PARKINSON'S DISEASE TREATED WITH SINEMET OR MADOPAR
Identifieur interne : 003118 ( Main/Corpus ); précédent : 003117; suivant : 003119PARKINSON'S DISEASE TREATED WITH SINEMET OR MADOPAR
Auteurs : Henning Pakkenberg ; Erik Birket-Smith ; Erik Dupont ; Erie Hansen ; Bent Mikkelsen ; Jan Presthus ; Ilkka Rautakorpi ; Eva Riman ; Urpo K. RinneSource :
- Acta Neurologica Scandinavica [ 0001-6314 ] ; 1976-06.
Abstract
92 patients with Parkinson's disease not previously treated with levodopa were considered as eligible for this triple‐blind trial. Patients were allocated at random to treatment with either levodopa + benserazide ratio 4:1 (Madopar®) or levodopa + carbidopa ratio 10:1 (Sinemet®) using dosage schedules recommended by the manufacturers which they had to adhere to for 6 months. Unless prohibitive side‐effects occurred daily maximum dosages of 800 mg levodopa + 200 mg benserazide respectively 1,500 mg levodopa + 150 mg carbidopa were obtained after 6 weeks and 3 weeks, respectively. the effect of the two schedules on the Parkinsonian symptoms were equal and appeared equally fast. the frequency of gastrointestinal side‐effects and involuntary movements were significantly higher and more severe for Sinemct® than for Madopar®. These side effects are usually symptoms of levodopa overdosing, but whether or not a different dosage schedule with Sinemet would have given fewer side‐effects without concurrent lower efficacy remains open to speculation. the treatment schedules did not differ with regard to other side‐effects and influence on blood pressure. Neither treatment seemed to influence liver function, renal function and hematological parameters in a statistically way.
Url:
DOI: 10.1111/j.1600-0404.1976.tb04355.x
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">PARKINSON'S DISEASE TREATED WITH SINEMET OR MADOPAR</title><author><name sortKey="Pakkenberg, Henning" sort="Pakkenberg, Henning" uniqKey="Pakkenberg H" first="Henning" last="Pakkenberg">Henning Pakkenberg</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Birket Mith, Erik" sort="Birket Mith, Erik" uniqKey="Birket Mith E" first="Erik" last="Birket-Smith">Erik Birket-Smith</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Dupont, Erik" sort="Dupont, Erik" uniqKey="Dupont E" first="Erik" last="Dupont">Erik Dupont</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Hansen, Erie" sort="Hansen, Erie" uniqKey="Hansen E" first="Erie" last="Hansen">Erie Hansen</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Mikkelsen, Bent" sort="Mikkelsen, Bent" uniqKey="Mikkelsen B" first="Bent" last="Mikkelsen">Bent Mikkelsen</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Presthus, Jan" sort="Presthus, Jan" uniqKey="Presthus J" first="Jan" last="Presthus">Jan Presthus</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Rautakorpi, Ilkka" sort="Rautakorpi, Ilkka" uniqKey="Rautakorpi I" first="Ilkka" last="Rautakorpi">Ilkka Rautakorpi</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Riman, Eva" sort="Riman, Eva" uniqKey="Riman E" first="Eva" last="Riman">Eva Riman</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Rinne, Urpo K" sort="Rinne, Urpo K" uniqKey="Rinne U" first="Urpo K." last="Rinne">Urpo K. Rinne</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C9BBBCFB906D4FFFF73A0E20EB39BDF27F59E9DF</idno><date when="1976" year="1976">1976</date><idno type="doi">10.1111/j.1600-0404.1976.tb04355.x</idno><idno type="url">https://api.istex.fr/document/C9BBBCFB906D4FFFF73A0E20EB39BDF27F59E9DF/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">003118</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">PARKINSON'S DISEASE TREATED WITH SINEMET OR MADOPAR</title><author><name sortKey="Pakkenberg, Henning" sort="Pakkenberg, Henning" uniqKey="Pakkenberg H" first="Henning" last="Pakkenberg">Henning Pakkenberg</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Birket Mith, Erik" sort="Birket Mith, Erik" uniqKey="Birket Mith E" first="Erik" last="Birket-Smith">Erik Birket-Smith</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Dupont, Erik" sort="Dupont, Erik" uniqKey="Dupont E" first="Erik" last="Dupont">Erik Dupont</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Hansen, Erie" sort="Hansen, Erie" uniqKey="Hansen E" first="Erie" last="Hansen">Erie Hansen</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Mikkelsen, Bent" sort="Mikkelsen, Bent" uniqKey="Mikkelsen B" first="Bent" last="Mikkelsen">Bent Mikkelsen</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Presthus, Jan" sort="Presthus, Jan" uniqKey="Presthus J" first="Jan" last="Presthus">Jan Presthus</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Rautakorpi, Ilkka" sort="Rautakorpi, Ilkka" uniqKey="Rautakorpi I" first="Ilkka" last="Rautakorpi">Ilkka Rautakorpi</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Riman, Eva" sort="Riman, Eva" uniqKey="Riman E" first="Eva" last="Riman">Eva Riman</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Rinne, Urpo K" sort="Rinne, Urpo K" uniqKey="Rinne U" first="Urpo K." last="Rinne">Urpo K. Rinne</name><affiliation><mods:affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neurologica Scandinavica</title><idno type="ISSN">0001-6314</idno><idno type="eISSN">1600-0404</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1976-06">1976-06</date><biblScope unit="volume">53</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="376">376</biblScope><biblScope unit="page" to="385">385</biblScope></imprint><idno type="ISSN">0001-6314</idno></series><idno type="istex">C9BBBCFB906D4FFFF73A0E20EB39BDF27F59E9DF</idno><idno type="DOI">10.1111/j.1600-0404.1976.tb04355.x</idno><idno type="ArticleID">ANE376</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6314</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">92 patients with Parkinson's disease not previously treated with levodopa were considered as eligible for this triple‐blind trial. Patients were allocated at random to treatment with either levodopa + benserazide ratio 4:1 (Madopar®) or levodopa + carbidopa ratio 10:1 (Sinemet®) using dosage schedules recommended by the manufacturers which they had to adhere to for 6 months. Unless prohibitive side‐effects occurred daily maximum dosages of 800 mg levodopa + 200 mg benserazide respectively 1,500 mg levodopa + 150 mg carbidopa were obtained after 6 weeks and 3 weeks, respectively. the effect of the two schedules on the Parkinsonian symptoms were equal and appeared equally fast. the frequency of gastrointestinal side‐effects and involuntary movements were significantly higher and more severe for Sinemct® than for Madopar®. These side effects are usually symptoms of levodopa overdosing, but whether or not a different dosage schedule with Sinemet would have given fewer side‐effects without concurrent lower efficacy remains open to speculation. the treatment schedules did not differ with regard to other side‐effects and influence on blood pressure. Neither treatment seemed to influence liver function, renal function and hematological parameters in a statistically way.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Henning Pakkenberg</name><affiliations><json:string>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</json:string></affiliations></json:item><json:item><name>Erik Birket‐Smith</name><affiliations><json:string>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</json:string></affiliations></json:item><json:item><name>Erik Dupont</name><affiliations><json:string>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</json:string></affiliations></json:item><json:item><name>Erie Hansen</name><affiliations><json:string>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</json:string></affiliations></json:item><json:item><name>Bent Mikkelsen</name><affiliations><json:string>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</json:string></affiliations></json:item><json:item><name>Jan Presthus</name><affiliations><json:string>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</json:string></affiliations></json:item><json:item><name>Ilkka Rautakorpi</name><affiliations><json:string>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</json:string></affiliations></json:item><json:item><name>Eva Riman</name><affiliations><json:string>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</json:string></affiliations></json:item><json:item><name>Urpo K. Rinne</name><affiliations><json:string>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</json:string></affiliations></json:item></author><articleId><json:string>ANE376</json:string></articleId><language><json:string>eng</json:string></language><abstract>92 patients with Parkinson's disease not previously treated with levodopa were considered as eligible for this triple‐blind trial. Patients were allocated at random to treatment with either levodopa + benserazide ratio 4:1 (Madopar®) or levodopa + carbidopa ratio 10:1 (Sinemet®) using dosage schedules recommended by the manufacturers which they had to adhere to for 6 months. Unless prohibitive side‐effects occurred daily maximum dosages of 800 mg levodopa + 200 mg benserazide respectively 1,500 mg levodopa + 150 mg carbidopa were obtained after 6 weeks and 3 weeks, respectively. the effect of the two schedules on the Parkinsonian symptoms were equal and appeared equally fast. the frequency of gastrointestinal side‐effects and involuntary movements were significantly higher and more severe for Sinemct® than for Madopar®. These side effects are usually symptoms of levodopa overdosing, but whether or not a different dosage schedule with Sinemet would have given fewer side‐effects without concurrent lower efficacy remains open to speculation. the treatment schedules did not differ with regard to other side‐effects and influence on blood pressure. Neither treatment seemed to influence liver function, renal function and hematological parameters in a statistically way.