Levodopa and subthalamic deep brain stimulation responses are not congruent
Identifieur interne : 003109 ( Main/Corpus ); précédent : 003108; suivant : 003110Levodopa and subthalamic deep brain stimulation responses are not congruent
Auteurs : Adam Zaidel ; Hagai Bergman ; Ya'Acov Ritov ; Zvi Israel MdSource :
- Movement Disorders [ 0885-3185 ] ; 2010-10-30.
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- KwdEn :
Abstract
There is a consensus that in Parkinson's disease, the extent of preoperative levodopa responsiveness predicts the efficacy of subthalamic nucleus deep brain stimulation (STN DBS). However, this may be the result of statistical methods and primary assumptions. We were able to reproduce previously published correlation results on our data (N = 49 patients). Yet, these same results were demonstrated even after random shuffling of our data. Notably, we did not observe a correlation between STN DBS efficacy and preoperative levodopa responsiveness when using their respective baselines and fractional scores of motor improvement. Furthermore, postoperative responses were not limited by preoperative scores, with tremor demonstrating the greatest discrepancy. We conclude that preoperative levodopa responsiveness does not predict or limit the outcome of STN DBS. These results imply different therapeutic mechanisms for levodopa and STN DBS and therefore question the validity of using substantial preoperative levodopa responsiveness as a selection criterion for STN DBS. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23294
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ISTEX:40F812414774F02DADD69780FA164044D49897E3Le document en format XML
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However, this may be the result of statistical methods and primary assumptions. We were able to reproduce previously published correlation results on our data (N = 49 patients). Yet, these same results were demonstrated even after random shuffling of our data. Notably, we did not observe a correlation between STN DBS efficacy and preoperative levodopa responsiveness when using their respective baselines and fractional scores of motor improvement. Furthermore, postoperative responses were not limited by preoperative scores, with tremor demonstrating the greatest discrepancy. We conclude that preoperative levodopa responsiveness does not predict or limit the outcome of STN DBS. These results imply different therapeutic mechanisms for levodopa and STN DBS and therefore question the validity of using substantial preoperative levodopa responsiveness as a selection criterion for STN DBS. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Adam Zaidel MSc</name><affiliations><json:string>The Interdisciplinary Center for Neural Computation, The Hebrew University of Jerusalem, Israel</json:string><json:string>Department of Medical Neurobiology, Canada‐Israel Institute for Medical Research, The Hebrew University Hadassah Medical School, Jerusalem, Israel</json:string></affiliations></json:item><json:item><name>Hagai Bergman MD, PhD</name><affiliations><json:string>The Interdisciplinary Center for Neural Computation, The Hebrew University of Jerusalem, Israel</json:string><json:string>Department of Medical Neurobiology, Canada‐Israel Institute for Medical Research, The Hebrew University Hadassah Medical School, Jerusalem, Israel</json:string></affiliations></json:item><json:item><name>Ya'acov Ritov PhD</name><affiliations><json:string>Department of Statistics, The Hebrew University of Jerusalem, Israel</json:string></affiliations></json:item><json:item><name>Zvi Israel MD</name><affiliations><json:string>Department of Neurosurgery, Hadassah University Hospital, Jerusalem, Israel</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>subthalamic nucleus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>basal ganglia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>deep brain stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>predictive factor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>levodopa</value></json:item></subject><articleId><json:string>MDS23294</json:string></articleId><language><json:string>eng</json:string></language><abstract>There is a consensus that in Parkinson's disease, the extent of preoperative levodopa responsiveness predicts the efficacy of subthalamic nucleus deep brain stimulation (STN DBS). 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#af2"><personName><givenNames>Hagai</givenNames><familyName>Bergman</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Ya'acov</givenNames><familyName>Ritov</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Zvi Israel</givenNames><familyName>MD</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IL" type="organization"><unparsedAffiliation>The Interdisciplinary Center for Neural Computation, The Hebrew University of Jerusalem, Israel</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IL" type="organization"><unparsedAffiliation>Department of Medical Neurobiology, Canada‐Israel Institute for Medical Research, The Hebrew University Hadassah Medical School, Jerusalem, Israel</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="IL" type="organization"><unparsedAffiliation>Department of Statistics, The Hebrew University of Jerusalem, Israel</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="IL" type="organization"><unparsedAffiliation>Department of Neurosurgery, Hadassah University Hospital, Jerusalem, Israel</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">subthalamic nucleus</keyword><keyword xml:id="kwd3">basal ganglia</keyword><keyword xml:id="kwd4">deep brain stimulation</keyword><keyword xml:id="kwd5">predictive factor</keyword><keyword