Serveur d'exploration sur la maladie de Parkinson

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The history of dopamine and levodopa in the treatment of Parkinson's disease

Identifieur interne : 000D87 ( Main/Curation ); précédent : 000D86; suivant : 000D88

The history of dopamine and levodopa in the treatment of Parkinson's disease

Auteurs : Stanley Fahn [États-Unis]

Source :

RBID : ISTEX:6C17BB4B527CC2DC350FB59E0CD1784A99B54001

English descriptors

Abstract

The discoveries of dopamine as a neurotransmitter in the brain, its depletion in patients with Parkinson disease, and its replacement with levodopa therapy were major revolutionary events in the rise to effective therapy for patients with this disorder. This review describes these events and the persons who carried out these accomplishments. Their impact went beyond a single clinical entity of parkinsonism, for it opened up the beginning of a much better understanding of the role of dopamine in other neurologic movement disorders and also in many psychiatric diseases. © 2008 Movement Disorder Society

Url:
DOI: 10.1002/mds.22028

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ISTEX:6C17BB4B527CC2DC350FB59E0CD1784A99B54001

Le document en format XML

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<title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
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<div type="abstract" xml:lang="en">The discoveries of dopamine as a neurotransmitter in the brain, its depletion in patients with Parkinson disease, and its replacement with levodopa therapy were major revolutionary events in the rise to effective therapy for patients with this disorder. This review describes these events and the persons who carried out these accomplishments. Their impact went beyond a single clinical entity of parkinsonism, for it opened up the beginning of a much better understanding of the role of dopamine in other neurologic movement disorders and also in many psychiatric diseases. © 2008 Movement Disorder Society</div>
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   |clé=     ISTEX:6C17BB4B527CC2DC350FB59E0CD1784A99B54001
   |texte=   The history of dopamine and levodopa in the treatment of Parkinson's disease
}}

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