Facilitated temporal summation of pain at spinal level in Parkinson's disease
Identifieur interne : 000938 ( Main/Curation ); précédent : 000937; suivant : 000939Facilitated temporal summation of pain at spinal level in Parkinson's disease
Auteurs : Armando Perrotta [Italie] ; Giorgio Sandrini [Italie] ; Mariano Serrao [Italie] ; Simona Buscone [Italie] ; Cristina Tassorelli [Italie] ; Michele Tinazzi [Italie] ; Roberta Zangaglia [Italie] ; Claudio Pacchetti [Italie] ; Michelangelo Bartolo [Italie] ; Francesco Pierelli [Italie] ; Emilia Martignoni [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-02-15.
English descriptors
Abstract
Background:: Pain is one of the major nonmotor symptoms of Parkinson's disease. We hypothesized that Parkinson's disease patients could show an early diffuse abnormal processing of the nociceptive inputs also in the absence of clinical pain syndrome and that this could represent the physiopathological substrate to explain the high incidence of diffuse pain symptoms. Materials and methods:: We used the temporal summation threshold of the nociceptive withdrawal reflex and the related pain sensation to evaluate the facilitation in pain processing at spinal level. Fifteen (7 Women; 8 Men; mean age 63.0 ± 9.1) Parkinson's disease patients without clinical pain and 12 (6 Women, 6 Men; mean age 61.2 ± 4.2) healthy subjects were recruited. Parkinson's disease group has been subdivided into two subgroups, 7 early‐stage Parkinson's disease patients with unilateral signs (Hoehn and Yahr stage 1) and 8 patients in a more advanced stage of the disease showing bilateral parkinsonian signs (Hoehn and Yahr stages 2 and 2.5), both “on” and “off” treatments with levodopa. Results:: A significant facilitation in temporal summation of pain (reduced temporal summation threshold and increased painful sensation) was found in Parkinson's disease patients when compared with controls. This facilitation is more evident in Parkinson's disease with bilateral signs and on the side more affected in Parkinson's disease with unilateral signs. Levodopa administration failed to significantly modify the neurophysiological abnormalities; however, a slight improvement has been detected. Conclusions:: The increased gain in pain processing at spinal level in Parkinson's disease patients could be a consequence of the degenerative phenomena involving supraspinal projections implicated in the modulation of pain processing and could make Parkinson's disease patients more predisposed to develop a pain condition. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23458
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Maugeri, Tradate, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical Medicine, University of Insubria, Varese, Neurorehabilitation Unit and Movement Disorders Unit, IRCCS Fondazione S. 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Mondino Institute of Neurology” Foundation, University of Pavia, Pavia, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, IRCCS “C. Mondino Institute of Neurology” Foundation, University of Pavia, Pavia</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>IRCCS “Neuromed”, University of Rome “Sapienza”, Pozzilli, Isernia, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS “Neuromed”, University of Rome “Sapienza”, Pozzilli, Isernia</wicri:regionArea></affiliation></author><author><name sortKey="Sandrini, Giorgio" sort="Sandrini, Giorgio" uniqKey="Sandrini G" first="Giorgio" last="Sandrini">Giorgio Sandrini</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, IRCCS “C. Mondino Institute of Neurology” Foundation, University of Pavia, Pavia, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, IRCCS “C. Mondino Institute of Neurology” Foundation, University of Pavia, Pavia</wicri:regionArea></affiliation></author><author><name sortKey="Serrao, Mariano" sort="Serrao, Mariano" uniqKey="Serrao M" first="Mariano" last="Serrao">Mariano Serrao</name><affiliation wicri:level="1"><mods:affiliation>Neurorehabilitation Unit, University of Rome “Sapienza” Polo Pontino‐ICOT, Latina, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Neurorehabilitation Unit, University of Rome “Sapienza” Polo Pontino‐ICOT, Latina</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Casa di Cura Policlinico Italia, Rome, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Casa di Cura Policlinico Italia, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Buscone, Simona" sort="Buscone, Simona" uniqKey="Buscone S" first="Simona" last="Buscone">Simona Buscone</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, IRCCS “C. Mondino Institute of Neurology” Foundation, University of Pavia, Pavia, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, IRCCS “C. Mondino Institute of Neurology” Foundation, University of Pavia, Pavia</wicri:regionArea></affiliation></author><author><name sortKey="Tassorelli, Cristina" sort="Tassorelli, Cristina" uniqKey="Tassorelli C" first="Cristina" last="Tassorelli">Cristina Tassorelli</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, IRCCS “C. Mondino Institute of Neurology” Foundation, University of Pavia, Pavia, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, IRCCS “C. Mondino Institute of Neurology” Foundation, University of Pavia, Pavia</wicri:regionArea></affiliation></author><author><name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name><affiliation wicri:level="1"><mods:affiliation>Dipartimento di Scienze Neurologiche e della Visione, Sezione di Neurologia Riabilitativa, Università di