A magnetization transfer study of mild and advanced Parkinson’s disease
Identifieur interne : 002D25 ( Main/Corpus ); précédent : 002D24; suivant : 002D26A magnetization transfer study of mild and advanced Parkinson’s disease
Auteurs : N. Tambasco ; V. Belcastro ; P. Sarchielli ; P. Floridi ; L. Pierguidi ; C. Menichetti ; A. Castrioto ; P. Chiarini ; L. Parnetti ; P. Eusebi ; P. Calabresi ; A. RossiSource :
- European Journal of Neurology [ 1351-5101 ] ; 2011-03.
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Abstract
Background and purpose: Magnetization transfer ratio (MTR) technique has identified brain changes in grey and white matter in Parkinson’s disease (PD), even in the early phase. However, how these tissue changes differ along the course of the illness is still unclear. This study was aimed at investigating how MTR values change from mild PD (PD1) to patients with advanced PD (PD2). Methods: We measured MTR values by region of interest, in 11 PD1, 11 PD2 and 10 healthy age‐matched subjects. Results: Compared with controls, patients with PD1 exhibited a significant MTR reduction in substantia nigra pars compacta, substantia nigra pars reticulata, putamen, periventricular white matter and parietal white matter. In addition to the changes observed in PD1, the PD2 group exhibited a significant MTR reduction in caudate, pons, frontal white matter and lateral thalamus. Conclusion: These results suggest that MTR might reflect morphological changes induced by the disease in distinct brain areas at different stages.
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DOI: 10.1111/j.1468-1331.2010.03184.x
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Tambasco</name><affiliation><mods:affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</mods:affiliation></affiliation></author><author><name sortKey="Belcastro, V" sort="Belcastro, V" uniqKey="Belcastro V" first="V." last="Belcastro">V. Belcastro</name><affiliation><mods:affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</mods:affiliation></affiliation><affiliation><mods:affiliation>I.R.C.C.S. – Fondazione S. Lucia, Roma</mods:affiliation></affiliation></author><author><name sortKey="Sarchielli, P" sort="Sarchielli, P" uniqKey="Sarchielli P" first="P." last="Sarchielli">P. Sarchielli</name><affiliation><mods:affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</mods:affiliation></affiliation></author><author><name sortKey="Floridi, P" sort="Floridi, P" uniqKey="Floridi P" first="P." last="Floridi">P. Floridi</name><affiliation><mods:affiliation>Servizio di Neuroradiologia, Azienda Ospedaliera di Perugia</mods:affiliation></affiliation></author><author><name sortKey="Pierguidi, L" sort="Pierguidi, L" uniqKey="Pierguidi L" first="L." last="Pierguidi">L. Pierguidi</name><affiliation><mods:affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</mods:affiliation></affiliation><affiliation><mods:affiliation>I.R.C.C.S. – Fondazione S. Lucia, Roma</mods:affiliation></affiliation></author><author><name sortKey="Menichetti, C" sort="Menichetti, C" uniqKey="Menichetti C" first="C." last="Menichetti">C. Menichetti</name><affiliation><mods:affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</mods:affiliation></affiliation><affiliation><mods:affiliation>I.R.C.C.S. – Fondazione S. Lucia, Roma</mods:affiliation></affiliation></author><author><name sortKey="Castrioto, A" sort="Castrioto, A" uniqKey="Castrioto A" first="A." last="Castrioto">A. Castrioto</name><affiliation><mods:affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</mods:affiliation></affiliation></author><author><name sortKey="Chiarini, P" sort="Chiarini, P" uniqKey="Chiarini P" first="P." last="Chiarini">P. Chiarini</name><affiliation><mods:affiliation>Servizio di Neuroradiologia, Azienda Ospedaliera di Perugia</mods:affiliation></affiliation></author><author><name sortKey="Parnetti, L" sort="Parnetti, L" uniqKey="Parnetti L" first="L." last="Parnetti">L. Parnetti</name><affiliation><mods:affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</mods:affiliation></affiliation></author><author><name sortKey="Eusebi, P" sort="Eusebi, P" uniqKey="Eusebi P" first="P." last="Eusebi">P. Eusebi</name><affiliation><mods:affiliation>Epidemiology Department, Regione Umbria, Perugia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Calabresi, P" sort="Calabresi, P" uniqKey="Calabresi P" first="P." last="Calabresi">P. Calabresi</name><affiliation><mods:affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</mods:affiliation></affiliation><affiliation><mods:affiliation>I.R.C.C.S. – Fondazione S. Lucia, Roma</mods:affiliation></affiliation></author><author><name sortKey="Rossi, A" sort="Rossi, A" uniqKey="Rossi