281 Occupations and Parkinson’s disease in a population-based case-control study
Identifieur interne : 002A06 ( Main/Corpus ); précédent : 002A05; suivant : 002A07281 Occupations and Parkinson’s disease in a population-based case-control study
Auteurs : M A Harris ; Marion ; Tsui ; Shen ; TeschkeSource :
- Occupational and Environmental Medicine [ 1351-0711 ] ; 2013-09.
Abstract
Objectives Despite mounting evidence on epidemiological risk factors, Parkinson’s disease (PD) incidence remains largely unexplained. The purpose of this study was to test associations between occupations and PD to complement analyses of occupational exposures. Methods We used a population-based case-control design in British Columbia, Canada, including 403 cases (users of antiparkinsonian medication) and 405 controls (from the provincial health insurance register, frequency matched on age and sex). Job histories were collected using structured questionnaires querying all jobs held since age 16. Odds ratios were calculated for associations between PD and occupational categories using unconditional logistic regression, adjusting for age, sex, and smoking. Results Significantly elevated risks were found for social science, law and library jobs (OR 1.82; 95% CI 1.01 - 3.29); and farming and horticulture jobs (OR 2.03; 95% CI 1.10 - 3.74). Nonsignificantly elevated risks were found for gas station jobs (OR 2.55; 95% CI 0.84 - 7.72); welders (OR 2.98; 95% CI 0.78 - 11.40); and drivers of heavy equipment (OR 1.95; 95% CI 0.66 - 5.81). Reduced risks were found for management and administration jobs (OR 0.70; 95% CI 0.49 - 0.99); other health care jobs (OR 0.44; 95% CI 0.20 - 0.99); repairers (OR 0.49; 95% CI 0.22 - 1.09); and electricians (OR 0.46; 95% CI 0.17 - 1.26). Conclusions Increased risks for social science jobs could be related to numbers of people contacted in a day and risk of infections. Severe influenza was associated with increased risk of PD but number of people contacted was not. Elevated risks for farmers are typically attributed to pesticide exposure, however our pesticide analyses did not support this attribution. Other exposures of interest for farmers could include animal contact, influenza, head injuries, and vibration from heavy equipment, all associated with PD in our study.
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DOI: 10.1136/oemed-2013-101717.281
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The purpose of this study was to test associations between occupations and PD to complement analyses of occupational exposures. Methods We used a population-based case-control design in British Columbia, Canada, including 403 cases (users of antiparkinsonian medication) and 405 controls (from the provincial health insurance register, frequency matched on age and sex). Job histories were collected using structured questionnaires querying all jobs held since age 16. Odds ratios were calculated for associations between PD and occupational categories using unconditional logistic regression, adjusting for age, sex, and smoking. Results Significantly elevated risks were found for social science, law and library jobs (OR 1.82; 95% CI 1.01 - 3.29); and farming and horticulture jobs (OR 2.03; 95% CI 1.10 - 3.74). Nonsignificantly elevated risks were found for gas station jobs (OR 2.55; 95% CI 0.84 - 7.72); welders (OR 2.98; 95% CI 0.78 - 11.40); and drivers of heavy equipment (OR 1.95; 95% CI 0.66 - 5.81). Reduced risks were found for management and administration jobs (OR 0.70; 95% CI 0.49 - 0.99); other health care jobs (OR 0.44; 95% CI 0.20 - 0.99); repairers (OR 0.49; 95% CI 0.22 - 1.09); and electricians (OR 0.46; 95% CI 0.17 - 1.26). Conclusions Increased risks for social science jobs could be related to numbers of people contacted in a day and risk of infections. Severe influenza was associated with increased risk of PD but number of people contacted was not. Elevated risks for farmers are typically attributed to pesticide exposure, however our pesticide analyses did not support this attribution. Other exposures of interest for farmers could include animal contact, influenza, head injuries, and vibration from heavy equipment, all associated with PD in our study.