Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders
Identifieur interne : 001797 ( Main/Curation ); précédent : 001796; suivant : 001798Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders
Auteurs : Susan R. Criswell [États-Unis] ; Joel S. Perlmutter [États-Unis] ; John L. Huang [États-Unis] ; Nima Golchin [États-Unis] ; Hubert P. Flores [États-Unis] ; Angela Hobson [États-Unis] ; Michael Aschner [États-Unis] ; Keith M. Erikson [États-Unis] ; Harvey Checkoway [États-Unis] ; Brad A. Racette [États-Unis]Source :
- Occupational and Environmental Medicine [ 1351-0711 ] ; 2012-06.
Abstract
Objectives Manganese exposure leads to diffuse cerebral metal deposition with the highest concentration in the globus pallidus associated with increased T1-weighted MRI signal. T1 signal intensity in extra-pallidal basal ganglia (caudate and putamen) has not been studied in occupationally exposed workers. Diffusion weighted imaging is a non-invasive measure of neuronal damage and may provide a quantification of neurotoxicity associated with welding and manganese exposure. This study investigated extra-pallidal T1 basal ganglia signal intensity as a marker of manganese exposure and basal ganglia diffusion weighted imaging abnormalities as a potential marker of neurotoxicity. Methods A 3T MR case:control imaging study was performed on 18 welders and 18 age- and gender-matched controls. Basal ganglia regions of interest were identified for each subject. T1-weighted intensity indices and apparent diffusion coefficients were generated for each region. Results All regional indices were higher in welders than controls (p≤0.05). Combined basal ganglia (ρ=0.610), caudate (ρ=0.645), anterior (ρ=0.595) and posterior putamen (ρ=0.511) indices were more correlated with exposure than pallidal (ρ=0.484) index. Welder apparent diffusion coefficient values were lower than controls for globus pallidus (p=0.03) and anterior putamen (p=0.004). Conclusions Welders demonstrated elevated T1 indices throughout the basal ganglia. Combined basal ganglia, caudate and putamen indices were more correlated with exposure than pallidal index suggesting more inclusive basal ganglia sampling results in better exposure markers. Elevated indices were associated with diffusion weighted abnormalities in the pallidum and anterior putamen suggesting neurotoxicity in these regions.
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DOI: 10.1136/oemed-2011-100119
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Huang</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>American Parkinson Disease Association Advanced Center for Parkinson Research, St. Louis, Missouri, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>American Parkinson Disease Association Advanced Center for Parkinson Research, St. Louis, Missouri</wicri:regionArea></affiliation></author><author><name sortKey="Golchin, Nima" sort="Golchin, Nima" uniqKey="Golchin N" first="Nima" last="Golchin">Nima Golchin</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea></affiliation></author><author><name sortKey="Flores, Hubert P" sort="Flores, Hubert P" uniqKey="Flores H" first="Hubert P" last="Flores">Hubert P. Flores</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea></affiliation></author><author><name sortKey="Hobson, Angela" sort="Hobson, Angela" uniqKey="Hobson A" first="Angela" last="Hobson">Angela Hobson</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>American Parkinson Disease Association Advanced Center for Parkinson Research, St. Louis, Missouri, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>American Parkinson Disease Association Advanced Center for Parkinson Research, St. Louis, Missouri</wicri:regionArea></affiliation></author><author><name sortKey="Aschner, Michael" sort="Aschner, Michael" uniqKey="Aschner M" first="Michael" last="Aschner">Michael Aschner</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Erikson, Keith M" sort="Erikson, Keith M" uniqKey="Erikson K" first="Keith M" last="Erikson">Keith M. Erikson</name><affiliation wicri:level="1"><mods:affiliation>Department of Nutrition, University of North Carolina-Greensboro, Greensboro, North Carolina, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, University of North Carolina-Greensboro, Greensboro, North Carolina</wicri:regionArea></affiliation></author><author><name sortKey="Checkoway, Harvey" sort="Checkoway, Harvey" uniqKey="Checkoway H" first="Harvey" last="Checkoway">Harvey Checkoway</name><affiliation wicri:level="1"><mods:affiliation>Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, Washington, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, Washington</wicri:regionArea></affiliation></author><author><name sortKey="Racette, Brad A" sort="Racette, Brad A" uniqKey="Racette B" first="Brad A" last="Racette">Brad A. Racette</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>American Parkinson Disease Association Advanced Center for Parkinson Research, St. Louis, Missouri, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>American Parkinson Disease Association Advanced Center for Parkinson Research, St. Louis, Missouri</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Occupational and Environmental Medicine</title><title level="j" type="abbrev">Occup Environ Med</title><idno type="ISSN">1351-0711</idno><idno type="eISSN">1470-7926</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2012-06">2012-06</date><biblScope unit="volume">69</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="437">437</biblScope></imprint><idno type="ISSN">1351-0711</idno></series><idno type="istex">9E73C1CBFAC19305105A94BF2B5F7D538A426F73</idno><idno type="DOI">10.1136/oemed-2011-100119</idno><idno type="href">oemed-69-437.pdf</idno><idno type="ArticleID">oemed-2011-100119</idno><idno type="PMID">22447645</idno><idno type="local">oemed;69/6/437</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-0711</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objectives Manganese exposure leads to diffuse cerebral metal deposition with the highest concentration in the globus pallidus associated with increased T1-weighted MRI signal. T1 signal intensity in extra-pallidal basal ganglia (caudate and putamen) has not been studied in occupationally exposed workers. Diffusion weighted imaging is a non-invasive measure of neuronal damage and may provide a quantification of neurotoxicity associated with welding and manganese exposure. This study investigated extra-pallidal T1 basal ganglia signal intensity as a marker of manganese exposure and basal ganglia diffusion weighted imaging abnormalities as a potential marker of neurotoxicity. Methods A 3T MR case:control imaging study was performed on 18 welders and 18 age- and gender-matched controls. Basal ganglia regions of interest were identified for each subject. T1-weighted intensity indices and apparent diffusion coefficients were generated for each region. Results All regional indices were higher in welders than controls (p≤0.05). Combined basal ganglia (ρ=0.610), caudate (ρ=0.645), anterior (ρ=0.595) and posterior putamen (ρ=0.511) indices were more correlated with exposure than pallidal (ρ=0.484) index. Welder apparent diffusion coefficient values were lower than controls for globus pallidus (p=0.03) and anterior putamen (p=0.004). Conclusions Welders demonstrated elevated T1 indices throughout the basal ganglia. Combined basal ganglia, caudate and putamen indices were more correlated with exposure than pallidal index suggesting more inclusive basal ganglia sampling results in better exposure markers. Elevated indices were associated with diffusion weighted abnormalities in the pallidum and anterior putamen suggesting neurotoxicity in these regions.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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