Double‐blind study of pardoprunox, a new partial dopamine agonist, in early Parkinson's disease
Identifieur interne : 000415 ( Main/Curation ); précédent : 000414; suivant : 000416Double‐blind study of pardoprunox, a new partial dopamine agonist, in early Parkinson's disease
Auteurs : Juliana Bronzova [Pays-Bas] ; Cristina Sampaio [Portugal] ; Robert A. Hauser [États-Unis] ; Anthony E. Lang [Canada] ; Olivier Rascol [France] ; Ad Theeuwes [Pays-Bas] ; Serge V. Van De Witte [Pays-Bas] ; Guus Van Scharrenburg [Pays-Bas]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-04-30.
English descriptors
- KwdEn :
Abstract
This study examined the efficacy and safety of the partial dopamine agonist, pardoprunox (SLV308), in the treatment of patients with early Parkinson's disease (PD). Patients were randomized to receive pardoprunox (n = 69) or placebo (n = 70). Pardoprunox was titrated to each patient's optimal dose (9–45 mg/d) over 2 to 6 weeks and then maintained at this dose for a further 3 weeks. Concomitant anti‐Parkinson treatment was not permitted. In the primary analysis, Unified PD Rating Scale (UPDRS)‐Motor score was improved in pardoprunox‐treated patients (overall mean dose 23.8 mg/d; −7.3 points), as compared with placebo (−3.0 points; P = 0.0001), from baseline to end point. At end point, there were more responders (≥30% reduction in UPDRS‐Motor score) in the pardoprunox group (50.7%) than in the placebo group (15.7%; P < 0.0001). In other secondary analyses, UPDRS‐activities of daily living (ADL) and ‐ADL+Motor scores were also significantly more improved in the pardoprunox group. Nausea was reported by 32 of 68 (47.1%) pardoprunox‐treated patients (vs. 3/70, 4.3%, placebo‐treated patients), with dizziness, somnolence, headache, and asthenia also reported by ≥10 patients. In this exploratory proof‐of‐concept study, pardoprunox significantly improved motor function in patients with early PD. The efficacy and safety profile of pardoprunox justifies its further investigation in PD. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.22948
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000478
Links to Exploration step
ISTEX:0818D0A3C93DD11E6F3ADC2E1A7E86F9C5BFF895Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Double‐blind study of pardoprunox, a new partial dopamine agonist, in early Parkinson's disease</title>
<author><name sortKey="Bronzova, Juliana" sort="Bronzova, Juliana" uniqKey="Bronzova J" first="Juliana" last="Bronzova">Juliana Bronzova</name>
<affiliation wicri:level="1"><mods:affiliation>Solvay Pharmaceuticals B.V., Clinical Neuroscience Department, Weesp, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Solvay Pharmaceuticals B.V., Clinical Neuroscience Department, Weesp</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sampaio, Cristina" sort="Sampaio, Cristina" uniqKey="Sampaio C" first="Cristina" last="Sampaio">Cristina Sampaio</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Pharmacology, Faculdade de Medicina de Lisboa, Lisbon, Portugal</mods:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Department of Pharmacology, Faculdade de Medicina de Lisboa, Lisbon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A." last="Hauser">Robert A. Hauser</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Neurology, Pharmacology and Experimental Therapeutics, University of South Florida, Tampa, Florida, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology, Pharmacology and Experimental Therapeutics, University of South Florida, Tampa, Florida</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<affiliation wicri:level="1"><mods:affiliation>Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</mods:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Neurosciences and Clinical Pharmacology, Clinical Investigation Center, University Hospital of Toulouse, INSERM UMR 825, Toulouse, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Departments of Neurosciences and Clinical Pharmacology, Clinical Investigation Center, University Hospital of Toulouse, INSERM UMR 825, Toulouse</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Theeuwes, Ad" sort="Theeuwes, Ad" uniqKey="Theeuwes A" first="Ad" last="Theeuwes">Ad Theeuwes</name>
<affiliation wicri:level="1"><mods:affiliation>Solvay Pharmaceuticals B.V., Clinical Neuroscience Department, Weesp, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Solvay Pharmaceuticals B.V., Clinical Neuroscience Department, Weesp</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van De Witte, Serge V" sort="Van De Witte, Serge V" uniqKey="Van De Witte S" first="Serge V." last="Van De Witte">Serge V. Van De Witte</name>
<affiliation wicri:level="1"><mods:affiliation>Solvay Pharmaceuticals B.V., Clinical Neuroscience Department, Weesp, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Solvay Pharmaceuticals B.V., Clinical Neuroscience Department, Weesp</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Scharrenburg, Guus" sort="Van Scharrenburg, Guus" uniqKey="Van Scharrenburg G" first="Guus" last="Van Scharrenburg">Guus Van Scharrenburg</name>
<affiliation wicri:level="1"><mods:affiliation>Solvay Pharmaceuticals B.V., Clinical Neuroscience Department, Weesp, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Solvay Pharmaceuticals B.V., Clinical Neuroscience Department, Weesp</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:0818D0A3C93DD11E6F3ADC2E1A7E86F9C5BFF895</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.22948</idno>
<idno type="url">https://api.istex.fr/document/0818D0A3C93DD11E6F3ADC2E1A7E86F9C5BFF895/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">000478</idno>
