Endoscopic characteristics and levodopa responsiveness of swallowing function in progressive supranuclear palsy
Identifieur interne : 001352 ( Main/Curation ); précédent : 001351; suivant : 001353Endoscopic characteristics and levodopa responsiveness of swallowing function in progressive supranuclear palsy
Auteurs : Tobias Warnecke [Allemagne] ; Stephan Oelenberg [Allemagne] ; Inga Teismann [Allemagne] ; Christina Hamacher [Allemagne] ; Hubertus Lohmann [Allemagne] ; Erich Bernd Ringelstein [Allemagne] ; Rainer Dziewas [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-07-15.
English descriptors
Abstract
Dysphagia is a frequent and early symptom in progressive supranuclear palsy (PSP) predisposing patients to aspiration pneumonia. Fiberoptic endoscopic evaluation of swallowing (FEES®) has emerged as a valuable apparative tool for objective evaluation of neurogenic dysphagia. This is the first study using FEES® to investigate the nature of swallowing impairment in PSP. Eighteen consecutive PSP patients (mean age 69.7 ± 9.0 years) were included. The salient findings of FEES® in PSP patients were compared with those of 15 patients with Parkinson's disease (PD). In 7 PSP patients, a standardized FEES® protocol was performed to explore levodopa (L‐dopa) responsiveness of dysphagia. Most frequent abnormalities detected by FEES® were bolus leakage, delayed swallowing reflex, and residues in valleculae and piriformes. Aspiration events with at least one food consistency occurred in nearly 30% of PSP patients. Significant pharyngeal saliva pooling was observed in 4 PSP patients. We found no difference of salient endoscopic findings between PSP and PD patients. Endoscopic dysphagia severity in PSP correlated positively with disease duration, clinical disability, and cognitive impairment. No correlation was found with dysarthria severity. In early PSP patients, swallowing dysfunction was solely characterized by liquid leakage with the risk of predeglutitive aspiration during the oral phase of swallowing. Two PSP patients showed relevant improvement of swallowing function after L‐dopa challenge. Chin tuck—maneuver, hard swallow, and modification of food consistency were identified as the most effective therapeutic interventions. In conclusion, FEES® assessment can deliver important findings for the diagnosis and refined therapy of dysphagia in PSP patients. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23060
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001583
Links to Exploration step
ISTEX:43680643A98B92A2BC5D3237F85FCF6AAE34F13BLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Endoscopic characteristics and levodopa responsiveness of swallowing function in progressive supranuclear palsy</title>
<author><name sortKey="Warnecke, Tobias" sort="Warnecke, Tobias" uniqKey="Warnecke T" first="Tobias" last="Warnecke">Tobias Warnecke</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Münster, Münster, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Münster, Münster</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oelenberg, Stephan" sort="Oelenberg, Stephan" uniqKey="Oelenberg S" first="Stephan" last="Oelenberg">Stephan Oelenberg</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Münster, Münster, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Münster, Münster</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Teismann, Inga" sort="Teismann, Inga" uniqKey="Teismann I" first="Inga" last="Teismann">Inga Teismann</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Münster, Münster, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Münster, Münster</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hamacher, Christina" sort="Hamacher, Christina" uniqKey="Hamacher C" first="Christina" last="Hamacher">Christina Hamacher</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Münster, Münster, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Münster, Münster</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lohmann, Hubertus" sort="Lohmann, Hubertus" uniqKey="Lohmann H" first="Hubertus" last="Lohmann">Hubertus Lohmann</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Münster, Münster, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Münster, Münster</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ringelstein, Erich Bernd" sort="Ringelstein, Erich Bernd" uniqKey="Ringelstein E" first="Erich Bernd" last="Ringelstein">Erich Bernd Ringelstein</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Münster, Münster, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Münster, Münster</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dziewas, Rainer" sort="Dziewas, Rainer" uniqKey="Dziewas R" first="Rainer" last="Dziewas">Rainer Dziewas</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Münster, Münster, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Münster, Münster</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:43680643A98B92A2BC5D3237F85FCF6AAE34F13B</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.23060</idno>
<idno type="url">https://api.istex.fr/document/43680643A98B92A2BC5D3237F85FCF6AAE34F13B/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">001583</idno>
