Subthalamic nucleus deep brain stimulation outcome in young onset Parkinson's disease: a role for age at disease onset?
Identifieur interne : 001A06 ( Main/Curation ); précédent : 001A05; suivant : 001A07Subthalamic nucleus deep brain stimulation outcome in young onset Parkinson's disease: a role for age at disease onset?
Auteurs : Aristide Merola [Italie] ; Maurizio Zibetti [Italie] ; Carlo Alberto Artusi [Italie] ; Alice Marchisio [Italie] ; Valeria Ricchi [Italie] ; Laura Rizzi [Italie] ; Serena Angrisano [Italie] ; Nichy Arduino [Italie] ; Michele Lanotte [Italie] ; Mario Rizzone [Italie] ; Leonardo Lopiano [Italie]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2012-03.
Abstract
Background Patients with young onset Parkinson's disease (YOPD) are often candidates for subthalamic nucleus–deep brain stimulation (STN–DBS). Nevertheless, few data have been reported on the long term STN–DBS clinical outcome of YOPD versus non-young onset Parkinson's disease (n-YOPD) patients. Aim In this study, the issue of whether YOPD might represent a long term positive predictive factor for STN–DBS was addressed, comparing follow-up data for 20 YOPD and 40 n-YOPD patients (20 treated after <15 years of disease duration and 20 treated after ≥15 years of disease duration). Materials and methods Mean scores for the Unified Parkinson's Disease Rating Scale (UPDRS) sections were compared 1 year, 5 years and, for 34 patients (12 YOPD and 22 n-YOPD), ≥7 years after surgery. Furthermore, a Cox proportional hazard regression model was used to determine the influence of age at PD onset, clinical phenotype, disease duration and duration of motor complications on the development of stimulation and medication resistant symptoms. Results YOPD patients showed a lower incidence of stimulation and medication resistant symptoms and a lower mortality rate; also, the tremor dominant clinical phenotype was associated with a lower risk of developing dementia, hallucinations and constipation. No significant differences in UPDRS scores were observed between n-YOPD patients treated after <15 years of PD and those treated after ≥15 years of PD. Conclusion In this series of STN–DBS treated patients, YOPD was associated with a medium to long term lower incidence of stimulation and medication resistant symptoms.
Url:
DOI: 10.1136/jnnp-2011-300470
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001C79
Links to Exploration step
ISTEX:BEF3A34B003D8B6CA9677F2C131AC5E3F9C82716Curation
No country items
Aristide Merola<affiliation><mods:affiliation>E-mail: aristidemerola@hotmail.com</mods:affiliation><wicri:noCountry code="no comma">E-mail: aristidemerola@hotmail.com</wicri:noCountry></affiliation>Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Subthalamic nucleus deep brain stimulation outcome in young onset Parkinson's disease: a role for age at disease onset?</title><author><name sortKey="Merola, Aristide" sort="Merola, Aristide" uniqKey="Merola A" first="Aristide" last="Merola">Aristide Merola</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation><affiliation><mods:affiliation>E-mail: aristidemerola@hotmail.com</mods:affiliation><wicri:noCountry code="no comma">E-mail: aristidemerola@hotmail.com</wicri:noCountry></affiliation></author><author><name sortKey="Zibetti, Maurizio" sort="Zibetti, Maurizio" uniqKey="Zibetti M" first="Maurizio" last="Zibetti">Maurizio Zibetti</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Artusi, Carlo Alberto" sort="Artusi, Carlo Alberto" uniqKey="Artusi C" first="Carlo Alberto" last="Artusi">Carlo Alberto Artusi</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Marchisio, Alice" sort="Marchisio, Alice" uniqKey="Marchisio A" first="Alice" last="Marchisio">Alice Marchisio</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Ricchi, Valeria" sort="Ricchi, Valeria" uniqKey="Ricchi V" first="Valeria" last="Ricchi">Valeria Ricchi</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Rizzi, Laura" sort="Rizzi, Laura" uniqKey="Rizzi L" first="Laura" last="Rizzi">Laura Rizzi</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Angrisano, Serena" sort="Angrisano, Serena" uniqKey="Angrisano S" first="Serena" last="Angrisano">Serena Angrisano</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Arduino, Nichy" sort="Arduino, Nichy" uniqKey="Arduino N" first="Nichy" last="Arduino">Nichy Arduino</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Lanotte, Michele" sort="Lanotte, Michele" uniqKey="Lanotte M" first="Michele" last="Lanotte">Michele Lanotte</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Rizzone, Mario" sort="Rizzone, Mario" uniqKey="Rizzone M" first="Mario" last="Rizzone">Mario Rizzone</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Lopiano, Leonardo" sort="Lopiano, Leonardo" uniqKey="Lopiano L" first="Leonardo" last="Lopiano">Leonardo Lopiano</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:BEF3A34B003D8B6CA9677F2C131AC5E3F9C82716</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1136/jnnp-2011-300470</idno><idno type="url">https://api.istex.fr/document/BEF3A34B003D8B6CA9677F2C131AC5E3F9C82716/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001C79</idno><idno type="wicri:Area/Main/Curation">001A06</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Subthalamic nucleus deep brain stimulation outcome in young onset Parkinson's disease: a role for age at disease onset?