Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease
Identifieur interne : 002F67 ( Main/Corpus ); précédent : 002F66; suivant : 002F68Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease
Auteurs : N. Kemppainen ; M. Laine ; M. P. Laakso ; V. Kaasinen ; K. N Gren ; T. Vahlberg ; T. Kurki ; J. O. RinneSource :
- European Journal of Neuroscience [ 0953-816X ] ; 2003-07.
English descriptors
Abstract
Post mortem studies have revealed a loss of dopamine D2 receptors in the temporal lobes in Alzheimer's disease (AD). Moreover, the role of hippocampal D2 receptors on memory performance has been suggested in experimental studies. However, there are no previous in vivo studies on extrastriatal D2 receptors in AD. Our aim was to examine in vivo whether hippocampal or temporal cortical dopamine D2 receptors are affected in AD and whether D2 receptor availability is associated with the memory dysfunction seen in AD. Fourteen patients with probable AD and 11 age‐ and sex‐matched controls were studied with positron emission tomography using a dopamine D2/D3 receptor antagonist [11C]FLB 457. The D2 receptor binding potentials (BPs) were measured in extrastriatal brain regions and a neuropsychological investigation was performed on the patients with AD. In AD, the D2 receptor availability was reduced in the hippocampus: by 34% (P = 0.03) in the right hippocampus and by 14% (P = 0.78) in the left hippocampus as compared with controls. Multiple linear regression analysis showed that the BP in the right hippocampus had a significant positive association with verbal memory performance (Wechsler Memory Scale – Revised) (P = 0.001) and picture naming (the Boston Naming Test) (P = 0.002). Our findings suggest a role for temporal lobe D2 receptors in the memory and naming performance in AD, and suggest that studies to evaluate the efficiency of dopaminergic medication on patients with early AD might be warranted.
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DOI: 10.1046/j.1460-9568.2003.02716.x
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Kemppainen</name><affiliation><mods:affiliation>Department of Neurology and</mods:affiliation></affiliation><affiliation><mods:affiliation>Turku PET Centre, PO Box 52, University of Turku, FIN‐20521 Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Laine, M" sort="Laine, M" uniqKey="Laine M" first="M." last="Laine">M. Laine</name><affiliation><mods:affiliation>Department of Psychology, Åbo Akademi University, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Laakso, M P" sort="Laakso, M P" uniqKey="Laakso M" first="M. P." last="Laakso">M. P. Laakso</name><affiliation><mods:affiliation>Department of Neurology and Clinical Radiology, Kuopio University Hospital, Kuopio, Finland</mods:affiliation></affiliation></author><author><name sortKey="Kaasinen, V" sort="Kaasinen, V" uniqKey="Kaasinen V" first="V." last="Kaasinen">V. Kaasinen</name><affiliation><mods:affiliation>Department of Neurology and</mods:affiliation></affiliation><affiliation><mods:affiliation>Turku PET Centre, PO Box 52, University of Turku, FIN‐20521 Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="N Gren, K" sort="N Gren, K" uniqKey="N Gren K" first="K." last="N Gren">K. N Gren</name><affiliation><mods:affiliation>Turku PET Centre, Radiochemistry Laboratory, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Vahlberg, T" sort="Vahlberg, T" uniqKey="Vahlberg T" first="T." last="Vahlberg">T. Vahlberg</name><affiliation><mods:affiliation>Department of Biostatistics, University of Turku, Turku, Finland</mods:affiliation></affiliation></author><author><name sortKey="Kurki, T" sort="Kurki, T" uniqKey="Kurki T" first="T." last="Kurki">T. 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Moreover, the role of hippocampal D2 receptors on memory performance has been suggested in experimental studies. However, there are no previous in vivo studies on extrastriatal D2 receptors in AD. Our aim was to examine in vivo whether hippocampal or temporal cortical dopamine D2 receptors are affected in AD and whether D2 receptor availability is associated with the memory dysfunction seen in AD. Fourteen patients with probable AD and 11 age‐ and sex‐matched controls were studied with positron emission tomography using a dopamine D2/D3 receptor antagonist [11C]FLB 457. The D2 receptor binding potentials (BPs) were measured in extrastriatal brain regions and a neuropsychological investigation was performed on the patients with AD. In AD, the D2 receptor availability was reduced in the hippocampus: by 34% (P = 0.03) in the right hippocampus and by 14% (P = 0.78) in the left hippocampus as compared with controls. Multiple linear regression analysis showed that the BP in the right hippocampus had a significant positive association with verbal memory performance (Wechsler Memory Scale – Revised) (P = 0.001) and picture naming (the Boston Naming Test) (P = 0.002). Our findings suggest a role for temporal lobe D2 receptors in the memory and naming performance in AD, and suggest that studies to evaluate the efficiency of dopaminergic medication on patients with early AD might be warranted.