</div></front></TEI><istex><corpusName>bmj</corpusName><author><json:item><name>M A Harris</name><affiliations><json:string>Ryerson University, Toronto, Canada</json:string></affiliations></json:item><json:item><name>Marion</name><affiliations><json:string>University of British Columbia, Vancouver, Canada</json:string></affiliations></json:item><json:item><name>Tsui</name><affiliations><json:string>University of British Columbia, Vancouver, Canada</json:string></affiliations></json:item><json:item><name>Shen</name><affiliations><json:string>University of British Columbia, Vancouver, Canada</json:string></affiliations></json:item><json:item><name>Teschke</name><affiliations><json:string>University of British Columbia, Vancouver, Canada</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Session: 11. Neurological outcomes</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Objectives Despite mounting evidence on epidemiological risk factors, Parkinson’s disease (PD) incidence remains largely unexplained. The purpose of this study was to test associations between occupations and PD to complement analyses of occupational exposures. Methods We used a population-based case-control design in British Columbia, Canada, including 403 cases (users of antiparkinsonian medication) and 405 controls (from the provincial health insurance register, frequency matched on age and sex). Job histories were collected using structured questionnaires querying all jobs held since age 16. Odds ratios were calculated for associations between PD and occupational categories using unconditional logistic regression, adjusting for age, sex, and smoking. Results Significantly elevated risks were found for social science, law and library jobs (OR 1.82; 95% CI 1.01 - 3.29); and farming and horticulture jobs (OR 2.03; 95% CI 1.10 - 3.74). Nonsignificantly elevated risks were found for gas station jobs (OR 2.55; 95% CI 0.84 - 7.72); welders (OR 2.98; 95% CI 0.78 - 11.40); and drivers of heavy equipment (OR 1.95; 95% CI 0.66 - 5.81). Reduced risks were found for management and administration jobs (OR 0.70; 95% CI 0.49 - 0.99); other health care jobs (OR 0.44; 95% CI 0.20 - 0.99); repairers (OR 0.49; 95% CI 0.22 - 1.09); and electricians (OR 0.46; 95% CI 0.17 - 1.26). Conclusions Increased risks for social science jobs could be related to numbers of people contacted in a day and risk of infections. Severe influenza was associated with increased risk of PD but number of people contacted was not. Elevated risks for farmers are typically attributed to pesticide exposure, however our pesticide analyses did not support this attribution. 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The purpose of this study was to test associations between occupations and PD to complement analyses of occupational exposures. Methods We used a population-based case-control design in British Columbia, Canada, including 403 cases (users of antiparkinsonian medication) and 405 controls (from the provincial health insurance register, frequency matched on age and sex). Job histories were collected using structured questionnaires querying all jobs held since age 16. Odds ratios were calculated for associations between PD and occupational categories using unconditional logistic regression, adjusting for age, sex, and smoking. Results Significantly elevated risks were found for social science, law and library jobs (OR 1.82; 95% CI 1.01 - 3.29); and farming and horticulture jobs (OR 2.03; 95% CI 1.10 - 3.74). Nonsignificantly elevated risks were found for gas station jobs (OR 2.55; 95% CI 0.84 - 7.72); welders (OR 2.98; 95% CI 0.78 - 11.40); and drivers of heavy equipment (OR 1.95; 95% CI 0.66 - 5.81). Reduced risks were found for management and administration jobs (OR 0.70; 95% CI 0.49 - 0.99); other health care jobs (OR 0.44; 95% CI 0.20 - 0.99); repairers (OR 0.49; 95% CI 0.22 - 1.09); and electricians (OR 0.46; 95% CI 0.17 - 1.26). Conclusions Increased risks for social science jobs could be related to numbers of people contacted in a day and risk of infections. Severe influenza was associated with increased risk of PD but number of people contacted was not. Elevated risks for farmers are typically attributed to pesticide exposure, however our pesticide analyses did not support this attribution. Other exposures of interest for farmers could include animal contact, influenza, head injuries, and vibration from heavy equipment, all associated with PD in our study.