<idno type="wicri:Area/Main/Curation">001352</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Endoscopic characteristics and levodopa responsiveness of swallowing function in progressive supranuclear palsy</title>
<author><name sortKey="Warnecke, Tobias" sort="Warnecke, Tobias" uniqKey="Warnecke T" first="Tobias" last="Warnecke">Tobias Warnecke</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Münster, Münster, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Münster, Münster</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oelenberg, Stephan" sort="Oelenberg, Stephan" uniqKey="Oelenberg S" first="Stephan" last="Oelenberg">Stephan Oelenberg</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Münster, Münster, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Münster, Münster</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Teismann, Inga" sort="Teismann, Inga" uniqKey="Teismann I" first="Inga" last="Teismann">Inga Teismann</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Münster, Münster, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Münster, Münster</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hamacher, Christina" sort="Hamacher, Christina" uniqKey="Hamacher C" first="Christina" last="Hamacher">Christina Hamacher</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Münster, Münster, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Münster, Münster</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lohmann, Hubertus" sort="Lohmann, Hubertus" uniqKey="Lohmann H" first="Hubertus" last="Lohmann">Hubertus Lohmann</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Münster, Münster, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Münster, Münster</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ringelstein, Erich Bernd" sort="Ringelstein, Erich Bernd" uniqKey="Ringelstein E" first="Erich Bernd" last="Ringelstein">Erich Bernd Ringelstein</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Münster, Münster, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Münster, Münster</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dziewas, Rainer" sort="Dziewas, Rainer" uniqKey="Dziewas R" first="Rainer" last="Dziewas">Rainer Dziewas</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University Hospital of Münster, Münster, Germany</mods:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University Hospital of Münster, Münster</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-07-15">2010-07-15</date>
<biblScope unit="volume">25</biblScope>
<biblScope unit="issue">9</biblScope>
<biblScope unit="page" from="1239">1239</biblScope>
<biblScope unit="page" to="1245">1245</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">43680643A98B92A2BC5D3237F85FCF6AAE34F13B</idno>
<idno type="DOI">10.1002/mds.23060</idno>
<idno type="ArticleID">MDS23060</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>FEES®</term>
<term>dysphagia</term>
<term>levodopa responsiveness</term>
<term>progressive supranuclear palsy</term>
<term>swallowing</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Dysphagia is a frequent and early symptom in progressive supranuclear palsy (PSP) predisposing patients to aspiration pneumonia. Fiberoptic endoscopic evaluation of swallowing (FEES®) has emerged as a valuable apparative tool for objective evaluation of neurogenic dysphagia. This is the first study using FEES® to investigate the nature of swallowing impairment in PSP. Eighteen consecutive PSP patients (mean age 69.7 ± 9.0 years) were included. The salient findings of FEES® in PSP patients were compared with those of 15 patients with Parkinson's disease (PD). In 7 PSP patients, a standardized FEES® protocol was performed to explore levodopa (L‐dopa) responsiveness of dysphagia. Most frequent abnormalities detected by FEES® were bolus leakage, delayed swallowing reflex, and residues in valleculae and piriformes. Aspiration events with at least one food consistency occurred in nearly 30% of PSP patients. Significant pharyngeal saliva pooling was observed in 4 PSP patients. We found no difference of salient endoscopic findings between PSP and PD patients. Endoscopic dysphagia severity in PSP correlated positively with disease duration, clinical disability, and cognitive impairment. No correlation was found with dysarthria severity. In early PSP patients, swallowing dysfunction was solely characterized by liquid leakage with the risk of predeglutitive aspiration during the oral phase of swallowing. Two PSP patients showed relevant improvement of swallowing function after L‐dopa challenge. Chin tuck—maneuver, hard swallow, and modification of food consistency were identified as the most effective therapeutic interventions. In conclusion, FEES® assessment can deliver important findings for the diagnosis and refined therapy of dysphagia in PSP patients. © 2010 Movement Disorder Society</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001352 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001352 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:43680643A98B92A2BC5D3237F85FCF6AAE34F13B |texte= Endoscopic characteristics and levodopa responsiveness of swallowing function in progressive supranuclear palsy }}
This area was generated with Dilib version V0.6.23. |