Priorities in Parkinson's disease research
Identifieur interne : 000002 ( Main/Curation ); précédent : 000001; suivant : 000003Priorities in Parkinson's disease research
Auteurs : Wassilios G. Meissner [France] ; Mark Frasier [États-Unis] ; Thomas Gasser [Allemagne] ; Christopher G. Goetz [États-Unis] ; Andres Lozano [Canada] ; Paola Piccini [Royaume-Uni] ; José A. Obeso [Espagne] ; Olivier Rascol [France] ; Anthony Schapira [Royaume-Uni] ; Valerie Voon [Royaume-Uni] ; David M. Weiner [États-Unis] ; François Tison [France] ; Erwan Bezard [France]Source :
- Nature Reviews Drug Discovery [ 1474-1776 ] ; 2011-05.
Abstract
The loss of dopaminergic neurons in the substantia nigra pars compacta leads to the characteristic motor symptoms of Parkinson's disease: bradykinesia, rigidity and resting tremors. Although these symptoms can be improved using currently available dopamine replacement strategies, there is still a need to improve current strategies of treating these symptoms, together with a need to alleviate non-motor symptoms of the disease. Moreover, treatments that provide neuroprotection and/or disease-modifying effects remain an urgent unmet clinical need. This Review describes the most promising biological targets and therapeutic agents that are currently being assessed to address these treatment goals. Progress will rely on understanding genetic mutations or susceptibility factors that lead to Parkinson's disease, better translation between preclinical animal models and clinical research, and improving the design of future clinical trials.>
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DOI: 10.1038/nrd3430
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Wassilios G. Meissner<affiliation><mods:affiliation>Service de Neurologie et Centre de référence atrophie multisystématisée, CHU de Bordeaux, Avenue Magellan F-33604 Pessac France.</mods:affiliation><wicri:noCountry code="subField">3604 Pessac France.</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: wassilios.meissner@chu-bordeaux.fr</mods:affiliation><country wicri:rule="url">France</country></affiliation><affiliation><mods:affiliation>Service de Neurologie et Centre de référence atrophie multisystématisée, CHU de Bordeaux, Avenue Magellan F-33604 Pessac France.</mods:affiliation><wicri:noCountry code="subField">3604 Pessac France.</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation><mods:affiliation>Service de Neurologie et Centre de référence atrophie multisystématisée, CHU de Bordeaux, Avenue Magellan F-33604 Pessac France.</mods:affiliation><wicri:noCountry code="subField">3604 Pessac France.</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation>Le document en format XML
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Meissner</name><affiliation><mods:affiliation>Service de Neurologie et Centre de référence atrophie multisystématisée, CHU de Bordeaux, Avenue Magellan F-33604 Pessac France.</mods:affiliation><wicri:noCountry code="subField">3604 Pessac France.</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: wassilios.meissner@chu-bordeaux.fr</mods:affiliation><country wicri:rule="url">France</country></affiliation></author><author><name sortKey="Frasier, Mark" sort="Frasier, Mark" uniqKey="Frasier M" first="Mark" last="Frasier">Mark Frasier</name><affiliation wicri:level="1"><mods:affiliation>Michael J. Fox Foundation for Parkinson's Research, New York, New York 10004, USA.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Michael J. Fox Foundation for Parkinson's Research, New York, New York 10004</wicri:regionArea></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen and DZNE — German Center for Neurodegenerative Diseases, D-72076 Tübingen, Germany.</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen and DZNE — German Center for Neurodegenerative Diseases, D-72076 Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G." last="Goetz">Christopher G. Goetz</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612</wicri:regionArea></affiliation></author><author><name sortKey="Lozano, Andres" sort="Lozano, Andres" uniqKey="Lozano A" first="Andres" last="Lozano">Andres Lozano</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario M5T 2S8, Canada.</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario M5T 2S8</wicri:regionArea></affiliation></author><author><name sortKey="Piccini, Paola" sort="Piccini, Paola" uniqKey="Piccini P" first="Paola" last="Piccini">Paola Piccini</name><affiliation wicri:level="1"><mods:affiliation>Centre for Neuroscience, Imperial College London, London, SW7 2AZ, UK.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Neuroscience, Imperial College London, London, SW7 2AZ</wicri:regionArea></affiliation></author><author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="José A." last="Obeso">José A. Obeso</name><affiliation wicri:level="1"><mods:affiliation>Movement Disorders Group, Neurosciences Division, CIMA, and Department of Neurology and Neurosurgery, Clínica Universitaria and CIBERNED, University of Navarra, 31008 Pamplona, Spain.