</p></abstract></profileDesc><revisionDesc><change when="2013-09">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-14">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/4CB8756CCCD97DD4EF7C87F27E2561DA88388112/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="abstract" xml:lang="EN"><front><journal-meta><journal-id journal-id-type="hwp">oemed</journal-id><journal-id journal-id-type="nlm-ta">Occup Environ Med</journal-id><journal-id journal-id-type="publisher-id">oemed</journal-id><journal-title>Occupational and Environmental Medicine</journal-title><abbrev-journal-title abbrev-type="publisher">Occup Environ Med</abbrev-journal-title><abbrev-journal-title>Occup Environ Med</abbrev-journal-title><issn pub-type="ppub">1351-0711</issn><issn pub-type="epub">1470-7926</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">oemed-2013-101717.281</article-id><article-id pub-id-type="doi">10.1136/oemed-2013-101717.281</article-id><article-id pub-id-type="other">oemed;70/Suppl_1/A95-b</article-id><article-id pub-id-type="other">oemed;oemed-2013-101717.281</article-id><article-id pub-id-type="other">A95.3</article-id><article-id pub-id-type="other">oemed-2013-101717.281</article-id><article-categories><subj-group subj-group-type="heading"><subject>Session: 11. Neurological outcomes</subject></subj-group></article-categories><title-group><article-title>281 Occupations and Parkinson’s disease in a population-based case-control study</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Harris</surname><given-names>M A</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Marion</surname><given-names></given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Tsui</surname><given-names></given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Shen</surname><given-names></given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Teschke</surname><given-names></given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib></contrib-group><aff id="AF0001"><sup>1</sup>Ryerson University, Toronto, Canada</aff><aff id="AF0002"><sup>2</sup>University of British Columbia, Vancouver, Canada</aff><pub-date pub-type="ppub"><month>09</month><year>2013</year></pub-date><volume>70</volume><volume-id pub-id-type="other">70</volume-id><volume-id pub-id-type="other">70</volume-id><issue>Suppl 1</issue><issue-id pub-id-type="other">oemed;70/Suppl_1</issue-id><issue-id pub-id-type="other" content-type="supplement">Suppl_1</issue-id><issue-id pub-id-type="other">70/Suppl_1</issue-id><issue-title>23rd Conference on Epidemiology in Occupational Health EPICOH 2013: Improving the Impact June 18–21, 2013, Utrecht, The Netherlands</issue-title><fpage seq="3">A95</fpage><permissions><copyright-statement>© 2013, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="oemed-70-A95-3.pdf"></self-uri><abstract><sec><title>Objectives</title><p>Despite mounting evidence on epidemiological risk factors, Parkinson’s disease (PD) incidence remains largely unexplained. The purpose of this study was to test associations between occupations and PD to complement analyses of occupational exposures.</p></sec><sec><title>Methods</title><p>We used a population-based case-control design in British Columbia, Canada, including 403 cases (users of antiparkinsonian medication) and 405 controls (from the provincial health insurance register, frequency matched on age and sex). Job histories were collected using structured questionnaires querying all jobs held since age 16. Odds ratios were calculated for associations between PD and occupational categories using unconditional logistic regression, adjusting for age, sex, and smoking.</p></sec><sec><title>Results</title><p>Significantly elevated risks were found for social science, law and library jobs (OR 1.82; 95% CI 1.01 - 3.29); and farming and horticulture jobs (OR 2.03; 95% CI 1.10 - 3.74). Nonsignificantly elevated risks were found for gas station jobs (OR 2.55; 95% CI 0.84 - 7.72); welders (OR 2.98; 95% CI 0.78 - 11.40); and drivers of heavy equipment (OR 1.95; 95% CI 0.66 - 5.81). Reduced risks were found for management and administration jobs (OR 0.70; 95% CI 0.49 - 0.99); other health care jobs (OR 0.44; 95% CI 0.20 - 0.99); repairers (OR 0.49; 95% CI 0.22 - 1.09); and electricians (OR 0.46; 95% CI 0.17 - 1.26).</p></sec><sec><title>Conclusions</title><p>Increased risks for social science jobs could be related to numbers of people contacted in a day and risk of infections. Severe influenza was associated with increased risk of PD but number of people contacted was not. Elevated risks for farmers are typically attributed to pesticide exposure, however our pesticide analyses did not support this attribution. Other exposures of interest for farmers could include animal contact, influenza, head injuries, and vibration from heavy equipment, all associated with PD in our study.