Long‐term neuroprotection and neurorestoration by glial cell‐derived neurotrophic factor microspheres for the treatment of Parkinson's disease
Identifieur interne : 000268 ( Main/Exploration ); précédent : 000267; suivant : 000269Long‐term neuroprotection and neurorestoration by glial cell‐derived neurotrophic factor microspheres for the treatment of Parkinson's disease
Auteurs : Elisa Garbayo [Espagne] ; Eduardo Ansorena [Espagne] ; Jose Luis Lanciego [Espagne] ; María Jose Blanco-Prieto [Espagne] ; María S. Aymerich [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-08-15.
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Abstract
Background:: Glial cell‐derived neurotrophic factor is a survival factor for dopaminergic neurons and a promising candidate for the treatment of Parkinson's disease. However, the delivery issue of the protein to the brain still remains unsolved. Our aim was to investigate the effect of long‐term delivery of encapsulated glial cell‐derived neurotrophic factor within microspheres. Methods:: A single dose of microspheres containing 2.5 μg of glial cell‐derived neurotrophic factor was implanted intrastriatally in animals 2 weeks after a 6‐hydroxydopamine lesion. Results:: The amphetamine test showed a complete behavioral recovery after 16 weeks of treatment, which was maintained until the end of the study (week 30). This effect was accompanied by an increase in dopaminergic striatal terminals and neuroprotection of dopaminergic neurons. Conclusions:: The main achievement was the long‐term neurorestoration in parkinsonian animals induced by encapsulated glial cell‐derived neurotrophic factor, suggesting that microspheres may be considered as a means to deliver glial cell‐derived neurotrophic factor for Parkinson's disease treatment. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23793
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-08-15">2011-08-15</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1943">1943</biblScope><biblScope unit="page" to="1947">1947</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C2B602219E6822B4FDB48470B82EAD900D9228F3</idno><idno type="DOI">10.1002/mds.23793</idno><idno type="ArticleID">MDS23793</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>6‐hydroxydopamine</term><term>Parkinson's disease</term><term>glial cell‐derived neurotrophic factor</term><term>microspheres</term><term>neurodegeneration</term><term>tyrosine hydroxylase</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Glial cell‐derived neurotrophic factor is a survival factor for dopaminergic neurons and a promising candidate for the treatment of Parkinson's disease. However, the delivery issue of the protein to the brain still remains unsolved. Our aim was to investigate the effect of long‐term delivery of encapsulated glial cell‐derived neurotrophic factor within microspheres. Methods:: A single dose of microspheres containing 2.5 μg of glial cell‐derived neurotrophic factor was implanted intrastriatally in animals 2 weeks after a 6‐hydroxydopamine lesion. Results:: The amphetamine test showed a complete behavioral recovery after 16 weeks of treatment, which was maintained until the end of the study (week 30). This effect was accompanied by an increase in dopaminergic striatal terminals and neuroprotection of dopaminergic neurons. Conclusions:: The main achievement was the long‐term neurorestoration in parkinsonian animals induced by encapsulated glial cell‐derived neurotrophic factor, suggesting that microspheres may be considered as a means to deliver glial cell‐derived neurotrophic factor for Parkinson's disease treatment. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Espagne</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Garbayo, Elisa" sort="Garbayo, Elisa" uniqKey="Garbayo E" first="Elisa" last="Garbayo">Elisa Garbayo</name></noRegion><name sortKey="Ansorena, Eduardo" sort="Ansorena, Eduardo" uniqKey="Ansorena E" first="Eduardo" last="Ansorena">Eduardo Ansorena</name><name sortKey="Aymerich, Maria S" sort="Aymerich, Maria S" uniqKey="Aymerich M" first="María S." last="Aymerich">María S. Aymerich</name><name sortKey="Aymerich, Maria S" sort="Aymerich, Maria S" uniqKey="Aymerich M" first="María S." last="Aymerich">María S. 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