</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Movement Disorders Group, Neurosciences Division, CIMA, and Department of Neurology and Neurosurgery, Clínica Universitaria and CIBERNED, University of Navarra, 31008 Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation wicri:level="1"><mods:affiliation>Departments of Clinical Pharmacology and Neurosciences, INSERM CIC9302, University Hospital of Toulouse, 31000 Toulouse, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Departments of Clinical Pharmacology and Neurosciences, INSERM CIC9302, University Hospital of Toulouse, 31000 Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Schapira, Anthony" sort="Schapira, Anthony" uniqKey="Schapira A" first="Anthony" last="Schapira">Anthony Schapira</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Neurosciences, Institute of Neurology, University College London, London NW3 2PF, UK.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurosciences, Institute of Neurology, University College London, London NW3 2PF</wicri:regionArea></affiliation></author><author><name sortKey="Voon, Valerie" sort="Voon, Valerie" uniqKey="Voon V" first="Valerie" last="Voon">Valerie Voon</name><affiliation wicri:level="1"><mods:affiliation>Behavioral and Clinical Neurosciences Institute, University of Cambridge, Cambridge CB2 0SZ, UK.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Behavioral and Clinical Neurosciences Institute, University of Cambridge, Cambridge CB2 0SZ</wicri:regionArea></affiliation></author><author><name sortKey="Weiner, David M" sort="Weiner, David M" uniqKey="Weiner D" first="David M." last="Weiner">David M. Weiner</name><affiliation wicri:level="1"><mods:affiliation>EMD Serono, Rockland, Massachusetts 02370, USA.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>EMD Serono, Rockland, Massachusetts 02370</wicri:regionArea></affiliation></author><author><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name><affiliation><mods:affiliation>Service de Neurologie et Centre de référence atrophie multisystématisée, CHU de Bordeaux, Avenue Magellan F-33604 Pessac France.</mods:affiliation><wicri:noCountry code="subField">3604 Pessac France.</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name><affiliation><mods:affiliation>Service de Neurologie et Centre de référence atrophie multisystématisée, CHU de Bordeaux, Avenue Magellan F-33604 Pessac France.</mods:affiliation><wicri:noCountry code="subField">3604 Pessac France.</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B18DB94A38D88A12D621F99E69D4EEFEBBE7059E</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1038/nrd3430</idno><idno type="url">https://api.istex.fr/document/B18DB94A38D88A12D621F99E69D4EEFEBBE7059E/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000002</idno><idno type="wicri:Area/Main/Curation">000002</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Priorities in Parkinson's disease research</title><author><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G." last="Meissner">Wassilios G. Meissner</name><affiliation><mods:affiliation>Service de Neurologie et Centre de référence atrophie multisystématisée, CHU de Bordeaux, Avenue Magellan F-33604 Pessac France.</mods:affiliation><wicri:noCountry code="subField">3604 Pessac France.</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: wassilios.meissner@chu-bordeaux.fr</mods:affiliation><country wicri:rule="url">France</country></affiliation></author><author><name sortKey="Frasier, Mark" sort="Frasier, Mark" uniqKey="Frasier M" first="Mark" last="Frasier">Mark Frasier</name><affiliation wicri:level="1"><mods:affiliation>Michael J. Fox Foundation for Parkinson's Research, New York, New York 10004, USA.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Michael J. Fox Foundation for Parkinson's Research, New York, New York 10004</wicri:regionArea></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen and DZNE — German Center for Neurodegenerative Diseases, D-72076 Tübingen, Germany.</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen and DZNE — German Center for Neurodegenerative Diseases, D-72076 Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G." last="Goetz">Christopher G. Goetz</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612</wicri:regionArea></affiliation></author><author><name sortKey="Lozano, Andres" sort="Lozano, Andres" uniqKey="Lozano A" first="Andres" last="Lozano">Andres Lozano</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario M5T 2S8, Canada.</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario M5T 2S8</wicri:regionArea></affiliation></author><author><name sortKey="Piccini, Paola" sort="Piccini, Paola" uniqKey="Piccini P" first="Paola" last="Piccini">Paola Piccini</name><affiliation wicri:level="1"><mods:affiliation>Centre for Neuroscience, Imperial College London, London, SW7 2AZ, UK.