Restoration of normal motor control in Parkinson's disease during REM sleep
Identifieur interne : 001391 ( Main/Curation ); précédent : 001390; suivant : 001392Restoration of normal motor control in Parkinson's disease during REM sleep
Auteurs : Valérie Cochen De Cock [France] ; Marie Vidailhet [France] ; Smaranda Leu [France] ; Antonio Texeira [France] ; Emmanuelle Apartis [France] ; Alexis Elbaz [France] ; Emmanuel Roze [France] ; Jean Claude Willer [France] ; Jean Philippe Derenne [France] ; Yves Agid [France] ; Isabelle Arnulf [France]Source :
- Brain [ 0006-8950 ] ; 2007-02.
Abstract
Although normal subjects do not move during REM sleep, patients with Parkinson's disease may experience REM sleep behaviour disorder (RBD). The characteristics of the abnormal REM sleep movements in RBD have, however, not been studied. We interviewed one hundred consecutive non-demented patients with Parkinson's disease and their bed partners using a structured questionnaire assessing the presence of RBD. They rated the quality of movements, voice and facial expression during RBD as being better, equal or worse than in awake ON levodopa condition. Night-time sleep and movements were video-monitored during polysomnography in 51 patients to evaluate the presence of bradykinesia, tremor and hypophonia during REM sleep. Fifty-nine patients had clinical RBD with 53/59 bed partners able to evaluate them. All 53 (100%) reported an improvement of at least one component of motor control during RBD. By history, movements were improved in 87% patients (faster, 87%; stronger, 87%; smoother, 51%), speech was better in 77% patients (more intelligible, 77%; louder, 38%; better articulated, 57%) and facial expression was normalized in 47% patients. Thirty-eight per cent of bed partners reported that movements were ‘much better’, even in the most disabled patients. The video-monitored purposeful movements in REM sleep were also surprisingly fast, ample, coordinated and symmetrical, without obvious sign of parkinsonism. The movements were, however, jerky, violent and often repetitive. While all patients had asymmetrical parkinsonism when awake, most of the time they used the more disabled arm, hand and leg during the RBD (P = 0.04). Movements involved six times as often the upper limbs and the face as the lower limbs (OR: 5.9, P = 0.004). The percentage of time containing tremor EMG activity decreased with sleep stages from 34.9 ± 15.5% during wakefulness, to 3.6 ± 5.7% during non-REM sleep stages 1–2, 1.4 ± 3.0% during non-REM sleep stages 3–4, and 0.06 ± 0.2% during REM sleep (in this last case, it was subclinical tremor). The restored motor control during REM sleep suggests a transient ‘levodopa-like’ reestablishment of the basal ganglia loop. Alternatively, parkinsonism may disappear by REM sleep-related disjunction between pyramidal and extrapyramidal systems. We suggest the following model: the movements during the RBD would be generated by the motor cortex and would follow the pyramidal tract bypassing the extrapyramidal system. These movements would eventually be transmitted to lower motor neurons because of brainstem lesions interrupting the pontomedullary pathways which mediate the REM sleep atonia.
