Long‐term deep brain stimulation for essential tremor: 12‐year clinicopathologic follow‐up
Identifieur interne : 002F74 ( Main/Corpus ); précédent : 002F73; suivant : 002F75Long‐term deep brain stimulation for essential tremor: 12‐year clinicopathologic follow‐up
Auteurs : Daniel J. Dilorenzo ; Joseph Jankovic ; Richard K. Simpson ; Hidehiro Takei ; Suzanne Z. PowellSource :
- Movement Disorders [ 0885-3185 ] ; 2010-01-30.
English descriptors
Abstract
We describe the clinical course and postmortem pathological findings in a patient with essential tremor (ET) treated with deep brain stimulation (DBS) for 12 years. This 75 year old woman had a 13‐year history of progressive ET prior to implantation of bilateral quadripolar DBS electrodes in the region of her ventral intermediate thalamic nuclei in 1996, producing immediate relief of arm tremor. Histopathological examination of the brain, performed 12 years after the initial implantation, demonstrated electrode catheter tracts rimmed by 20‐25 micron fibrous sheaths, with multinucleated giant cells and reactive gliosis. Lymphocytic infiltration was seen by L26 immunoreactivity with CD3 (T cells) staining predominating over CD20 (B cells). Cerebellar axonal spheroids and Purkinje cell loss were found. The minimal foreign body reaction and gliosis around the electrodes 12 years after implantation supports the long‐term safety of DBS. The case represents the longest reported follow‐up with autopsy examination after DBS and confirmed histological changes associated with ET. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22935
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This 75 year old woman had a 13‐year history of progressive ET prior to implantation of bilateral quadripolar DBS electrodes in the region of her ventral intermediate thalamic nuclei in 1996, producing immediate relief of arm tremor. Histopathological examination of the brain, performed 12 years after the initial implantation, demonstrated electrode catheter tracts rimmed by 20‐25 micron fibrous sheaths, with multinucleated giant cells and reactive gliosis. Lymphocytic infiltration was seen by L26 immunoreactivity with CD3 (T cells) staining predominating over CD20 (B cells). Cerebellar axonal spheroids and Purkinje cell loss were found. The minimal foreign body reaction and gliosis around the electrodes 12 years after implantation supports the long‐term safety of DBS. The case represents the longest reported follow‐up with autopsy examination after DBS and confirmed histological changes associated with ET. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Daniel J. DiLorenzo MD, PhD</name><affiliations><json:string>Department of Neurosurgery, The Methodist Hospital, Houston, Texas, USA</json:string></affiliations></json:item><json:item><name>Joseph Jankovic MD</name><affiliations><json:string>Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</json:string></affiliations></json:item><json:item><name>Richard K. Simpson MD</name><affiliations><json:string>Department of Neurosurgery, The Methodist Hospital, Houston, Texas, USA</json:string></affiliations></json:item><json:item><name>Hidehiro Takei MD</name><affiliations><json:string>Department of Pathology, The Methodist Hospital, Houston, Texas, USA</json:string></affiliations></json:item><json:item><name>Suzanne Z. Powell MD</name><affiliations><json:string>Department of Pathology, The Methodist Hospital, Houston, Texas, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>deep brain stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>essential tremor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>postmortem</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>clinicopathologic</value></json:item></subject><articleId><json:string>MDS22935</json:string></articleId><language><json:string>eng</json:string></language><abstract>We describe the clinical course and postmortem pathological findings in a patient with essential tremor (ET) treated with deep brain stimulation (DBS) for 12 years. This 75 year old woman had a 13‐year history of progressive ET prior to implantation of bilateral quadripolar DBS electrodes in the region of her ventral intermediate thalamic nuclei in 1996, producing immediate relief of arm tremor. Histopathological examination of the brain, performed 12 years after the initial implantation, demonstrated electrode catheter tracts rimmed by 20‐25 micron fibrous sheaths, with multinucleated giant cells and reactive gliosis. Lymphocytic infiltration was seen by L26 immunoreactivity with CD3 (T cells) staining predominating over CD20 (B cells). Cerebellar axonal spheroids and Purkinje cell loss were found. The minimal foreign body reaction and gliosis around the electrodes 12 years after implantation supports the long‐term safety of DBS. 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Dr. DiLorenzo is the founder of and stockholder of two neural implant / neurostimulator companies: NeuroVista (originally NeuroBionics, then BioNeuronics) and Barinetics. Dr. Simpson is a consultant and speaker for Medtronic. Drs. Powell and Taki have nothing to disclose.</note><note>National Parkinson Foundation (NPF)</note><note>NPF Center of Excellence at Baylor College of Medicine</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Long‐term deep brain stimulation for essential tremor: 12‐year clinicopathologic follow‐up</title><author><persName><forename type="first">Daniel J.</forename><surname>DiLorenzo</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurosurgery, The Methodist Hospital, Houston, Texas, USA</affiliation></author><author><persName><forename type="first">Joseph</forename><surname>Jankovic</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Baylor College of Medicine, Department of Neurology, The Smith Tower, Suite 1801, 6550 Fannin, Houston, Texas 77030, USA</p></note><affiliation>Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation></author><author><persName><forename type="first">Richard K.</forename><surname>Simpson</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurosurgery, The Methodist Hospital, Houston, Texas, USA</affiliation></author><author><persName><forename type="first">Hidehiro</forename><surname>Takei</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Pathology, The Methodist Hospital, Houston, Texas, USA</affiliation></author><author><persName><forename type="first">Suzanne Z.