Verona, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Neurologiche e della Visione, Sezione di Neurologia Riabilitativa, Università di Verona</wicri:regionArea></affiliation></author><author><name sortKey="Zangaglia, Roberta" sort="Zangaglia, Roberta" uniqKey="Zangaglia R" first="Roberta" last="Zangaglia">Roberta Zangaglia</name><affiliation wicri:level="1"><mods:affiliation>Parkinson Unit, IRCCS “C. Mondino Institute of Neurology” Foundation, University of Pavia, Pavia, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Unit, IRCCS “C. Mondino Institute of Neurology” Foundation, University of Pavia, Pavia</wicri:regionArea></affiliation></author><author><name sortKey="Pacchetti, Claudio" sort="Pacchetti, Claudio" uniqKey="Pacchetti C" first="Claudio" last="Pacchetti">Claudio Pacchetti</name><affiliation wicri:level="1"><mods:affiliation>Parkinson Unit, IRCCS “C. Mondino Institute of Neurology” Foundation, University of Pavia, Pavia, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Unit, IRCCS “C. Mondino Institute of Neurology” Foundation, University of Pavia, Pavia</wicri:regionArea></affiliation></author><author><name sortKey="Bartolo, Michelangelo" sort="Bartolo, Michelangelo" uniqKey="Bartolo M" first="Michelangelo" last="Bartolo">Michelangelo Bartolo</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, IRCCS “C. Mondino Institute of Neurology” Foundation, University of Pavia, Pavia, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, IRCCS “C. Mondino Institute of Neurology” Foundation, University of Pavia, Pavia</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>IRCCS “Neuromed”, University of Rome “Sapienza”, Pozzilli, Isernia, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS “Neuromed”, University of Rome “Sapienza”, Pozzilli, Isernia</wicri:regionArea></affiliation></author><author><name sortKey="Pierelli, Francesco" sort="Pierelli, Francesco" uniqKey="Pierelli F" first="Francesco" last="Pierelli">Francesco Pierelli</name><affiliation wicri:level="1"><mods:affiliation>IRCCS “Neuromed”, University of Rome “Sapienza”, Pozzilli, Isernia, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS “Neuromed”, University of Rome “Sapienza”, Pozzilli, Isernia</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Neurorehabilitation Unit, University of Rome “Sapienza” Polo Pontino‐ICOT, Latina, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Neurorehabilitation Unit, University of Rome “Sapienza” Polo Pontino‐ICOT, Latina</wicri:regionArea></affiliation></author><author><name sortKey="Martignoni, Emilia" sort="Martignoni, Emilia" uniqKey="Martignoni E" first="Emilia" last="Martignoni">Emilia Martignoni</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Medicine, University of Insubria, Varese, Neurorehabilitation Unit and Movement Disorders Unit, IRCCS Fondazione S. Maugeri, Tradate, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical Medicine, University of Insubria, Varese, Neurorehabilitation Unit and Movement Disorders Unit, IRCCS Fondazione S. Maugeri, Tradate</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-02-15">2011-02-15</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="442">442</biblScope><biblScope unit="page" to="448">448</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">7B0E1E674C04E5BF6B3E68DDF85C0E01CF32FAEB</idno><idno type="DOI">10.1002/mds.23458</idno><idno type="ArticleID">MDS23458</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>nociceptive withdrawal reflex</term><term>pain</term><term>temporal summation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Pain is one of the major nonmotor symptoms of Parkinson's disease. We hypothesized that Parkinson's disease patients could show an early diffuse abnormal processing of the nociceptive inputs also in the absence of clinical pain syndrome and that this could represent the physiopathological substrate to explain the high incidence of diffuse pain symptoms. Materials and methods:: We used the temporal summation threshold of the nociceptive withdrawal reflex and the related pain sensation to evaluate the facilitation in pain processing at spinal level. Fifteen (7 Women; 8 Men; mean age 63.0 ± 9.1) Parkinson's disease patients without clinical pain and 12 (6 Women, 6 Men; mean age 61.2 ± 4.2) healthy subjects were recruited. Parkinson's disease group has been subdivided into two subgroups, 7 early‐stage Parkinson's disease patients with unilateral signs (Hoehn and Yahr stage 1) and 8 patients in a more advanced stage of the disease showing bilateral parkinsonian signs (Hoehn and Yahr stages 2 and 2.5), both “on” and “off” treatments with levodopa. Results:: A significant facilitation in temporal summation of pain (reduced temporal summation threshold and increased painful sensation) was found in Parkinson's disease patients when compared with controls. This facilitation is more evident in Parkinson's disease with bilateral signs and on the side more affected in Parkinson's disease with unilateral signs. Levodopa administration failed to significantly modify the neurophysiological abnormalities; however, a slight improvement has been detected. Conclusions:: The increased gain in pain processing at spinal level in Parkinson's disease patients could be a consequence of the degenerative phenomena involving supraspinal projections implicated in the modulation of pain processing and could make Parkinson's disease patients more predisposed to develop a pain condition. © 2010 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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