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>N. Kemppainen</name><affiliations><json:string>Department of Neurology and</json:string><json:string>Turku PET Centre, PO Box 52, University of Turku, FIN‐20521 Turku, Finland</json:string></affiliations></json:item><json:item><name>M. Laine</name><affiliations><json:string>Department of Psychology, Åbo Akademi University, Turku, Finland</json:string></affiliations></json:item><json:item><name>M. P. Laakso</name><affiliations><json:string>Department of Neurology and Clinical Radiology, Kuopio University Hospital, Kuopio, Finland</json:string></affiliations></json:item><json:item><name>V. Kaasinen</name><affiliations><json:string>Department of Neurology and</json:string><json:string>Turku PET Centre, PO Box 52, University of Turku, FIN‐20521 Turku, Finland</json:string></affiliations></json:item><json:item><name>K. Någren</name><affiliations><json:string>Turku PET Centre, Radiochemistry Laboratory, Turku, Finland</json:string></affiliations></json:item><json:item><name>T. Vahlberg</name><affiliations><json:string>Department of Biostatistics, University of Turku, Turku, Finland</json:string></affiliations></json:item><json:item><name>T. Kurki</name><affiliations><json:string>Department of Clinical Radiology, Turku University Central Hospital, Turku, Finland</json:string></affiliations></json:item><json:item><name>J. O. Rinne</name><affiliations><json:string>Turku PET Centre, PO Box 52, University of Turku, FIN‐20521 Turku, Finland</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>cognitive function</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>FLB</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>positron emission tomography (PET)</value></json:item></subject><articleId><json:string>EJN2716</json:string></articleId><language><json:string>eng</json:string></language><abstract>Post mortem studies have revealed a loss of dopamine D2 receptors in the temporal lobes in Alzheimer's disease (AD). Moreover, the role of hippocampal D2 receptors on memory performance has been suggested in experimental studies. However, there are no previous in vivo studies on extrastriatal D2 receptors in AD. Our aim was to examine in vivo whether hippocampal or temporal cortical dopamine D2 receptors are affected in AD and whether D2 receptor availability is associated with the memory dysfunction seen in AD. Fourteen patients with probable AD and 11 age‐ and sex‐matched controls were studied with positron emission tomography using a dopamine D2/D3 receptor antagonist [11C]FLB 457. The D2 receptor binding potentials (BPs) were measured in extrastriatal brain regions and a neuropsychological investigation was performed on the patients with AD. In AD, the D2 receptor availability was reduced in the hippocampus: by 34% (P = 0.03) in the right hippocampus and by 14% (P = 0.78) in the left hippocampus as compared with controls. Multiple linear regression analysis showed that the BP in the right hippocampus had a significant positive association with verbal memory performance (Wechsler Memory Scale – Revised) (P = 0.001) and picture naming (the Boston Naming Test) (P = 0.002). Our findings suggest a role for temporal lobe D2 receptors in the memory and naming performance in AD, and suggest that studies to evaluate the efficiency of dopaminergic medication on patients with early AD might be warranted.</abstract><qualityIndicators><score>7.544</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595 x 782 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>3</keywordCount><abstractCharCount>1522</abstractCharCount><pdfWordCount>4760</pdfWordCount><pdfCharCount>29201</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>232</abstractWordCount></qualityIndicators><title>Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease</title><genre><json:string>article</json:string></genre><host><volume>18</volume><publisherId><json:string>EJN</json:string></publisherId><pages><last>154</last><first>149</first></pages><issn><json:string>0953-816X</json:string></issn><issue>1</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1460-9568</json:string></eissn><title>European Journal of Neuroscience</title><doi><json:string>10.1111/(ISSN)1460-9568</json:string></doi></host><publicationDate>2003</publicationDate><copyrightDate>2003</copyrightDate><doi><json:string>10.1046/j.1460-9568.2003.02716.x</json:string></doi><id>33385C6F3BC414104D4D72F11C9714D3C05A98A9</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/33385C6F3BC414104D4D72F11C9714D3C05A98A9/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/33385C6F3BC414104D4D72F11C9714D3C05A98A9/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/33385C6F3BC414104D4D72F11C9714D3C05A98A9/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Science, Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2003</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease</title><author><persName><forename type="first">N.