Association Between Lifetime Cigarette Smoking and Lewy Body Accumulation
Identifieur interne : 001A84 ( Main/Curation ); précédent : 001A83; suivant : 001A85Association Between Lifetime Cigarette Smoking and Lewy Body Accumulation
Auteurs : Debby Tsuang ; Eric B. Larson ; Ge Li ; Jane B. Shofer ; Kathleen S. Montine ; Mary Lou Thompson ; Joshua A. Sonnen ; Paul K. Crane ; James B. Leverenz ; Thomas J. MontineSource :
- Brain Pathology [ 1015-6305 ] ; 2010-03.
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Abstract
Cigarette smoking has been associated repeatedly in observational studies with decreased risk of Parkinson's disease (PD), but its relationship to the risk of dementia or Alzheimer's disease (AD) is inconsistent. All of these studies have used clinical diagnoses of disease. We tested the hypothesis that lifetime cigarette use might be associated with reduced risk of neuropathologic changes of Lewy‐related pathology (LRP) in multiple brain regions or with reduced risk of consensus neuropathologic changes of AD in a prospective community‐based study of brain aging and dementia, the Adult Changes in Thought (ACT) study. We observed that heavy lifetime cigarette smoking (>50 pack years) was associated with significantly reduced relative risk (RR) for LRP, but not AD‐type pathologic changes, after correcting for selection bias, and with significantly reduced frequency of LRP in the substantia nigra. These findings are the first of which we are aware to associate reduced LRP in human brain with any exposure, and substantiate observational studies that have associated cigarette smoking with reduced risk of PD. Although cigarette smoking is too toxic to suggest as a treatment, if confirmed, these findings may guide future therapeutic strategies that attempt to suppress LRP in human brain by other means.
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DOI: 10.1111/j.1750-3639.2009.00296.x
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Debby Tsuang<affiliation><mods:affiliation>Departments of Psychiatry and Behavioral Sciences,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Mental Illness and</mods:affiliation><wicri:noCountry code="no comma">Mental Illness and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Mental Illness and</mods:affiliation><wicri:noCountry code="no comma">Mental Illness and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Internal Medicine,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Center for Health Studies, Group Health Cooperative, Seattle, Wash.</mods:affiliation><wicri:noCountry code="subField">Wash</wicri:noCountry></affiliation><affiliation><mods:affiliation>Center for Health Studies, Group Health Cooperative, Seattle, Wash.</mods:affiliation><wicri:noCountry code="subField">Wash</wicri:noCountry></affiliation><affiliation><mods:affiliation>Departments of Psychiatry and Behavioral Sciences,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Mental Illness and</mods:affiliation><wicri:noCountry code="no comma">Mental Illness and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Mental Illness and</mods:affiliation><wicri:noCountry code="no comma">Mental Illness and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Departments of Psychiatry and Behavioral Sciences,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Pathology, University of Washington, Seattle, Wash.</mods:affiliation><wicri:noCountry code="subField">Wash</wicri:noCountry></affiliation><affiliation><mods:affiliation>Biostatistics,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Pathology, University of Washington, Seattle, Wash.</mods:affiliation><wicri:noCountry code="subField">Wash</wicri:noCountry></affiliation><affiliation><mods:affiliation>Internal Medicine,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Departments of Psychiatry and Behavioral Sciences,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Neurology, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Mental Illness and</mods:affiliation><wicri:noCountry code="no comma">Mental Illness and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Parkinson's Disease Research, Education, and Clinical Centers, VA Puget Sound Health Care System, Seattle, Wash.</mods:affiliation><wicri:noCountry code="subField">Wash</wicri:noCountry></affiliation><affiliation><mods:affiliation>Neurology, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Mental Illness and</mods:affiliation><wicri:noCountry code="no comma">Mental Illness and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Parkinson's Disease Research, Education, and Clinical Centers, VA Puget Sound Health Care System, Seattle, Wash.</mods:affiliation><wicri:noCountry code="subField">Wash</wicri:noCountry></affiliation><affiliation><mods:affiliation>Mental Illness and</mods:affiliation><wicri:noCountry code="no comma">Mental Illness and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Parkinson's Disease Research, Education, and Clinical Centers, VA Puget Sound Health Care System, Seattle, Wash.</mods:affiliation><wicri:noCountry code="subField">Wash</wicri:noCountry></affiliation><affiliation><mods:affiliation>Parkinson's Disease Research, Education, and Clinical Centers, VA Puget Sound Health Care System, Seattle, Wash.</mods:affiliation><wicri:noCountry code="subField">Wash</wicri:noCountry></affiliation><affiliation><mods:affiliation>Pathology, University of Washington, Seattle, Wash.</mods:affiliation><wicri:noCountry code="subField">Wash</wicri:noCountry></affiliation>Le document en format XML
