Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease
Identifieur interne : 001B92 ( Main/Curation ); précédent : 001B91; suivant : 001B93Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease
Auteurs : Julien Chapuis ; Frdric Moisan ; Georges Mellick ; Alexis Elbaz ; Peter Silburn ; Florence Pasquier ; Didier Hannequin [France] ; Corinne Lendon ; Dominique Campion [France] ; Philippe Amouyel ; Jean-Charles Lambert [France]Source :
- Human Molecular Genetics [ 0964-6906 ] ; 2008-09-15.
Abstract
Alzheimer's disease (AD) and Parkinson's disease (PD), the two most common neurodegenerative disorders in the elderly, have been hypothesized to share genetic determinants. Recently, Li et al. proposed that a variant in the NEDD9 gene may be one of these common genetic factors. We attempted to confirm this initial observation by conducting an equivalent analysis in terms of pathologies and sample size. We genotyped the NEDD9 rs760678 SNP in three independent AD casecontrol studies (n 3176) and two independent PD casecontrol studies (n 1855). However, we failed to detect an association of this SNP with the risk of developing AD or PD, in any of these populations. In conclusion, these data indicate that the rs760678 SNP of the NEDD9 gene is at best a weak genetic determinant of AD or PD.
Url:
DOI: 10.1093/hmg/ddn183
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001E81
Links to Exploration step
ISTEX:A41BD80097BCF3CF1F839BFB926EC2C53657A76ECuration
No country items
Julien Chapuis<affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: jean-charles.lambert@pasteur-lille.fr</mods:affiliation><country wicri:rule="url">France</country></affiliation>Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease</title><author><name sortKey="Chapuis, Julien" sort="Chapuis, Julien" uniqKey="Chapuis J" first="Julien" last="Chapuis">Julien Chapuis</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Moisan, Frdric" sort="Moisan, Frdric" uniqKey="Moisan F" first="Frdric" last="Moisan">Frdric Moisan</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Mellick, Georges" sort="Mellick, Georges" uniqKey="Mellick G" first="Georges" last="Mellick">Georges Mellick</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Silburn, Peter" sort="Silburn, Peter" uniqKey="Silburn P" first="Peter" last="Silburn">Peter Silburn</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><affiliation wicri:level="1"><mods:affiliation>14, Faculty of Medicine, IFRMP, Rouen, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>14, Faculty of Medicine, IFRMP, Rouen</wicri:regionArea></affiliation></author><author><name sortKey="Lendon, Corinne" sort="Lendon, Corinne" uniqKey="Lendon C" first="Corinne" last="Lendon">Corinne Lendon</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><affiliation wicri:level="1"><mods:affiliation>14, Faculty of Medicine, IFRMP, Rouen, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>14, Faculty of Medicine, IFRMP, Rouen</wicri:regionArea></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: jean-charles.lambert@pasteur-lille.fr</mods:affiliation><country wicri:rule="url">France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A41BD80097BCF3CF1F839BFB926EC2C53657A76E</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1093/hmg/ddn183</idno><idno type="url">https://api.istex.fr/document/A41BD80097BCF3CF1F839BFB926EC2C53657A76E/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001E81</idno><idno type="wicri:Area/Main/Curation">001B92</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease</title><author><name sortKey="Chapuis, Julien" sort="Chapuis, Julien" uniqKey="Chapuis J" first="Julien" last="Chapuis">Julien Chapuis</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Moisan, Frdric" sort="Moisan, Frdric" uniqKey="Moisan F" first="Frdric" last="Moisan">Frdric Moisan</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Mellick, Georges" sort="Mellick, Georges" uniqKey="Mellick G" first="Georges" last="Mellick">Georges Mellick</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Silburn, Peter" sort="Silburn, Peter" uniqKey="Silburn P" first="Peter" last="Silburn">Peter Silburn</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><affiliation wicri:level="1"><mods:affiliation>14, Faculty of Medicine, IFRMP, Rouen, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>14, Faculty of Medicine, IFRMP, Rouen</wicri:regionArea></affiliation></author><author><name sortKey="Lendon, Corinne" sort="Lendon, Corinne" uniqKey="Lendon C" first="Corinne" last="Lendon">Corinne Lendon</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><affiliation wicri:level="1"><mods:affiliation>14, Faculty of Medicine, IFRMP, Rouen, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>14, Faculty of Medicine, IFRMP, Rouen</wicri:regionArea></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: jean-charles.lambert@pasteur-lille.fr</mods:affiliation><country wicri:rule="url">France</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2008-09-15">2008-09-15</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">18</biblScope><biblScope unit="page" from="2863">2863</biblScope><biblScope unit="page" to="2867">2867</biblScope></imprint><idno type="ISSN">0964-6906</idno></series><idno type="istex">A41BD80097BCF3CF1F839BFB926EC2C53657A76E</idno><idno type="DOI">10.1093/hmg/ddn183</idno><idno type="ArticleID">ddn183</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0964-6906</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Alzheimer's disease (AD) and Parkinson's disease (PD), the two most common neurodegenerative disorders in the elderly, have been hypothesized to share genetic determinants. Recently, Li et al. proposed that a variant in the NEDD9 gene may be one of these common genetic factors. We attempted to confirm this initial observation by conducting an equivalent analysis in terms of pathologies and sample size. We genotyped the NEDD9 rs760678 SNP in three independent AD casecontrol studies (n 3176) and two independent PD casecontrol studies (n 1855). However, we failed to detect an association of this SNP with the risk of developing AD or PD, in any of these populations. In conclusion, these data indicate that the rs760678 SNP of the NEDD9 gene is at best a weak genetic determinant of AD or PD.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B92 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001B92 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Curation
|type= RBID
|clé= ISTEX:A41BD80097BCF3CF1F839BFB926EC2C53657A76E
|texte= Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |