Independent and joint effects of the MAPT and SNCA genes in Parkinson disease
Identifieur interne : 000995 ( Main/Curation ); précédent : 000994; suivant : 000996Independent and joint effects of the MAPT and SNCA genes in Parkinson disease
Auteurs : Alexis Elbaz [France] ; Owen A. Ross [États-Unis] ; John P. A. Ioannidis [Grèce, États-Unis] ; Alexandra I. Soto-Ortolaza [États-Unis] ; Frédéric Moisan [France] ; Jan Aasly [Norvège] ; Grazia Annesi [Italie] ; Maria Bozi [Grèce] ; Laura Brighina [Italie] ; Marie-Christine Chartier-Harlin [France] ; Alain Destée [France] ; Carlo Ferrarese [Italie] ; Alessandro Ferraris [Italie] ; J. Mark Gibson [Irlande (pays)] ; Suzana Gispert [Allemagne] ; Georgios M. Hadjigeorgiou [Grèce] ; Barbara Jasinska-Myga [Pologne] ; Christine Klein [Allemagne] ; Rejko Krüger [Allemagne] ; Jean-Charles Lambert [France] ; Katja Lohmann [Allemagne] ; Simone Van De Loo [Allemagne] ; Marie-Anne Loriot [France] ; Timothy Lynch [Irlande (pays)] ; George D. Mellick [Australie] ; Eugénie Mutez [France] ; Christer Nilsson [Suède] ; Grzegorz Opala [Pologne] ; Andreas Puschmann [Suède] ; Aldo Quattrone [Italie] ; Manu Sharma [Allemagne] ; Peter A. Silburn [Australie] ; Leonidas Stefanis [Grèce] ; Ryan J. Uitti [États-Unis] ; Enza Maria Valente [Italie] ; Carles Vilari O-Güell [États-Unis, Canada] ; Karin Wirdefeldt [Suède] ; Zbigniew K. Wszolek [États-Unis] ; Georgia Xiromerisiou [Grèce] ; Demetrius M. Maraganore [États-Unis] ; Matthew J. Farrer [États-Unis, Canada]Source :
- Annals of Neurology [ 0364-5134 ] ; 2011-05.
Abstract
Objective:: We studied the independent and joint effects of the genes encoding alpha‐synuclein (SNCA) and microtubule‐associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta‐analysis of individual data from case–control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) consortium. Methods:: Participants of Caucasian ancestry were genotyped for a total of 4 SNCA (rs2583988, rs181489, rs356219, rs11931074) and 2 MAPT (rs1052553, rs242557) single nucleotide polymorphism (SNPs). Individual and joint effects of SNCA and MAPT SNPs were investigated using fixed‐ and random‐effects logistic regression models. Interactions were studied on both a multiplicative and an additive scale, and using a case–control and case‐only approach. Results:: Fifteen GEO‐PD sites contributed a total of 5,302 cases and 4,161 controls. All 4 SNCA SNPs and the MAPT H1‐haplotype–defining SNP (rs1052553) displayed a highly significant marginal association with PD at the significance level adjusted for multiple comparisons. For SNCA, the strongest associations were observed for SNPs located at the 3′ end of the gene. There was no evidence of statistical interaction between any of the 4 SNCA SNPs and rs1052553 or rs242557, neither on the multiplicative nor on the additive scale. Interpretation:: This study confirms the association between PD and both SNCA SNPs and the H1 MAPT haplotype. It shows, based on a variety of approaches, that the joint action of variants in these 2 loci is consistent with independent effects of the genes without additional interacting effects. ANN NEUROL 2011
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DOI: 10.1002/ana.22321
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Monza</wicri:regionArea></affiliation></author><author><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name><affiliation wicri:level="1"><mods:affiliation>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. 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Poland</mods:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><mods:affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck</wicri:regionArea></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation wicri:level="1"><mods:affiliation>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Lambert, Jean Harles" sort="Lambert, Jean Harles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="1"><mods:affiliation>INSERM, U744, Pasteur Institute from Lille, University of Lille‐Nord de France, Lille, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U744, Pasteur Institute from Lille, University of Lille‐Nord de France, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name><affiliation wicri:level="1"><mods:affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck</wicri:regionArea></affiliation></author><author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Goethe University, Frankfurt am Main</wicri:regionArea></affiliation></author><author><name sortKey="Loriot, Marie Nne" sort="Loriot, Marie Nne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name><affiliation wicri:level="1"><mods:affiliation>INSERM, UMR‐S 775, Molecular basis of response to xenobiotics, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR‐S 775, Molecular basis of response to xenobiotics, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University Paris Descartes, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Assistance‐Publique Hôpitaux de Paris, Georges Pompidou European Hospital (HEGP), Department of Biochemistry, Pharmacogenetics and Molecular Oncology, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Assistance‐Publique Hôpitaux de Paris, Georges Pompidou European Hospital (HEGP), Department of Biochemistry, Pharmacogenetics and Molecular Oncology, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation wicri:level="1"><mods:affiliation>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin, Ireland</mods:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin</wicri:regionArea></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation wicri:level="1"><mods:affiliation>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><affiliation wicri:level="1"><mods:affiliation>UMR 837 INSERM, Lille, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR 837 INSERM, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Univ Lille Nord de France, Lille, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ Lille Nord de France, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University Hospital, CHRU, Lille, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Hospital, CHRU, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</mods:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Skåne University Hospital, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurology, Skåne University Hospital, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neurology, University Magna Graecia, Catanzaro and Neuroimaging Research Unit, National Research Council, Germaneto, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University Magna Graecia, Catanzaro and Neuroimaging Research Unit, National Research Council, Germaneto</wicri:regionArea></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation wicri:level="1"><mods:affiliation>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation wicri:level="1"><mods:affiliation>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation wicri:level="1"><mods:affiliation>Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens and Second Department of Neurology, University of Athens Medical School, Athens, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens and Second Department of Neurology, University of Athens Medical School, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation wicri:level="2"><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation wicri:level="1"><mods:affiliation>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea></affiliation></author><author><name sortKey="Vilari O Ell, Carles" sort="Vilari O Ell, Carles" uniqKey="Vilari O Ell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name><affiliation wicri:level="2"><mods:affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia</wicri:regionArea></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="2"><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Biomedical Research and Technology, CERETETH, Larissa</wicri:regionArea></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="2"><mods:affiliation>Department of Neurology, NorthShore University HealthSystem, Evanston, IL</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="2"><mods:affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/ana.22321</idno><idno type="url">https://api.istex.fr/document/E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000B37</idno><idno type="wicri:Area/Main/Curation">000995</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Independent and joint effects of the MAPT and SNCA genes in Parkinson disease</title><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="1"><mods:affiliation>INSERM, U708, Neuroepidemiology, F‐75013, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Neuroepidemiology, F‐75013, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation wicri:level="2"><mods:affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation wicri:level="1"><mods:affiliation>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina</wicri:regionArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, MA</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Soto Rtolaza, Alexandra I" sort="Soto Rtolaza, Alexandra I" uniqKey="Soto Rtolaza A" first="Alexandra I." last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name><affiliation wicri:level="2"><mods:affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><affiliation wicri:level="1"><mods:affiliation>INSERM, U708, Neuroepidemiology, F‐75013, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Neuroepidemiology, F‐75013, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, St Olav Hospital, Trondheim, Norway</mods:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, St Olav Hospital, Trondheim</wicri:regionArea></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neurological Sciences, National Research Council, Cosenza, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurological Sciences, National Research Council, Cosenza</wicri:regionArea></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation wicri:level="1"><mods:affiliation>General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School, Athens, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza</wicri:regionArea></affiliation></author><author><name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation wicri:level="1"><mods:affiliation>UMR 837 INSERM, Lille, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR 837 INSERM, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Univ Lille Nord de France, Lille, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ Lille Nord de France, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation wicri:level="1"><mods:affiliation>UMR 837 INSERM, Lille, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR 837 INSERM, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Univ Lille Nord de France, Lille, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ Lille Nord de France, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University Hospital, CHRU, Lille, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Hospital, CHRU, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza</wicri:regionArea></affiliation></author><author><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name><affiliation wicri:level="1"><mods:affiliation>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</mods:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Neurology, Royal Victoria Hospital, Belfast</wicri:regionArea></affiliation></author><author><name sortKey="Gispert, Suzana" sort="Gispert, Suzana" uniqKey="Gispert S" first="Suzana" last="Gispert">Suzana Gispert</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Goethe University, Frankfurt am Main</wicri:regionArea></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Biomedical Research and Technology, CERETETH, Larissa</wicri:regionArea></affiliation></author><author><name sortKey="Jasinska Yga, Barbara" sort="Jasinska Yga, Barbara" uniqKey="Jasinska Yga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</mods:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><mods:affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck</wicri:regionArea></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation wicri:level="1"><mods:affiliation>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Lambert, Jean Harles" sort="Lambert, Jean Harles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="1"><mods:affiliation>INSERM, U744, Pasteur Institute from Lille, University of Lille‐Nord de France, Lille, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U744, Pasteur