High‐frequency stimulation of the subthalamic nucleus prolongs the increase in striatal dopamine induced by acute l‐3,4‐dihydroxyphenylalanine in dopaminergic denervated rats
Identifieur interne : 001789 ( Main/Curation ); précédent : 001788; suivant : 001790High‐frequency stimulation of the subthalamic nucleus prolongs the increase in striatal dopamine induced by acute l‐3,4‐dihydroxyphenylalanine in dopaminergic denervated rats
Auteurs : Emilie Lacombe ; Carole Carcenac ; Sabrina Boulet ; Claude Feuerstein [France] ; Anne Bertrand ; Annie Poupard ; Marc Savasta [France]Source :
- European Journal of Neuroscience [ 0953-816X ] ; 2007-09.
English descriptors
- KwdEn :
Abstract
High‐frequency stimulation of the subthalamic nucleus (STN‐HFS) is a powerful approach for treating the motor symptoms of Parkinson's disease (PD). It results in clinical improvement in patients with PD, further reducing the l‐3,4‐dihydroxyphenylalanine (L‐DOPA) requirement and thus L‐DOPA‐induced dyskinesia. However, it remains unclear how STN‐HFS modifies the response to L‐DOPA. We investigated the effect of STN‐HFS on striatal extracellular concentrations of dopamine and its metabolites following acute L‐DOPA administration in intact or partially dopaminergic denervated (DA‐PL) rats. L‐DOPA treatment significantly increased striatal dopamine levels in intact and DA‐PL animals, with the maximal effect observed 1 h after L‐DOPA injection. This increase was more pronounced in DA‐PL rats (ipsilateral to the lesion) than in intact animals. It remained fairly stable 1 h after the maximal effect of L‐DOPA and then decreased towards basal values. STN‐HFS in intact rats had no effect on the maximal L‐DOPA‐induced increase in striatal extracellular dopamine concentration or the return to basal values, the profiles observed being similar to those for non‐stimulated intact animals. Conversely, STN‐HFS amplified the L‐DOPA‐induced increase in striatal dopamine levels during the stimulation period (1 h) in DA‐PL rats and this increase was sustained throughout the post‐stimulation period (2.5 h), without the return to basal levels observed in stimulated intact and non‐stimulated rats. These new neurochemical data suggest that STN‐HFS interferes with L‐DOPA effects, probably synergically, by stabilizing dopamine levels in the striatum and shed light on the mechanisms of STN‐HFS in PD.
Url:
DOI: 10.1111/j.1460-9568.2007.05747.x
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001A47
Links to Exploration step
ISTEX:E9089923F3EF1906FF4AD539ED2F26EFCE5872EECuration
No country items
Emilie Lacombe<affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre Hospitalier Universitaire de Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire de Grenoble, Grenoble</wicri:regionArea></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre Hospitalier Universitaire de Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire de Grenoble, Grenoble</wicri:regionArea></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre Hospitalier Universitaire de Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire de Grenoble, Grenoble</wicri:regionArea></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre Hospitalier Universitaire de Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire de Grenoble, Grenoble</wicri:regionArea></affiliation>Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">High‐frequency stimulation of the subthalamic nucleus prolongs the increase in striatal dopamine induced by acute l‐3,4‐dihydroxyphenylalanine in dopaminergic denervated rats</title><author><name sortKey="Lacombe, Emilie" sort="Lacombe, Emilie" uniqKey="Lacombe E" first="Emilie" last="Lacombe">Emilie Lacombe</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation></author><author><name sortKey="Carcenac, Carole" sort="Carcenac, Carole" uniqKey="Carcenac C" first="Carole" last="Carcenac">Carole Carcenac</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation></author><author><name sortKey="Boulet, Sabrina" sort="Boulet, Sabrina" uniqKey="Boulet S" first="Sabrina" last="Boulet">Sabrina Boulet</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation></author><author><name sortKey="Feuerstein, Claude" sort="Feuerstein, Claude" uniqKey="Feuerstein C" first="Claude" last="Feuerstein">Claude Feuerstein</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre Hospitalier Universitaire de Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire de Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Bertrand, Anne" sort="Bertrand, Anne" uniqKey="Bertrand A" first="Anne" last="Bertrand">Anne Bertrand</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation></author><author><name sortKey="Poupard, Annie" sort="Poupard, Annie" uniqKey="Poupard A" first="Annie" last="Poupard">Annie Poupard</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation></author><author><name sortKey="Savasta, Marc" sort="Savasta, Marc" uniqKey="Savasta M" first="Marc" last="Savasta">Marc Savasta</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre Hospitalier Universitaire de Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire de Grenoble, Grenoble</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E9089923F3EF1906FF4AD539ED2F26EFCE5872EE</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1111/j.1460-9568.2007.05747.x</idno><idno