Perspectives on recent advances in the understanding and treatment of Parkinson’s disease
Identifieur interne : 000164 ( Main/Curation ); précédent : 000163; suivant : 000165Perspectives on recent advances in the understanding and treatment of Parkinson’s disease
Auteurs : A. H. Schapira [Royaume-Uni] ; Y. Agid [France] ; P. Barone [Italie] ; P. Jenner [Royaume-Uni] ; M. R. Lemke [Allemagne] ; W. Poewe [Autriche] ; O. Rascol [France] ; H. Reichmann [Allemagne] ; E. Tolosa [Espagne]Source :
- European Journal of Neurology [ 1351-5101 ] ; 2009-10.
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Abstract
There have been numerous important recent advances in our understanding of the causes of Parkinson’s disease (PD), the treatments available and how these are best applied for the long‐term management of patients. Novel genes causing familial PD have been discovered and mechanisms leading to cell dysfunction and death identified. The PD prodrome is now a subject of great interest and clinical markers are being defined that may in future, together with biochemical markers, support an early, pre‐motor diagnosis of PD. This will become important as new therapies are developed to modify disease progression. In the interim, the optimization of existing therapies remains an important priority. The value of existing and novel continuous drug delivery systems in PD is seen as providing simplified regimens, maintenance of motor control, reduction in motor complications and improved patient adherence to drug use.
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DOI: 10.1111/j.1468-1331.2009.02793.x
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Tolosa</name><affiliation wicri:level="1"><mods:affiliation>Neurology Service, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, IDIBAPS, Universitat de Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Service, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, IDIBAPS, Universitat de Barcelona</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-10">2009-10</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1090">1090</biblScope><biblScope unit="page" to="1099">1099</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">D88BCA9904F670DD3121DAAB11B4163D17FFBE3E</idno><idno type="DOI">10.1111/j.1468-1331.2009.02793.x</idno><idno type="ArticleID">ENE2793</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson’s disease</term><term>autophagy</term><term>depression</term><term>dopamine agonist</term><term>levodopa</term><term>mitochondrial</term><term>neuroprotection</term><term>non‐motor</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There have been numerous important recent advances in our understanding of the causes of Parkinson’s disease (PD), the treatments available and how these are best applied for the long‐term management of patients. Novel genes causing familial PD have been discovered and mechanisms leading to cell dysfunction and death identified. The PD prodrome is now a subject of great interest and clinical markers are being defined that may in future, together with biochemical markers, support an early, pre‐motor diagnosis of PD. This will become important as new therapies are developed to modify disease progression. In the interim, the optimization of existing therapies remains an important priority. The value of existing and novel continuous drug delivery systems in PD is seen as providing simplified regimens, maintenance of motor control, reduction in motor complications and improved patient adherence to drug use.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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