Monoamine metabolites in human cerebrospinal fluid. HPLC/ED method
Identifieur interne : 002B29 ( Main/Corpus ); précédent : 002B28; suivant : 002B30Monoamine metabolites in human cerebrospinal fluid. HPLC/ED method
Auteurs : M. A. Mena ; E G. Aguado ; J. G. De YebenesSource :
- Acta Neurologica Scandinavica [ 0001-6314 ] ; 1984-04.
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Abstract
ABSTRACT— Catecholamines and indolealkylamines are of clinical interest in neurological and psychiatric disorders. We measured 3‐methoxy‐DOPA, 3‐methoxy‐4‐hydroxyphenylglycol, dihydroxyphenylacetic acid, tryptophan, 5‐hydroxyindoleacetic acid and homovanillic acid in human cerebrospinal fluid with a simple, sensitive, inexpensive, rapid and accurate procedure using high performance liquid chromatography coupled to an electrochemical detector. Patients with Parkinson's disease have a decrement in homovanillic acid that is reversed by treatment with L‐3,4‐dihydroxyphenylalanine. After this medication, 3‐methoxy‐DOPA is measurable in cerebrospinal fluid. Patients with depression show a decrease in serotonin turnover expressed by diminished 5‐hydroxyindoleacetic acid content in cerebrospinal fluid. Depressed patients also show low levels of tryptophan. Monoamine metabolites are augmented in patients with subarachnoid hemorrhage.
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DOI: 10.1111/j.1600-0404.1984.tb07804.x
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ISTEX:5E56DE541E36C627E45AF0F6B54C3E0C2C5F886FLe document en format XML
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We measured 3‐methoxy‐DOPA, 3‐methoxy‐4‐hydroxyphenylglycol, dihydroxyphenylacetic acid, tryptophan, 5‐hydroxyindoleacetic acid and homovanillic acid in human cerebrospinal fluid with a simple, sensitive, inexpensive, rapid and accurate procedure using high performance liquid chromatography coupled to an electrochemical detector. Patients with Parkinson's disease have a decrement in homovanillic acid that is reversed by treatment with L‐3,4‐dihydroxyphenylalanine. After this medication, 3‐methoxy‐DOPA is measurable in cerebrospinal fluid. Patients with depression show a decrease in serotonin turnover expressed by diminished 5‐hydroxyindoleacetic acid content in cerebrospinal fluid. Depressed patients also show low levels of tryptophan. 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A.</namePart><namePart type="family">Mena</namePart><affiliation>Departamento de Investigación, Centro “Ramón y Cajal”, Madrid, Spain</affiliation><description>Correspondence: Department of Research Centro Ramón y Cajal Ctra, Colmenar Km 9 Madrid 34 Spain</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E G.</namePart><namePart type="family">Aguado</namePart><affiliation>Departamento de Investigación, Centro “Ramón y Cajal”, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. G.</namePart><namePart type="family">de Yebenes</namePart><affiliation>Servicio de Neurologia, Centro “Ramón y Cajal”, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1984-04</dateIssued><edition>Accepted for publication December 30, 1983</edition><copyrightDate encoding="w3cdtf">1984</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">21</extent></physicalDescription><abstract lang="en">ABSTRACT— Catecholamines and indolealkylamines are of clinical interest in neurological and psychiatric disorders. We measured 3‐methoxy‐DOPA, 3‐methoxy‐4‐hydroxyphenylglycol, dihydroxyphenylacetic acid, tryptophan, 5‐hydroxyindoleacetic acid and homovanillic acid in human cerebrospinal fluid with a simple, sensitive, inexpensive, rapid and accurate procedure using high performance liquid chromatography coupled to an electrochemical detector. Patients with Parkinson's disease have a decrement in homovanillic acid that is reversed by treatment with L‐3,4‐dihydroxyphenylalanine. After this medication, 3‐methoxy‐DOPA is measurable in cerebrospinal fluid. Patients with depression show a decrease in serotonin turnover expressed by diminished 5‐hydroxyindoleacetic acid content in cerebrospinal fluid. Depressed patients also show low levels of tryptophan. Monoamine metabolites are augmented in patients with subarachnoid hemorrhage.</abstract><subject lang="en"><genre>Keywords</genre><topic>CSF</topic><topic>depression</topic><topic>metabolites</topic><topic>mono‐amines</topic><topic>Parkinson's</topic></subject><relatedItem type="host"><titleInfo><title>Acta Neurologica Scandinavica</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0001-6314</identifier><identifier type="eISSN">1600-0404</identifier><identifier type="DOI">10.1111/(ISSN)1600-0404</identifier><identifier type="PublisherID">ANE</identifier><part><date>1984</date><detail type="volume"><caption>vol.</caption><number>69</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>218</start><end>225</end><total>8</total></extent></part></relatedItem><identifier type="istex">5E56DE541E36C627E45AF0F6B54C3E0C2C5F886F</identifier><identifier type="DOI">10.1111/j.1600-0404.1984.tb07804.x</identifier><identifier type="ArticleID">ANE218</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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