Predictors of time to requiring dopaminergic treatment in 2 Parkinson's disease cohorts
Identifieur interne : 000228 ( Main/Curation ); précédent : 000227; suivant : 000229Predictors of time to requiring dopaminergic treatment in 2 Parkinson's disease cohorts
Auteurs : Connie Marras [Canada] ; Michael P. Mcdermott [États-Unis] ; Ken Marek [États-Unis] ; Paula Rochon [Canada] ; Gary Naglie [Canada] ; Caroline M. Tanner [États-Unis] ; Alice Rudolph [États-Unis] ; Ira Shoulson [États-Unis] ; Anthony E. Lang [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-03.
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Abstract
The rate of progression of Parkinson's disease (PD) is highly variable. Knowledge of factors associated with disease milestones and commonly used research outcome measures helps with patient counseling and guides the design and interpretation of clinical studies. The objective of the study was to identify prognostic factors for time to acquiring disability requiring dopaminergic therapy that are reproducible within 2 large prospectively followed cohorts. Potential prognostic factors were identified using data from the Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) trial, and their reproducibility was examined using data from the Parkinson Research Examination of CEP‐1347 trial (PRECEPT). In multivariable analyses of the DATATOP cohort, higher baseline Unified Parkinson's Disease Rating Scale (UPDRS) scores, full‐time employment, a lesser smoking history, and onset on the left side were associated with a shorter time to disability requiring dopaminergic therapy. PRECEPT data confirmed the associations of higher baseline UPDRS scores and full‐time employment with shorter time to requiring treatment. Any clinical trial using the end point of time to disability requiring dopaminergic therapy should ensure that groups are well balanced with respect to baseline UPDRS scores and the proportion of subjects employed full time and should consider including these variables as covariates in the statistical model for primary analysis of treatment effects. We suspect that individuals employed full time may have a lower threshold for requiring dopaminergic therapy because of occupational demands. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23581
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Gary Naglie<affiliation><mods:affiliation>Toronto Rehabilitation Institute, Toronto, Ontario Canada</mods:affiliation><wicri:noCountry code="subField">Ontario Canada</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Division of Clinical Decision Making and Health Care, Toronto General Research Institute, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Clinical Decision Making and Health Care, Toronto General Research Institute, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University Health Network, Divisions of General Internal Medicine and Geriatrics Program, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University Health Network, Divisions of General Internal Medicine and Geriatrics Program, Toronto, Ontario</wicri:regionArea></affiliation>Le document en format XML
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Mcdermott</name><affiliation wicri:level="1"><mods:affiliation>University of Rochester, Rochester, New York, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Rochester, Rochester, New York</wicri:regionArea></affiliation></author><author><name sortKey="Marek, Ken" sort="Marek, Ken" uniqKey="Marek K" first="Ken" last="Marek">Ken Marek</name><affiliation wicri:level="1"><mods:affiliation>Institute for Neurodegenerative Disorders, New Haven, Connecticut, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Neurodegenerative Disorders, New Haven, Connecticut</wicri:regionArea></affiliation></author><author><name sortKey="Rochon, Paula" sort="Rochon, Paula" uniqKey="Rochon P" first="Paula" last="Rochon">Paula Rochon</name><affiliation wicri:level="1"><mods:affiliation>University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Women's College Research Institute, Women's College Hospital, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institute for Clinical Evaluative Sciences, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Naglie, Gary" sort="Naglie, Gary" uniqKey="Naglie G" first="Gary" last="Naglie">Gary Naglie</name><affiliation wicri:level="1"><mods:affiliation>University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation><affiliation><mods:affiliation>Toronto Rehabilitation Institute, Toronto, Ontario Canada</mods:affiliation><wicri:noCountry code="subField">Ontario Canada</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Division of Clinical Decision Making and Health Care, Toronto General Research Institute, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Clinical Decision Making and Health Care, Toronto General Research Institute, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University Health Network, Divisions of General Internal Medicine and Geriatrics Program, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University Health Network, Divisions of General Internal Medicine and Geriatrics Program, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M." last="Tanner">Caroline M. 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Lang</name><affiliation wicri:level="1"><mods:affiliation>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-03">2011-03</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="608">608</biblScope><biblScope unit="page" to="613">613</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">86D7BA3E8F5196138DC85683158DA557FCFD657F</idno><idno type="DOI">10.1002/mds.23581</idno><idno type="ArticleID">MDS23581</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>prognosis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The rate of progression of Parkinson's disease (PD) is highly variable. Knowledge of factors associated with disease milestones and commonly used research outcome measures helps with patient counseling and guides the design and interpretation of clinical studies. The objective of the study was to identify prognostic factors for time to acquiring disability requiring dopaminergic therapy that are reproducible within 2 large prospectively followed cohorts. Potential prognostic factors were identified using data from the Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) trial, and their reproducibility was examined using data from the Parkinson Research Examination of CEP‐1347 trial (PRECEPT). In multivariable analyses of the DATATOP cohort, higher baseline Unified Parkinson's Disease Rating Scale (UPDRS) scores, full‐time employment, a lesser smoking history, and onset on the left side were associated with a shorter time to disability requiring dopaminergic therapy. PRECEPT data confirmed the associations of higher baseline UPDRS scores and full‐time employment with shorter time to requiring treatment. Any clinical trial using the end point of time to disability requiring dopaminergic therapy should ensure that groups are well balanced with respect to baseline UPDRS scores and the proportion of subjects employed full time and should consider including these variables as covariates in the statistical model for primary analysis of treatment effects. We suspect that individuals employed full time may have a lower threshold for requiring dopaminergic therapy because of occupational demands. © 2011 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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