Progressive changes in a recognition memory network in Parkinson's disease
Identifieur interne : 001060 ( Main/Curation ); précédent : 001059; suivant : 001061Progressive changes in a recognition memory network in Parkinson's disease
Auteurs : Bàrbara Segura [Espagne] ; Naroa Ibarretxe-Bilbao [Espagne] ; Roser Sala-Llonch [Espagne] ; Hugo Cesar Baggio [Espagne] ; María Jose Martí [Espagne] ; Francesc Valldeoriola [Espagne] ; Pere Vendrell [Espagne] ; Nuria Bargall [Espagne] ; Eduard Tolosa [Espagne] ; Carme Junqué [Espagne]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2013-04.
Abstract
Background In a previous functional MRI (fMRI) study, we found that patients with Parkinson's disease (PD) presented with dysfunctions in the recruitment of recognition memory networks. We aimed to investigate the changes in these networks over time. Methods We studied 17 PD patients and 13 age and sex matched healthy subjects. In both groups fMRI (recognition memory paradigm) and neuropsychological assessments were obtained at baseline and at follow-up. To analyse changes over time in functional networks, model free (independent component analysis) analyses of the fMRI data were carried out. Then, a cross correlation approach was used to assess the changes in the strength of functional connectivity. Results At follow-up, patients showed reduced recruitment of one network, including decreased activation in the orbitofrontal cortices, middle frontal gyri, frontal poles, anterior paracingulate cortex, superior parietal lobes and left middle temporal gyrus, as well as decreased deactivation in the anterior paracingulate gyrus and precuneus. Cross correlation analyses over time showed a decrease in the strength of functional connectivity between the middle frontal gyrus and the superior parietal lobe in PD patients. Conclusions Model free fMRI and cross correlation connectivity analyses were able to detect progressive changes in functional networks involved in recognition memory in PD patients at early disease stages and without overt clinical deterioration. Functional connectivity analyses could be useful to monitor changes in brain networks underlying neuropsychological deficits in PD.
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DOI: 10.1136/jnnp-2012-302822
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Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="María Jose" last="Martí">María Jose Martí</name><affiliation wicri:level="1"><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, 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Barcelona, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Ibarretxe Bilbao, Naroa" sort="Ibarretxe Bilbao, Naroa" uniqKey="Ibarretxe Bilbao N" first="Naroa" last="Ibarretxe-Bilbao">Naroa Ibarretxe-Bilbao</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao</wicri:regionArea></affiliation></author><author><name sortKey="Sala Llonch, Roser" sort="Sala Llonch, Roser" uniqKey="Sala Llonch R" first="Roser" last="Sala-Llonch">Roser Sala-Llonch</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Baggio, Hugo Cesar" sort="Baggio, Hugo Cesar" uniqKey="Baggio H" first="Hugo Cesar" last="Baggio">Hugo Cesar Baggio</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="María Jose" last="Martí">María Jose Martí</name><affiliation wicri:level="1"><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name><affiliation wicri:level="1"><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Vendrell, Pere" sort="Vendrell, Pere" uniqKey="Vendrell P" first="Pere" last="Vendrell">Pere Vendrell</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Bargall, Nuria" sort="Bargall, Nuria" uniqKey="Bargall N" first="Nuria" last="Bargall">Nuria Bargall</name><affiliation wicri:level="1"><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre de Diagnòstic per la Imatge Hospital Clinic de Barcelona (CDIC), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centre de Diagnòstic per la Imatge Hospital Clinic de Barcelona (CDIC), Hospital Clínic de Barcelona, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Tolosa, Eduard" sort="Tolosa, Eduard" uniqKey="Tolosa E" first="Eduard" last="Tolosa">Eduard Tolosa</name><affiliation wicri:level="1"><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències (ICN), Hospital Clínic de Barcelona, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junqué">Carme Junqué</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic de Barcelona, Barcelona</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2013-04">2013-04</date><biblScope unit="volume">84</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="370">370</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">283D5F4E54A3E450F99855B57AA9DED34E58FE94</idno><idno type="DOI">10.1136/jnnp-2012-302822</idno><idno type="href">jnnp-84-370.pdf</idno><idno type="ArticleID">jnnp-2012-302822</idno><idno type="PMID">23117490</idno><idno type="local">jnnp;84/4/370</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background In a previous functional MRI (fMRI) study, we found that patients with Parkinson's disease (PD) presented with dysfunctions in the recruitment of recognition memory networks. We aimed to investigate the changes in these networks over time. Methods We studied 17 PD patients and 13 age and sex matched healthy subjects. In both groups fMRI (recognition memory paradigm) and neuropsychological assessments were obtained at baseline and at follow-up. To analyse changes over time in functional networks, model free (independent component analysis) analyses of the fMRI data were carried out. Then, a cross correlation approach was used to assess the changes in the strength of functional connectivity. Results At follow-up, patients showed reduced recruitment of one network, including decreased activation in the orbitofrontal cortices, middle frontal gyri, frontal poles, anterior paracingulate cortex, superior parietal lobes and left middle temporal gyrus, as well as decreased deactivation in the anterior paracingulate gyrus and precuneus. Cross correlation analyses over time showed a decrease in the strength of functional connectivity between the middle frontal gyrus and the superior parietal lobe in PD patients. Conclusions Model free fMRI and cross correlation connectivity analyses were able to detect progressive changes in functional networks involved in recognition memory in PD patients at early disease stages and without overt clinical deterioration. Functional connectivity analyses could be useful to monitor changes in brain networks underlying neuropsychological deficits in PD.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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