</forename><surname>Kemppainen</surname></persName><affiliation>Department of Neurology and</affiliation><affiliation>Turku PET Centre, PO Box 52, University of Turku, FIN‐20521 Turku, Finland</affiliation></author><author><persName><forename type="first">M.</forename><surname>Laine</surname></persName><affiliation>Department of Psychology, Åbo Akademi University, Turku, Finland</affiliation></author><author><persName><forename type="first">M. P.</forename><surname>Laakso</surname></persName><affiliation>Department of Neurology and Clinical Radiology, Kuopio University Hospital, Kuopio, Finland</affiliation></author><author><persName><forename type="first">V.</forename><surname>Kaasinen</surname></persName><affiliation>Department of Neurology and</affiliation><affiliation>Turku PET Centre, PO Box 52, University of Turku, FIN‐20521 Turku, Finland</affiliation></author><author><persName><forename type="first">K.</forename><surname>Någren</surname></persName><affiliation>Turku PET Centre, Radiochemistry Laboratory, Turku, Finland</affiliation></author><author><persName><forename type="first">T.</forename><surname>Vahlberg</surname></persName><affiliation>Department of Biostatistics, University of Turku, Turku, Finland</affiliation></author><author><persName><forename type="first">T.</forename><surname>Kurki</surname></persName><affiliation>Department of Clinical Radiology, Turku University Central Hospital, Turku, Finland</affiliation></author><author><persName><forename type="first">J. O.</forename><surname>Rinne</surname></persName><affiliation>Turku PET Centre, PO Box 52, University of Turku, FIN‐20521 Turku, Finland</affiliation></author></analytic><monogr><title level="j">European Journal of Neuroscience</title><idno type="pISSN">0953-816X</idno><idno type="eISSN">1460-9568</idno><idno type="DOI">10.1111/(ISSN)1460-9568</idno><imprint><publisher>Blackwell Science, Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2003-07"></date><biblScope unit="volume">18</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="149">149</biblScope><biblScope unit="page" to="154">154</biblScope></imprint></monogr><idno type="istex">33385C6F3BC414104D4D72F11C9714D3C05A98A9</idno><idno type="DOI">10.1046/j.1460-9568.2003.02716.x</idno><idno type="ArticleID">EJN2716</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2003</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Post mortem studies have revealed a loss of dopamine D2 receptors in the temporal lobes in Alzheimer's disease (AD). Moreover, the role of hippocampal D2 receptors on memory performance has been suggested in experimental studies. However, there are no previous in vivo studies on extrastriatal D2 receptors in AD. Our aim was to examine in vivo whether hippocampal or temporal cortical dopamine D2 receptors are affected in AD and whether D2 receptor availability is associated with the memory dysfunction seen in AD. Fourteen patients with probable AD and 11 age‐ and sex‐matched controls were studied with positron emission tomography using a dopamine D2/D3 receptor antagonist [11C]FLB 457. The D2 receptor binding potentials (BPs) were measured in extrastriatal brain regions and a neuropsychological investigation was performed on the patients with AD. In AD, the D2 receptor availability was reduced in the hippocampus: by 34% (P = 0.03) in the right hippocampus and by 14% (P = 0.78) in the left hippocampus as compared with controls. Multiple linear regression analysis showed that the BP in the right hippocampus had a significant positive association with verbal memory performance (Wechsler Memory Scale – Revised) (P = 0.001) and picture naming (the Boston Naming Test) (P = 0.002). Our findings suggest a role for temporal lobe D2 receptors in the memory and naming performance in AD, and suggest that studies to evaluate the efficiency of dopaminergic medication on patients with early AD might be warranted.