Url:
DOI: 10.1093/brain/awl363
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001625
Links to Exploration step
ISTEX:E9B14481487841897E570D969D95635B318B81E0Curation
No country items
Valérie Cochen De Cock<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de parisFrance</mods:affiliation>
<wicri:noCountry code="subField">Assistance Publique Hôpitaux de parisFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>INSERM U 679, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de parisFrance</mods:affiliation>
<wicri:noCountry code="subField">Assistance Publique Hôpitaux de parisFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>INSERM U 679, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>INSERM U 679, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>INSERM U 679, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>INSERM U 679, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Service de Physiologie Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="no comma">Service de Physiologie Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>INSERM U 732, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>INSERM U 732, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>INSERM U 708, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>INSERM U 708, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de parisFrance</mods:affiliation>
<wicri:noCountry code="subField">Assistance Publique Hôpitaux de parisFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>INSERM U 731, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>INSERM U 731, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de parisFrance</mods:affiliation>
<wicri:noCountry code="subField">Assistance Publique Hôpitaux de parisFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>INSERM U 679, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de parisFrance</mods:affiliation>
<wicri:noCountry code="subField">Assistance Publique Hôpitaux de parisFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Restoration of normal motor control in Parkinson's disease during REM sleep</title>
<author><name sortKey="De Cock, Valerie Cochen" sort="De Cock, Valerie Cochen" uniqKey="De Cock V" first="Valérie Cochen" last="De Cock">Valérie Cochen De Cock</name>
<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de parisFrance</mods:affiliation>
<wicri:noCountry code="subField">Assistance Publique Hôpitaux de parisFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>INSERM U 679, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name>
<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>INSERM U 679, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Leu, Smaranda" sort="Leu, Smaranda" uniqKey="Leu S" first="Smaranda" last="Leu">Smaranda Leu</name>
<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Texeira, Antonio" sort="Texeira, Antonio" uniqKey="Texeira A" first="Antonio" last="Texeira">Antonio Texeira</name>
<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Apartis, Emmanuelle" sort="Apartis, Emmanuelle" uniqKey="Apartis E" first="Emmanuelle" last="Apartis">Emmanuelle Apartis</name>
<affiliation><mods:affiliation>Service de Physiologie Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="no comma">Service de Physiologie Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>INSERM U 732, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>INSERM U 708, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Roze, Emmanuel" sort="Roze, Emmanuel" uniqKey="Roze E" first="Emmanuel" last="Roze">Emmanuel Roze</name>
<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Willer, Jean Claude" sort="Willer, Jean Claude" uniqKey="Willer J" first="Jean Claude" last="Willer">Jean Claude Willer</name>
<affiliation><mods:affiliation>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de parisFrance</mods:affiliation>
<wicri:noCountry code="subField">Assistance Publique Hôpitaux de parisFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>INSERM U 731, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Derenne, Jean Philippe" sort="Derenne, Jean Philippe" uniqKey="Derenne J" first="Jean Philippe" last="Derenne">Jean Philippe Derenne</name>
<affiliation><mods:affiliation>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de parisFrance</mods:affiliation>
<wicri:noCountry code="subField">Assistance Publique Hôpitaux de parisFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<affiliation><mods:affiliation>INSERM U 679, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
<affiliation><mods:affiliation>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de parisFrance</mods:affiliation>
<wicri:noCountry code="subField">Assistance Publique Hôpitaux de parisFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:E9B14481487841897E570D969D95635B318B81E0</idno>
<date when="2007" year="2007">2007</date>
<idno type="doi">10.1093/brain/awl363</idno>
<idno type="url">https://api.istex.fr/document/E9B14481487841897E570D969D95635B318B81E0/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">001625</idno>
<idno type="wicri:Area/Main/Curation">001391</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Restoration of normal motor control in Parkinson's disease during REM sleep</title>
<author><name sortKey="De Cock, Valerie Cochen" sort="De Cock, Valerie Cochen" uniqKey="De Cock V" first="Valérie Cochen" last="De Cock">Valérie Cochen De Cock</name>
<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de parisFrance</mods:affiliation>
<wicri:noCountry code="subField">Assistance Publique Hôpitaux de parisFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>INSERM U 679, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name>
<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>INSERM U 679, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Leu, Smaranda" sort="Leu, Smaranda" uniqKey="Leu S" first="Smaranda" last="Leu">Smaranda Leu</name>
