BDNF Val66Met polymorphism is associated with cognitive impairment in Italian patients with Parkinson’s disease
Identifieur interne : 000D38 ( Main/Curation ); précédent : 000D37; suivant : 000D39BDNF Val66Met polymorphism is associated with cognitive impairment in Italian patients with Parkinson’s disease
Auteurs : F. R. Guerini [Italie] ; E. Beghi [Italie] ; G. Riboldazzi ; R. Zangaglia ; C. Pianezzola ; G. Bono ; C. Casali [Italie] ; C. Di Lorenzo [Italie] ; C. Agliardi [Italie] ; G. Nappi [Italie] ; M. Clerici [Italie] ; E. Martignoni [Italie]Source :
- European Journal of Neurology [ 1351-5101 ] ; 2009-11.
English descriptors
Abstract
Background and purpose: A possible association between Parkinson’s disease (PD) and the polymorphism of Brain Derived Neurotrophic Factor (BDNF) G196A (Val66Met) has been suggested by different studies that nevertheless yielded‐contrasting result. The purpose of this study was to analyze such possible association in a cohort of Italian PD patients. Methods: The BDNF polymorphisms were analyzed in 294 Italian patients with PD; results were compared to those obtained in 233 age‐ and sex‐matched healthy controls (HC) enrolled from two tertiary centres in Italy. Polymorphisms were determined by Restriction Fragment Length Polymorphism (RFLP) analysis; correlations between BDNF G196A polymorphism, and cognitive function were established by sub analyzing the results upon dividing PD patients based on their Mini Mental State Examination (MMSE) score. Results: Univariate analysis showed a highly significant correlation between the BDNF(AA) genotype and a MMSE score ≤24. Hence, the distribution of this genotype in PD individuals with a MMSE score ≤24 was significantly increased compared to PD patients with an MMSE score >24 and HC (P < 0.001 in both cases). Multivariate analyses showed that BDNF (AA) genotype was associated to a sixfold risk of cognitive impairment. Conclusions: The BDNF(AA) homozygote genotype is over‐represented in PD patients compared with normal individuals; this genotype was significantly correlated to cognitive impairment, age and disease severity. These results, although preliminary, could be important in establishing novel diagnostic and therapeutic approaches to PD.
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DOI: 10.1111/j.1468-1331.2009.02706.x
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G. Riboldazzi<affiliation><mods:affiliation>Center for Parkinson’s Disease and Movement Disorders, Ospedale di Circolo e Fondazioni Macchi, Varese</mods:affiliation><wicri:noCountry code="subField">Varese</wicri:noCountry></affiliation><affiliation><mods:affiliation>Parkinson’s disease and Movement Disorders Unit, IRCCS Neurological Institute “C. Mondino”, Pavia</mods:affiliation><wicri:noCountry code="subField">Pavia</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Neurology, University of Insubria, Varese</mods:affiliation><wicri:noCountry code="subField">Varese</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Neurology, University of Insubria, Varese</mods:affiliation><wicri:noCountry code="subField">Varese</wicri:noCountry></affiliation><affiliation><mods:affiliation>Interdepartmental Research Center for Parkinson’s disease, IRCCS Neurological Institute “C. Mondino”, Pavia</mods:affiliation><wicri:noCountry code="subField">Pavia</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Clinical and Experimental Medicine, University of Piemonte Orientale, Novara</mods:affiliation><wicri:noCountry code="subField">Novara</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Unit of Neurorehabilitation and Movement Disorders, IRCCS Maugeri, Scientific Institute of Veruno, Novara, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Neurorehabilitation and Movement Disorders, IRCCS Maugeri, Scientific Institute of Veruno, Novara</wicri:regionArea></affiliation><affiliation><mods:affiliation>Department of Clinical and Experimental Medicine, University of Piemonte Orientale, Novara</mods:affiliation><wicri:noCountry code="subField">Novara</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Unit of Neurorehabilitation and Movement Disorders, IRCCS Maugeri, Scientific Institute of Veruno, Novara, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Neurorehabilitation and Movement Disorders, IRCCS Maugeri, Scientific Institute of Veruno, Novara</wicri:regionArea></affiliation>Le document en format XML
