Detrimental deletions: mitochondria, aging and Parkinson's disease
Identifieur interne : 002A67 ( Main/Curation ); précédent : 002A66; suivant : 002A68Detrimental deletions: mitochondria, aging and Parkinson's disease
Auteurs : Saskia Biskup [États-Unis] ; Darren J. Moore [États-Unis]Source :
- BioEssays [ 0265-9247 ] ; 2006-10.
Abstract
As individuals enter their 80s, they are inevitably confronted with the problem of neuronal loss in the brain. The incidence of the common movement disorder ‘mild parkinsonian signs’ (MPS) is approximately 50% over the age of 85 years. It has long been known that the loss of dopaminergic neurons in the substantia nigra pars compacta is a neuropathological hallmark of Parkinson's disease (PD). Recently, two papers1,2 present clear evidence for a high burden of mitochondrial DNA deletions within substantia nigra neurons in aged individuals and individuals with PD, pointing towards a common pathway inevitably leading to neuronal dysfunction and death. BioEssays 28: 963–967, 2006. © 2006 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/bies.20471
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002E50
Links to Exploration step
ISTEX:E1B714F29AF3653C720CE13483687B581007197ELe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Detrimental deletions: mitochondria, aging and Parkinson's disease</title>
<author><name sortKey="Biskup, Saskia" sort="Biskup, Saskia" uniqKey="Biskup S" first="Saskia" last="Biskup">Saskia Biskup</name>
<affiliation wicri:level="2"><mods:affiliation>Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><mods:affiliation>Department of Neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Moore, Darren J" sort="Moore, Darren J" uniqKey="Moore D" first="Darren J." last="Moore">Darren J. Moore</name>
<affiliation wicri:level="2"><mods:affiliation>Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><mods:affiliation>Department of Neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:E1B714F29AF3653C720CE13483687B581007197E</idno>
<date when="2006" year="2006">2006</date>
<idno type="doi">10.1002/bies.20471</idno>
<idno type="url">https://api.istex.fr/document/E1B714F29AF3653C720CE13483687B581007197E/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">002E50</idno>
<idno type="wicri:Area/Main/Curation">002A67</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Detrimental deletions: mitochondria, aging and Parkinson's disease</title>
<author><name sortKey="Biskup, Saskia" sort="Biskup, Saskia" uniqKey="Biskup S" first="Saskia" last="Biskup">Saskia Biskup</name>
<affiliation wicri:level="2"><mods:affiliation>Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><mods:affiliation>Department of Neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Moore, Darren J" sort="Moore, Darren J" uniqKey="Moore D" first="Darren J." last="Moore">Darren J. Moore</name>
<affiliation wicri:level="2"><mods:affiliation>Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><mods:affiliation>Department of Neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">BioEssays</title>
<title level="j" type="abbrev">Bioessays</title>
<idno type="ISSN">0265-9247</idno>
<idno type="eISSN">1521-1878</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2006-10">2006-10</date>
<biblScope unit="volume">28</biblScope>
<biblScope unit="issue">10</biblScope>
<biblScope unit="page" from="963">963</biblScope>
<biblScope unit="page" to="967">967</biblScope>
</imprint>
<idno type="ISSN">0265-9247</idno>
</series>
<idno type="istex">E1B714F29AF3653C720CE13483687B581007197E</idno>
<idno type="DOI">10.1002/bies.20471</idno>
<idno type="ArticleID">BIES20471</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0265-9247</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">As individuals enter their 80s, they are inevitably confronted with the problem of neuronal loss in the brain. The incidence of the common movement disorder ‘mild parkinsonian signs’ (MPS) is approximately 50% over the age of 85 years. It has long been known that the loss of dopaminergic neurons in the substantia nigra pars compacta is a neuropathological hallmark of Parkinson's disease (PD). Recently, two papers1,2 present clear evidence for a high burden of mitochondrial DNA deletions within substantia nigra neurons in aged individuals and individuals with PD, pointing towards a common pathway inevitably leading to neuronal dysfunction and death. BioEssays 28: 963–967, 2006. © 2006 Wiley Periodicals, Inc.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002A67 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 002A67 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:E1B714F29AF3653C720CE13483687B581007197E |texte= Detrimental deletions: mitochondria, aging and Parkinson's disease }}
This area was generated with Dilib version V0.6.23. |