Memory and executive function in sporadic and familial Parkinson's disease
Identifieur interne : 001020 ( Main/Curation ); précédent : 001019; suivant : 001021Memory and executive function in sporadic and familial Parkinson's disease
Auteurs : Kathy Dujardin ; Luc Defebvre ; Christine Grunberg ; Estelle Becquet ; Alain Deste ESource :
- Brain [ 0006-8950 ] ; 2001-02.
English descriptors
- KwdEn :
- MDRS = Mattis Dementia Rating Scale, UKPDBB = United Kingdom Parkinson's Disease Brain Bank, UPDRS = Unified Parkinson's Disease Rating Scale, VIQ = verbal intelligence quotient, WAIS-R = Wechsler Adult Intelligence Scale—revised, WCST = Wisconsin Card Sorting Test, dysexecutive syndrome, familial Parkinson's disease, frontostriatal circuit.
Abstract
Some studies have demonstrated that the motor symptomatology in sporadic and familial Parkinson's disease was identical. From a physiopathological point of view, and perhaps in the future from a therapeutic point of view, it seems important to determine whether sporadic and familial Parkinson's disease are also similar with regard to cognitive impairment. The aim of the present study was to assess cognitive functions in patients suffering from sporadic and familial Parkinson's disease. Executive functions and memory were investigated in particular. Two groups of 12 patients with Parkinson's disease (sporadic and familial) and 12 healthy controls performed a set of tasks known to evaluate different aspects of executive function and memory. One-way analysis of variance tested for significant group effects, and when justified, post hoc analysis was performed. Cognitive impairment was different in sporadic and familial forms of Parkinson's disease. Indeed, although executive function was impaired in both groups of patients, deficits in tests of explicit memory recall were only observed in patients with sporadic Parkinson's disease. Although the impairment observed in both groups of patients suggests a disruption of the striatoprefrontal circuits, this disruption seems to be quantitatively more important and more widespread in the sporadic patients than in the familial ones. In both patient groups, the deficits probably result from dopaminergic and nondopaminergic deprivation and a greater participation of nondopaminergic factors in patients with sporadic Parkinson's disease could be suggested. In this group, a xenobiotic could be responsible for an acquired metabolic defect involving more widespread structures of the striatoprefrontal circuits, leading to disruption of nondopaminergic loops. Cholinergic deprivation is considered in particular.
Url:
DOI: 10.1093/brain/124.2.389
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001221
Links to Exploration step
ISTEX:817CE9DAB893BA333B39ECA3F23B2A3D4DF9150BCuration
No country items
Kathy Dujardin<affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation>Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Memory and executive function in sporadic and familial Parkinson's disease</title><author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Grunberg, Christine" sort="Grunberg, Christine" uniqKey="Grunberg C" first="Christine" last="Grunberg">Christine Grunberg</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Becquet, Estelle" sort="Becquet, Estelle" uniqKey="Becquet E" first="Estelle" last="Becquet">Estelle Becquet</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Deste E, Alain" sort="Deste E, Alain" uniqKey="Deste E A" first="Alain" last="Deste E">Alain Deste E</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:817CE9DAB893BA333B39ECA3F23B2A3D4DF9150B</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1093/brain/124.2.389</idno><idno type="url">https://api.istex.fr/document/817CE9DAB893BA333B39ECA3F23B2A3D4DF9150B/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001221</idno><idno type="wicri:Area/Main/Curation">001020</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Memory and executive function in sporadic and familial Parkinson's disease</title><author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Grunberg, Christine" sort="Grunberg, Christine" uniqKey="Grunberg C" first="Christine" last="Grunberg">Christine Grunberg</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Becquet, Estelle" sort="Becquet, Estelle" uniqKey="Becquet E" first="Estelle" last="Becquet">Estelle Becquet</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author><author><name sortKey="Deste E, Alain" sort="Deste E, Alain" uniqKey="Deste E A" first="Alain" last="Deste E">Alain Deste E</name><affiliation><mods:affiliation></mods:affiliation><wicri:noCountry code="syntax">???</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain</title><title level="j" type="abbrev">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2001-02">2001-02</date><biblScope unit="volume">124</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="389">389</biblScope><biblScope unit="page" to="398">398</biblScope></imprint><idno type="ISSN">0006-8950</idno></series><idno type="istex">817CE9DAB893BA333B39ECA3F23B2A3D4DF9150B</idno><idno type="DOI">10.1093/brain/124.2.389</idno><idno type="PII">1460-2156</idno><idno type="local">1240389</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MDRS = Mattis Dementia Rating Scale</term><term>UKPDBB = United Kingdom Parkinson's Disease Brain Bank</term><term>UPDRS = Unified Parkinson's Disease Rating Scale</term><term>VIQ = verbal intelligence quotient</term><term>WAIS-R = Wechsler Adult Intelligence Scale—revised</term><term>WCST = Wisconsin Card Sorting Test</term><term>dysexecutive syndrome</term><term>familial Parkinson's disease</term><term>frontostriatal circuit</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Some studies have demonstrated that the motor symptomatology in sporadic and familial Parkinson's disease was identical. From a physiopathological point of view, and perhaps in the future from a therapeutic point of view, it seems important to determine whether sporadic and familial Parkinson's disease are also similar with regard to cognitive impairment. The aim of the present study was to assess cognitive functions in patients suffering from sporadic and familial Parkinson's disease. Executive functions and memory were investigated in particular. Two groups of 12 patients with Parkinson's disease (sporadic and familial) and 12 healthy controls performed a set of tasks known to evaluate different aspects of executive function and memory. One-way analysis of variance tested for significant group effects, and when justified, post hoc analysis was performed. Cognitive impairment was different in sporadic and familial forms of Parkinson's disease. Indeed, although executive function was impaired in both groups of patients, deficits in tests of explicit memory recall were only observed in patients with sporadic Parkinson's disease. Although the impairment observed in both groups of patients suggests a disruption of the striatoprefrontal circuits, this disruption seems to be quantitatively more important and more widespread in the sporadic patients than in the familial ones. In both patient groups, the deficits probably result from dopaminergic and nondopaminergic deprivation and a greater participation of nondopaminergic factors in patients with sporadic Parkinson's disease could be suggested. In this group, a xenobiotic could be responsible for an acquired metabolic defect involving more widespread structures of the striatoprefrontal circuits, leading to disruption of nondopaminergic loops. Cholinergic deprivation is considered in particular.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001020 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001020 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Curation
|type= RBID
|clé= ISTEX:817CE9DAB893BA333B39ECA3F23B2A3D4DF9150B
|texte= Memory and executive function in sporadic and familial Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |