Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients
Identifieur interne : 003095 ( Main/Corpus ); précédent : 003094; suivant : 003096Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients
Auteurs : Erik Mullaart ; Michael E. T. I. Boerrigter ; Rivka Ravid ; Dick F. Swaab ; Jan VijgSource :
- Neurobiology of Aging [ 0197-4580 ] ; 1989.
Abstract
It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.
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DOI: 10.1016/0197-4580(90)90542-8
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Box 5815, 2280 HV Rijswijk, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Ravid, Rivka" sort="Ravid, Rivka" uniqKey="Ravid R" first="Rivka" last="Ravid">Rivka Ravid</name><affiliation><mods:affiliation>Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Swaab, Dick F" sort="Swaab, Dick F" uniqKey="Swaab D" first="Dick F." last="Swaab">Dick F. Swaab</name><affiliation><mods:affiliation>Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Vijg, Jan" sort="Vijg, Jan" uniqKey="Vijg J" first="Jan" last="Vijg">Jan Vijg</name><affiliation><mods:affiliation>Requests for reprints should be addressed to Dr. J. Vijg, TNO Institute for Experimental Gerontology, P.O. Box 5815, 2280 HV Rijswijk, The Netherlands.</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Molecular Biology, TNO Institute for Experimental Gerontology P.O. 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Box 5815, 2280 HV Rijswijk, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Boerrigter, Michael E T I" sort="Boerrigter, Michael E T I" uniqKey="Boerrigter M" first="Michael E. T. I." last="Boerrigter">Michael E. T. I. Boerrigter</name><affiliation><mods:affiliation>Department of Molecular Biology, TNO Institute for Experimental Gerontology P.O. Box 5815, 2280 HV Rijswijk, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Ravid, Rivka" sort="Ravid, Rivka" uniqKey="Ravid R" first="Rivka" last="Ravid">Rivka Ravid</name><affiliation><mods:affiliation>Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Swaab, Dick F" sort="Swaab, Dick F" uniqKey="Swaab D" first="Dick F." last="Swaab">Dick F. Swaab</name><affiliation><mods:affiliation>Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Vijg, Jan" sort="Vijg, Jan" uniqKey="Vijg J" first="Jan" last="Vijg">Jan Vijg</name><affiliation><mods:affiliation>Requests for reprints should be addressed to Dr. J. Vijg, TNO Institute for Experimental Gerontology, P.O. Box 5815, 2280 HV Rijswijk, The Netherlands.</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Molecular Biology, TNO Institute for Experimental Gerontology P.O. Box 5815, 2280 HV Rijswijk, The Netherlands</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Neurobiology of Aging</title><title level="j" type="abbrev">NBA</title><idno type="ISSN">0197-4580</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1989">1989</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="169">169</biblScope><biblScope unit="page" to="173">173</biblScope></imprint><idno type="ISSN">0197-4580</idno></series><idno type="istex">B68E750C844CACD85DA5A5240030B4386D1F343B</idno><idno type="DOI">10.1016/0197-4580(90)90542-8</idno><idno type="PII">0197-4580(90)90542-8</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0197-4580</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Erik Mullaart</name><affiliations><json:string>Department of Molecular Biology, TNO Institute for Experimental Gerontology P.O. Box 5815, 2280 HV Rijswijk, The Netherlands</json:string></affiliations></json:item><json:item><name>Michael E.T.I. Boerrigter</name><affiliations><json:string>Department of Molecular Biology, TNO Institute for Experimental Gerontology P.O. Box 5815, 2280 HV Rijswijk, The Netherlands</json:string></affiliations></json:item><json:item><name>Rivka Ravid</name><affiliations><json:string>Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO, The Netherlands</json:string></affiliations></json:item><json:item><name>Dick F. Swaab</name><affiliations><json:string>Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO, The Netherlands</json:string></affiliations></json:item><json:item><name>Jan Vijg</name><affiliations><json:string>Requests for reprints should be addressed to Dr. J. Vijg, TNO Institute for Experimental Gerontology, P.O. Box 5815, 2280 HV Rijswijk, The Netherlands.