MRI-Stereotactical Approach for Neural Grafting in Basal Ganglia Disorders
Identifieur interne : 002F98 ( Main/Corpus ); précédent : 002F97; suivant : 002F99MRI-Stereotactical Approach for Neural Grafting in Basal Ganglia Disorders
Auteurs : S. Palfi ; J. P. Nguyen ; P. Brugieres ; C. Le Guerinel ; P. Hantraye ; P. Remy ; S. Rostaing ; G. L. Defer ; P. Cesaro ; Y. Keravel ; M. PeschanskiSource :
- Experimental Neurology [ 0014-4886 ] ; 1997.
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- KwdEn :
Abstract
Optimization of the procedures for neural grafting is a timely issue, as this technique has proven beneficial for a few patients with late-stage Parkinson's disease in pilot studies and therefore may expand to become a more widely available therapeutic. In this research, one major issue is that of the placement of the cell deposits in the right target areas within the striatum. Although it is widely accepted that these suitable regions are the sensorimotor regions of the putamen, reliable delineation of these areas using classical stereotactical mapping techniques remains difficult. Along the course of a 5-year-long clinical transplantation program, we have developed an original procedure based on magnetic resonance imaging of the striatum on parasagittal views. This technique allowed us to identify precisely, and reproducibly in each patient, three subregions of the putamen (precommissural, commissural, and postcommissural) to be implanted. On the basis of the literature defining the sensorimotor putaminal regions in nonhuman primates, it was subsequently possible to extrapolate and localize these regions in each patient, thus providing a basis for the placement of cell deposits. Examples taken from our series of grafted patients demonstrate the value of this procedure that, in addition, minimizes interference of interindividual variability in the interpretation of clinical results.
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DOI: 10.1006/exnr.1997.6754
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In this research, one major issue is that of the placement of the cell deposits in the right target areas within the striatum. Although it is widely accepted that these suitable regions are the sensorimotor regions of the putamen, reliable delineation of these areas using classical stereotactical mapping techniques remains difficult. Along the course of a 5-year-long clinical transplantation program, we have developed an original procedure based on magnetic resonance imaging of the striatum on parasagittal views. This technique allowed us to identify precisely, and reproducibly in each patient, three subregions of the putamen (precommissural, commissural, and postcommissural) to be implanted. On the basis of the literature defining the sensorimotor putaminal regions in nonhuman primates, it was subsequently possible to extrapolate and localize these regions in each patient, thus providing a basis for the placement of cell deposits. Examples taken from our series of grafted patients demonstrate the value of this procedure that, in addition, minimizes interference of interindividual variability in the interpretation of clinical results.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>S. Palfi</name><affiliations><json:string>Service de Neurochirurgie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>J.P. Nguyen</name><affiliations><json:string>Service de Neurochirurgie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>P. Brugieres</name><affiliations><json:string>Service de Neuroradiologie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>C. Le Guerinel</name><affiliations><json:string>Service de Neurochirurgie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>P. Hantraye</name><affiliations><json:string>CEA CNRS URA 2210, Service Hospitalier Frédéric Joliot, CEA, DSV, DRIPP, 4 place du Général Leclerc, 91401, Orsay Cedex, France</json:string></affiliations></json:item><json:item><name>P. Remy</name><affiliations><json:string>Service de Neurologie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>S. Rostaing</name><affiliations><json:string>Service d'Anesthésie Réanimation, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>G.L. Defer</name><affiliations><json:string>Service de Neurologie Déjerine, CHU Côte de Nâcre, 14000, Caen, France</json:string></affiliations></json:item><json:item><name>P. Cesaro</name><affiliations><json:string>Service de Neurologie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>Y. Keravel</name><affiliations><json:string>Service de Neurochirurgie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</json:string></affiliations></json:item><json:item><name>M. Peschanski</name><affiliations><json:string>Inserm U 421, IM3, Faculté de médecine, 8 rue du Général Sarrail, 94010, Créteil, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>stereotaxy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>magnetic resonance imaging</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>striatum</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>grafting</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>fetal mesencephalic tissue.