</p></sec></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>281 Occupations and Parkinson’s disease in a population-based case-control study</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>281 Occupations and Parkinson’s disease in a population-based case-control study</title></titleInfo><name type="personal"><namePart type="given">M A</namePart><namePart type="family">Harris</namePart><affiliation>Ryerson University, Toronto, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="family">Marion</namePart><affiliation>University of British Columbia, Vancouver, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="family">Tsui</namePart><affiliation>University of British Columbia, Vancouver, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="family">Shen</namePart><affiliation>University of British Columbia, Vancouver, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="family">Teschke</namePart><affiliation>University of British Columbia, Vancouver, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="abstract" displayLabel="abstract"></genre><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">2013-09</dateIssued><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Objectives Despite mounting evidence on epidemiological risk factors, Parkinson’s disease (PD) incidence remains largely unexplained. The purpose of this study was to test associations between occupations and PD to complement analyses of occupational exposures. Methods We used a population-based case-control design in British Columbia, Canada, including 403 cases (users of antiparkinsonian medication) and 405 controls (from the provincial health insurance register, frequency matched on age and sex). Job histories were collected using structured questionnaires querying all jobs held since age 16. Odds ratios were calculated for associations between PD and occupational categories using unconditional logistic regression, adjusting for age, sex, and smoking. Results Significantly elevated risks were found for social science, law and library jobs (OR 1.82; 95% CI 1.01 - 3.29); and farming and horticulture jobs (OR 2.03; 95% CI 1.10 - 3.74). Nonsignificantly elevated risks were found for gas station jobs (OR 2.55; 95% CI 0.84 - 7.72); welders (OR 2.98; 95% CI 0.78 - 11.40); and drivers of heavy equipment (OR 1.95; 95% CI 0.66 - 5.81). Reduced risks were found for management and administration jobs (OR 0.70; 95% CI 0.49 - 0.99); other health care jobs (OR 0.44; 95% CI 0.20 - 0.99); repairers (OR 0.49; 95% CI 0.22 - 1.09); and electricians (OR 0.46; 95% CI 0.17 - 1.26). Conclusions Increased risks for social science jobs could be related to numbers of people contacted in a day and risk of infections. Severe influenza was associated with increased risk of PD but number of people contacted was not. Elevated risks for farmers are typically attributed to pesticide exposure, however our pesticide analyses did not support this attribution. Other exposures of interest for farmers could include animal contact, influenza, head injuries, and vibration from heavy equipment, all associated with PD in our study.</abstract><relatedItem type="host"><titleInfo><title>Occupational and Environmental Medicine</title></titleInfo><titleInfo type="abbreviated"><title>Occup Environ Med</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1351-0711</identifier><identifier type="eISSN">1470-7926</identifier><identifier type="PublisherID">oemed</identifier><identifier type="PublisherID-hwp">oemed</identifier><identifier type="PublisherID-nlm-ta">Occup Environ Med</identifier><part><date>2013</date><detail type="title"><title>23rd Conference on Epidemiology in Occupational Health EPICOH 2013: Improving the Impact June 18–21, 2013, Utrecht, The Netherlands</title></detail><detail type="volume"><caption>vol.</caption><number>70</number></detail><detail type="issue"><caption>no.</caption><number>Suppl 1</number></detail><extent unit="pages"><start>A95</start></extent></part></relatedItem><identifier type="istex">4CB8756CCCD97DD4EF7C87F27E2561DA88388112</identifier><identifier type="DOI">10.1136/oemed-2013-101717.281</identifier><identifier type="href">oemed-70-A95-3.pdf</identifier><identifier type="ArticleID">oemed-2013-101717.281</identifier><identifier type="local">oemed;70/Suppl_1/A95-b</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2013, Published by the BMJ Publishing Group Limited. 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