Serveur d'exploration sur la maladie de Parkinson

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Neurodegenerative disorders: Parkinson’s disease and Huntington’s disease

Identifieur interne : 002996 ( Main/Curation ); précédent : 002995; suivant : 002997

Neurodegenerative disorders: Parkinson’s disease and Huntington’s disease

Auteurs : S M Hague [Royaume-Uni] ; S. Klaffke [Royaume-Uni] ; O. Bandmann [Royaume-Uni]

Source :

RBID : ISTEX:D540A881E7B65944EF4F038D17C4DC24937CAE4C

English descriptors

Abstract

Parkinson’s disease and Huntington’s disease are both model diseases. Parkinson’s disease is the most common of several akinetic-rigid syndromes and Huntington’s disease is only one of an ever growing number of trinucleotide repeat disorders. Molecular genetic studies and subsequent molecular biological studies have provided fascinating new insights into the pathogenesis of both disorders and there is now real hope for disease modifying treatment in the not too distant future for patients with Parkinson’s disease or Huntington’s disease.

Url:
DOI: 10.1136/jnnp.2004.060186

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ISTEX:D540A881E7B65944EF4F038D17C4DC24937CAE4C

Le document en format XML

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<mods:affiliation>Academic Neurology Unit, Division of Genomic Medicine, University of Sheffield, UK</mods:affiliation>
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<term>A-S, α-synuclein</term>
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<term>COX2, cyclo-oxygenase 2</term>
<term>Huntington’s disease</term>
<term>MPTP, 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine</term>
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<div type="abstract" xml:lang="en">Parkinson’s disease and Huntington’s disease are both model diseases. Parkinson’s disease is the most common of several akinetic-rigid syndromes and Huntington’s disease is only one of an ever growing number of trinucleotide repeat disorders. Molecular genetic studies and subsequent molecular biological studies have provided fascinating new insights into the pathogenesis of both disorders and there is now real hope for disease modifying treatment in the not too distant future for patients with Parkinson’s disease or Huntington’s disease.</div>
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