</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Optimization of the procedures for neural grafting is a timely issue, as this technique has proven beneficial for a few patients with late-stage Parkinson's disease in pilot studies and therefore may expand to become a more widely available therapeutic. In this research, one major issue is that of the placement of the cell deposits in the right target areas within the striatum. Although it is widely accepted that these suitable regions are the sensorimotor regions of the putamen, reliable delineation of these areas using classical stereotactical mapping techniques remains difficult. Along the course of a 5-year-long clinical transplantation program, we have developed an original procedure based on magnetic resonance imaging of the striatum on parasagittal views. This technique allowed us to identify precisely, and reproducibly in each patient, three subregions of the putamen (precommissural, commissural, and postcommissural) to be implanted. On the basis of the literature defining the sensorimotor putaminal regions in nonhuman primates, it was subsequently possible to extrapolate and localize these regions in each patient, thus providing a basis for the placement of cell deposits. Examples taken from our series of grafted patients demonstrate the value of this procedure that, in addition, minimizes interference of interindividual variability in the interpretation of clinical results.</abstract><qualityIndicators><score>7.46</score><pdfVersion>1.1</pdfVersion><pdfPageSize>554 x 734 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1406</abstractCharCount><pdfWordCount>5264</pdfWordCount><pdfCharCount>31971</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>205</abstractWordCount></qualityIndicators><title>MRI-Stereotactical Approach for Neural Grafting in Basal Ganglia Disorders</title><pii><json:string>S0014-4886(97)96754-6</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>150</volume><pii><json:string>S0014-4886(00)X0043-X</json:string></pii><pages><last>281</last><first>272</first></pages><issn><json:string>0014-4886</json:string></issn><issue>2</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Experimental Neurology</title><publicationDate>1998</publicationDate></host><categories><wos><json:string>NEUROSCIENCES</json:string></wos></categories><publicationDate>1997</publicationDate><copyrightDate>1998</copyrightDate><doi><json:string>10.1006/exnr.1997.6754</json:string></doi><id>9105FA6589BDD47225A65820FD0A4BB2D827BC54</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/9105FA6589BDD47225A65820FD0A4BB2D827BC54/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/9105FA6589BDD47225A65820FD0A4BB2D827BC54/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/9105FA6589BDD47225A65820FD0A4BB2D827BC54/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">MRI-Stereotactical Approach for Neural Grafting in Basal Ganglia Disorders</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1998</date></publicationStmt><notesStmt><note>O. LindvallA. BjörklundH. Widner</note><note type="content">Section title: Regular Article</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">MRI-Stereotactical Approach for Neural Grafting in Basal Ganglia Disorders</title><author><persName><forename type="first">S.</forename><surname>Palfi</surname></persName><affiliation>Service de Neurochirurgie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">J.P.</forename><surname>Nguyen</surname></persName><affiliation>Service de Neurochirurgie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">P.</forename><surname>Brugieres</surname></persName><affiliation>Service de Neuroradiologie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">C.</forename><surname>Le Guerinel</surname></persName><affiliation>Service de Neurochirurgie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">P.</forename><surname>Hantraye</surname></persName><affiliation>CEA CNRS URA 2210, Service Hospitalier Frédéric Joliot, CEA, DSV, DRIPP, 4 place du Général Leclerc, 91401, Orsay Cedex, France</affiliation></author><author><persName><forename type="first">P.