</abstract><qualityIndicators><score>6.009</score><pdfVersion>1.5</pdfVersion><pdfPageSize>435.6 x 669.84 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1282</abstractCharCount><pdfWordCount>2765</pdfWordCount><pdfCharCount>16260</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>187</abstractWordCount></qualityIndicators><title>PARKINSON'S DISEASE TREATED WITH SINEMET OR MADOPAR</title><genre><json:string>article</json:string></genre><host><volume>53</volume><publisherId><json:string>ANE</json:string></publisherId><pages><total>10</total><last>385</last><first>376</first></pages><issn><json:string>0001-6314</json:string></issn><issue>5</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1600-0404</json:string></eissn><title>Acta Neurologica Scandinavica</title><doi><json:string>10.1111/(ISSN)1600-0404</json:string></doi></host><publicationDate>1976</publicationDate><copyrightDate>1976</copyrightDate><doi><json:string>10.1111/j.1600-0404.1976.tb04355.x</json:string></doi><id>C9BBBCFB906D4FFFF73A0E20EB39BDF27F59E9DF</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/C9BBBCFB906D4FFFF73A0E20EB39BDF27F59E9DF/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/C9BBBCFB906D4FFFF73A0E20EB39BDF27F59E9DF/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/C9BBBCFB906D4FFFF73A0E20EB39BDF27F59E9DF/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">PARKINSON'S DISEASE TREATED WITH SINEMET OR MADOPAR</title><title level="a" type="sub" xml:lang="en">A Controlled Multicenter Trial</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>1976</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">PARKINSON'S DISEASE TREATED WITH SINEMET OR MADOPAR</title><title level="a" type="sub" xml:lang="en">A Controlled Multicenter Trial</title><author><persName><forename type="first">Henning</forename><surname>Pakkenberg</surname></persName><note type="correspondence"><p>Correspondence: *Henning Pakkenberg, M.D., Department of Neurology, Hvidovre Hospital, DK‐2650 Hvidovre, Denmark.</p></note><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation></author><author><persName><forename type="first">Erik</forename><surname>Birket‐Smith</surname></persName><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation></author><author><persName><forename type="first">Erik</forename><surname>Dupont</surname></persName><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation></author><author><persName><forename type="first">Erie</forename><surname>Hansen</surname></persName><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation></author><author><persName><forename type="first">Bent</forename><surname>Mikkelsen</surname></persName><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation></author><author><persName><forename type="first">Jan</forename><surname>Presthus</surname></persName><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation></author><author><persName><forename type="first">Ilkka</forename><surname>Rautakorpi</surname></persName><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation></author><author><persName><forename type="first">Eva</forename><surname>Riman</surname></persName><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation></author><author><persName><forename type="first">Urpo K.</forename><surname>Rinne</surname></persName><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation></author></analytic><monogr><title level="j">Acta Neurologica Scandinavica</title><idno type="pISSN">0001-6314</idno><idno type="eISSN">1600-0404</idno><idno type="DOI">10.1111/(ISSN)1600-0404</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1976-06"></date><biblScope unit="volume">53</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="376">376</biblScope><biblScope unit="page" to="385">385</biblScope></imprint></monogr><idno type="istex">C9BBBCFB906D4FFFF73A0E20EB39BDF27F59E9DF</idno><idno type="DOI">10.1111/j.1600-0404.1976.tb04355.x</idno><idno type="ArticleID">ANE376</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1976</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>92 patients with Parkinson's disease not previously treated with levodopa were considered as eligible for this triple‐blind trial. Patients were allocated at random to treatment with either levodopa + benserazide ratio 4:1 (Madopar®) or levodopa + carbidopa ratio 10:1 (Sinemet®) using dosage schedules recommended by the manufacturers which they had to adhere to for 6 months. Unless prohibitive side‐effects occurred daily maximum dosages of 800 mg levodopa + 200 mg benserazide respectively 1,500 mg levodopa + 150 mg carbidopa were obtained after 6 weeks and 3 weeks, respectively. the effect of the two schedules on the Parkinsonian symptoms were equal and appeared equally fast. the frequency of gastrointestinal side‐effects and involuntary movements were significantly higher and more severe for Sinemct® than for Madopar®. These side effects are usually symptoms of levodopa overdosing, but whether or not a different dosage schedule with Sinemet would have given fewer side‐effects without concurrent lower efficacy remains open to speculation. the treatment schedules did not differ with regard to other side‐effects and influence on blood pressure. Neither treatment seemed to influence liver function, renal function and hematological parameters in a statistically way.</p></abstract></profileDesc><revisionDesc><change when="1976-06">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/C9BBBCFB906D4FFFF73A0E20EB39BDF27F59E9DF/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0404</doi><issn type="print">0001-6314</issn><issn type="electronic">1600-0404</issn><idGroup><id type="product" value="ANE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ACTA NEUROLOGICA SCANDINAVICA">Acta Neurologica Scandinavica</title></titleGroup></publicationMeta><publicationMeta level="part" position="06005"><doi origin="wiley">10.1111/ane.1976.53.issue-5</doi><numberingGroup><numbering type="journalVolume" number="53">53</numbering><numbering type="journalIssue" number="5">5</numbering></numberingGroup><coverDate startDate="1976-06">June 1976</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0037600" status="forIssue"><doi origin="wiley">10.1111/j.1600-0404.1976.tb04355.x</doi><idGroup><id type="unit" value="ANE376"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="tocHeading1">Article</title></titleGroup><copyright>1976 Blackwell Munksgaard</copyright><eventGroup><event type="firstOnline" date="2009-01-29"></event><event type="publishedOnlineFinalForm" date="2009-01-29"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-10"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-15"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="376">376</numbering><numbering type="pageLast" number="385">385</numbering></numberingGroup><correspondenceTo>*Henning Pakkenberg, M.D., Department of Neurology, Hvidovre Hospital, DK‐2650 Hvidovre, Denmark.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ANE.ANE376.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received Received December 3, 1975.</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="5"></count><count type="linksCrossRef" number="10"></count></countGroup><titleGroup><title type="main">PARKINSON'S DISEASE TREATED WITH SINEMET OR MADOPAR</title><title type="subtitle">A Controlled Multicenter Trial</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>Henning</givenNames><familyName>Pakkenberg</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Erik</givenNames><familyName>Birket‐Smith</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Erik</givenNames><familyName>Dupont</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Erie</givenNames><familyName>Hansen</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>Bent</givenNames><familyName>Mikkelsen</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>Jan</givenNames><familyName>Presthus</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a1"><personName><givenNames>Ilkka</givenNames><familyName>Rautakorpi</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a1"><personName><givenNames>Eva</givenNames><familyName>Riman</familyName></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a1"><personName><givenNames>Urpo K.</givenNames><familyName>Rinne</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">ABSTRACT</title><p>92 patients with Parkinson's disease not previously treated with levodopa were considered as eligible for this triple‐blind trial. Patients were allocated at random to treatment with either levodopa + benserazide ratio 4:1 (Madopar®) or levodopa + carbidopa ratio 10:1 (Sinemet®) using dosage schedules recommended by the manufacturers which they had to adhere to for 6 months. Unless prohibitive side‐effects occurred daily maximum dosages of 800 mg levodopa + 200 mg benserazide respectively 1,500 mg levodopa + 150 mg carbidopa were obtained after 6 weeks and 3 weeks, respectively. the effect of the two schedules on the Parkinsonian symptoms were equal and appeared equally fast. the frequency of gastrointestinal side‐effects and involuntary movements were significantly higher and more severe for Sinemct® than for Madopar®. These side effects are usually symptoms of levodopa overdosing, but whether or not a different dosage schedule with Sinemet would have given fewer side‐effects without concurrent lower efficacy remains open to speculation. the treatment schedules did not differ with regard to other side‐effects and influence on blood pressure. Neither treatment seemed to influence liver function, renal function and hematological parameters in a statistically way.