A" first="A." last="Rossi">A. Rossi</name><affiliation><mods:affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-03">2011-03</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="471">471</biblScope><biblScope unit="page" to="477">477</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">60FB9ADBD7B1A04038D91B2F5369DED975B4888A</idno><idno type="DOI">10.1111/j.1468-1331.2010.03184.x</idno><idno type="ArticleID">ENE3184</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson’s disease</term><term>basal ganglia</term><term>magnetic resonance imaging</term><term>magnetization transfer ratio</term><term>substantia nigra</term><term>white matter</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background and purpose: Magnetization transfer ratio (MTR) technique has identified brain changes in grey and white matter in Parkinson’s disease (PD), even in the early phase. However, how these tissue changes differ along the course of the illness is still unclear. This study was aimed at investigating how MTR values change from mild PD (PD1) to patients with advanced PD (PD2). Methods: We measured MTR values by region of interest, in 11 PD1, 11 PD2 and 10 healthy age‐matched subjects. Results: Compared with controls, patients with PD1 exhibited a significant MTR reduction in substantia nigra pars compacta, substantia nigra pars reticulata, putamen, periventricular white matter and parietal white matter. In addition to the changes observed in PD1, the PD2 group exhibited a significant MTR reduction in caudate, pons, frontal white matter and lateral thalamus. Conclusion: These results suggest that MTR might reflect morphological changes induced by the disease in distinct brain areas at different stages.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>N. Tambasco</name><affiliations><json:string>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</json:string></affiliations></json:item><json:item><name>V. Belcastro</name><affiliations><json:string>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</json:string><json:string>I.R.C.C.S. – Fondazione S. Lucia, Roma</json:string></affiliations></json:item><json:item><name>P. Sarchielli</name><affiliations><json:string>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</json:string></affiliations></json:item><json:item><name>P. Floridi</name><affiliations><json:string>Servizio di Neuroradiologia, Azienda Ospedaliera di Perugia</json:string></affiliations></json:item><json:item><name>L. Pierguidi</name><affiliations><json:string>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</json:string><json:string>I.R.C.C.S. – Fondazione S. Lucia, Roma</json:string></affiliations></json:item><json:item><name>C. Menichetti</name><affiliations><json:string>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</json:string><json:string>I.R.C.C.S. – Fondazione S. Lucia, Roma</json:string></affiliations></json:item><json:item><name>A. Castrioto</name><affiliations><json:string>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</json:string></affiliations></json:item><json:item><name>P. Chiarini</name><affiliations><json:string>Servizio di Neuroradiologia, Azienda Ospedaliera di Perugia</json:string></affiliations></json:item><json:item><name>L. Parnetti</name><affiliations><json:string>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</json:string></affiliations></json:item><json:item><name>P. Eusebi</name><affiliations><json:string>Epidemiology Department, Regione Umbria, Perugia, Italy</json:string></affiliations></json:item><json:item><name>P. Calabresi</name><affiliations><json:string>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</json:string><json:string>I.R.C.C.S. – Fondazione S. Lucia, Roma</json:string></affiliations></json:item><json:item><name>A. Rossi</name><affiliations><json:string>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>basal ganglia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>magnetization transfer ratio</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>magnetic resonance imaging</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson’s disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>substantia nigra</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>white matter</value></json:item></subject><articleId><json:string>ENE3184</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background and purpose: Magnetization transfer ratio (MTR) technique has identified brain changes in grey and white matter in Parkinson’s disease (PD), even in the early phase. However, how these tissue changes differ along the course of the illness is still unclear. This study was aimed at investigating how MTR values change from mild PD (PD1) to patients with advanced PD (PD2). Methods: We measured MTR values by region of interest, in 11 PD1, 11 PD2 and 10 healthy age‐matched subjects. Results: Compared with controls, patients with PD1 exhibited a significant MTR reduction in substantia nigra pars compacta, substantia nigra pars reticulata, putamen, periventricular white matter and parietal white matter. In addition to the changes observed in PD1, the PD2 group exhibited a significant MTR reduction in caudate, pons, frontal white matter and lateral thalamus. Conclusion: These results suggest that MTR might reflect morphological changes induced by the disease in distinct brain areas at different stages.