Francisco J" uniqKey="Barrero F" first="Francisco J." last="Barrero">Francisco J. Barrero</name><name sortKey="Luna, Juan D" sort="Luna, Juan D" uniqKey="Luna J" first="Juan D." last="Luna">Juan D. 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