Pathophysiology of diurnal drooling in Parkinson's disease
Identifieur interne : 002655 ( Main/Curation ); précédent : 002654; suivant : 002656Pathophysiology of diurnal drooling in Parkinson's disease
Auteurs : Johanna G. Kalf [Pays-Bas] ; Marten Munneke [Pays-Bas] ; Lenie Van Den Engel-Hoek [Pays-Bas] ; Bert J. De Swart [Pays-Bas] ; George F. Borm [Pays-Bas] ; Bastiaan R. Bloem [Pays-Bas] ; Machiel J. Zwarts [Pays-Bas]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-08-01.
English descriptors
- KwdEn :
Abstract
Drooling is an incapacitating feature of Parkinson's disease. Better pathophysiological insights are needed to improve treatment. In this study, we tested the hypothesis that the cause of drooling is multifactorial. We examined 15 patients with Parkinson's disease with distinct diurnal saliva loss (“droolers”) and 15 patients with Parkinson's disease without drooling complaints (“nondroolers”). We evaluated all factors that could potentially contribute to drooling: swallowing capacity (maximum volume), functional swallowing (assessed with the dysphagia subscale of the Therapy Outcome Measures for rehabilitation specialists), unintentional mouth opening due to hypomimia (Unified Parkinson's Disease Rating Scale item), posture (quantified from sagittal photographs), and nose‐breathing ability. We also quantified the frequency of spontaneous swallowing during 45 minutes of quiet sitting, using polygraphy. Droolers had more advanced Parkinson's disease than nondroolers (Unified Parkinson's Disease Rating Scale motor score 31 vs 22; P = .014). Droolers also scored significantly worse on all recorded variables except for nose breathing. Swallowing frequency tended to be higher, possibly to compensate for less efficient swallowing. Logistic regression with adjustment for age and disease severity showed that hypomimia correlated best with drooling. Linear regression with hypomimia as the dependent variable identified disease severity, dysphagia, and male sex as significant explanatory factors. Drooling in Parkinson's disease results from multiple risk factors, with hypomimia being the most prominent. When monitored, patients appear to compensate by increasing their swallowing frequency, much like the increased cadence that is used to compensate for stepping akinesia. These findings can provide a rationale for behavioral approaches to treat drooling. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23720
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002A10
Links to Exploration step
ISTEX:7D62E3CABD85719E8FF1613FE6E344556F57BB31Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pathophysiology of diurnal drooling in Parkinson's disease</title>
<author><name sortKey="Kalf, Johanna G" sort="Kalf, Johanna G" uniqKey="Kalf J" first="Johanna G." last="Kalf">Johanna G. Kalf</name>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, Department of Rehabilitation, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, Department of Rehabilitation, Nijmegen</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neurology, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neurology, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Munneke, Marten" sort="Munneke, Marten" uniqKey="Munneke M" first="Marten" last="Munneke">Marten Munneke</name>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, Department of Rehabilitation, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, Department of Rehabilitation, Nijmegen</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, IQ Healthcare, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, IQ Healthcare, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Den Engel Oek, Lenie" sort="Van Den Engel Oek, Lenie" uniqKey="Van Den Engel Oek L" first="Lenie" last="Van Den Engel-Hoek">Lenie Van Den Engel-Hoek</name>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, Department of Rehabilitation, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, Department of Rehabilitation, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Swart, Bert J" sort="De Swart, Bert J" uniqKey="De Swart B" first="Bert J." last="De Swart">Bert J. De Swart</name>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, Department of Rehabilitation, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, Department of Rehabilitation, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Borm, George F" sort="Borm, George F" uniqKey="Borm G" first="George F." last="Borm">George F. Borm</name>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice Department of Epidemiology, Biostatistics and HTA, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice Department of Epidemiology, Biostatistics and HTA, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bloem, Bastiaan R" sort="Bloem, Bastiaan R" uniqKey="Bloem B" first="Bastiaan R." last="Bloem">Bastiaan R. Bloem</name>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neurology, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neurology, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zwarts, Machiel J" sort="Zwarts, Machiel J" uniqKey="Zwarts M" first="Machiel J." last="Zwarts">Machiel J. Zwarts</name>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neurology, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neurology, Nijmegen</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:7D62E3CABD85719E8FF1613FE6E344556F57BB31</idno>
<date when="2011" year="2011">2011</date>
<idno type="doi">10.1002/mds.23720</idno>
<idno type="url">https://api.istex.fr/document/7D62E3CABD85719E8FF1613FE6E344556F57BB31/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">002A10</idno>