</abstract><qualityIndicators><score>5.74</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1023</abstractCharCount><pdfWordCount>3880</pdfWordCount><pdfCharCount>24430</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>155</abstractWordCount></qualityIndicators><title>A magnetization transfer study of mild and advanced Parkinson’s disease</title><genre><json:string>article</json:string></genre><host><volume>18</volume><publisherId><json:string>ENE</json:string></publisherId><pages><total>7</total><last>477</last><first>471</first></pages><issn><json:string>1351-5101</json:string></issn><issue>3</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-1331</json:string></eissn><title>European Journal of Neurology</title><doi><json:string>10.1111/(ISSN)1468-1331</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1111/j.1468-1331.2010.03184.x</json:string></doi><id>60FB9ADBD7B1A04038D91B2F5369DED975B4888A</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/60FB9ADBD7B1A04038D91B2F5369DED975B4888A/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/60FB9ADBD7B1A04038D91B2F5369DED975B4888A/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/60FB9ADBD7B1A04038D91B2F5369DED975B4888A/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">A magnetization transfer study of mild and advanced Parkinson’s disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">A magnetization transfer study of mild and advanced Parkinson’s disease</title><author><persName><forename type="first">N.</forename><surname>Tambasco</surname></persName><affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</affiliation></author><author><persName><forename type="first">V.</forename><surname>Belcastro</surname></persName><affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</affiliation><affiliation>I.R.C.C.S. – Fondazione S. 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Lucia, Roma</affiliation></author><author><persName><forename type="first">A.</forename><surname>Rossi</surname></persName><affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</affiliation></author></analytic><monogr><title level="j">European Journal of Neurology</title><idno type="pISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><idno type="DOI">10.1111/(ISSN)1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-03"></date><biblScope unit="volume">18</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="471">471</biblScope><biblScope unit="page" to="477">477</biblScope></imprint></monogr><idno type="istex">60FB9ADBD7B1A04038D91B2F5369DED975B4888A</idno><idno type="DOI">10.1111/j.1468-1331.2010.03184.x</idno><idno type="ArticleID">ENE3184</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background and purpose: Magnetization transfer ratio (MTR) technique has identified brain changes in grey and white matter in Parkinson’s disease (PD), even in the early phase. However, how these tissue changes differ along the course of the illness is still unclear. This study was aimed at investigating how MTR values change from mild PD (PD1) to patients with advanced PD (PD2). Methods: We measured MTR values by region of interest, in 11 PD1, 11 PD2 and 10 healthy age‐matched subjects. Results: Compared with controls, patients with PD1 exhibited a significant MTR reduction in substantia nigra pars compacta, substantia nigra pars reticulata, putamen, periventricular white matter and parietal white matter. In addition to the changes observed in PD1, the PD2 group exhibited a significant MTR reduction in caudate, pons, frontal white matter and lateral thalamus. Conclusion: These results suggest that MTR might reflect morphological changes induced by the disease in distinct brain areas at different stages.