Dopaminergic and cholinergic lesions in progressive supranuclear palsy
Identifieur interne : 001430 ( Main/Curation ); précédent : 001429; suivant : 001431Dopaminergic and cholinergic lesions in progressive supranuclear palsy
Auteurs : Merle Ruberg [France] ; France Javoy-Agid [France] ; Etienne Hirsch [France] ; Bernard Scatton [France] ; Rémy Lheureux [France] ; Jean-Jacques Hauw [France] ; Charles Duyckaerts [France] ; Françloise Gray [France] ; Ariel Morel-Maroger [France] ; André Rascol [France] ; Michel Serdaru [France] ; Agid [France]Source :
- Annals of Neurology [ 0364-5134 ] ; 1985-11.
Abstract
In 9 patients with progressive supranuclear palsy and in 27 controls, dopamine and homovanillic acid concentrations, choline acetyltransferase (CAT) activity, and the number of [3H]spiperone and [3H]quinuclidinyl benzilate binding sites were measured post mortem in the striatum (caudate nucleus, putamen, and nucleus accumbens), substantia innominata, and frontal cortex. Dopamine and homovanillic acid concentrations were reduced in the caudate nucleus and putamen but not in the nucleus accumbens or frontal cortex, indicating that the nigrostriatal dopaminergic system is lesioned in patients with progressive supranuclear palsy (as in those with Parkinson's disease) but not the mesocortical and mesolimbic dopaminergic systems, which are lesioned in parkinsonian patients. CAT activity and [3H]spiperone binding decreased in parallel fashion in all the structures. In the striatum, this suggests that the cholinergic neurons, which are target cells of the nigrostriatal system, also degenerate in this disease. This might explain the decrease in the number of dopamine receptors as well as the inefficacy of levodopa or anticholinergic therapy in these patients. The decrease in CAT activity in the substantia innominata and the frontal cortex indicates that the innominatocortical cholinergic system is lesioned in patients with progressive supranuclear palsy and may play a role in the intellectual deterioration observed. This lesion is also found in demented patients with Alzheimer's and Parkinson's diseases.
Url:
DOI: 10.1002/ana.410180503
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001665
Links to Exploration step
ISTEX:ED5C79FF895C5038FEE8C38B0834F33C52B85A1ALe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dopaminergic and cholinergic lesions in progressive supranuclear palsy</title><author><name sortKey="Ruberg, Merle" sort="Ruberg, Merle" uniqKey="Ruberg M" first="Merle" last="Ruberg">Merle Ruberg</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Javoy Gid, France" sort="Javoy Gid, France" uniqKey="Javoy Gid F" first="France" last="Javoy-Agid">France Javoy-Agid</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Hirsch, Etienne" sort="Hirsch, Etienne" uniqKey="Hirsch E" first="Etienne" last="Hirsch">Etienne Hirsch</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Scatton, Bernard" sort="Scatton, Bernard" uniqKey="Scatton B" first="Bernard" last="Scatton">Bernard Scatton</name><affiliation wicri:level="1"><mods:affiliation>Synthélabo—LERS, Boulevard P. V. Couturier, 92220 Bagneux, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Synthélabo—LERS, Boulevard P. V. Couturier, 92220 Bagneux</wicri:regionArea></affiliation></author><author><name sortKey="Lheureux, Remy" sort="Lheureux, Remy" uniqKey="Lheureux R" first="Rémy" last="Lheureux">Rémy Lheureux</name><affiliation wicri:level="1"><mods:affiliation>Synthélabo—LERS, Boulevard P. V. Couturier, 92220 Bagneux, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Synthélabo—LERS, Boulevard P. V. Couturier, 92220 Bagneux</wicri:regionArea></affiliation></author><author><name sortKey="Hauw, Jean Acques" sort="Hauw, Jean Acques" uniqKey="Hauw J" first="Jean-Jacques" last="Hauw">Jean-Jacques Hauw</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Duyckaerts, Charles" sort="Duyckaerts, Charles" uniqKey="Duyckaerts C" first="Charles" last="Duyckaerts">Charles Duyckaerts</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Gray, Francloise" sort="Gray, Francloise" uniqKey="Gray F" first="Françloise" last="Gray">Françloise Gray</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Morel Aroger, Ariel" sort="Morel Aroger, Ariel" uniqKey="Morel Aroger A" first="Ariel" last="Morel-Maroger">Ariel Morel-Maroger</name><affiliation wicri:level="1"><mods:affiliation>Hôpital de Corbeil‐Essones, 91 Corbeil Essonnes, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital de Corbeil‐Essones, 91 Corbeil Essonnes</wicri:regionArea></affiliation></author><author><name sortKey="Rascol, Andre" sort="Rascol, Andre" uniqKey="Rascol A" first="André" last="Rascol">André Rascol</name><affiliation wicri:level="1"><mods:affiliation>Hôpital Purpan, 31 Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Purpan, 31 Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Serdaru, Michel" sort="Serdaru, Michel" uniqKey="Serdaru M" first="Michel" last="Serdaru">Michel Serdaru</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Agid" sort="Agid" uniqKey="Agid" last="Agid">Agid</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:ED5C79FF895C5038FEE8C38B0834F33C52B85A1A</idno><date when="1985" year="1985">1985</date><idno type="doi">10.1002/ana.410180503</idno><idno type="url">https://api.istex.fr/document/ED5C79FF895C5038FEE8C38B0834F33C52B85A1A/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001665</idno><idno