Reduced sympathetically driven heart rate variability during sleep in Parkinson's disease: A case‐control polysomnography‐based study
Identifieur interne : 000173 ( Main/Exploration ); précédent : 000172; suivant : 000174Reduced sympathetically driven heart rate variability during sleep in Parkinson's disease: A case‐control polysomnography‐based study
Auteurs : Nicolas Sauvageot [Luxembourg (pays)] ; Michel Vaillant [Luxembourg (pays)] ; Nico J. Diederich [Luxembourg (pays)]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-02-01.
English descriptors
Abstract
Objectives:: To study heart rate variability during nocturnal sleep in idiopathic Parkinson's disease. Methods:: Retrospective study, using part of the data set accumulated in an earlier study, in which polysomnography was performed in 35 idiopathic Parkinson's disease patients under their usual medication and in 35 non‐idiopathic Parkinson's disease controls, matched for age, gender, and amount of apneas/hypopneas per hour. R‐R intervals were calculated separately for non‐rapid eye movements and rapid eye movements sleep stages. R‐R variability was analyzed for time and frequency domains. Selected variables considered were high frequency band (0.15–0.40 Hz) influenced by parasympathetic input and low frequency band (0.04–0.15 Hz) influenced by sympathetic input. Both frequency bands were considered in normalized units (low frequency and high frequency normalized units). Low frequency/high frequency ratio was calculated as an estimate of sympathicovagal balance. Results:: All respiratory and sleep stage characteristics were similar in both groups. Low frequency normalized unit was reduced in idiopathic Parkinson's disease patients, both for non‐rapid eye movements and rapid eye movements sleep (P = 0.005). Low frequency/high frequency was smaller in idiopathic Parkinson's disease for both sleep portions (P = 0.02). Conclusions:: Idiopathic Parkinson's disease patients show reduced sympathetic influence on heart rate variability in both non‐rapid eye movements and rapid eye movements sleep stages. We speculate that these findings are a consequence of the postganglionic noradrenergic cardiac denervation found in idiopathic Parkinson's disease patients. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23479
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Diederich</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:100AC1F45A11A555788353E3DDE5EAE12BE005B8</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23479</idno><idno type="url">https://api.istex.fr/document/100AC1F45A11A555788353E3DDE5EAE12BE005B8/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001A65</idno><idno type="wicri:Area/Main/Curation">001806</idno><idno type="wicri:Area/Main/Exploration">000173</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Reduced sympathetically driven heart rate variability during sleep in Parkinson's disease: A case‐control polysomnography‐based study</title><author><name sortKey="Sauvageot, Nicolas" sort="Sauvageot, Nicolas" uniqKey="Sauvageot N" first="Nicolas" last="Sauvageot">Nicolas Sauvageot</name><affiliation wicri:level="1"><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Centre de Recherche Publique Santé, Centre d'Etudes en Santé, Strassen</wicri:regionArea><wicri:noRegion>Strassen</wicri:noRegion></affiliation></author><author><name sortKey="Vaillant, Michel" sort="Vaillant, Michel" uniqKey="Vaillant M" first="Michel" last="Vaillant">Michel Vaillant</name><affiliation wicri:level="1"><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Centre de Recherche Publique Santé, Centre d'Etudes en Santé, Strassen</wicri:regionArea><wicri:noRegion>Strassen</wicri:noRegion></affiliation></author><author><name sortKey="Diederich, Nico J" sort="Diederich, Nico J" uniqKey="Diederich N" first="Nico J." last="Diederich">Nico J. Diederich</name><affiliation wicri:level="1"><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Department of Neurosciences and Interdisciplinary Sleep Laboratory, Centre Hospitalier de Luxembourg, Luxembourg‐City</wicri:regionArea><wicri:noRegion>Luxembourg‐City</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-01">2011-02-01</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="234">234</biblScope><biblScope unit="page" to="240">240</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">100AC1F45A11A555788353E3DDE5EAE12BE005B8</idno><idno type="DOI">10.1002/mds.23479</idno><idno type="ArticleID">MDS23479</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MIBG‐SPECT</term><term>Parkinson's disease</term><term>dysautonomia</term><term>heart rate variability</term><term>sleep</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives:: To study heart rate variability during nocturnal sleep in idiopathic Parkinson's disease. Methods:: Retrospective study, using part of the data set accumulated in an earlier study, in which polysomnography was performed in 35 idiopathic Parkinson's disease patients under their usual medication and in 35 non‐idiopathic Parkinson's disease controls, matched for age, gender, and amount of apneas/hypopneas per hour. R‐R intervals were calculated separately for non‐rapid eye movements and rapid eye movements sleep stages. R‐R variability was analyzed for time and frequency domains. Selected variables considered were high frequency band (0.15–0.40 Hz) influenced by parasympathetic input and low frequency band (0.04–0.15 Hz) influenced by sympathetic input. Both frequency bands were considered in normalized units (low frequency and high frequency normalized units). Low frequency/high frequency ratio was calculated as an estimate of sympathicovagal balance. Results:: All respiratory and sleep stage characteristics were similar in both groups. Low frequency normalized unit was reduced in idiopathic Parkinson's disease patients, both for non‐rapid eye movements and rapid eye movements sleep (P = 0.005). Low frequency/high frequency was smaller in idiopathic Parkinson's disease for both sleep portions (P = 0.02). Conclusions:: Idiopathic Parkinson's disease patients show reduced sympathetic influence on heart rate variability in both non‐rapid eye movements and rapid eye movements sleep stages. We speculate that these findings are a consequence of the postganglionic noradrenergic cardiac denervation found in idiopathic Parkinson's disease patients. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Luxembourg (pays)</li></country></list><tree><country name="Luxembourg (pays)"><noRegion><name sortKey="Sauvageot, Nicolas" sort="Sauvageot, Nicolas" uniqKey="Sauvageot N" first="Nicolas" last="Sauvageot">Nicolas Sauvageot</name></noRegion><name sortKey="Diederich, Nico J" sort="Diederich, Nico J" uniqKey="Diederich N" first="Nico J." last="Diederich">Nico J. Diederich</name><name sortKey="Vaillant, Michel" sort="Vaillant, Michel" uniqKey="Vaillant M" first="Michel" last="Vaillant">Michel Vaillant</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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