type="url">https://api.istex.fr/document/E9089923F3EF1906FF4AD539ED2F26EFCE5872EE/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001A47</idno><idno type="wicri:Area/Main/Curation">001789</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">High‐frequency stimulation of the subthalamic nucleus prolongs the increase in striatal dopamine induced by acute l‐3,4‐dihydroxyphenylalanine in dopaminergic denervated rats</title><author><name sortKey="Lacombe, Emilie" sort="Lacombe, Emilie" uniqKey="Lacombe E" first="Emilie" last="Lacombe">Emilie Lacombe</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation></author><author><name sortKey="Carcenac, Carole" sort="Carcenac, Carole" uniqKey="Carcenac C" first="Carole" last="Carcenac">Carole Carcenac</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation></author><author><name sortKey="Boulet, Sabrina" sort="Boulet, Sabrina" uniqKey="Boulet S" first="Sabrina" last="Boulet">Sabrina Boulet</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation></author><author><name sortKey="Feuerstein, Claude" sort="Feuerstein, Claude" uniqKey="Feuerstein C" first="Claude" last="Feuerstein">Claude Feuerstein</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre Hospitalier Universitaire de Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire de Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Bertrand, Anne" sort="Bertrand, Anne" uniqKey="Bertrand A" first="Anne" last="Bertrand">Anne Bertrand</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation></author><author><name sortKey="Poupard, Annie" sort="Poupard, Annie" uniqKey="Poupard A" first="Annie" last="Poupard">Annie Poupard</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation></author><author><name sortKey="Savasta, Marc" sort="Savasta, Marc" uniqKey="Savasta M" first="Marc" last="Savasta">Marc Savasta</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, Unité 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Université Joseph Fourier and</mods:affiliation><wicri:noCountry code="no comma">Université Joseph Fourier and</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre Hospitalier Universitaire de Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire de Grenoble, Grenoble</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neuroscience</title><idno type="ISSN">0953-816X</idno><idno type="eISSN">1460-9568</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2007-09">2007-09</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1670">1670</biblScope><biblScope unit="page" to="1680">1680</biblScope></imprint><idno type="ISSN">0953-816X</idno></series><idno type="istex">E9089923F3EF1906FF4AD539ED2F26EFCE5872EE</idno><idno type="DOI">10.1111/j.1460-9568.2007.05747.x</idno><idno type="ArticleID">EJN5747</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0953-816X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>L‐3, 4‐dihydroxyphenylalanine treatment</term><term>Parkinson's disease</term><term>dopamine</term><term>high‐frequency stimulation</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High‐frequency stimulation of the subthalamic nucleus (STN‐HFS) is a powerful approach for treating the motor symptoms of Parkinson's disease (PD). It results in clinical improvement in patients with PD, further reducing the l‐3,4‐dihydroxyphenylalanine (L‐DOPA) requirement and thus L‐DOPA‐induced dyskinesia. However, it remains unclear how STN‐HFS modifies the response to L‐DOPA. We investigated the effect of STN‐HFS on striatal extracellular concentrations of dopamine and its metabolites following acute L‐DOPA administration in intact or partially dopaminergic denervated (DA‐PL) rats. L‐DOPA treatment significantly increased striatal dopamine levels in intact and DA‐PL animals, with the maximal effect observed 1 h after L‐DOPA injection. This increase was more pronounced in DA‐PL rats (ipsilateral to the lesion) than in intact animals. It remained fairly stable 1 h after the maximal effect of L‐DOPA and then decreased towards basal values. STN‐HFS in intact rats had no effect on the maximal L‐DOPA‐induced increase in striatal extracellular dopamine concentration or the return to basal values, the profiles observed being similar to those for non‐stimulated intact animals. Conversely, STN‐HFS amplified the L‐DOPA‐induced increase in striatal dopamine levels during the stimulation period (1 h) in DA‐PL rats and this increase was sustained throughout the post‐stimulation period (2.5 h), without the return to basal levels observed in stimulated intact and non‐stimulated rats. These new neurochemical data suggest that STN‐HFS interferes with L‐DOPA effects, probably synergically, by stabilizing dopamine levels in the striatum and shed light on the mechanisms of STN‐HFS in PD.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001789 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001789 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Curation
|type= RBID
|clé= ISTEX:E9089923F3EF1906FF4AD539ED2F26EFCE5872EE
|texte= High‐frequency stimulation of the subthalamic nucleus prolongs the increase in striatal dopamine induced by acute l‐3,4‐dihydroxyphenylalanine in dopaminergic denervated rats
}}
| This area was generated with Dilib version V0.6.23. |  |