Lysosomal storage disorders and Parkinson's disease: Gaucher disease and beyond
Identifieur interne : 000264 ( Main/Exploration ); précédent : 000263; suivant : 000265Lysosomal storage disorders and Parkinson's disease: Gaucher disease and beyond
Auteurs : Tamar Shachar [Israël] ; Christophe Lo Bianco [Suisse] ; Alessandra Recchia [Suisse] ; Christoph Wiessner [Suisse] ; Annick Raas-Rothschild [Israël] ; Anthony H. Futerman [Israël]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-08-01.
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Abstract
Parkinson's disease is associated with mutations in the glucocerebrosidase gene, which result in the enzyme deficiency causing Gaucher disease, the most common lysosomal storage disorder. We have performed an exhaustive literature search and found that additional lysosomal storage disorders might be associated with Parkinson's disease, based on case reports, the appearance of pathological features such as α‐synuclein deposits in the brain, and substantia nigra pathology. Our findings suggest that the search for biochemical and cellular pathways that link Parkinson's disease with lysosomal storage disorders should not be limited exclusively to changes that occur in Gaucher disease, such as changes in glucocerebrosidase activity or in glucosylceramide levels, but rather include changes that might be common to a wide variety of lysosomal storage disorders. Moreover, we propose that additional genetic, epidemiological, and clinical studies should be performed to check the precise incidence of mutations in genes encoding lysosomal proteins in patients displaying Parkinson's symptoms. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23774
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-08-01">2011-08-01</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1593">1593</biblScope><biblScope unit="page" to="1604">1604</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">E025F7F26B0389BF0EE0B0595D55E1D36BA6B2CE</idno><idno type="DOI">10.1002/mds.23774</idno><idno type="ArticleID">MDS23774</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gaucher disease</term><term>Parkinson's disease</term><term>glucosylceramide</term><term>lipid</term><term>lysosomal storage disorders</term><term>neurodegenerative diseases</term><term>parkinsonism</term><term>synuclein</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease is associated with mutations in the glucocerebrosidase gene, which result in the enzyme deficiency causing Gaucher disease, the most common lysosomal storage disorder. We have performed an exhaustive literature search and found that additional lysosomal storage disorders might be associated with Parkinson's disease, based on case reports, the appearance of pathological features such as α‐synuclein deposits in the brain, and substantia nigra pathology. Our findings suggest that the search for biochemical and cellular pathways that link Parkinson's disease with lysosomal storage disorders should not be limited exclusively to changes that occur in Gaucher disease, such as changes in glucocerebrosidase activity or in glucosylceramide levels, but rather include changes that might be common to a wide variety of lysosomal storage disorders. 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