Localization of endocardial ectopic activity by means of noninvasive endocardial surface current density reconstruction
Identifieur interne : 000081 ( Main/Exploration ); précédent : 000080; suivant : 000082Localization of endocardial ectopic activity by means of noninvasive endocardial surface current density reconstruction
Auteurs : Dakun Lai [États-Unis] ; Chenguang Liu [États-Unis] ; Michael D. Eggen [États-Unis] ; Paul A. Iaizzo [États-Unis] ; Bin He [États-Unis]Source :
- Physics in Medicine and Biology [ 0031-9155 ] ; 2011.
Abstract
Localization of the source of cardiac ectopic activity has direct clinical benefits for determining the location of the corresponding ectopic focus. In this study, a recently developed current-density (CD)-based localization approach was experimentally evaluated in noninvasively localizing the origin of the cardiac ectopic activity from body-surface potential maps (BSPMs) in a well-controlled experimental setting. The cardiac ectopic activities were induced in four well-controlled intact pigs by single-site pacing at various sites within the left ventricle (LV). In each pacing study, the origin of the induced ectopic activity was localized by reconstructing the CD distribution on the endocardial surface of the LV from the measured BSPMs and compared with the estimated single moving dipole (SMD) solution and precise pacing site (PS). Over the 60 analyzed beats corresponding to ten pacing sites (six for each), the mean and standard deviation of the distance between the locations of maximum CD value and the corresponding PSs were 16.9 mm and 4.6 mm, respectively. In comparison, the averaged distance between the SMD locations and the corresponding PSs was slightly larger (18.4 3.4 mm). The obtained CD distribution of activated sources extending from the stimulus site also showed high consistency with the endocardial potential maps estimated by a minimally invasive endocardial mapping system. The present experimental results suggest that the CD method is able to locate the approximate site of the origin of a cardiac ectopic activity, and that the distribution of the CD can portray the propagation of early activation of an ectopic beat.
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Iaizzo</name></author><author><name sortKey="He, Bin" sort="He, Bin" uniqKey="He B" first="Bin" last="He">Bin He</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DDB5D004D21EEA5E8F3227E48A1359A3C14F2C57</idno><date when="2011" year="2011">2011</date><idno type="url">https://api.istex.fr/document/DDB5D004D21EEA5E8F3227E48A1359A3C14F2C57/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002596</idno><idno type="wicri:Area/Main/Curation">002259</idno><idno type="wicri:Area/Main/Exploration">000081</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Localization of endocardial ectopic activity by means of noninvasive endocardial surface current density reconstruction</title><author><name sortKey="Lai, Dakun" sort="Lai, Dakun" uniqKey="Lai D" first="Dakun" last="Lai">Dakun Lai</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, University of Minnesota, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Liu, Chenguang" sort="Liu, Chenguang" uniqKey="Liu C" first="Chenguang" last="Liu">Chenguang Liu</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, University of Minnesota, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Eggen, Michael D" sort="Eggen, Michael D" uniqKey="Eggen M" first="Michael D" last="Eggen">Michael D. 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Biol.</title><idno type="ISSN">0031-9155</idno><idno type="eISSN">1361-6560</idno><imprint><publisher>IOP Publishing</publisher><date type="published" when="2011">2011</date><biblScope unit="volume">56</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="4161">4161</biblScope><biblScope unit="page" to="4176">4176</biblScope><biblScope unit="production">Printed in the UK</biblScope></imprint></series><idno type="istex">DDB5D004D21EEA5E8F3227E48A1359A3C14F2C57</idno><idno type="DOI">10.1088/0031-9155/56/13/027</idno><idno type="PII">S0031-9155(11)88829-9</idno><idno type="articleID">388829</idno><idno type="articleNumber">027</idno></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Localization of the source of cardiac ectopic activity has direct clinical benefits for determining the location of the corresponding ectopic focus. In this study, a recently developed current-density (CD)-based localization approach was experimentally evaluated in noninvasively localizing the origin of the cardiac ectopic activity from body-surface potential maps (BSPMs) in a well-controlled experimental setting. The cardiac ectopic activities were induced in four well-controlled intact pigs by single-site pacing at various sites within the left ventricle (LV). In each pacing study, the origin of the induced ectopic activity was localized by reconstructing the CD distribution on the endocardial surface of the LV from the measured BSPMs and compared with the estimated single moving dipole (SMD) solution and precise pacing site (PS). Over the 60 analyzed beats corresponding to ten pacing sites (six for each), the mean and standard deviation of the distance between the locations of maximum CD value and the corresponding PSs were 16.9 mm and 4.6 mm, respectively. In comparison, the averaged distance between the SMD locations and the corresponding PSs was slightly larger (18.4 3.4 mm). The obtained CD distribution of activated sources extending from the stimulus site also showed high consistency with the endocardial potential maps estimated by a minimally invasive endocardial mapping system. The present experimental results suggest that the CD method is able to locate the approximate site of the origin of a cardiac ectopic activity, and that the distribution of the CD can portray the propagation of early activation of an ectopic beat.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Minnesota</li></region></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Lai, Dakun" sort="Lai, Dakun" uniqKey="Lai D" first="Dakun" last="Lai">Dakun Lai</name></region><name sortKey="Eggen, Michael D" sort="Eggen, Michael D" uniqKey="Eggen M" first="Michael D" last="Eggen">Michael D. Eggen</name><name sortKey="Eggen, Michael D" sort="Eggen, Michael D" uniqKey="Eggen M" first="Michael D" last="Eggen">Michael D. Eggen</name><name sortKey="He, Bin" sort="He, Bin" uniqKey="He B" first="Bin" last="He">Bin He</name><name sortKey="He, Bin" sort="He, Bin" uniqKey="He B" first="Bin" last="He">Bin He</name><name sortKey="Iaizzo, Paul A" sort="Iaizzo, Paul A" uniqKey="Iaizzo P" first="Paul A" last="Iaizzo">Paul A. Iaizzo</name><name sortKey="Liu, Chenguang" sort="Liu, Chenguang" uniqKey="Liu C" first="Chenguang" last="Liu">Chenguang Liu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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