Cerebrospinal fluid tau and phosphorylated tau protein are elevated in corticobasal syndrome
Identifieur interne : 000371 ( Main/Exploration ); précédent : 000370; suivant : 000372Cerebrospinal fluid tau and phosphorylated tau protein are elevated in corticobasal syndrome
Auteurs : M. B. Aerts [Pays-Bas] ; R. A. J. Esselink [Pays-Bas] ; B. R. Bloem [Pays-Bas] ; M. M. Verbeek [Pays-Bas]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-01.
English descriptors
- KwdEn :
Abstract
Differentiating corticobasal syndrome (CBS) from progressive supranuclear palsy (PSP) and idiopathic Parkinson's disease (PD) can be difficult. To investigate the additional value of cerebrospinal fluid (CSF) biomarkers in the diagnostic differentiation of parkinsonism, we analyzed the CSF concentrations of total protein, lactate and brain specific proteins amyloid‐β42 protein, tau protein (t‐tau), and tau protein phosphorylated at Thr181 (p‐tau), in CSF samples from patients with PSP (n = 21), CBS (n = 12), and PD (n = 28). CBS patients demonstrated higher concentrations of t‐tau and p‐tau compared with PSP and PD patients. In discriminating CBS and PD, t‐tau offered the best combination of sensitivity (75%) and specificity (90.9%), followed by p‐tau (sensitivity 87.5% and specificity 75%). The p‐tau/t‐tau ratio resulted in sensitivity of 84.2% and specificity of 66.7% in discriminating PSP and CBS. In conclusion, our results suggest that CSF parameters are of additional value in the diagnostic differentiation of CBS and PD. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23341
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cerebrospinal fluid tau and phosphorylated tau protein are elevated in corticobasal syndrome</title><author><name sortKey="Aerts, M B" sort="Aerts, M B" uniqKey="Aerts M" first="M. B." last="Aerts">M. B. Aerts</name></author><author><name sortKey="Esselink, R A J" sort="Esselink, R A J" uniqKey="Esselink R" first="R. A. J." last="Esselink">R. A. J. Esselink</name></author><author><name sortKey="Bloem, B R" sort="Bloem, B R" uniqKey="Bloem B" first="B. R." last="Bloem">B. R. Bloem</name></author><author><name sortKey="Verbeek, M M" sort="Verbeek, M M" uniqKey="Verbeek M" first="M. M." last="Verbeek">M. M. Verbeek</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:59F9BCCA0CD5F9A51493A8062579483803FF4534</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23341</idno><idno type="url">https://api.istex.fr/document/59F9BCCA0CD5F9A51493A8062579483803FF4534/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002D86</idno><idno type="wicri:Area/Main/Curation">002A07</idno><idno type="wicri:Area/Main/Exploration">000371</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cerebrospinal fluid tau and phosphorylated tau protein are elevated in corticobasal syndrome</title><author><name sortKey="Aerts, M B" sort="Aerts, M B" uniqKey="Aerts M" first="M. B." last="Aerts">M. B. Aerts</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Parkinson Center Nijmegen (ParC) and Alzheimer Centre Nijmegen, and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre</wicri:regionArea><wicri:noRegion>Radboud University Nijmegen Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Esselink, R A J" sort="Esselink, R A J" uniqKey="Esselink R" first="R. A. J." last="Esselink">R. A. J. Esselink</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Parkinson Center Nijmegen (ParC) and Alzheimer Centre Nijmegen, and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre</wicri:regionArea><wicri:noRegion>Radboud University Nijmegen Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Bloem, B R" sort="Bloem, B R" uniqKey="Bloem B" first="B. R." last="Bloem">B. R. Bloem</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Parkinson Center Nijmegen (ParC) and Alzheimer Centre Nijmegen, and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre</wicri:regionArea><wicri:noRegion>Radboud University Nijmegen Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Verbeek, M M" sort="Verbeek, M M" uniqKey="Verbeek M" first="M. M." last="Verbeek">M. M. Verbeek</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Parkinson Center Nijmegen (ParC) and Alzheimer Centre Nijmegen, and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre</wicri:regionArea><wicri:noRegion>Radboud University Nijmegen Medical Centre</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Laboratory Medicine, Parkinson Center Nijmegen (ParC) and Alzheimer Centre Nijmegen, and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre</wicri:regionArea><wicri:noRegion>Radboud University Nijmegen Medical Centre</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-01">2011-01</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="169">169</biblScope><biblScope unit="page" to="173">173</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">59F9BCCA0CD5F9A51493A8062579483803FF4534</idno><idno type="DOI">10.1002/mds.23341</idno><idno type="ArticleID">MDS23341</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cerebrospinal fluid</term><term>corticobasal syndrome</term><term>progressive supranuclear palsy</term><term>sensitivity and specificity</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Differentiating corticobasal syndrome (CBS) from progressive supranuclear palsy (PSP) and idiopathic Parkinson's disease (PD) can be difficult. To investigate the additional value of cerebrospinal fluid (CSF) biomarkers in the diagnostic differentiation of parkinsonism, we analyzed the CSF concentrations of total protein, lactate and brain specific proteins amyloid‐β42 protein, tau protein (t‐tau), and tau protein phosphorylated at Thr181 (p‐tau), in CSF samples from patients with PSP (n = 21), CBS (n = 12), and PD (n = 28). CBS patients demonstrated higher concentrations of t‐tau and p‐tau compared with PSP and PD patients. In discriminating CBS and PD, t‐tau offered the best combination of sensitivity (75%) and specificity (90.9%), followed by p‐tau (sensitivity 87.5% and specificity 75%). The p‐tau/t‐tau ratio resulted in sensitivity of 84.2% and specificity of 66.7% in discriminating PSP and CBS. In conclusion, our results suggest that CSF parameters are of additional value in the diagnostic differentiation of CBS and PD. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Aerts, M B" sort="Aerts, M B" uniqKey="Aerts M" first="M. B." last="Aerts">M. B. Aerts</name></noRegion><name sortKey="Bloem, B R" sort="Bloem, B R" uniqKey="Bloem B" first="B. R." last="Bloem">B. R. Bloem</name><name sortKey="Esselink, R A J" sort="Esselink, R A J" uniqKey="Esselink R" first="R. A. J." last="Esselink">R. A. J. Esselink</name><name sortKey="Verbeek, M M" sort="Verbeek, M M" uniqKey="Verbeek M" first="M. M." last="Verbeek">M. M. Verbeek</name><name sortKey="Verbeek, M M" sort="Verbeek, M M" uniqKey="Verbeek M" first="M. M." last="Verbeek">M. M. Verbeek</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000371 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000371 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:59F9BCCA0CD5F9A51493A8062579483803FF4534
|texte= Cerebrospinal fluid tau and phosphorylated tau protein are elevated in corticobasal syndrome
}}
| This area was generated with Dilib version V0.6.23. |  |