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Larson</name><affiliation><mods:affiliation>Internal Medicine,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Center for Health Studies, Group Health Cooperative, Seattle, Wash.</mods:affiliation><wicri:noCountry code="subField">Wash</wicri:noCountry></affiliation></author><author><name sortKey="Li, Ge" sort="Li, Ge" uniqKey="Li G" first="Ge" last="Li">Ge Li</name><affiliation><mods:affiliation>Departments of Psychiatry and Behavioral Sciences,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Mental Illness and</mods:affiliation><wicri:noCountry code="no comma">Mental Illness and</wicri:noCountry></affiliation></author><author><name sortKey="Shofer, Jane B" sort="Shofer, Jane B" uniqKey="Shofer J" first="Jane B." last="Shofer">Jane B. 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Montine</name><affiliation><mods:affiliation>Pathology, University of Washington, Seattle, Wash.</mods:affiliation><wicri:noCountry code="subField">Wash</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:0F1863979E03ADF4E80E9BC55A406F116EF9B18A</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1111/j.1750-3639.2009.00296.x</idno><idno type="url">https://api.istex.fr/document/0F1863979E03ADF4E80E9BC55A406F116EF9B18A/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001D64</idno><idno type="wicri:Area/Main/Curation">001A84</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Association Between Lifetime Cigarette Smoking and Lewy Body Accumulation</title><author><name sortKey="Tsuang, Debby" sort="Tsuang, Debby" uniqKey="Tsuang D" first="Debby" last="Tsuang">Debby Tsuang</name><affiliation><mods:affiliation>Departments of Psychiatry and Behavioral Sciences,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Mental Illness and</mods:affiliation><wicri:noCountry code="no comma">Mental Illness and</wicri:noCountry></affiliation></author><author><name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B." last="Larson">Eric B. Larson</name><affiliation><mods:affiliation>Internal Medicine,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Center for Health Studies, Group Health Cooperative, Seattle, Wash.</mods:affiliation><wicri:noCountry code="subField">Wash</wicri:noCountry></affiliation></author><author><name sortKey="Li, Ge" sort="Li, Ge" uniqKey="Li G" first="Ge" last="Li">Ge Li</name><affiliation><mods:affiliation>Departments of Psychiatry and Behavioral Sciences,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Mental Illness and</mods:affiliation><wicri:noCountry code="no comma">Mental Illness and</wicri:noCountry></affiliation></author><author><name sortKey="Shofer, Jane B" sort="Shofer, Jane B" uniqKey="Shofer J" first="Jane B." last="Shofer">Jane B. Shofer</name><affiliation><mods:affiliation>Departments of Psychiatry and Behavioral Sciences,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Montine, Kathleen S" sort="Montine, Kathleen S" uniqKey="Montine K" first="Kathleen S." last="Montine">Kathleen S. Montine</name><affiliation><mods:affiliation>Pathology, University of Washington, Seattle, Wash.</mods:affiliation><wicri:noCountry code="subField">Wash</wicri:noCountry></affiliation></author><author><name sortKey="Thompson, Mary Lou" sort="Thompson, Mary Lou" uniqKey="Thompson M" first="Mary Lou" last="Thompson">Mary Lou Thompson</name><affiliation><mods:affiliation>Biostatistics,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Sonnen, Joshua A" sort="Sonnen, Joshua A" uniqKey="Sonnen J" first="Joshua A." last="Sonnen">Joshua A. Sonnen</name><affiliation><mods:affiliation>Pathology, University of Washington, Seattle, Wash.</mods:affiliation><wicri:noCountry code="subField">Wash</wicri:noCountry></affiliation></author><author><name sortKey="Crane, Paul K" sort="Crane, Paul K" uniqKey="Crane P" first="Paul K." last="Crane">Paul K. Crane</name><affiliation><mods:affiliation>Internal Medicine,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name><affiliation><mods:affiliation>Departments of Psychiatry and Behavioral Sciences,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Neurology, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Mental Illness and</mods:affiliation><wicri:noCountry code="no comma">Mental Illness and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Parkinson's Disease Research, Education, and Clinical Centers, VA Puget Sound Health Care System, Seattle, Wash.</mods:affiliation><wicri:noCountry code="subField">Wash</wicri:noCountry></affiliation></author><author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name><affiliation><mods:affiliation>Pathology, University of Washington, Seattle, Wash.</mods:affiliation><wicri:noCountry code="subField">Wash</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Pathology</title><idno type="ISSN">1015-6305</idno><idno type="eISSN">1750-3639</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-03">2010-03</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="412">412</biblScope><biblScope unit="page" to="418">418</biblScope></imprint><idno type="ISSN">1015-6305</idno></series><idno type="istex">0F1863979E03ADF4E80E9BC55A406F116EF9B18A</idno><idno type="DOI">10.1111/j.1750-3639.2009.00296.x</idno><idno type="ArticleID">BPA296</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1015-6305</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer's disease</term><term>Lewy body</term><term>neuropathology</term><term>smoking</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cigarette smoking has been associated repeatedly in observational studies with decreased risk of Parkinson's disease (PD), but its relationship to the risk of dementia or Alzheimer's disease (AD) is inconsistent. All of these studies have used clinical diagnoses of disease. We tested the hypothesis that lifetime cigarette use might be associated with reduced risk of neuropathologic changes of Lewy‐related pathology (LRP) in multiple brain regions or with reduced risk of consensus neuropathologic changes of AD in a prospective community‐based study of brain aging and dementia, the Adult Changes in Thought (ACT) study. We observed that heavy lifetime cigarette smoking (>50 pack years) was associated with significantly reduced relative risk (RR) for LRP, but not AD‐type pathologic changes, after correcting for selection bias, and with significantly reduced frequency of LRP in the substantia nigra. These findings are the first of which we are aware to associate reduced LRP in human brain with any exposure, and substantiate observational studies that have associated cigarette smoking with reduced risk of PD. Although cigarette smoking is too toxic to suggest as a treatment, if confirmed, these findings may guide future therapeutic strategies that attempt to suppress LRP in human brain by other means.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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