<idno type="wicri:Area/Main/Curation">000415</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Double‐blind study of pardoprunox, a new partial dopamine agonist, in early Parkinson's disease</title>
<author><name sortKey="Bronzova, Juliana" sort="Bronzova, Juliana" uniqKey="Bronzova J" first="Juliana" last="Bronzova">Juliana Bronzova</name>
<affiliation wicri:level="1"><mods:affiliation>Solvay Pharmaceuticals B.V., Clinical Neuroscience Department, Weesp, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Solvay Pharmaceuticals B.V., Clinical Neuroscience Department, Weesp</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sampaio, Cristina" sort="Sampaio, Cristina" uniqKey="Sampaio C" first="Cristina" last="Sampaio">Cristina Sampaio</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Pharmacology, Faculdade de Medicina de Lisboa, Lisbon, Portugal</mods:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Department of Pharmacology, Faculdade de Medicina de Lisboa, Lisbon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A." last="Hauser">Robert A. Hauser</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Neurology, Pharmacology and Experimental Therapeutics, University of South Florida, Tampa, Florida, USA</mods:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology, Pharmacology and Experimental Therapeutics, University of South Florida, Tampa, Florida</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<affiliation wicri:level="1"><mods:affiliation>Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</mods:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
<affiliation wicri:level="1"><mods:affiliation>Departments of Neurosciences and Clinical Pharmacology, Clinical Investigation Center, University Hospital of Toulouse, INSERM UMR 825, Toulouse, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Departments of Neurosciences and Clinical Pharmacology, Clinical Investigation Center, University Hospital of Toulouse, INSERM UMR 825, Toulouse</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Theeuwes, Ad" sort="Theeuwes, Ad" uniqKey="Theeuwes A" first="Ad" last="Theeuwes">Ad Theeuwes</name>
<affiliation wicri:level="1"><mods:affiliation>Solvay Pharmaceuticals B.V., Clinical Neuroscience Department, Weesp, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Solvay Pharmaceuticals B.V., Clinical Neuroscience Department, Weesp</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van De Witte, Serge V" sort="Van De Witte, Serge V" uniqKey="Van De Witte S" first="Serge V." last="Van De Witte">Serge V. Van De Witte</name>
<affiliation wicri:level="1"><mods:affiliation>Solvay Pharmaceuticals B.V., Clinical Neuroscience Department, Weesp, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Solvay Pharmaceuticals B.V., Clinical Neuroscience Department, Weesp</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Scharrenburg, Guus" sort="Van Scharrenburg, Guus" uniqKey="Van Scharrenburg G" first="Guus" last="Van Scharrenburg">Guus Van Scharrenburg</name>
<affiliation wicri:level="1"><mods:affiliation>Solvay Pharmaceuticals B.V., Clinical Neuroscience Department, Weesp, The Netherlands</mods:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Solvay Pharmaceuticals B.V., Clinical Neuroscience Department, Weesp</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-04-30">2010-04-30</date>
<biblScope unit="volume">25</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="738">738</biblScope>
<biblScope unit="page" to="746">746</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">0818D0A3C93DD11E6F3ADC2E1A7E86F9C5BFF895</idno>
<idno type="DOI">10.1002/mds.22948</idno>
<idno type="ArticleID">MDS22948</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term>
<term>monotherapy</term>
<term>pardoprunox</term>
<term>partial dopamine agonist</term>
<term>randomized controlled clinical trial</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">This study examined the efficacy and safety of the partial dopamine agonist, pardoprunox (SLV308), in the treatment of patients with early Parkinson's disease (PD). Patients were randomized to receive pardoprunox (n = 69) or placebo (n = 70). Pardoprunox was titrated to each patient's optimal dose (9–45 mg/d) over 2 to 6 weeks and then maintained at this dose for a further 3 weeks. Concomitant anti‐Parkinson treatment was not permitted. In the primary analysis, Unified PD Rating Scale (UPDRS)‐Motor score was improved in pardoprunox‐treated patients (overall mean dose 23.8 mg/d; −7.3 points), as compared with placebo (−3.0 points; P = 0.0001), from baseline to end point. At end point, there were more responders (≥30% reduction in UPDRS‐Motor score) in the pardoprunox group (50.7%) than in the placebo group (15.7%; P < 0.0001). In other secondary analyses, UPDRS‐activities of daily living (ADL) and ‐ADL+Motor scores were also significantly more improved in the pardoprunox group. Nausea was reported by 32 of 68 (47.1%) pardoprunox‐treated patients (vs. 3/70, 4.3%, placebo‐treated patients), with dizziness, somnolence, headache, and asthenia also reported by ≥10 patients. In this exploratory proof‐of‐concept study, pardoprunox significantly improved motor function in patients with early PD. The efficacy and safety profile of pardoprunox justifies its further investigation in PD. © 2010 Movement Disorder Society</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000415 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000415 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:0818D0A3C93DD11E6F3ADC2E1A7E86F9C5BFF895 |texte= Double‐blind study of pardoprunox, a new partial dopamine agonist, in early Parkinson's disease }}
This area was generated with Dilib version V0.6.23. |