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>PARKINSON'S DISEASE TREATED WITH SINEMET OR MADOPAR</title><subTitle>A Controlled Multicenter Trial</subTitle></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>PARKINSON'S DISEASE TREATED WITH SINEMET OR MADOPAR</title></titleInfo><name type="personal"><namePart type="given">Henning</namePart><namePart type="family">Pakkenberg</namePart><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation><description>Correspondence: *Henning Pakkenberg, M.D., Department of Neurology, Hvidovre Hospital, DK‐2650 Hvidovre, Denmark.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Erik</namePart><namePart type="family">Birket‐Smith</namePart><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Erik</namePart><namePart type="family">Dupont</namePart><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Erie</namePart><namePart type="family">Hansen</namePart><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bent</namePart><namePart type="family">Mikkelsen</namePart><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan</namePart><namePart type="family">Presthus</namePart><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ilkka</namePart><namePart type="family">Rautakorpi</namePart><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eva</namePart><namePart type="family">Riman</namePart><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Urpo K.</namePart><namePart type="family">Rinne</namePart><affiliation>Departments of Neurology, Kommunehospitalet, Copenhagen; Aalborg Hospital South; Kommunehospitalet, University of Aarhus; Vejle Hospital; Hjørring Hospital, Denmark: Ullevål Hospital, Norway; Turku University Central Hospital, Finland; Västra Frölunda, Sweden.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1976-06</dateIssued><edition>Received Received December 3, 1975.</edition><copyrightDate encoding="w3cdtf">1976</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">5</extent></physicalDescription><abstract lang="en">92 patients with Parkinson's disease not previously treated with levodopa were considered as eligible for this triple‐blind trial. Patients were allocated at random to treatment with either levodopa + benserazide ratio 4:1 (Madopar®) or levodopa + carbidopa ratio 10:1 (Sinemet®) using dosage schedules recommended by the manufacturers which they had to adhere to for 6 months. Unless prohibitive side‐effects occurred daily maximum dosages of 800 mg levodopa + 200 mg benserazide respectively 1,500 mg levodopa + 150 mg carbidopa were obtained after 6 weeks and 3 weeks, respectively. the effect of the two schedules on the Parkinsonian symptoms were equal and appeared equally fast. the frequency of gastrointestinal side‐effects and involuntary movements were significantly higher and more severe for Sinemct® than for Madopar®. These side effects are usually symptoms of levodopa overdosing, but whether or not a different dosage schedule with Sinemet would have given fewer side‐effects without concurrent lower efficacy remains open to speculation. the treatment schedules did not differ with regard to other side‐effects and influence on blood pressure. Neither treatment seemed to influence liver function, renal function and hematological parameters in a statistically way.</abstract><relatedItem type="host"><titleInfo><title>Acta Neurologica Scandinavica</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0001-6314</identifier><identifier type="eISSN">1600-0404</identifier><identifier type="DOI">10.1111/(ISSN)1600-0404</identifier><identifier type="PublisherID">ANE</identifier><part><date>1976</date><detail type="volume"><caption>vol.</caption><number>53</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>376</start><end>385</end><total>10</total></extent></part></relatedItem><identifier type="istex">C9BBBCFB906D4FFFF73A0E20EB39BDF27F59E9DF</identifier><identifier type="DOI">10.1111/j.1600-0404.1976.tb04355.x</identifier><identifier type="ArticleID">ANE376</identifier><accessCondition type="use and reproduction" contentType="copyright">1976 Blackwell Munksgaard</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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