Institute from Lille, University of Lille‐Nord de France, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name><affiliation wicri:level="1"><mods:affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck</wicri:regionArea></affiliation></author><author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Goethe University, Frankfurt am Main</wicri:regionArea></affiliation></author><author><name sortKey="Loriot, Marie Nne" sort="Loriot, Marie Nne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name><affiliation wicri:level="1"><mods:affiliation>INSERM, UMR‐S 775, Molecular basis of response to xenobiotics, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR‐S 775, Molecular basis of response to xenobiotics, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University Paris Descartes, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Assistance‐Publique Hôpitaux de Paris, Georges Pompidou European Hospital (HEGP), Department of Biochemistry, Pharmacogenetics and Molecular Oncology, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Assistance‐Publique Hôpitaux de Paris, Georges Pompidou European Hospital (HEGP), Department of Biochemistry, Pharmacogenetics and Molecular Oncology, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation wicri:level="1"><mods:affiliation>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin, Ireland</mods:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin</wicri:regionArea></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation wicri:level="1"><mods:affiliation>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea></affiliation></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><affiliation wicri:level="1"><mods:affiliation>UMR 837 INSERM, Lille, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR 837 INSERM, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Univ Lille Nord de France, Lille, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ Lille Nord de France, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University Hospital, CHRU, Lille, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Hospital, CHRU, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</mods:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Skåne University Hospital, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurology, Skåne University Hospital, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neurology, University Magna Graecia, Catanzaro and Neuroimaging Research Unit, National Research Council, Germaneto, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University Magna Graecia, Catanzaro and Neuroimaging Research Unit, National Research Council, Germaneto</wicri:regionArea></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation wicri:level="1"><mods:affiliation>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation wicri:level="1"><mods:affiliation>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation wicri:level="1"><mods:affiliation>Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens and Second Department of Neurology, University of Athens Medical School, Athens, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens and Second Department of Neurology, University of Athens Medical School, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation wicri:level="2"><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation wicri:level="1"><mods:affiliation>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea></affiliation></author><author><name sortKey="Vilari O Ell, Carles" sort="Vilari O Ell, Carles" uniqKey="Vilari O Ell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name><affiliation wicri:level="2"><mods:affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia</wicri:regionArea></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="2"><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Biomedical Research and Technology, CERETETH, Larissa</wicri:regionArea></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="2"><mods:affiliation>Department of Neurology, NorthShore University HealthSystem, Evanston, IL</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="2"><mods:affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</mods:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-05">2011-05</date><biblScope unit="volume">69</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="778">778</biblScope><biblScope unit="page" to="792">792</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948</idno><idno type="DOI">10.1002/ana.22321</idno><idno type="ArticleID">ANA22321</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective:: We studied the independent and joint effects of the genes encoding alpha‐synuclein (SNCA) and microtubule‐associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta‐analysis of individual data from case–control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) consortium. Methods:: Participants of Caucasian ancestry were genotyped for a total of 4 SNCA (rs2583988, rs181489, rs356219, rs11931074) and 2 MAPT (rs1052553, rs242557) single nucleotide polymorphism (SNPs). Individual and joint effects of SNCA and MAPT SNPs were investigated using fixed‐ and random‐effects logistic regression models. Interactions were studied on both a multiplicative and an additive scale, and using a case–control and case‐only approach. Results:: Fifteen GEO‐PD sites contributed a total of 5,302 cases and 4,161 controls. All 4 SNCA SNPs and the MAPT H1‐haplotype–defining SNP (rs1052553) displayed a highly significant marginal association with PD at the significance level adjusted for multiple comparisons. For SNCA, the strongest associations were observed for SNPs located at the 3′ end of the gene. There was no evidence of statistical interaction between any of the 4 SNCA SNPs and rs1052553 or rs242557, neither on the multiplicative nor on the additive scale. Interpretation:: This study confirms the association between PD and both SNCA SNPs and the H1 MAPT haplotype. It shows, based on a variety of approaches, that the joint action of variants in these 2 loci is consistent with independent effects of the genes without additional interacting effects. ANN NEUROL 2011</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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