</forename><surname>Remy</surname></persName><affiliation>Service de Neurologie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">S.</forename><surname>Rostaing</surname></persName><affiliation>Service d'Anesthésie Réanimation, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">G.L.</forename><surname>Defer</surname></persName><affiliation>Service de Neurologie Déjerine, CHU Côte de Nâcre, 14000, Caen, France</affiliation></author><author><persName><forename type="first">P.</forename><surname>Cesaro</surname></persName><affiliation>Service de Neurologie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">Y.</forename><surname>Keravel</surname></persName><affiliation>Service de Neurochirurgie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</affiliation></author><author><persName><forename type="first">M.</forename><surname>Peschanski</surname></persName><affiliation>Inserm U 421, IM3, Faculté de médecine, 8 rue du Général Sarrail, 94010, Créteil, France</affiliation></author></analytic><monogr><title level="j">Experimental Neurology</title><title level="j" type="abbrev">YEXNR</title><idno type="pISSN">0014-4886</idno><idno type="PII">S0014-4886(00)X0043-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997"></date><biblScope unit="volume">150</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="272">272</biblScope><biblScope unit="page" to="281">281</biblScope></imprint></monogr><idno type="istex">9105FA6589BDD47225A65820FD0A4BB2D827BC54</idno><idno type="DOI">10.1006/exnr.1997.6754</idno><idno type="PII">S0014-4886(97)96754-6</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1998</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Optimization of the procedures for neural grafting is a timely issue, as this technique has proven beneficial for a few patients with late-stage Parkinson's disease in pilot studies and therefore may expand to become a more widely available therapeutic. In this research, one major issue is that of the placement of the cell deposits in the right target areas within the striatum. Although it is widely accepted that these suitable regions are the sensorimotor regions of the putamen, reliable delineation of these areas using classical stereotactical mapping techniques remains difficult. Along the course of a 5-year-long clinical transplantation program, we have developed an original procedure based on magnetic resonance imaging of the striatum on parasagittal views. This technique allowed us to identify precisely, and reproducibly in each patient, three subregions of the putamen (precommissural, commissural, and postcommissural) to be implanted. On the basis of the literature defining the sensorimotor putaminal regions in nonhuman primates, it was subsequently possible to extrapolate and localize these regions in each patient, thus providing a basis for the placement of cell deposits. Examples taken from our series of grafted patients demonstrate the value of this procedure that, in addition, minimizes interference of interindividual variability in the interpretation of clinical results.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>stereotaxy</term></item><item><term>magnetic resonance imaging</term></item><item><term>Parkinson disease</term></item><item><term>striatum</term></item><item><term>grafting</term></item><item><term>fetal mesencephalic tissue.</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1997-11-12">Registration</change><change when="1997">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/9105FA6589BDD47225A65820FD0A4BB2D827BC54/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>YEXNR</jid><aid>96754</aid><ce:pii>S0014-4886(97)96754-6</ce:pii><ce:doi>10.1006/exnr.1997.6754</ce:doi><ce:copyright type="full-transfer" year="1998">Academic Press</ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>O. LindvallA. BjörklundH. Widner</ce:note-para></ce:article-footnote><ce:dochead><ce:textfn>Regular Article</ce:textfn></ce:dochead><ce:title>MRI-Stereotactical Approach for Neural Grafting in Basal Ganglia Disorders</ce:title><ce:author-group><ce:author><ce:given-name>S.</ce:given-name><ce:surname>Palfi</ce:surname><ce:cross-ref refid="EN976754A1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="EN976754A2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.P.</ce:given-name><ce:surname>Nguyen</ce:surname><ce:cross-ref refid="EN976754A1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="EN976754A3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Brugieres</ce:surname><ce:cross-ref refid="EN976754A4"><ce:sup>d</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>C.