Drug related problems with Antiparkinsonian agents: consumer Internet reports versus published data
Identifieur interne : 000901 ( Main/Curation ); précédent : 000900; suivant : 000902Drug related problems with Antiparkinsonian agents: consumer Internet reports versus published data
Auteurs : Sabrina Schröder [Allemagne] ; York Francis Zöllner [Allemagne] ; Marion Schaefer [Allemagne]Source :
- Pharmacoepidemiology and Drug Safety [ 1053-8569 ] ; 2007-10.
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- topic : Internet.
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Abstract
Purpose: There is currently a lack of detailed information concerning drug related problems in the outpatient treatment of Parkinson's disease. Methods: Problems associated with drug treatment communicated anonymously in Parkinson's disease online forums were therefore retrospectively searched and documented for 1 year. Results: Based on postings concerning 12 drugs for the treatment of Parkinson's disease, a total of 238 drug related problems were identified and categorised using the Problem Intervention Documentation (PI‐Doc). Of these, 153 were adverse drug reactions. Adverse drug reactions associated with the skin were relatively common, but central effects such as cognitive or psychiatric changes, effects on the sleep/waking system and other problems like headache and dizziness accounted for the highest percentage of adverse events. A comparison with data from scientific literature revealed a number of differences. This means that an analysis of online forums detected a number of drug related problems that were otherwise largely invisible. These were mainly associated with the qualitative aspects of treatment such as medication handling, dosage and individual problems concerning adverse events. In addition, the described method of identifying and classifying drug related problems in Internet forums may also be seen as a contribution to the international discussion about consumer reports and pharmacovigilance. The information about adverse drug reactions given by Internet users can be seen as a valuable adjunct to clinical trial data and as being very timely with regard to the event itself. Conclusion: Online forums may be considered as a suitable source of observational information to complement data from randomised clinical trials. Copyright © 2007 John Wiley & Sons, Ltd.
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DOI: 10.1002/pds.1415
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Drug Safe.</title><idno type="ISSN">1053-8569</idno><idno type="eISSN">1099-1557</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2007-10">2007-10</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1161">1161</biblScope><biblScope unit="page" to="1166">1166</biblScope></imprint><idno type="ISSN">1053-8569</idno></series><idno type="istex">A2F140BD49F49AB72BF9B059F7A2F6F519D197CC</idno><idno type="DOI">10.1002/pds.1415</idno><idno type="ArticleID">PDS1415</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1053-8569</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinsonian agents</term><term>Internet</term><term>Parkinson's disease</term><term>adverse drug reactions</term><term>consumer reports</term><term>drug related problems</term><term>pharmacovigilance</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Internet</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose: There is currently a lack of detailed information concerning drug related problems in the outpatient treatment of Parkinson's disease. Methods: Problems associated with drug treatment communicated anonymously in Parkinson's disease online forums were therefore retrospectively searched and documented for 1 year. Results: Based on postings concerning 12 drugs for the treatment of Parkinson's disease, a total of 238 drug related problems were identified and categorised using the Problem Intervention Documentation (PI‐Doc). Of these, 153 were adverse drug reactions. Adverse drug reactions associated with the skin were relatively common, but central effects such as cognitive or psychiatric changes, effects on the sleep/waking system and other problems like headache and dizziness accounted for the highest percentage of adverse events. A comparison with data from scientific literature revealed a number of differences. This means that an analysis of online forums detected a number of drug related problems that were otherwise largely invisible. These were mainly associated with the qualitative aspects of treatment such as medication handling, dosage and individual problems concerning adverse events. In addition, the described method of identifying and classifying drug related problems in Internet forums may also be seen as a contribution to the international discussion about consumer reports and pharmacovigilance. The information about adverse drug reactions given by Internet users can be seen as a valuable adjunct to clinical trial data and as being very timely with regard to the event itself. Conclusion: Online forums may be considered as a suitable source of observational information to complement data from randomised clinical trials. Copyright © 2007 John Wiley & Sons, Ltd.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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