<idno type="wicri:Area/Main/Curation">002655</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Pathophysiology of diurnal drooling in Parkinson's disease</title>
<author><name sortKey="Kalf, Johanna G" sort="Kalf, Johanna G" uniqKey="Kalf J" first="Johanna G." last="Kalf">Johanna G. Kalf</name>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, Department of Rehabilitation, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, Department of Rehabilitation, Nijmegen</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neurology, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neurology, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Munneke, Marten" sort="Munneke, Marten" uniqKey="Munneke M" first="Marten" last="Munneke">Marten Munneke</name>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, Department of Rehabilitation, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, Department of Rehabilitation, Nijmegen</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, IQ Healthcare, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, IQ Healthcare, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Den Engel Oek, Lenie" sort="Van Den Engel Oek, Lenie" uniqKey="Van Den Engel Oek L" first="Lenie" last="Van Den Engel-Hoek">Lenie Van Den Engel-Hoek</name>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, Department of Rehabilitation, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, Department of Rehabilitation, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Swart, Bert J" sort="De Swart, Bert J" uniqKey="De Swart B" first="Bert J." last="De Swart">Bert J. De Swart</name>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, Department of Rehabilitation, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice, Department of Rehabilitation, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Borm, George F" sort="Borm, George F" uniqKey="Borm G" first="George F." last="Borm">George F. Borm</name>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice Department of Epidemiology, Biostatistics and HTA, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen Medical Centre, Nijmegen Centre of Evidence‐Based Practice Department of Epidemiology, Biostatistics and HTA, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bloem, Bastiaan R" sort="Bloem, Bastiaan R" uniqKey="Bloem B" first="Bastiaan R." last="Bloem">Bastiaan R. Bloem</name>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neurology, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neurology, Nijmegen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zwarts, Machiel J" sort="Zwarts, Machiel J" uniqKey="Zwarts M" first="Machiel J." last="Zwarts">Machiel J. Zwarts</name>
<affiliation wicri:level="1"><mods:affiliation>Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neurology, Nijmegen, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neurology, Nijmegen</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2011-08-01">2011-08-01</date>
<biblScope unit="volume">26</biblScope>
<biblScope unit="issue">9</biblScope>
<biblScope unit="page" from="1670">1670</biblScope>
<biblScope unit="page" to="1676">1676</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">7D62E3CABD85719E8FF1613FE6E344556F57BB31</idno>
<idno type="DOI">10.1002/mds.23720</idno>
<idno type="ArticleID">MDS23720</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term>
<term>drooling</term>
<term>dysphagia</term>
<term>hypomimia</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Drooling is an incapacitating feature of Parkinson's disease. Better pathophysiological insights are needed to improve treatment. In this study, we tested the hypothesis that the cause of drooling is multifactorial. We examined 15 patients with Parkinson's disease with distinct diurnal saliva loss (“droolers”) and 15 patients with Parkinson's disease without drooling complaints (“nondroolers”). We evaluated all factors that could potentially contribute to drooling: swallowing capacity (maximum volume), functional swallowing (assessed with the dysphagia subscale of the Therapy Outcome Measures for rehabilitation specialists), unintentional mouth opening due to hypomimia (Unified Parkinson's Disease Rating Scale item), posture (quantified from sagittal photographs), and nose‐breathing ability. We also quantified the frequency of spontaneous swallowing during 45 minutes of quiet sitting, using polygraphy. Droolers had more advanced Parkinson's disease than nondroolers (Unified Parkinson's Disease Rating Scale motor score 31 vs 22; P = .014). Droolers also scored significantly worse on all recorded variables except for nose breathing. Swallowing frequency tended to be higher, possibly to compensate for less efficient swallowing. Logistic regression with adjustment for age and disease severity showed that hypomimia correlated best with drooling. Linear regression with hypomimia as the dependent variable identified disease severity, dysphagia, and male sex as significant explanatory factors. Drooling in Parkinson's disease results from multiple risk factors, with hypomimia being the most prominent. When monitored, patients appear to compensate by increasing their swallowing frequency, much like the increased cadence that is used to compensate for stepping akinesia. These findings can provide a rationale for behavioral approaches to treat drooling. © 2011 Movement Disorder Society</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002655 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 002655 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:7D62E3CABD85719E8FF1613FE6E344556F57BB31 |texte= Pathophysiology of diurnal drooling in Parkinson's disease }}
This area was generated with Dilib version V0.6.23. |