</forename><surname>Powell</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Pathology, The Methodist Hospital, Houston, Texas, USA</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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This 75 year old woman had a 13‐year history of progressive ET prior to implantation of bilateral quadripolar DBS electrodes in the region of her ventral intermediate thalamic nuclei in 1996, producing immediate relief of arm tremor. Histopathological examination of the brain, performed 12 years after the initial implantation, demonstrated electrode catheter tracts rimmed by 20‐25 micron fibrous sheaths, with multinucleated giant cells and reactive gliosis. Lymphocytic infiltration was seen by L26 immunoreactivity with CD3 (T cells) staining predominating over CD20 (B cells). Cerebellar axonal spheroids and Purkinje cell loss were found. The minimal foreign body reaction and gliosis around the electrodes 12 years after implantation supports the long‐term safety of DBS. The case represents the longest reported follow‐up with autopsy examination after DBS and confirmed histological changes associated with ET. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>deep brain stimulation</term></item><item><term>essential tremor</term></item><item><term>postmortem</term></item><item><term>clinicopathologic</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-04-19">Received</change><change when="2009-11-06">Registration</change><change when="2010-01-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/C0216E910B6A87AA3E744FEA26C8BB5AB9B192BF/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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alt="supporting information" href="urn-x:wiley:08853185:media:mds22935:22935"></mediaResource><caption>Video</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We describe the clinical course and postmortem pathological findings in a patient with essential tremor (ET) treated with deep brain stimulation (DBS) for 12 years. This 75 year old woman had a 13‐year history of progressive ET prior to implantation of bilateral quadripolar DBS electrodes in the region of her ventral intermediate thalamic nuclei in 1996, producing immediate relief of arm tremor. Histopathological examination of the brain, performed 12 years after the initial implantation, demonstrated electrode catheter tracts rimmed by 20‐25 micron fibrous sheaths, with multinucleated giant cells and reactive gliosis. Lymphocytic infiltration was seen by L26 immunoreactivity with CD3 (T cells) staining predominating over CD20 (B cells). Cerebellar axonal spheroids and Purkinje cell loss were found. The minimal foreign body reaction and gliosis around the electrodes 12 years after implantation supports the long‐term safety of DBS. The case represents the longest reported follow‐up with autopsy examination after DBS and confirmed histological changes associated with ET. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Dr. Jankovic has received research grants from Medtronic and St. Jude Medical. Dr. DiLorenzo is the founder of and stockholder of two neural implant / neurostimulator companies: NeuroVista (originally NeuroBionics, then BioNeuronics) and Barinetics. Dr. Simpson is a consultant and speaker for Medtronic. Drs. Powell and Taki have nothing to disclose.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Long‐term deep brain stimulation for essential tremor: 12‐year clinicopathologic follow‐up</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>DBS for ET with 12‐Year Clinicopathologic Follow‐Up</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Long‐term deep brain stimulation for essential tremor: 12‐year clinicopathologic follow‐up</title></titleInfo><name type="personal"><namePart type="given">Daniel J.</namePart><namePart type="family">DiLorenzo</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurosurgery, The Methodist Hospital, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joseph</namePart><namePart type="family">Jankovic</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Baylor College of Medicine, Houston, Texas, USA</affiliation><description>Correspondence: Baylor College of Medicine, Department of Neurology, The Smith Tower, Suite 1801, 6550 Fannin, Houston, Texas 77030, USA</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Richard K.</namePart><namePart type="family">Simpson</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosurgery, The Methodist Hospital, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hidehiro</namePart><namePart type="family">Takei</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Pathology, The Methodist Hospital, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Suzanne Z.</namePart><namePart type="family">Powell</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Pathology, The Methodist Hospital, Houston, Texas, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-01-30</dateIssued><dateCaptured encoding="w3cdtf">2009-04-19</dateCaptured><dateValid encoding="w3cdtf">2009-11-06</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="references">20</extent><extent unit="words">3348</extent></physicalDescription><abstract lang="en">We describe the clinical course and postmortem pathological findings in a patient with essential tremor (ET) treated with deep brain stimulation (DBS) for 12 years. This 75 year old woman had a 13‐year history of progressive ET prior to implantation of bilateral quadripolar DBS electrodes in the region of her ventral intermediate thalamic nuclei in 1996, producing immediate relief of arm tremor. Histopathological examination of the brain, performed 12 years after the initial implantation, demonstrated electrode catheter tracts rimmed by 20‐25 micron fibrous sheaths, with multinucleated giant cells and reactive gliosis. Lymphocytic infiltration was seen by L26 immunoreactivity with CD3 (T cells) staining predominating over CD20 (B cells). Cerebellar axonal spheroids and Purkinje cell loss were found. The minimal foreign body reaction and gliosis around the electrodes 12 years after implantation supports the long‐term safety of DBS. The case represents the longest reported follow‐up with autopsy examination after DBS and confirmed histological changes associated with ET. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Dr. Jankovic has received research grants from Medtronic and St. Jude Medical. Dr. DiLorenzo is the founder of and stockholder of two neural implant / neurostimulator companies: NeuroVista (originally NeuroBionics, then BioNeuronics) and Barinetics. Dr. Simpson is a consultant and speaker for Medtronic. Drs. Powell and Taki have nothing to disclose.</note><note type="funding">National Parkinson Foundation (NPF)</note><note type="funding">NPF Center of Excellence at Baylor College of Medicine</note><subject lang="en"><genre>Keywords</genre><topic>deep brain stimulation</topic><topic>essential tremor</topic><topic>postmortem</topic><topic>clinicopathologic</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Video - </note><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>232</start><end>238</end><total>7</total></extent></part></relatedItem><identifier type="istex">C0216E910B6A87AA3E744FEA26C8BB5AB9B192BF</identifier><identifier type="DOI">10.1002/mds.22935</identifier><identifier type="ArticleID">MDS22935</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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