xml:id="kwd6">levodopa</keyword></keywordGroup><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23294:MDS_23294_sm_SuppFig1"></mediaResource><caption>Supporting Figure 1</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23294:MDS_23294_sm_SuppFig2"></mediaResource><caption>Supporting Figure 2</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23294:MDS_23294_sm_SuppTable-S1"></mediaResource><caption>Supporting Table 1</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds23294:MDS_23294_sm_Suppinfo"></mediaResource><caption>Supporting Information</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>There is a consensus that in Parkinson's disease, the extent of preoperative levodopa responsiveness predicts the efficacy of subthalamic nucleus deep brain stimulation (STN DBS). However, this may be the result of statistical methods and primary assumptions. We were able to reproduce previously published correlation results on our data (N = 49 patients). Yet, these same results were demonstrated even after random shuffling of our data. Notably, we did not observe a correlation between STN DBS efficacy and preoperative levodopa responsiveness when using their respective baselines and fractional scores of motor improvement. Furthermore, postoperative responses were not limited by preoperative scores, with tremor demonstrating the greatest discrepancy. We conclude that preoperative levodopa responsiveness does not predict or limit the outcome of STN DBS. These results imply different therapeutic mechanisms for levodopa and STN DBS and therefore question the validity of using substantial preoperative levodopa responsiveness as a selection criterion for STN DBS. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Levodopa and subthalamic deep brain stimulation responses are not congruent</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Does L‐Dopa Response Predict STN DBS Efficacy?</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Levodopa and subthalamic deep brain stimulation responses are not congruent</title></titleInfo><name type="personal"><namePart type="given">Adam</namePart><namePart type="family">Zaidel</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>The Interdisciplinary Center for Neural Computation, The Hebrew University of Jerusalem, Israel</affiliation><affiliation>Department of Medical Neurobiology, Canada‐Israel Institute for Medical Research, The Hebrew University Hadassah Medical School, Jerusalem, Israel</affiliation><description>Correspondence: Department of Medical Neurobiology, Canada‐Israel Institute for Medical Research, The Hebrew University Hadassah Medical School, Jerusalem Israel</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hagai</namePart><namePart type="family">Bergman</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>The Interdisciplinary Center for Neural Computation, The Hebrew University of Jerusalem, Israel</affiliation><affiliation>Department of Medical Neurobiology, Canada‐Israel Institute for Medical Research, The Hebrew University Hadassah Medical School, Jerusalem, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ya'acov</namePart><namePart type="family">Ritov</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Statistics, The Hebrew University of Jerusalem, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Zvi Israel</namePart><namePart type="family">MD</namePart><affiliation>Department of Neurosurgery, Hadassah University Hospital, Jerusalem, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-10-30</dateIssued><dateCaptured encoding="w3cdtf">2009-11-05</dateCaptured><dateValid encoding="w3cdtf">2010-04-28</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">4</extent><extent unit="tables">1</extent><extent unit="references">25</extent><extent unit="words">4656</extent></physicalDescription><abstract lang="en">There is a consensus that in Parkinson's disease, the extent of preoperative levodopa responsiveness predicts the efficacy of subthalamic nucleus deep brain stimulation (STN DBS). However, this may be the result of statistical methods and primary assumptions. We were able to reproduce previously published correlation results on our data (N = 49 patients). Yet, these same results were demonstrated even after random shuffling of our data. Notably, we did not observe a correlation between STN DBS efficacy and preoperative levodopa responsiveness when using their respective baselines and fractional scores of motor improvement. Furthermore, postoperative responses were not limited by preoperative scores, with tremor demonstrating the greatest discrepancy. We conclude that preoperative levodopa responsiveness does not predict or limit the outcome of STN DBS. These results imply different therapeutic mechanisms for levodopa and STN DBS and therefore question the validity of using substantial preoperative levodopa responsiveness as a selection criterion for STN DBS. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>subthalamic nucleus</topic><topic>basal ganglia</topic><topic>deep brain stimulation</topic><topic>predictive factor</topic><topic>levodopa</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Supporting Figure 1 - Supporting Figure 2 - Supporting Table 1 - Supporting Information - </note><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>14</number></detail><extent unit="pages"><start>2379</start><end>2386</end><total>8</total></extent></part></relatedItem><identifier type="istex">40F812414774F02DADD69780FA164044D49897E3</identifier><identifier type="DOI">10.1002/mds.23294</identifier><identifier type="ArticleID">MDS23294</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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