<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Texeira, Antonio" sort="Texeira, Antonio" uniqKey="Texeira A" first="Antonio" last="Texeira">Antonio Texeira</name>
<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Apartis, Emmanuelle" sort="Apartis, Emmanuelle" uniqKey="Apartis E" first="Emmanuelle" last="Apartis">Emmanuelle Apartis</name>
<affiliation><mods:affiliation>Service de Physiologie Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="no comma">Service de Physiologie Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>INSERM U 732, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>INSERM U 708, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Roze, Emmanuel" sort="Roze, Emmanuel" uniqKey="Roze E" first="Emmanuel" last="Roze">Emmanuel Roze</name>
<affiliation><mods:affiliation>Service de Neurologie, Hôpital Saint AntoineFrance</mods:affiliation>
<wicri:noCountry code="subField">Hôpital Saint AntoineFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Willer, Jean Claude" sort="Willer, Jean Claude" uniqKey="Willer J" first="Jean Claude" last="Willer">Jean Claude Willer</name>
<affiliation><mods:affiliation>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de parisFrance</mods:affiliation>
<wicri:noCountry code="subField">Assistance Publique Hôpitaux de parisFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>INSERM U 731, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Derenne, Jean Philippe" sort="Derenne, Jean Philippe" uniqKey="Derenne J" first="Jean Philippe" last="Derenne">Jean Philippe Derenne</name>
<affiliation><mods:affiliation>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de parisFrance</mods:affiliation>
<wicri:noCountry code="subField">Assistance Publique Hôpitaux de parisFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<affiliation><mods:affiliation>INSERM U 679, Université Pierre et Marie CurieFrance</mods:affiliation>
<wicri:noCountry code="subField">Université Pierre et Marie CurieFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
<affiliation><mods:affiliation>Fédération des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux de parisFrance</mods:affiliation>
<wicri:noCountry code="subField">Assistance Publique Hôpitaux de parisFrance</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Correspondence to: Dr Valérie Cochen, Service de Neurologie, Hôpital Saint Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Brain</title>
<idno type="ISSN">0006-8950</idno>
<idno type="eISSN">1460-2156</idno>
<imprint><publisher>Oxford University Press</publisher>
<date type="published" when="2007-02">2007-02</date>
<biblScope unit="volume">130</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="450">450</biblScope>
<biblScope unit="page" to="456">456</biblScope>
</imprint>
<idno type="ISSN">0006-8950</idno>
</series>
<idno type="istex">E9B14481487841897E570D969D95635B318B81E0</idno>
<idno type="DOI">10.1093/brain/awl363</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0006-8950</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Although normal subjects do not move during REM sleep, patients with Parkinson's disease may experience REM sleep behaviour disorder (RBD). The characteristics of the abnormal REM sleep movements in RBD have, however, not been studied. We interviewed one hundred consecutive non-demented patients with Parkinson's disease and their bed partners using a structured questionnaire assessing the presence of RBD. They rated the quality of movements, voice and facial expression during RBD as being better, equal or worse than in awake ON levodopa condition. Night-time sleep and movements were video-monitored during polysomnography in 51 patients to evaluate the presence of bradykinesia, tremor and hypophonia during REM sleep. Fifty-nine patients had clinical RBD with 53/59 bed partners able to evaluate them. All 53 (100%) reported an improvement of at least one component of motor control during RBD. By history, movements were improved in 87% patients (faster, 87%; stronger, 87%; smoother, 51%), speech was better in 77% patients (more intelligible, 77%; louder, 38%; better articulated, 57%) and facial expression was normalized in 47% patients. Thirty-eight per cent of bed partners reported that movements were ‘much better’, even in the most disabled patients. The video-monitored purposeful movements in REM sleep were also surprisingly fast, ample, coordinated and symmetrical, without obvious sign of parkinsonism. The movements were, however, jerky, violent and often repetitive. While all patients had asymmetrical parkinsonism when awake, most of the time they used the more disabled arm, hand and leg during the RBD (P = 0.04). Movements involved six times as often the upper limbs and the face as the lower limbs (OR: 5.9, P = 0.004). The percentage of time containing tremor EMG activity decreased with sleep stages from 34.9 ± 15.5% during wakefulness, to 3.6 ± 5.7% during non-REM sleep stages 1–2, 1.4 ± 3.0% during non-REM sleep stages 3–4, and 0.06 ± 0.2% during REM sleep (in this last case, it was subclinical tremor). The restored motor control during REM sleep suggests a transient ‘levodopa-like’ reestablishment of the basal ganglia loop. Alternatively, parkinsonism may disappear by REM sleep-related disjunction between pyramidal and extrapyramidal systems. We suggest the following model: the movements during the RBD would be generated by the motor cortex and would follow the pyramidal tract bypassing the extrapyramidal system. These movements would eventually be transmitted to lower motor neurons because of brainstem lesions interrupting the pontomedullary pathways which mediate the REM sleep atonia.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001391 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001391 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:E9B14481487841897E570D969D95635B318B81E0 |texte= Restoration of normal motor control in Parkinson's disease during REM sleep }}
This area was generated with Dilib version V0.6.23. |