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Centre for Neuroscience, Imperial College London, London, SW7 2AZ</wicri:regionArea></affiliation></author><author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="José A." last="Obeso">José A. Obeso</name><affiliation wicri:level="1"><mods:affiliation>Movement Disorders Group, Neurosciences Division, CIMA, and Department of Neurology and Neurosurgery, Clínica Universitaria and CIBERNED, University of Navarra, 31008 Pamplona, Spain.</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Movement Disorders Group, Neurosciences Division, CIMA, and Department of Neurology and Neurosurgery, Clínica Universitaria and CIBERNED, University of Navarra, 31008 Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation wicri:level="1"><mods:affiliation>Departments of Clinical Pharmacology and Neurosciences, INSERM CIC9302, University Hospital of Toulouse, 31000 Toulouse, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Departments of Clinical Pharmacology and Neurosciences, INSERM CIC9302, University Hospital of Toulouse, 31000 Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Schapira, Anthony" sort="Schapira, Anthony" uniqKey="Schapira A" first="Anthony" last="Schapira">Anthony Schapira</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Neurosciences, Institute of Neurology, University College London, London NW3 2PF, UK.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurosciences, Institute of Neurology, University College London, London NW3 2PF</wicri:regionArea></affiliation></author><author><name sortKey="Voon, Valerie" sort="Voon, Valerie" uniqKey="Voon V" first="Valerie" last="Voon">Valerie Voon</name><affiliation wicri:level="1"><mods:affiliation>Behavioral and Clinical Neurosciences Institute, University of Cambridge, Cambridge CB2 0SZ, UK.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Behavioral and Clinical Neurosciences Institute, University of Cambridge, Cambridge CB2 0SZ</wicri:regionArea></affiliation></author><author><name sortKey="Weiner, David M" sort="Weiner, David M" uniqKey="Weiner D" first="David M." last="Weiner">David M. Weiner</name><affiliation wicri:level="1"><mods:affiliation>EMD Serono, Rockland, Massachusetts 02370, USA.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>EMD Serono, Rockland, Massachusetts 02370</wicri:regionArea></affiliation></author><author><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name><affiliation><mods:affiliation>Service de Neurologie et Centre de référence atrophie multisystématisée, CHU de Bordeaux, Avenue Magellan F-33604 Pessac France.</mods:affiliation><wicri:noCountry code="subField">3604 Pessac France.</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name><affiliation><mods:affiliation>Service de Neurologie et Centre de référence atrophie multisystématisée, CHU de Bordeaux, Avenue Magellan F-33604 Pessac France.</mods:affiliation><wicri:noCountry code="subField">3604 Pessac France.</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Nature Reviews Drug Discovery</title><idno type="ISSN">1474-1776</idno><idno type="eISSN">1474-1784</idno><imprint><publisher>Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</publisher><date type="published" when="2011-05">2011-05</date><biblScope unit="volume">10</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="377">377</biblScope><biblScope unit="page" to="393">393</biblScope></imprint><idno type="ISSN">1474-1776</idno></series><idno type="istex">B18DB94A38D88A12D621F99E69D4EEFEBBE7059E</idno><idno type="DOI">10.1038/nrd3430</idno><idno type="ArticleID">nrd3430</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1474-1776</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">The loss of dopaminergic neurons in the substantia nigra pars compacta leads to the characteristic motor symptoms of Parkinson's disease: bradykinesia, rigidity and resting tremors. Although these symptoms can be improved using currently available dopamine replacement strategies, there is still a need to improve current strategies of treating these symptoms, together with a need to alleviate non-motor symptoms of the disease. Moreover, treatments that provide neuroprotection and/or disease-modifying effects remain an urgent unmet clinical need. This Review describes the most promising biological targets and therapeutic agents that are currently being assessed to address these treatment goals. Progress will rely on understanding genetic mutations or susceptibility factors that lead to Parkinson's disease, better translation between preclinical animal models and clinical research, and improving the design of future clinical trials.></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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