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>basal ganglia</term></item><item><term>magnetization transfer ratio</term></item><item><term>magnetic resonance imaging</term></item><item><term>Parkinson’s disease</term></item><item><term>substantia nigra</term></item><item><term>white matter</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2011-03">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/60FB9ADBD7B1A04038D91B2F5369DED975B4888A/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1468-1331</doi><issn type="print">1351-5101</issn><issn type="electronic">1468-1331</issn><idGroup><id type="product" value="ENE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROLOGY">European Journal of Neurology</title></titleGroup></publicationMeta><publicationMeta level="part" position="03103"><doi origin="wiley">10.1111/ene.2011.18.issue-3</doi><numberingGroup><numbering type="journalVolume" number="18">18</numbering><numbering type="journalIssue" number="3">3</numbering></numberingGroup><coverDate startDate="2011-03">March 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="17" status="forIssue"><doi origin="wiley">10.1111/j.1468-1331.2010.03184.x</doi><idGroup><id type="unit" value="ENE3184"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2010 The Author(s). European Journal of Neurology © 2010 EFNS</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.4.6 mode:FullText" date="2011-02-17"></event><event type="publishedOnlineEarlyUnpaginated" date="2010-08-16"></event><event type="firstOnline" date="2010-08-16"></event><event type="publishedOnlineFinalForm" date="2011-02-17"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="471">471</numbering><numbering type="pageLast" number="477">477</numbering></numberingGroup><correspondenceTo>N. Tambasco, Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, S. Andrea delle Fratte, 06156 Perugia, Italy (tel.: +39 075 5784233; fax: +39 075 5784229; e‐mail: <email>n.tambasco@libero.it</email>).</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ENE.ENE3184.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 8 March 2010 Accepted 6 July 2010</unparsedEditorialHistory><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="2"></count></countGroup><titleGroup><title type="main">A magnetization transfer study of mild and advanced Parkinson’s disease</title><title type="shortAuthors">N. Tambasco <i>et al.</i></title><title type="short">MTR in Parkinson’s disease</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>N.</givenNames><familyName>Tambasco</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1 #a2"><personName><givenNames>V.</givenNames><familyName>Belcastro</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>P.</givenNames><familyName>Sarchielli</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a3"><personName><givenNames>P.</givenNames><familyName>Floridi</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1 #a2"><personName><givenNames>L.</givenNames><familyName>Pierguidi</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1 #a2"><personName><givenNames>C.</givenNames><familyName>Menichetti</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a1"><personName><givenNames>A.</givenNames><familyName>Castrioto</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a3"><personName><givenNames>P.</givenNames><familyName>Chiarini</familyName></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a1"><personName><givenNames>L.</givenNames><familyName>Parnetti</familyName></personName></creator><creator creatorRole="author" xml:id="cr10" affiliationRef="#a4"><personName><givenNames>P.</givenNames><familyName>Eusebi</familyName></personName></creator><creator creatorRole="author" xml:id="cr11" affiliationRef="#a1 #a2"><personName><givenNames>P.</givenNames><familyName>Calabresi</familyName></personName></creator><creator creatorRole="author" xml:id="cr12" affiliationRef="#a1"><personName><givenNames>A.</givenNames><familyName>Rossi</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="PE"><unparsedAffiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>I.R.C.C.S. – Fondazione S. Lucia, Roma</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="PE"><unparsedAffiliation>Servizio di Neuroradiologia, Azienda Ospedaliera di Perugia</unparsedAffiliation></affiliation><affiliation xml:id="a4"><unparsedAffiliation>Epidemiology Department, Regione Umbria, Perugia, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">basal ganglia</keyword><keyword xml:id="k2">magnetization transfer ratio</keyword><keyword xml:id="k3">magnetic resonance imaging</keyword><keyword xml:id="k4">Parkinson’s disease</keyword><keyword xml:id="k5">substantia nigra</keyword><keyword xml:id="k6">white matter</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Background and purpose: </b> Magnetization transfer ratio (MTR) technique has identified brain changes in grey and white matter in Parkinson’s disease (PD), even in the early phase. However, how these tissue changes differ along the course of the illness is still unclear. This study was aimed at investigating how MTR values change from mild PD (PD1) to patients with advanced PD (PD2).</p><p><b>Methods: </b> We measured MTR values by region of interest, in 11 PD1, 11 PD2 and 10 healthy age‐matched subjects.