A subcortico-cortical cholinergic system is affected in Parkinson's disease
Identifieur interne : 001805 ( Main/Curation ); précédent : 001804; suivant : 001806A subcortico-cortical cholinergic system is affected in Parkinson's disease
Auteurs : Bruno Dunois ; Merle Ruberg ; France Javoy-Agid ; Alain Ploska ; Yves AgidSource :
- Brain Research [ 0006-8993 ] ; 1983.
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Abstract
CAT activity was decreased in the frontal cortex and the substantia innominata of parkinsonians subjects, post-mortem. The decrease was greater in the frontal cortex of parkinsonians with dimentia. The density of muscarinic cholinergic receptors increased in the cortex. This increase was inversely correlated with tremor. The effectsof these parameters of both neuronal degeneration and anticholinergic therapy are discussed.
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DOI: 10.1016/0006-8993(83)90096-3
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Bruno Dunois<affiliation><mods:affiliation>Laboratoire de Medicine Experimentale, UER Pitie-Salpetriere, 91 Boulevard de l'Hopital, 75634 Paris Cedex 13 (France)</mods:affiliation><wicri:noCountry code="subField">75634 Paris Cedex 13 (France)</wicri:noCountry></affiliation><affiliation><mods:affiliation>Laboratoire de Medicine Experimentale, UER Pitie-Salpetriere, 91 Boulevard de l'Hopital, 75634 Paris Cedex 13 (France)</mods:affiliation><wicri:noCountry code="subField">75634 Paris Cedex 13 (France)</wicri:noCountry></affiliation><affiliation><mods:affiliation>Laboratoire de Medicine Experimentale, UER Pitie-Salpetriere, 91 Boulevard de l'Hopital, 75634 Paris Cedex 13 (France)</mods:affiliation><wicri:noCountry code="subField">75634 Paris Cedex 13 (France)</wicri:noCountry></affiliation><affiliation><mods:affiliation>Laboratoire de Medicine Experimentale, UER Pitie-Salpetriere, 91 Boulevard de l'Hopital, 75634 Paris Cedex 13 (France)</mods:affiliation><wicri:noCountry code="subField">75634 Paris Cedex 13 (France)</wicri:noCountry></affiliation><affiliation><mods:affiliation>Laboratoire de Medicine Experimentale, UER Pitie-Salpetriere, 91 Boulevard de l'Hopital, 75634 Paris Cedex 13 (France)</mods:affiliation><wicri:noCountry code="subField">75634 Paris Cedex 13 (France)</wicri:noCountry></affiliation>Le document en format XML
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(France)</wicri:noCountry></affiliation></author><author><name sortKey="Ploska, Alain" sort="Ploska, Alain" uniqKey="Ploska A" first="Alain" last="Ploska">Alain Ploska</name><affiliation><mods:affiliation>Laboratoire de Medicine Experimentale, UER Pitie-Salpetriere, 91 Boulevard de l'Hopital, 75634 Paris Cedex 13 (France)</mods:affiliation><wicri:noCountry code="subField">75634 Paris Cedex 13 (France)</wicri:noCountry></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation><mods:affiliation>Laboratoire de Medicine Experimentale, UER Pitie-Salpetriere, 91 Boulevard de l'Hopital, 75634 Paris Cedex 13 (France)</mods:affiliation><wicri:noCountry code="subField">75634 Paris Cedex 13 (France)</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1983">1983</date><biblScope unit="volume">288</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="213">213</biblScope><biblScope unit="page" to="218">218</biblScope></imprint><idno type="ISSN">0006-8993</idno></series><idno type="istex">8CFDB99E814D27460574B10D4E18983E86D02CC2</idno><idno type="DOI">10.1016/0006-8993(83)90096-3</idno><idno type="PII">0006-8993(83)90096-3</idno><idno type="ArticleID">83900963</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term><term>Parkinson's disease</term><term>cerebral cortex</term><term>choline acetyltransferase</term><term>human brain</term><term>muscarinic receptors</term><term>substantia innominata</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">CAT activity was decreased in the frontal cortex and the substantia innominata of parkinsonians subjects, post-mortem. The decrease was greater in the frontal cortex of parkinsonians with dimentia. The density of muscarinic cholinergic receptors increased in the cortex. This increase was inversely correlated with tremor. The effectsof these parameters of both neuronal degeneration and anticholinergic therapy are discussed.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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