Association of olfactory dysfunction and brain. Metabolism in Parkinson's disease
Identifieur interne : 001687 ( Main/Curation ); précédent : 001686; suivant : 001688Association of olfactory dysfunction and brain. Metabolism in Parkinson's disease
Auteurs : Toru Baba [Japon] ; Atsushi Takeda [Japon] ; Akio Kikuchi [Japon] ; Yoshiyuki Nishio [Japon] ; Yoshiyuki Hosokai [Japon] ; Kazumi Hirayama [Japon] ; Takafumi Hasegawa [Japon] ; Naoto Sugeno [Japon] ; Kyoko Suzuki [Japon] ; Etsuro Mori [Japon] ; Shoki Takahashi [Japon] ; Hiroshi Fukuda [Japon] ; Yasuto Itoyama [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-03.
English descriptors
Abstract
Hyposmia is one of the cardinal early symptoms of Parkinson disease (PD). Accumulating clinical and pathological evidence suggests that dysfunction of the olfactory‐related cortices may be responsible for the impaired olfactory processing observed in PD; however, there are no clear data showing a direct association between altered brain metabolism and hyposmia in PD. In this study, we evaluated brain glucose metabolism and smell‐identification ability in 69 Japanese patients with nondemented PD. Olfactory function was assessed using the Odor Stick Identification Test for Japanese. The regional cerebral metabolic rate of glucose consumption at rest was measured using 18F‐fluorodeoxyglucose positron emission tomography and was analyzed using SPM‐based group comparisons and the brain–behavior partial least‐squares method. We found that olfactory dysfunction was closely related to cognitive dysfunction, including memory impairment. Moreover, brain–behavior partial least‐squares analysis revealed that odor‐identification performance was closely associated with broad cortical dysfunction, including dysfunction of the piriform cortex and amygdala. Our results suggest that the cognitive deficit in olfactory perception is an important aspect of hyposmia in PD and that this deficit is caused by altered brain metabolism in the amygdala and piriform cortex. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23602
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Metabolism in Parkinson's disease</title><author><name sortKey="Baba, Toru" sort="Baba, Toru" uniqKey="Baba T" first="Toru" last="Baba">Toru Baba</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Tohoku University Graduate School of Medicine, Sendai</wicri:regionArea></affiliation></author><author><name sortKey="Takeda, Atsushi" sort="Takeda, Atsushi" uniqKey="Takeda A" first="Atsushi" last="Takeda">Atsushi Takeda</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Tohoku University Graduate School of Medicine, Sendai</wicri:regionArea></affiliation></author><author><name sortKey="Kikuchi, Akio" sort="Kikuchi, Akio" 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Yoshiyuki" uniqKey="Hosokai Y" first="Yoshiyuki" last="Hosokai">Yoshiyuki Hosokai</name><affiliation wicri:level="1"><mods:affiliation>Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai</wicri:regionArea></affiliation></author><author><name sortKey="Hirayama, Kazumi" sort="Hirayama, Kazumi" uniqKey="Hirayama K" first="Kazumi" last="Hirayama">Kazumi Hirayama</name><affiliation wicri:level="1"><mods:affiliation>Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Occupational Therapy, Yamagata Prefectural University of Health Sciences, Yamagata, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Occupational Therapy, Yamagata Prefectural University of Health Sciences, Yamagata</wicri:regionArea></affiliation></author><author><name sortKey="Hasegawa, Takafumi" sort="Hasegawa, Takafumi" uniqKey="Hasegawa T" first="Takafumi" last="Hasegawa">Takafumi Hasegawa</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Tohoku University Graduate School of Medicine, Sendai</wicri:regionArea></affiliation></author><author><name sortKey="Sugeno, Naoto" sort="Sugeno, Naoto" uniqKey="Sugeno N" first="Naoto" last="Sugeno">Naoto Sugeno</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Tohoku University Graduate School of Medicine, Sendai</wicri:regionArea></affiliation></author><author><name sortKey="Suzuki, Kyoko" sort="Suzuki, Kyoko" uniqKey="Suzuki K" first="Kyoko" last="Suzuki">Kyoko Suzuki</name><affiliation wicri:level="1"><mods:affiliation>Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Neuroscience, Yamagata University, Graduate School of Medical Science, Yamagata, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Clinical Neuroscience, Yamagata University, Graduate School of Medical Science, Yamagata</wicri:regionArea></affiliation></author><author><name sortKey="Mori, Etsuro" sort="Mori, Etsuro" uniqKey="Mori E" first="Etsuro" last="Mori">Etsuro Mori</name><affiliation wicri:level="1"><mods:affiliation>Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai</wicri:regionArea></affiliation></author><author><name sortKey="Takahashi, Shoki" sort="Takahashi, Shoki" uniqKey="Takahashi S" first="Shoki" last="Takahashi">Shoki Takahashi</name><affiliation wicri:level="1"><mods:affiliation>Department of Diagnostic Radiology, Tohoku University Graduate School of Medicine, Sendai, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Diagnostic Radiology, Tohoku University Graduate School of Medicine, Sendai</wicri:regionArea></affiliation></author><author><name sortKey="Fukuda, Hiroshi" sort="Fukuda, Hiroshi" uniqKey="Fukuda H" first="Hiroshi" last="Fukuda">Hiroshi Fukuda</name><affiliation wicri:level="1"><mods:affiliation>Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai</wicri:regionArea></affiliation></author><author><name sortKey="Itoyama, Yasuto" sort="Itoyama, Yasuto" uniqKey="Itoyama Y" first="Yasuto" last="Itoyama">Yasuto Itoyama</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Tohoku University Graduate School of Medicine, Sendai</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-03">2011-03</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="621">621</biblScope><biblScope unit="page" to="628">628</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">E7EF91B718D8B797727CF69D72E0EB6A3240F025</idno><idno type="DOI">10.1002/mds.23602</idno><idno type="ArticleID">MDS23602</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>PET, amygdala</term><term>cluster analysis</term><term>hyposmia</term><term>piriform cortex</term><term>spatial covariance analysis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hyposmia is one of the cardinal early symptoms of Parkinson disease (PD). Accumulating clinical and pathological evidence suggests that dysfunction of the olfactory‐related cortices may be responsible for the impaired olfactory processing observed in PD; however, there are no clear data showing a direct association between altered brain metabolism and hyposmia in PD. In this study, we evaluated brain glucose metabolism and smell‐identification ability in 69 Japanese patients with nondemented PD. Olfactory function was assessed using the Odor Stick Identification Test for Japanese. The regional cerebral metabolic rate of glucose consumption at rest was measured using 18F‐fluorodeoxyglucose positron emission tomography and was analyzed using SPM‐based group comparisons and the brain–behavior partial least‐squares method. We found that olfactory dysfunction was closely related to cognitive dysfunction, including memory impairment. Moreover, brain–behavior partial least‐squares analysis revealed that odor‐identification performance was closely associated with broad cortical dysfunction, including dysfunction of the piriform cortex and amygdala. Our results suggest that the cognitive deficit in olfactory perception is an important aspect of hyposmia in PD and that this deficit is caused by altered brain metabolism in the amygdala and piriform cortex. © 2011 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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