Handedness and motor symptom asymmetry in Parkinson's disease
Identifieur interne : 001873 ( Main/Curation ); précédent : 001872; suivant : 001874Handedness and motor symptom asymmetry in Parkinson's disease
Auteurs : Matthew J. Barrett [États-Unis] ; Scott A. Wylie [États-Unis] ; Madaline B. Harrison [États-Unis] ; G Frederick Wooten [États-Unis]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2011-10.
Abstract
Background The objective of this study was to confirm whether an association between handedness and the side of symptom onset exists and to evaluate the impact of this association on specific clinical characteristics of Parkinson's disease (PD). Methods 1173 PD patients were identified from a clinical database. Patients with asymmetrical onset (n=1015) were divided into those with dominant-side onset and those with non-dominant-side onset, and the clinical characteristics of the two subgroups were compared. Results In our PD sample, 86.5% of patients presented asymmetrically. There was a significant association between handedness and the side of the initial symptom; that is, the dominant side was affected first in the majority of both left- and right-handed patients. Compared with patients with non-dominant side onset, more patients with dominant-side onset presented with bradykinesia, while fewer patients presented with gait difficulty. Patients with dominant-side onset were diagnosed and began dopaminergic medication after a longer symptom duration than patients with non-dominant-side onset. The only difference in Unified Parkinson Disease Rating Scale scores between the two groups was in a subscore addressing dominant-hand tasks. Conclusions An association exists between the dominant hand and the side of the initial motor symptom in PD. Whether the initial symptom occurs on the dominant or non-dominant side has implications for the reported first symptom, the time to diagnosis and the time to dopaminergic treatment initiation. The side of disease onset does not affect the severity of disease, as measured by the Unified Parkinson Disease Rating Scale.
Url:
DOI: 10.1136/jnnp.2010.209783
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001B36
Links to Exploration step
ISTEX:AEFA399C6EA9022BCC5242FC0C27D141CD8DB5E1Curation
No country items
Matthew J. Barrett<affiliation><mods:affiliation>E-mail: mabarrett@chpnet.org</mods:affiliation>
<wicri:noCountry code="no comma">E-mail: mabarrett@chpnet.org</wicri:noCountry>
</affiliation>
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Handedness and motor symptom asymmetry in Parkinson's disease</title>
<author><name sortKey="Barrett, Matthew J" sort="Barrett, Matthew J" uniqKey="Barrett M" first="Matthew J" last="Barrett">Matthew J. Barrett</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Beth Israel Medical Center, New York, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Beth Israel Medical Center, New York</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>E-mail: mabarrett@chpnet.org</mods:affiliation>
<wicri:noCountry code="no comma">E-mail: mabarrett@chpnet.org</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wylie, Scott A" sort="Wylie, Scott A" uniqKey="Wylie S" first="Scott A" last="Wylie">Scott A. Wylie</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Virginia, Charlottesville, Virginia, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Virginia, Charlottesville, Virginia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harrison, Madaline B" sort="Harrison, Madaline B" uniqKey="Harrison M" first="Madaline B" last="Harrison">Madaline B. Harrison</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Virginia, Charlottesville, Virginia, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Virginia, Charlottesville, Virginia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wooten, G Frederick" sort="Wooten, G Frederick" uniqKey="Wooten G" first="G Frederick" last="Wooten">G Frederick Wooten</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Virginia, Charlottesville, Virginia, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Virginia, Charlottesville, Virginia</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:AEFA399C6EA9022BCC5242FC0C27D141CD8DB5E1</idno>
<date when="2011" year="2011">2011</date>
<idno type="doi">10.1136/jnnp.2010.209783</idno>
<idno type="url">https://api.istex.fr/document/AEFA399C6EA9022BCC5242FC0C27D141CD8DB5E1/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">001B36</idno>
<idno type="wicri:Area/Main/Curation">001873</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Handedness and motor symptom asymmetry in Parkinson's disease</title>
<author><name sortKey="Barrett, Matthew J" sort="Barrett, Matthew J" uniqKey="Barrett M" first="Matthew J" last="Barrett">Matthew J. Barrett</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Beth Israel Medical Center, New York, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Beth Israel Medical Center, New York</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>E-mail: mabarrett@chpnet.org</mods:affiliation>
<wicri:noCountry code="no comma">E-mail: mabarrett@chpnet.org</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wylie, Scott A" sort="Wylie, Scott A" uniqKey="Wylie S" first="Scott A" last="Wylie">Scott A. Wylie</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Virginia, Charlottesville, Virginia, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Virginia, Charlottesville, Virginia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harrison, Madaline B" sort="Harrison, Madaline B" uniqKey="Harrison M" first="Madaline B" last="Harrison">Madaline B. Harrison</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Virginia, Charlottesville, Virginia, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Virginia, Charlottesville, Virginia</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wooten, G Frederick" sort="Wooten, G Frederick" uniqKey="Wooten G" first="G Frederick" last="Wooten">G Frederick Wooten</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Virginia, Charlottesville, Virginia, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Virginia, Charlottesville, Virginia</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title>
<title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title>
<idno type="ISSN">0022-3050</idno>
<idno type="eISSN">1468-330X</idno>
<imprint><publisher>BMJ Publishing Group Ltd</publisher>
<date type="published" when="2011-10">2011-10</date>
<biblScope unit="volume">82</biblScope>
<biblScope unit="issue">10</biblScope>
<biblScope unit="page" from="1122">1122</biblScope>
</imprint>
<idno type="ISSN">0022-3050</idno>
</series>
<idno type="istex">AEFA399C6EA9022BCC5242FC0C27D141CD8DB5E1</idno>
<idno type="DOI">10.1136/jnnp.2010.209783</idno>
<idno type="href">jnnp-82-1122.pdf</idno>
<idno type="ArticleID">jnnp209783</idno>
<idno type="PMID">20861062</idno>
<idno type="local">jnnp;82/10/1122</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0022-3050</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract">Background The objective of this study was to confirm whether an association between handedness and the side of symptom onset exists and to evaluate the impact of this association on specific clinical characteristics of Parkinson's disease (PD). Methods 1173 PD patients were identified from a clinical database. Patients with asymmetrical onset (n=1015) were divided into those with dominant-side onset and those with non-dominant-side onset, and the clinical characteristics of the two subgroups were compared. Results In our PD sample, 86.5% of patients presented asymmetrically. There was a significant association between handedness and the side of the initial symptom; that is, the dominant side was affected first in the majority of both left- and right-handed patients. Compared with patients with non-dominant side onset, more patients with dominant-side onset presented with bradykinesia, while fewer patients presented with gait difficulty. Patients with dominant-side onset were diagnosed and began dopaminergic medication after a longer symptom duration than patients with non-dominant-side onset. The only difference in Unified Parkinson Disease Rating Scale scores between the two groups was in a subscore addressing dominant-hand tasks. Conclusions An association exists between the dominant hand and the side of the initial motor symptom in PD. Whether the initial symptom occurs on the dominant or non-dominant side has implications for the reported first symptom, the time to diagnosis and the time to dopaminergic treatment initiation. The side of disease onset does not affect the severity of disease, as measured by the Unified Parkinson Disease Rating Scale.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001873 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001873 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:AEFA399C6EA9022BCC5242FC0C27D141CD8DB5E1 |texte= Handedness and motor symptom asymmetry in Parkinson's disease }}
This area was generated with Dilib version V0.6.23. |