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>cognitive function</term></item><item><term>FLB</term></item><item><term>positron emission tomography (PET)</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2003-07">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/33385C6F3BC414104D4D72F11C9714D3C05A98A9/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Science, Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1460-9568</doi><issn type="print">0953-816X</issn><issn type="electronic">1460-9568</issn><idGroup><id type="product" value="EJN"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROSCIENCE">European Journal of Neuroscience</title></titleGroup></publicationMeta><publicationMeta level="part" position="07001"><doi origin="wiley">10.1111/ejn.2003.18.issue-1</doi><numberingGroup><numbering type="journalVolume" number="18">18</numbering><numbering type="journalIssue" number="1">1</numbering></numberingGroup><coverDate startDate="2003-07">July 2003</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0014900" status="forIssue"><doi origin="wiley">10.1046/j.1460-9568.2003.02716.x</doi><idGroup><id type="unit" value="EJN2716"></id></idGroup><titleGroup><title type="tocHeading1">Research Reports</title></titleGroup><eventGroup><event type="firstOnline" date="2003-07-11"></event><event type="publishedOnlineFinalForm" date="2003-07-11"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.4 mode:FullText source:FullText result:FullText" date="2010-03-29"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-12"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="149">149</numbering><numbering type="pageLast" number="154">154</numbering></numberingGroup><correspondenceTo> : Dr Juha O. Rinne, as above.
E‐mail: <email>juha.rinne@pet.tyks.fi</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:EJN.EJN2716.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 27 September 2002, revised 11 April 2003, accepted 15 April 2003</unparsedEditorialHistory><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="2"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="32"></count><count type="wordTotal" number="3910"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease</title><title type="shortAuthors">N. Kemppainen <i>et al.</i></title><title type="short">Dopamine D2 receptors in Alzheimer's disease</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2"><personName><givenNames>N.</givenNames><familyName>Kemppainen</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a3"><personName><givenNames>M.</givenNames><familyName>Laine</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a4"><personName><givenNames>M. P.</givenNames><familyName>Laakso</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1 #a2"><personName><givenNames>V.</givenNames><familyName>Kaasinen</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a5"><personName><givenNames>K.</givenNames><familyName>Någren</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a6"><personName><givenNames>T.</givenNames><familyName>Vahlberg</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a7"><personName><givenNames>T.</givenNames><familyName>Kurki</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a2"><personName><givenNames>J. O.</givenNames><familyName>Rinne</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Department of Neurology and</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="FI"><unparsedAffiliation>Turku PET Centre, PO Box 52, University of Turku, FIN‐20521 Turku, Finland</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="FI"><unparsedAffiliation>Department of Psychology, Åbo Akademi University, Turku, Finland</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="FI"><unparsedAffiliation>Department of Neurology and Clinical Radiology, Kuopio University Hospital, Kuopio, Finland</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="FI"><unparsedAffiliation>Turku PET Centre, Radiochemistry Laboratory, Turku, Finland</unparsedAffiliation></affiliation><affiliation xml:id="a6" countryCode="FI"><unparsedAffiliation>Department of Biostatistics, University of Turku, Turku, Finland</unparsedAffiliation></affiliation><affiliation xml:id="a7" countryCode="FI"><unparsedAffiliation>Department of Clinical Radiology, Turku University Central Hospital, Turku, Finland</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">cognitive function</keyword><keyword xml:id="k2">FLB</keyword><keyword xml:id="k3">positron emission tomography (PET)</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p> <i>Post mortem</i> studies have revealed a loss of dopamine D2 receptors in the temporal lobes in Alzheimer's disease (AD). Moreover, the role of hippocampal D2 receptors on memory performance has been suggested in experimental studies. However, there are no previous <i>in vivo</i> studies on extrastriatal D2 receptors in AD. Our aim was to examine <i>in vivo</i> whether hippocampal or temporal cortical dopamine D2 receptors are affected in AD and whether D2 receptor availability is associated with the memory dysfunction seen in AD. Fourteen patients with probable AD and 11 age‐ and sex‐matched controls were studied with positron emission tomography using a dopamine D2/D3 receptor antagonist [<sup>11</sup>C]FLB 457. The D2 receptor binding potentials (BPs) were measured in extrastriatal brain regions and a neuropsychological investigation was performed on the patients with AD. In AD, the D2 receptor availability was reduced in the hippocampus: by 34% (<i>P =</i> 0.03) in the right hippocampus and by 14% (<i>P =</i> 0.78) in the left hippocampus as compared with controls. Multiple linear regression analysis showed that the BP in the right hippocampus had a significant positive association with verbal memory performance (Wechsler Memory Scale – Revised) (<i>P =</i> 0.001) and picture naming (the Boston Naming Test) (<i>P =</i> 0.002). Our findings suggest a role for temporal lobe D2 receptors in the memory and naming performance in AD, and suggest that studies to evaluate the efficiency of dopaminergic medication on patients with early AD might be warranted.