</title><author><name sortKey="Merola, Aristide" sort="Merola, Aristide" uniqKey="Merola A" first="Aristide" last="Merola">Aristide Merola</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation><affiliation><mods:affiliation>E-mail: aristidemerola@hotmail.com</mods:affiliation><wicri:noCountry code="no comma">E-mail: aristidemerola@hotmail.com</wicri:noCountry></affiliation></author><author><name sortKey="Zibetti, Maurizio" sort="Zibetti, Maurizio" uniqKey="Zibetti M" first="Maurizio" last="Zibetti">Maurizio Zibetti</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Artusi, Carlo Alberto" sort="Artusi, Carlo Alberto" uniqKey="Artusi C" first="Carlo Alberto" last="Artusi">Carlo Alberto Artusi</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Marchisio, Alice" sort="Marchisio, Alice" uniqKey="Marchisio A" first="Alice" last="Marchisio">Alice Marchisio</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Ricchi, Valeria" sort="Ricchi, Valeria" uniqKey="Ricchi V" first="Valeria" last="Ricchi">Valeria Ricchi</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Rizzi, Laura" sort="Rizzi, Laura" uniqKey="Rizzi L" first="Laura" last="Rizzi">Laura Rizzi</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Angrisano, Serena" sort="Angrisano, Serena" uniqKey="Angrisano S" first="Serena" last="Angrisano">Serena Angrisano</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Arduino, Nichy" sort="Arduino, Nichy" uniqKey="Arduino N" first="Nichy" last="Arduino">Nichy Arduino</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Lanotte, Michele" sort="Lanotte, Michele" uniqKey="Lanotte M" first="Michele" last="Lanotte">Michele Lanotte</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Rizzone, Mario" sort="Rizzone, Mario" uniqKey="Rizzone M" first="Mario" last="Rizzone">Mario Rizzone</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author><author><name sortKey="Lopiano, Leonardo" sort="Lopiano, Leonardo" uniqKey="Lopiano L" first="Leonardo" last="Lopiano">Leonardo Lopiano</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, University of Turin, Turin, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Turin, Turin</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2012-03">2012-03</date><biblScope unit="volume">83</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="251">251</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">BEF3A34B003D8B6CA9677F2C131AC5E3F9C82716</idno><idno type="DOI">10.1136/jnnp-2011-300470</idno><idno type="href">jnnp-83-251.pdf</idno><idno type="ArticleID">jnnp-2011-300470</idno><idno type="PMID">22180646</idno><idno type="local">jnnp;83/3/251</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background Patients with young onset Parkinson's disease (YOPD) are often candidates for subthalamic nucleus–deep brain stimulation (STN–DBS). Nevertheless, few data have been reported on the long term STN–DBS clinical outcome of YOPD versus non-young onset Parkinson's disease (n-YOPD) patients. Aim In this study, the issue of whether YOPD might represent a long term positive predictive factor for STN–DBS was addressed, comparing follow-up data for 20 YOPD and 40 n-YOPD patients (20 treated after <15 years of disease duration and 20 treated after ≥15 years of disease duration). Materials and methods Mean scores for the Unified Parkinson's Disease Rating Scale (UPDRS) sections were compared 1 year, 5 years and, for 34 patients (12 YOPD and 22 n-YOPD), ≥7 years after surgery. Furthermore, a Cox proportional hazard regression model was used to determine the influence of age at PD onset, clinical phenotype, disease duration and duration of motor complications on the development of stimulation and medication resistant symptoms. Results YOPD patients showed a lower incidence of stimulation and medication resistant symptoms and a lower mortality rate; also, the tremor dominant clinical phenotype was associated with a lower risk of developing dementia, hallucinations and constipation. No significant differences in UPDRS scores were observed between n-YOPD patients treated after <15 years of PD and those treated after ≥15 years of PD. Conclusion In this series of STN–DBS treated patients, YOPD was associated with a medium to long term lower incidence of stimulation and medication resistant symptoms.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A06 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001A06 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Curation
|type= RBID
|clé= ISTEX:BEF3A34B003D8B6CA9677F2C131AC5E3F9C82716
|texte= Subthalamic nucleus deep brain stimulation outcome in young onset Parkinson's disease: a role for age at disease onset?
}}
| This area was generated with Dilib version V0.6.23. |  |