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Clerici</name><affiliation wicri:level="3"><mods:affiliation>Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation IRCCS, Milan</mods:affiliation><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName><wicri:orgArea>Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation IRCCS</wicri:orgArea></affiliation><affiliation wicri:level="3"><mods:affiliation>Department of Biomedical Sciences and Technology, University of Milan, Milan</mods:affiliation><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName><wicri:orgArea>Department of Biomedical Sciences and Technology, University of Milan</wicri:orgArea></affiliation></author><author><name sortKey="Martignoni, E" sort="Martignoni, E" uniqKey="Martignoni E" first="E." last="Martignoni">E. Martignoni</name><affiliation><mods:affiliation>Interdepartmental Research Center for Parkinson’s disease, IRCCS Neurological Institute “C. Mondino”, Pavia</mods:affiliation><wicri:noCountry code="subField">Pavia</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Clinical and Experimental Medicine, University of Piemonte Orientale, Novara</mods:affiliation><wicri:noCountry code="subField">Novara</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Unit of Neurorehabilitation and Movement Disorders, IRCCS Maugeri, Scientific Institute of Veruno, Novara, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Neurorehabilitation and Movement Disorders, IRCCS Maugeri, Scientific Institute of Veruno, Novara</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3A8EF4C4150EB8E31B07FFD9927254575D144DD0</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1111/j.1468-1331.2009.02706.x</idno><idno type="url">https://api.istex.fr/document/3A8EF4C4150EB8E31B07FFD9927254575D144DD0/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000F10</idno><idno type="wicri:Area/Main/Curation">000D38</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">BDNF Val66Met polymorphism is associated with cognitive impairment in Italian patients with Parkinson’s disease</title><author><name sortKey="Guerini, F R" sort="Guerini, F R" uniqKey="Guerini F" first="F. R." last="Guerini">F. R. Guerini</name><affiliation wicri:level="3"><mods:affiliation>Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation IRCCS, Milan</mods:affiliation><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName><wicri:orgArea>Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation IRCCS</wicri:orgArea></affiliation></author><author><name sortKey="Beghi, E" sort="Beghi, E" uniqKey="Beghi E" first="E." last="Beghi">E. Beghi</name><affiliation wicri:level="3"><mods:affiliation>Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation IRCCS, Milan</mods:affiliation><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName><wicri:orgArea>Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation IRCCS</wicri:orgArea></affiliation><affiliation wicri:level="3"><mods:affiliation>Laboratory of Neurological Disorders, Mario Negri Institute, Milan</mods:affiliation><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName><wicri:orgArea>Laboratory of Neurological Disorders, Mario Negri Institute</wicri:orgArea></affiliation></author><author><name sortKey="Riboldazzi, G" sort="Riboldazzi, G" uniqKey="Riboldazzi G" first="G." last="Riboldazzi">G. Riboldazzi</name><affiliation><mods:affiliation>Center for Parkinson’s Disease and Movement Disorders, Ospedale di Circolo e Fondazioni Macchi, Varese</mods:affiliation><wicri:noCountry code="subField">Varese</wicri:noCountry></affiliation></author><author><name sortKey="Zangaglia, R" sort="Zangaglia, R" uniqKey="Zangaglia R" first="R." last="Zangaglia">R. Zangaglia</name><affiliation><mods:affiliation>Parkinson’s disease and Movement Disorders Unit, IRCCS Neurological Institute “C. Mondino”, Pavia</mods:affiliation><wicri:noCountry code="subField">Pavia</wicri:noCountry></affiliation></author><author><name sortKey="Pianezzola, C" sort="Pianezzola, C" uniqKey="Pianezzola C" first="C." last="Pianezzola">C. Pianezzola</name><affiliation><mods:affiliation>Department of Neurology, University of Insubria, Varese</mods:affiliation><wicri:noCountry code="subField">Varese</wicri:noCountry></affiliation></author><author><name sortKey="Bono, G" sort="Bono, G" uniqKey="Bono G" first="G." last="Bono">G. Bono</name><affiliation><mods:affiliation>Department of Neurology, University of Insubria, Varese</mods:affiliation><wicri:noCountry code="subField">Varese</wicri:noCountry></affiliation></author><author><name sortKey="Casali, C" sort="Casali, C" uniqKey="Casali C" first="C." last="Casali">C. Casali</name><affiliation wicri:level="3"><mods:affiliation>Laboratory of Molecolar Neurogenetics, IRCCS Neurological Institute “C. Mondino”, Rome</mods:affiliation><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName><wicri:orgArea>Laboratory of Molecolar Neurogenetics, IRCCS Neurological Institute “C. Mondino”</wicri:orgArea></affiliation></author><author><name sortKey="Di Lorenzo, C" sort="Di Lorenzo, C" uniqKey="Di Lorenzo C" first="C." last="Di Lorenzo">C. Di Lorenzo</name><affiliation wicri:level="3"><mods:affiliation>Laboratory of Molecolar Neurogenetics, IRCCS Neurological Institute “C. Mondino”, Rome</mods:affiliation><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName><wicri:orgArea>Laboratory