</ce:given-name><ce:surname>Le Guerinel</ce:surname><ce:cross-ref refid="EN976754A1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Hantraye</ce:surname><ce:cross-ref refid="EN976754A2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Remy</ce:surname><ce:cross-ref refid="EN976754A5"><ce:sup>e</ce:sup></ce:cross-ref><ce:cross-ref refid="EN976754A6"><ce:sup>f</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>S.</ce:given-name><ce:surname>Rostaing</ce:surname><ce:cross-ref refid="EN976754A7"><ce:sup>g</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>G.L.</ce:given-name><ce:surname>Defer</ce:surname><ce:cross-ref refid="EN976754A8"><ce:sup>h</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Cesaro</ce:surname><ce:cross-ref refid="EN976754A3"><ce:sup>c</ce:sup></ce:cross-ref><ce:cross-ref refid="EN976754A5"><ce:sup>e</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Y.</ce:given-name><ce:surname>Keravel</ce:surname><ce:cross-ref refid="EN976754A1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.</ce:given-name><ce:surname>Peschanski</ce:surname><ce:cross-ref refid="EN976754A3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="EN976754A1"><ce:label>a</ce:label><ce:textfn>Service de Neurochirurgie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</ce:textfn></ce:affiliation><ce:affiliation id="EN976754A4"><ce:label>d</ce:label><ce:textfn>Service de Neuroradiologie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</ce:textfn></ce:affiliation><ce:affiliation id="EN976754A5"><ce:label>e</ce:label><ce:textfn>Service de Neurologie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</ce:textfn></ce:affiliation><ce:affiliation id="EN976754A7"><ce:label>g</ce:label><ce:textfn>Service d'Anesthésie Réanimation, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</ce:textfn></ce:affiliation><ce:affiliation id="EN976754A3"><ce:label>c</ce:label><ce:textfn>Inserm U 421, IM3, Faculté de médecine, 8 rue du Général Sarrail, 94010, Créteil, France</ce:textfn></ce:affiliation><ce:affiliation id="EN976754A2"><ce:label>b</ce:label><ce:textfn>CEA CNRS URA 2210, Service Hospitalier Frédéric Joliot, CEA, DSV, DRIPP, 4 place du Général Leclerc, 91401, Orsay Cedex, France</ce:textfn></ce:affiliation><ce:affiliation id="EN976754A6"><ce:label>f</ce:label><ce:textfn>Service Hospitalier Frédéric Joliot, CEA, DSV, DRIPP, 4 place du Général Leclerc, 91401, Orsay Cedex, France</ce:textfn></ce:affiliation><ce:affiliation id="EN976754A8"><ce:label>h</ce:label><ce:textfn>Service de Neurologie Déjerine, CHU Côte de Nâcre, 14000, Caen, France</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="19" month="5" year="1997"></ce:date-received><ce:date-accepted day="12" month="11" year="1997"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Optimization of the procedures for neural grafting is a timely issue, as this technique has proven beneficial for a few patients with late-stage Parkinson's disease in pilot studies and therefore may expand to become a more widely available therapeutic. In this research, one major issue is that of the placement of the cell deposits in the right target areas within the striatum. Although it is widely accepted that these suitable regions are the sensorimotor regions of the putamen, reliable delineation of these areas using classical stereotactical mapping techniques remains difficult. Along the course of a 5-year-long clinical transplantation program, we have developed an original procedure based on magnetic resonance imaging of the striatum on parasagittal views. This technique allowed us to identify precisely, and reproducibly in each patient, three subregions of the putamen (precommissural, commissural, and postcommissural) to be implanted. On the basis of the literature defining the sensorimotor putaminal regions in nonhuman primates, it was subsequently possible to extrapolate and localize these regions in each patient, thus providing a basis for the placement of cell deposits. Examples taken from our series of grafted patients demonstrate the value of this procedure that, in addition, minimizes interference of interindividual variability in the interpretation of clinical results.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>stereotaxy</ce:text></ce:keyword><ce:keyword><ce:text>magnetic resonance imaging</ce:text></ce:keyword><ce:keyword><ce:text>Parkinson disease</ce:text></ce:keyword><ce:keyword><ce:text>striatum</ce:text></ce:keyword><ce:keyword><ce:text>grafting</ce:text></ce:keyword><ce:keyword><ce:text>fetal mesencephalic tissue.</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>MRI-Stereotactical Approach for Neural Grafting in Basal Ganglia Disorders</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>MRI-Stereotactical Approach for Neural Grafting in Basal Ganglia Disorders</title></titleInfo><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Palfi</namePart><affiliation>Service de Neurochirurgie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.P.