</p><p><b>Results: </b> Compared with controls, patients with PD1 exhibited a significant MTR reduction in substantia nigra pars compacta, substantia nigra pars reticulata, putamen, periventricular white matter and parietal white matter. In addition to the changes observed in PD1, the PD2 group exhibited a significant MTR reduction in caudate, pons, frontal white matter and lateral thalamus.</p><p><b>Conclusion: </b> These results suggest that MTR might reflect morphological changes induced by the disease in distinct brain areas at different stages.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>A magnetization transfer study of mild and advanced Parkinson’s disease</title></titleInfo><titleInfo type="abbreviated"><title>MTR in Parkinson’s disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>A magnetization transfer study of mild and advanced Parkinson’s disease</title></titleInfo><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Tambasco</namePart><affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Belcastro</namePart><affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</affiliation><affiliation>I.R.C.C.S. – Fondazione S. Lucia, Roma</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Sarchielli</namePart><affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Floridi</namePart><affiliation>Servizio di Neuroradiologia, Azienda Ospedaliera di Perugia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Pierguidi</namePart><affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</affiliation><affiliation>I.R.C.C.S. – Fondazione S. Lucia, Roma</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Menichetti</namePart><affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</affiliation><affiliation>I.R.C.C.S. – Fondazione S. Lucia, Roma</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Castrioto</namePart><affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Chiarini</namePart><affiliation>Servizio di Neuroradiologia, Azienda Ospedaliera di Perugia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Parnetti</namePart><affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Eusebi</namePart><affiliation>Epidemiology Department, Regione Umbria, Perugia, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Calabresi</namePart><affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</affiliation><affiliation>I.R.C.C.S. – Fondazione S. Lucia, Roma</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Rossi</namePart><affiliation>Clinica Neurologica, Azienda Ospedaliera – Università di Perugia, Perugia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2011-03</dateIssued><edition>Received 8 March 2010 Accepted 6 July 2010</edition><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">2</extent></physicalDescription><abstract lang="en">Background and purpose: Magnetization transfer ratio (MTR) technique has identified brain changes in grey and white matter in Parkinson’s disease (PD), even in the early phase. However, how these tissue changes differ along the course of the illness is still unclear. This study was aimed at investigating how MTR values change from mild PD (PD1) to patients with advanced PD (PD2). Methods: We measured MTR values by region of interest, in 11 PD1, 11 PD2 and 10 healthy age‐matched subjects. Results: Compared with controls, patients with PD1 exhibited a significant MTR reduction in substantia nigra pars compacta, substantia nigra pars reticulata, putamen, periventricular white matter and parietal white matter. In addition to the changes observed in PD1, the PD2 group exhibited a significant MTR reduction in caudate, pons, frontal white matter and lateral thalamus. Conclusion: These results suggest that MTR might reflect morphological changes induced by the disease in distinct brain areas at different stages.</abstract><subject lang="en"><genre>Keywords</genre><topic>basal ganglia</topic><topic>magnetization transfer ratio</topic><topic>magnetic resonance imaging</topic><topic>Parkinson’s disease</topic><topic>substantia nigra</topic><topic>white matter</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neurology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1351-5101</identifier><identifier type="eISSN">1468-1331</identifier><identifier type="DOI">10.1111/(ISSN)1468-1331</identifier><identifier type="PublisherID">ENE</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>471</start><end>477</end><total>7</total></extent></part></relatedItem><identifier type="istex">60FB9ADBD7B1A04038D91B2F5369DED975B4888A</identifier><identifier type="DOI">10.1111/j.1468-1331.2010.03184.x</identifier><identifier type="ArticleID">ENE3184</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010 The Author(s). 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