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease</title></titleInfo><titleInfo type="abbreviated"><title>Dopamine D2 receptors in Alzheimer's disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease</title></titleInfo><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Kemppainen</namePart><affiliation>Department of Neurology and</affiliation><affiliation>Turku PET Centre, PO Box 52, University of Turku, FIN‐20521 Turku, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Laine</namePart><affiliation>Department of Psychology, Åbo Akademi University, Turku, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. P.</namePart><namePart type="family">Laakso</namePart><affiliation>Department of Neurology and Clinical Radiology, Kuopio University Hospital, Kuopio, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Kaasinen</namePart><affiliation>Department of Neurology and</affiliation><affiliation>Turku PET Centre, PO Box 52, University of Turku, FIN‐20521 Turku, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Någren</namePart><affiliation>Turku PET Centre, Radiochemistry Laboratory, Turku, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Vahlberg</namePart><affiliation>Department of Biostatistics, University of Turku, Turku, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Kurki</namePart><affiliation>Department of Clinical Radiology, Turku University Central Hospital, Turku, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. O.</namePart><namePart type="family">Rinne</namePart><affiliation>Turku PET Centre, PO Box 52, University of Turku, FIN‐20521 Turku, Finland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Science, Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2003-07</dateIssued><edition>Received 27 September 2002, revised 11 April 2003, accepted 15 April 2003</edition><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">32</extent><extent unit="words">3910</extent></physicalDescription><abstract lang="en">Post mortem studies have revealed a loss of dopamine D2 receptors in the temporal lobes in Alzheimer's disease (AD). Moreover, the role of hippocampal D2 receptors on memory performance has been suggested in experimental studies. However, there are no previous in vivo studies on extrastriatal D2 receptors in AD. Our aim was to examine in vivo whether hippocampal or temporal cortical dopamine D2 receptors are affected in AD and whether D2 receptor availability is associated with the memory dysfunction seen in AD. Fourteen patients with probable AD and 11 age‐ and sex‐matched controls were studied with positron emission tomography using a dopamine D2/D3 receptor antagonist [11C]FLB 457. The D2 receptor binding potentials (BPs) were measured in extrastriatal brain regions and a neuropsychological investigation was performed on the patients with AD. In AD, the D2 receptor availability was reduced in the hippocampus: by 34% (P = 0.03) in the right hippocampus and by 14% (P = 0.78) in the left hippocampus as compared with controls. Multiple linear regression analysis showed that the BP in the right hippocampus had a significant positive association with verbal memory performance (Wechsler Memory Scale – Revised) (P = 0.001) and picture naming (the Boston Naming Test) (P = 0.002). Our findings suggest a role for temporal lobe D2 receptors in the memory and naming performance in AD, and suggest that studies to evaluate the efficiency of dopaminergic medication on patients with early AD might be warranted.</abstract><subject lang="en"><genre>Keywords</genre><topic>cognitive function</topic><topic>FLB</topic><topic>positron emission tomography (PET)</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neuroscience</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0953-816X</identifier><identifier type="eISSN">1460-9568</identifier><identifier type="DOI">10.1111/(ISSN)1460-9568</identifier><identifier type="PublisherID">EJN</identifier><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>149</start><end>154</end></extent></part></relatedItem><identifier type="istex">33385C6F3BC414104D4D72F11C9714D3C05A98A9</identifier><identifier type="DOI">10.1046/j.1460-9568.2003.02716.x</identifier><identifier type="ArticleID">EJN2716</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Science, Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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