</json:string><json:string>Department of Molecular Biology, TNO Institute for Experimental Gerontology P.O. Box 5815, 2280 HV Rijswijk, The Netherlands</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>DNA breaks</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Alzheimer's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Cerebral cortex</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Alkaline elution</value></json:item></subject><language><json:string>eng</json:string></language><abstract>It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.</abstract><qualityIndicators><score>5.442</score><pdfVersion>1.2</pdfVersion><pdfPageSize>613 x 807 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>755</abstractCharCount><pdfWordCount>3978</pdfWordCount><pdfCharCount>21689</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>122</abstractWordCount></qualityIndicators><title>Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients</title><pii><json:string>0197-4580(90)90542-8</json:string></pii><genre><json:string>research-article</json:string></genre><serie><genre></genre><language><json:string>unknown</json:string></language><title>Thesis</title></serie><host><volume>11</volume><pii><json:string>S0197-4580(00)X0125-X</json:string></pii><pages><last>173</last><first>169</first></pages><issn><json:string>0197-4580</json:string></issn><issue>3</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Neurobiology of Aging</title><publicationDate>1990</publicationDate></host><categories><wos><json:string>GERIATRICS & GERONTOLOGY</json:string><json:string>NEUROSCIENCES</json:string></wos></categories><publicationDate>1989</publicationDate><copyrightDate>1990</copyrightDate><doi><json:string>10.1016/0197-4580(90)90542-8</json:string></doi><id>B68E750C844CACD85DA5A5240030B4386D1F343B</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/B68E750C844CACD85DA5A5240030B4386D1F343B/fulltext/pdf</uri></json:item><json:item><original>true</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/B68E750C844CACD85DA5A5240030B4386D1F343B/fulltext/txt</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/B68E750C844CACD85DA5A5240030B4386D1F343B/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/B68E750C844CACD85DA5A5240030B4386D1F343B/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1990</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients</title><author><persName><forename type="first">Erik</forename><surname>Mullaart</surname></persName><affiliation>Department of Molecular Biology, TNO Institute for Experimental Gerontology P.O. Box 5815, 2280 HV Rijswijk, The Netherlands</affiliation></author><author><persName><forename type="first">Michael E.T.I.</forename><surname>Boerrigter</surname></persName><affiliation>Department of Molecular Biology, TNO Institute for Experimental Gerontology P.O. Box 5815, 2280 HV Rijswijk, The Netherlands</affiliation></author><author><persName><forename type="first">Rivka</forename><surname>Ravid</surname></persName><affiliation>Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO, The Netherlands</affiliation></author><author><persName><forename type="first">Dick F.</forename><surname>Swaab</surname></persName><affiliation>Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO, The Netherlands</affiliation></author><author><persName><forename type="first">Jan</forename><surname>Vijg</surname></persName><affiliation>Requests for reprints should be addressed to Dr. J. Vijg, TNO Institute for Experimental Gerontology, P.O. Box 5815, 2280 HV Rijswijk, The Netherlands.</affiliation><affiliation>Department of Molecular Biology, TNO Institute for Experimental Gerontology P.O. Box 5815, 2280 HV Rijswijk, The Netherlands</affiliation></author></analytic><monogr><title level="j">Neurobiology of Aging</title><title level="j" type="abbrev">NBA</title><idno type="pISSN">0197-4580</idno><idno type="PII">S0197-4580(00)X0125-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1989"></date><biblScope unit="volume">11</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="169">169</biblScope><biblScope unit="page" to="173">173</biblScope></imprint></monogr><idno type="istex">B68E750C844CACD85DA5A5240030B4386D1F343B</idno><idno type="DOI">10.1016/0197-4580(90)90542-8</idno><idno type="PII">0197-4580(90)90542-8</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1990</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>DNA breaks</term></item><item><term>Alzheimer's disease</term></item><item><term>Cerebral cortex</term></item><item><term>Alkaline elution</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1989-11-21">Registration</change><change when="1989">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>NBA</jid><aid>90905428</aid><ce:pii>0197-4580(90)90542-8</ce:pii><ce:doi>10.1016/0197-4580(90)90542-8</ce:doi><ce:copyright type="unknown" year="1990"></ce:copyright></item-info><head><ce:title>Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients</ce:title><ce:author-group><ce:author><ce:given-name>Erik</ce:given-name><ce:surname>Mullaart</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Michael E.T.I.