Pathological gambling in patients with Parkinson's disease is associated with fronto‐striatal disconnection: A path modeling analysis
Identifieur interne : 000B78 ( Main/Curation ); précédent : 000B77; suivant : 000B79Pathological gambling in patients with Parkinson's disease is associated with fronto‐striatal disconnection: A path modeling analysis
Auteurs : Roberto Cilia [Canada, Italie] ; Sang Soo Cho [Canada] ; Thilo Van Eimeren [Canada] ; Giorgio Marotta [Italie] ; Chiara Siri [Italie] ; Ji Hyun Ko [Canada] ; Giovanna Pellecchia [Canada] ; Gianni Pezzoli [Italie] ; Angelo Antonini [Italie] ; Antonio P. Strafella [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-02-01.
English descriptors
Abstract
Background:: Pathological gambling may occur in Parkinson's disease (PD) as a complication of dopaminergic therapy. Neuroimaging studies have suggested an abnormal dopamine transmission within the reward system, but the changes in the neural network characterizing PD patients with pathological gambling have never been investigated. Methods:: Thirty PD patients (15 with active gambling and 15 matched controls, on‐medication) and 15 healthy subjects underwent brain perfusion single photon emission tomography at rest. The severity of gambling was assessed using the South Oaks Gambling Scale. Covariance analysis was applied to identify brain regions whose activity was associated with gambling severity. These regions were used as volume‐of‐interest to identify functionally interconnected areas using voxel‐wise covariance analysis. A path model was defined by means of effective connectivity analysis within the Structural Equation Modeling framework. Results:: Gambling severity in PD was associated with a dysfunction of the brain network implicated in decision making, risk processing, and response inhibition, including the ventrolateral prefrontal cortex, anterior (ACC) and posterior cingulate cortex, medial prefrontal cortex, insula and striatum. PD gamblers showed a disconnection between the ACC and the striatum, while this interaction was very robust in both control groups. Discussion:: ACC‐striatal disconnection may underlie a specific impairment of shifting behaviors after negative outcomes, possibly explaining why PD gamblers use to perseverate into risktaking behaviors despite self‐destructive consequences. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23480
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Strafella</name><affiliation wicri:level="1"><mods:affiliation>Division of Brain, Imaging and Behaviorur‐Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Brain, Imaging and Behaviorur‐Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:989B859FEEE651B1B0AC5F763254C422B0CA3649</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23480</idno><idno type="url">https://api.istex.fr/document/989B859FEEE651B1B0AC5F763254C422B0CA3649/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000D34</idno><idno type="wicri:Area/Main/Curation">000B78</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Pathological gambling in patients with Parkinson's disease is associated with fronto‐striatal disconnection: A path modeling analysis</title><author><name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name><affiliation wicri:level="1"><mods:affiliation>Division of Brain, Imaging and Behaviorur‐Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Brain, Imaging and Behaviorur‐Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Parkinson Institute, Department of Neurology, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Department of Neurology, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Cho, Sang Soo" sort="Cho, Sang Soo" uniqKey="Cho S" first="Sang Soo" last="Cho">Sang Soo Cho</name><affiliation wicri:level="1"><mods:affiliation>Division of Brain, Imaging and Behaviorur‐Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Brain, Imaging and Behaviorur‐Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name><affiliation wicri:level="1"><mods:affiliation>Division of Brain, Imaging and Behaviorur‐Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Brain, Imaging and Behaviorur‐Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Marotta, Giorgio" sort="Marotta, Giorgio" uniqKey="Marotta G" first="Giorgio" last="Marotta">Giorgio Marotta</name><affiliation wicri:level="1"><mods:affiliation>Nuclear Medicine Department, IRCCS‐OSpedale Maggiore, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Nuclear Medicine Department, IRCCS‐OSpedale Maggiore, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Siri, Chiara" sort="Siri, Chiara" uniqKey="Siri C" first="Chiara" last="Siri">Chiara Siri</name><affiliation wicri:level="1"><mods:affiliation>Parkinson Institute, Department of Neurology, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Department of Neurology, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name><affiliation wicri:level="1"><mods:affiliation>Division of Brain, Imaging and Behaviorur‐Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Brain, Imaging and Behaviorur‐Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Pellecchia, Giovanna" sort="Pellecchia, Giovanna" uniqKey="Pellecchia G" first="Giovanna" last="Pellecchia">Giovanna Pellecchia</name><affiliation wicri:level="1"><mods:affiliation>Division of Brain, Imaging and Behaviorur‐Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Brain, Imaging and Behaviorur‐Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name><affiliation wicri:level="1"><mods:affiliation>Parkinson Institute, Department of Neurology, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Department of Neurology, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><affiliation wicri:level="1"><mods:affiliation>Parkinson Institute, Department of Neurology, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Department of Neurology, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Neurology, IRCCS San Camillo Venice, University of Padua, Padua, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, IRCCS San Camillo Venice, University of Padua, Padua</wicri:regionArea></affiliation></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><affiliation wicri:level="1"><mods:affiliation>Division of Brain, Imaging and Behaviorur‐Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Brain, Imaging and Behaviorur‐Systems Neuroscience, Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-01">2011-02-01</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="225">225</biblScope><biblScope unit="page" to="233">233</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">989B859FEEE651B1B0AC5F763254C422B0CA3649</idno><idno type="DOI">10.1002/mds.23480</idno><idno type="ArticleID">MDS23480</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>SPECT</term><term>SPM</term><term>effective connectivity</term><term>pathological gambling</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Pathological gambling may occur in Parkinson's disease (PD) as a complication of dopaminergic therapy. Neuroimaging studies have suggested an abnormal dopamine transmission within the reward system, but the changes in the neural network characterizing PD patients with pathological gambling have never been investigated. Methods:: Thirty PD patients (15 with active gambling and 15 matched controls, on‐medication) and 15 healthy subjects underwent brain perfusion single photon emission tomography at rest. The severity of gambling was assessed using the South Oaks Gambling Scale. Covariance analysis was applied to identify brain regions whose activity was associated with gambling severity. These regions were used as volume‐of‐interest to identify functionally interconnected areas using voxel‐wise covariance analysis. A path model was defined by means of effective connectivity analysis within the Structural Equation Modeling framework. Results:: Gambling severity in PD was associated with a dysfunction of the brain network implicated in decision making, risk processing, and response inhibition, including the ventrolateral prefrontal cortex, anterior (ACC) and posterior cingulate cortex, medial prefrontal cortex, insula and striatum. PD gamblers showed a disconnection between the ACC and the striatum, while this interaction was very robust in both control groups. Discussion:: ACC‐striatal disconnection may underlie a specific impairment of shifting behaviors after negative outcomes, possibly explaining why PD gamblers use to perseverate into risktaking behaviors despite self‐destructive consequences. © 2011 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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