</namePart><namePart type="family">Nguyen</namePart><affiliation>Service de Neurochirurgie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Brugieres</namePart><affiliation>Service de Neuroradiologie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Le Guerinel</namePart><affiliation>Service de Neurochirurgie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Hantraye</namePart><affiliation>CEA CNRS URA 2210, Service Hospitalier Frédéric Joliot, CEA, DSV, DRIPP, 4 place du Général Leclerc, 91401, Orsay Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Remy</namePart><affiliation>Service de Neurologie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Rostaing</namePart><affiliation>Service d'Anesthésie Réanimation, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.L.</namePart><namePart type="family">Defer</namePart><affiliation>Service de Neurologie Déjerine, CHU Côte de Nâcre, 14000, Caen, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Cesaro</namePart><affiliation>Service de Neurologie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Keravel</namePart><affiliation>Service de Neurochirurgie, Hôpital Henri Mondor, 55 Avenue du Maréchal De Lattre de Tassigny, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Peschanski</namePart><affiliation>Inserm U 421, IM3, Faculté de médecine, 8 rue du Général Sarrail, 94010, Créteil, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1997</dateIssued><dateValid encoding="w3cdtf">1997-11-12</dateValid><copyrightDate encoding="w3cdtf">1998</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Optimization of the procedures for neural grafting is a timely issue, as this technique has proven beneficial for a few patients with late-stage Parkinson's disease in pilot studies and therefore may expand to become a more widely available therapeutic. In this research, one major issue is that of the placement of the cell deposits in the right target areas within the striatum. Although it is widely accepted that these suitable regions are the sensorimotor regions of the putamen, reliable delineation of these areas using classical stereotactical mapping techniques remains difficult. Along the course of a 5-year-long clinical transplantation program, we have developed an original procedure based on magnetic resonance imaging of the striatum on parasagittal views. This technique allowed us to identify precisely, and reproducibly in each patient, three subregions of the putamen (precommissural, commissural, and postcommissural) to be implanted. On the basis of the literature defining the sensorimotor putaminal regions in nonhuman primates, it was subsequently possible to extrapolate and localize these regions in each patient, thus providing a basis for the placement of cell deposits. Examples taken from our series of grafted patients demonstrate the value of this procedure that, in addition, minimizes interference of interindividual variability in the interpretation of clinical results.</abstract><note>O. LindvallA. BjörklundH. Widner</note><note type="content">Section title: Regular Article</note><subject lang="en"><genre>Keywords</genre><topic>stereotaxy</topic><topic>magnetic resonance imaging</topic><topic>Parkinson disease</topic><topic>striatum</topic><topic>grafting</topic><topic>fetal mesencephalic tissue.</topic></subject><relatedItem type="host"><titleInfo><title>Experimental Neurology</title></titleInfo><titleInfo type="abbreviated"><title>YEXNR</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199804</dateIssued></originInfo><identifier type="ISSN">0014-4886</identifier><identifier type="PII">S0014-4886(00)X0043-X</identifier><part><date>199804</date><detail type="volume"><number>150</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue pages"><start>171</start><end>347</end></extent><extent unit="pages"><start>272</start><end>281</end></extent></part></relatedItem><identifier type="istex">9105FA6589BDD47225A65820FD0A4BB2D827BC54</identifier><identifier type="DOI">10.1006/exnr.1997.6754</identifier><identifier type="PII">S0014-4886(97)96754-6</identifier><accessCondition type="use and reproduction" contentType="">© 1998Academic Press</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Academic Press, ©1998</recordOrigin></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/9105FA6589BDD47225A65820FD0A4BB2D827BC54/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">NEUROSCIENCES</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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