type="wicri:Area/Main/Curation">001430</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Dopaminergic and cholinergic lesions in progressive supranuclear palsy</title><author><name sortKey="Ruberg, Merle" sort="Ruberg, Merle" uniqKey="Ruberg M" first="Merle" last="Ruberg">Merle Ruberg</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Javoy Gid, France" sort="Javoy Gid, France" uniqKey="Javoy Gid F" first="France" last="Javoy-Agid">France Javoy-Agid</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Hirsch, Etienne" sort="Hirsch, Etienne" uniqKey="Hirsch E" first="Etienne" last="Hirsch">Etienne Hirsch</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Scatton, Bernard" sort="Scatton, Bernard" uniqKey="Scatton B" first="Bernard" last="Scatton">Bernard Scatton</name><affiliation wicri:level="1"><mods:affiliation>Synthélabo—LERS, Boulevard P. V. Couturier, 92220 Bagneux, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Synthélabo—LERS, Boulevard P. V. Couturier, 92220 Bagneux</wicri:regionArea></affiliation></author><author><name sortKey="Lheureux, Remy" sort="Lheureux, Remy" uniqKey="Lheureux R" first="Rémy" last="Lheureux">Rémy Lheureux</name><affiliation wicri:level="1"><mods:affiliation>Synthélabo—LERS, Boulevard P. V. Couturier, 92220 Bagneux, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Synthélabo—LERS, Boulevard P. V. Couturier, 92220 Bagneux</wicri:regionArea></affiliation></author><author><name sortKey="Hauw, Jean Acques" sort="Hauw, Jean Acques" uniqKey="Hauw J" first="Jean-Jacques" last="Hauw">Jean-Jacques Hauw</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Duyckaerts, Charles" sort="Duyckaerts, Charles" uniqKey="Duyckaerts C" first="Charles" last="Duyckaerts">Charles Duyckaerts</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Gray, Francloise" sort="Gray, Francloise" uniqKey="Gray F" first="Françloise" last="Gray">Françloise Gray</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Morel Aroger, Ariel" sort="Morel Aroger, Ariel" uniqKey="Morel Aroger A" first="Ariel" last="Morel-Maroger">Ariel Morel-Maroger</name><affiliation wicri:level="1"><mods:affiliation>Hôpital de Corbeil‐Essones, 91 Corbeil Essonnes, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital de Corbeil‐Essones, 91 Corbeil Essonnes</wicri:regionArea></affiliation></author><author><name sortKey="Rascol, Andre" sort="Rascol, Andre" uniqKey="Rascol A" first="André" last="Rascol">André Rascol</name><affiliation wicri:level="1"><mods:affiliation>Hôpital Purpan, 31 Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Purpan, 31 Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Serdaru, Michel" sort="Serdaru, Michel" uniqKey="Serdaru M" first="Michel" last="Serdaru">Michel Serdaru</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris</wicri:regionArea></affiliation></author><author><name sortKey="Agid" sort="Agid" uniqKey="Agid" last="Agid">Agid</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Medécine Expérimentale, Laboratoire de Neuropathologie Charles Foix, Hôpital de la Salpêtrière, 91 Boulevard de l'Hǒpital, 75005 Paris</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Little, Brown and Company</publisher><pubPlace>Boston</pubPlace><date type="published" when="1985-11">1985-11</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="523">523</biblScope><biblScope unit="page" to="529">529</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">ED5C79FF895C5038FEE8C38B0834F33C52B85A1A</idno><idno type="DOI">10.1002/ana.410180503</idno><idno type="ArticleID">ANA410180503</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In 9 patients with progressive supranuclear palsy and in 27 controls, dopamine and homovanillic acid concentrations, choline acetyltransferase (CAT) activity, and the number of [3H]spiperone and [3H]quinuclidinyl benzilate binding sites were measured post mortem in the striatum (caudate nucleus, putamen, and nucleus accumbens), substantia innominata, and frontal cortex. Dopamine and homovanillic acid concentrations were reduced in the caudate nucleus and putamen but not in the nucleus accumbens or frontal cortex, indicating that the nigrostriatal dopaminergic system is lesioned in patients with progressive supranuclear palsy (as in those with Parkinson's disease) but not the mesocortical and mesolimbic dopaminergic systems, which are lesioned in parkinsonian patients. CAT activity and [3H]spiperone binding decreased in parallel fashion in all the structures. In the striatum, this suggests that the cholinergic neurons, which are target cells of the nigrostriatal system, also degenerate in this disease. This might explain the decrease in the number of dopamine receptors as well as the inefficacy of levodopa or anticholinergic therapy in these patients. The decrease in CAT activity in the substantia innominata and the frontal cortex indicates that the innominatocortical cholinergic system is lesioned in patients with progressive supranuclear palsy and may play a role in the intellectual deterioration observed. This lesion is also found in demented patients with Alzheimer's and Parkinson's diseases.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001430 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001430 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Curation
|type= RBID
|clé= ISTEX:ED5C79FF895C5038FEE8C38B0834F33C52B85A1A
|texte= Dopaminergic and cholinergic lesions in progressive supranuclear palsy
}}
| This area was generated with Dilib version V0.6.23. |  |