</ce:given-name><ce:surname>Boerrigter</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Rivka</ce:given-name><ce:surname>Ravid</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Dick F.</ce:given-name><ce:surname>Swaab</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Jan</ce:given-name><ce:surname>Vijg</ce:surname><ce:cross-ref refid="COR1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Molecular Biology, TNO Institute for Experimental Gerontology P.O. Box 5815, 2280 HV Rijswijk, The Netherlands</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO, The Netherlands</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>1</ce:label><ce:text>Requests for reprints should be addressed to Dr. J. Vijg, TNO Institute for Experimental Gerontology, P.O. Box 5815, 2280 HV Rijswijk, The Netherlands.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="30" month="5" year="1989"></ce:date-received><ce:date-accepted day="21" month="11" year="1989"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>DNA breaks</ce:text></ce:keyword><ce:keyword><ce:text>Alzheimer's disease</ce:text></ce:keyword><ce:keyword><ce:text>Cerebral cortex</ce:text></ce:keyword><ce:keyword><ce:text>Alkaline elution</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients</title></titleInfo><name type="personal"><namePart type="given">Erik</namePart><namePart type="family">Mullaart</namePart><affiliation>Department of Molecular Biology, TNO Institute for Experimental Gerontology P.O. Box 5815, 2280 HV Rijswijk, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael E.T.I.</namePart><namePart type="family">Boerrigter</namePart><affiliation>Department of Molecular Biology, TNO Institute for Experimental Gerontology P.O. Box 5815, 2280 HV Rijswijk, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rivka</namePart><namePart type="family">Ravid</namePart><affiliation>Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dick F.</namePart><namePart type="family">Swaab</namePart><affiliation>Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam ZO, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan</namePart><namePart type="family">Vijg</namePart><affiliation>Requests for reprints should be addressed to Dr. J. Vijg, TNO Institute for Experimental Gerontology, P.O. Box 5815, 2280 HV Rijswijk, The Netherlands.</affiliation><affiliation>Department of Molecular Biology, TNO Institute for Experimental Gerontology P.O. Box 5815, 2280 HV Rijswijk, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1989</dateIssued><dateValid encoding="w3cdtf">1989-11-21</dateValid><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.</abstract><subject><genre>Keywords</genre><topic>DNA breaks</topic><topic>Alzheimer's disease</topic><topic>Cerebral cortex</topic><topic>Alkaline elution</topic></subject><relatedItem type="host"><titleInfo><title>Neurobiology of Aging</title></titleInfo><titleInfo type="abbreviated"><title>NBA</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199005</dateIssued></originInfo><identifier type="ISSN">0197-4580</identifier><identifier type="PII">S0197-4580(00)X0125-X</identifier><part><date>199005</date><detail type="volume"><number>11</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue pages"><start>169</start><end>357</end></extent><extent unit="pages"><start>169</start><end>173</end></extent></part></relatedItem><identifier type="istex">B68E750C844CACD85DA5A5240030B4386D1F343B</identifier><identifier type="DOI">10.1016/0197-4580(90)90542-8</identifier><identifier type="PII">0197-4580(90)90542-8</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/B68E750C844CACD85DA5A5240030B4386D1F343B/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">GERIATRICS & GERONTOLOGY</classCode><classCode scheme="WOS">NEUROSCIENCES</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
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