of Molecolar Neurogenetics, IRCCS Neurological Institute “C. Mondino”</wicri:orgArea></affiliation></author><author><name sortKey="Agliardi, C" sort="Agliardi, C" uniqKey="Agliardi C" first="C." last="Agliardi">C. Agliardi</name><affiliation wicri:level="3"><mods:affiliation>Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation IRCCS, Milan</mods:affiliation><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName><wicri:orgArea>Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation IRCCS</wicri:orgArea></affiliation></author><author><name sortKey="Nappi, G" sort="Nappi, G" uniqKey="Nappi G" first="G." last="Nappi">G. Nappi</name><affiliation wicri:level="3"><mods:affiliation>Department of Neurology and Otorhinolaryngology, University of Rome “La Sapienza”, Rome</mods:affiliation><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName><wicri:orgArea>Department of Neurology and Otorhinolaryngology, University of Rome “La Sapienza”</wicri:orgArea></affiliation></author><author><name sortKey="Clerici, M" sort="Clerici, M" uniqKey="Clerici M" first="M." last="Clerici">M. Clerici</name><affiliation wicri:level="3"><mods:affiliation>Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation IRCCS, Milan</mods:affiliation><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName><wicri:orgArea>Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation IRCCS</wicri:orgArea></affiliation><affiliation wicri:level="3"><mods:affiliation>Department of Biomedical Sciences and Technology, University of Milan, Milan</mods:affiliation><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName><wicri:orgArea>Department of Biomedical Sciences and Technology, University of Milan</wicri:orgArea></affiliation></author><author><name sortKey="Martignoni, E" sort="Martignoni, E" uniqKey="Martignoni E" first="E." last="Martignoni">E. Martignoni</name><affiliation><mods:affiliation>Interdepartmental Research Center for Parkinson’s disease, IRCCS Neurological Institute “C. Mondino”, Pavia</mods:affiliation><wicri:noCountry code="subField">Pavia</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Clinical and Experimental Medicine, University of Piemonte Orientale, Novara</mods:affiliation><wicri:noCountry code="subField">Novara</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Unit of Neurorehabilitation and Movement Disorders, IRCCS Maugeri, Scientific Institute of Veruno, Novara, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Neurorehabilitation and Movement Disorders, IRCCS Maugeri, Scientific Institute of Veruno, Novara</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-11">2009-11</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1240">1240</biblScope><biblScope unit="page" to="1245">1245</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">3A8EF4C4150EB8E31B07FFD9927254575D144DD0</idno><idno type="DOI">10.1111/j.1468-1331.2009.02706.x</idno><idno type="ArticleID">ENE2706</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain Derived Neurotrophic Factor</term><term>Mini Mental State Examination</term><term>Parkinson's disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background and purpose: A possible association between Parkinson’s disease (PD) and the polymorphism of Brain Derived Neurotrophic Factor (BDNF) G196A (Val66Met) has been suggested by different studies that nevertheless yielded‐contrasting result. The purpose of this study was to analyze such possible association in a cohort of Italian PD patients. Methods: The BDNF polymorphisms were analyzed in 294 Italian patients with PD; results were compared to those obtained in 233 age‐ and sex‐matched healthy controls (HC) enrolled from two tertiary centres in Italy. Polymorphisms were determined by Restriction Fragment Length Polymorphism (RFLP) analysis; correlations between BDNF G196A polymorphism, and cognitive function were established by sub analyzing the results upon dividing PD patients based on their Mini Mental State Examination (MMSE) score. Results: Univariate analysis showed a highly significant correlation between the BDNF(AA) genotype and a MMSE score ≤24. Hence, the distribution of this genotype in PD individuals with a MMSE score ≤24 was significantly increased compared to PD patients with an MMSE score >24 and HC (P < 0.001 in both cases). Multivariate analyses showed that BDNF (AA) genotype was associated to a sixfold risk of cognitive impairment. Conclusions: The BDNF(AA) homozygote genotype is over‐represented in PD patients compared with normal individuals; this genotype was significantly correlated to cognitive impairment, age and disease severity. These results, although preliminary, could be important in establishing novel diagnostic and therapeutic approaches to PD.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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