Decades of delayed diagnosis in 4 levodopa‐responsive young‐onset monogenetic parkinsonism patients
Identifieur interne : 000345 ( Main/Exploration ); précédent : 000344; suivant : 000346Decades of delayed diagnosis in 4 levodopa‐responsive young‐onset monogenetic parkinsonism patients
Auteurs : Helen Ling [Royaume-Uni] ; Mark Braschinsky [Estonie] ; Pille Taba [Estonie] ; Siiri-Merike Lüüs [Estonie] ; Karen Doherty [Royaume-Uni] ; Anna Hotter [Autriche] ; Werner Poewe [Autriche] ; Andrew Lees (neurologue) [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-06.
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Abstract
Background:: We report 4 patients with young‐onset monogenetic parkinsonism, each of whom was misdiagnosed with either a psychogenic movement disorder or chronic fatigue syndrome for 10 to 23 years after the onset of their first symptoms. Results:: Once the diagnosis was eventually made, they all had a rapid and excellent response to levodopa, albeit with the early appearance of interdose dyskinesias in 3. Conclusions:: We discuss possible reasons for the missed diagnosis despite the relentless progression of their motor handicap. DAT scanning supported the revised clinical diagnosis of parkinsonism. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23563
Affiliations:
- Autriche, Estonie, Royaume-Uni
- Angleterre, Grand Londres, Tyrol (Land)
- Innsbruck, Londres
- National Hospital for Neurology and Neurosurgery, Université de médecine d'Innsbruck
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-06">2011-06</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1337">1337</biblScope><biblScope unit="page" to="1340">1340</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">72C21080A8E8CE2AD63870860B6499130C6401BD</idno><idno type="DOI">10.1002/mds.23563</idno><idno type="ArticleID">MDS23563</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>chronic fatigue syndrome</term><term>conversion disorder</term><term>monogenetic parkinsonism</term><term>parkin</term><term>psychogenic movement disorders</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: We report 4 patients with young‐onset monogenetic parkinsonism, each of whom was misdiagnosed with either a psychogenic movement disorder or chronic fatigue syndrome for 10 to 23 years after the onset of their first symptoms. Results:: Once the diagnosis was eventually made, they all had a rapid and excellent response to levodopa, albeit with the early appearance of interdose dyskinesias in 3. Conclusions:: We discuss possible reasons for the missed diagnosis despite the relentless progression of their motor handicap. DAT scanning supported the revised clinical diagnosis of parkinsonism. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Autriche</li><li>Estonie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Tyrol (Land)</li></region><settlement><li>Innsbruck</li><li>Londres</li></settlement><orgName><li>National Hospital for Neurology and Neurosurgery</li><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ling, Helen" sort="Ling, Helen" uniqKey="Ling H" first="Helen" last="Ling">Helen Ling</name></region><name sortKey="Doherty, Karen" sort="Doherty, Karen" uniqKey="Doherty K" first="Karen" last="Doherty">Karen Doherty</name><name sortKey="Doherty, Karen" sort="Doherty, Karen" uniqKey="Doherty K" first="Karen" last="Doherty">Karen Doherty</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><name sortKey="Ling, Helen" sort="Ling, Helen" uniqKey="Ling H" first="Helen" last="Ling">Helen Ling</name></country><country name="Estonie"><noRegion><name sortKey="Braschinsky, Mark" sort="Braschinsky, Mark" uniqKey="Braschinsky M" first="Mark" last="Braschinsky">Mark Braschinsky</name></noRegion><name sortKey="Luus, Siiri Erike" sort="Luus, Siiri Erike" uniqKey="Luus S" first="Siiri-Merike" last="Lüüs">Siiri-Merike Lüüs</name><name sortKey="Taba, Pille" sort="Taba, Pille" uniqKey="Taba P" first="Pille" last="Taba">Pille Taba</name></country><country name="Autriche"><noRegion><name sortKey="Hotter, Anna" sort="Hotter, Anna" uniqKey="Hotter A" first="Anna" last="Hotter">Anna Hotter</name></noRegion><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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