Correlation of frataxin content in blood and skeletal muscle endorses frataxin as a biomarker in Friedreich ataxia
Identifieur interne : 002973 ( Main/Corpus ); précédent : 002972; suivant : 002974Correlation of frataxin content in blood and skeletal muscle endorses frataxin as a biomarker in Friedreich ataxia
Auteurs : Wolfgang Nachbauer ; Julia Wanschitz ; Hannes Steinkellner ; Andreas Eigentler ; Brigitte Sturm ; Kurt Hufler ; Barbara Scheiber-Mojdehkar ; Werner Poewe ; Markus Reindl ; Sylvia BoeschSource :
- Movement Disorders [ 0885-3185 ] ; 2011-08-15.
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Abstract
Background:: Friedreich ataxia is an autosomal recessive disorder caused by mutations in the frataxin gene, leading to reduced levels of the mitochondrial protein frataxin. Assays to quantitatively measure frataxin in peripheral blood have been established. To determine the validity of frataxin as a biomarker for clinical trials, we assessed frataxin in clinically affected tissue. Methods:: In 7 patients with Friedreich ataxia, frataxin content was measured in blood and skeletal muscle before and after treatment with recombinant human erythropoietin, applying the electrochemiluminescence immunoassay. Results:: We found frataxin content to be correlated in peripheral blood mononuclear cells and skeletal muscle in drug‐naive patients with Friedreich ataxia. The correlation of frataxin content in both compartments remained significant after 8 weeks of treatment. Skeletal‐muscle frataxin values correlated with ataxia using the Scale for the Assessment and Rating of Ataxia score. Conclusions:: Our results endorse frataxin measurements in peripheral blood cells as a valid biomarker in Friedreich ataxia. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23789
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Austria</mods:affiliation></affiliation></author><author><name sortKey="Sturm, Brigitte" sort="Sturm, Brigitte" uniqKey="Sturm B" first="Brigitte" last="Sturm">Brigitte Sturm</name><affiliation><mods:affiliation>Department of Medical Chemistry, Medical University Vienna, Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Hufler, Kurt" sort="Hufler, Kurt" uniqKey="Hufler K" first="Kurt" last="Hufler">Kurt Hufler</name><affiliation><mods:affiliation>Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Scheiber Ojdehkar, Barbara" sort="Scheiber Ojdehkar, Barbara" uniqKey="Scheiber Ojdehkar B" first="Barbara" last="Scheiber-Mojdehkar">Barbara Scheiber-Mojdehkar</name><affiliation><mods:affiliation>Department of Medical Chemistry, Medical University Vienna, Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Poewe, 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Assays to quantitatively measure frataxin in peripheral blood have been established. To determine the validity of frataxin as a biomarker for clinical trials, we assessed frataxin in clinically affected tissue. Methods:: In 7 patients with Friedreich ataxia, frataxin content was measured in blood and skeletal muscle before and after treatment with recombinant human erythropoietin, applying the electrochemiluminescence immunoassay. Results:: We found frataxin content to be correlated in peripheral blood mononuclear cells and skeletal muscle in drug‐naive patients with Friedreich ataxia. The correlation of frataxin content in both compartments remained significant after 8 weeks of treatment. Skeletal‐muscle frataxin values correlated with ataxia using the Scale for the Assessment and Rating of Ataxia score. Conclusions:: Our results endorse frataxin measurements in peripheral blood cells as a valid biomarker in Friedreich ataxia. © 2011 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Wolfgang Nachbauer MD</name><affiliations><json:string>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Julia Wanschitz MD</name><affiliations><json:string>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Hannes Steinkellner PhD</name><affiliations><json:string>Department of Medical Chemistry, Medical University Vienna, Vienna, Austria</json:string></affiliations></json:item><json:item><name>Andreas Eigentler MD</name><affiliations><json:string>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Brigitte Sturm PhD</name><affiliations><json:string>Department of Medical Chemistry, Medical University Vienna, Vienna, Austria</json:string></affiliations></json:item><json:item><name>Kurt Hufler MD</name><affiliations><json:string>Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Barbara Scheiber‐Mojdehkar PhD</name><affiliations><json:string>Department of Medical Chemistry, Medical University Vienna, Vienna, Austria</json:string></affiliations></json:item><json:item><name>Werner Poewe MD</name><affiliations><json:string>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Markus Reindl PhD</name><affiliations><json:string>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>Sylvia Boesch MD</name><affiliations><json:string>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Friedreich ataxia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>frataxin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>skeletal muscle</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>erythropoietin</value></json:item></subject><articleId><json:string>MDS23789</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background:: Friedreich ataxia is an autosomal recessive disorder caused by mutations in the frataxin gene, leading to reduced levels of the mitochondrial protein frataxin. Assays to quantitatively measure frataxin in peripheral blood have been established. To determine the validity of frataxin as a biomarker for clinical trials, we assessed frataxin in clinically affected tissue. Methods:: In 7 patients with Friedreich ataxia, frataxin content was measured in blood and skeletal muscle before and after treatment with recombinant human erythropoietin, applying the electrochemiluminescence immunoassay. Results:: We found frataxin content to be correlated in peripheral blood mononuclear cells and skeletal muscle in drug‐naive patients with Friedreich ataxia. The correlation of frataxin content in both compartments remained significant after 8 weeks of treatment. Skeletal‐muscle frataxin values correlated with ataxia using the Scale for the Assessment and Rating of Ataxia score. Conclusions:: Our results endorse frataxin measurements in peripheral blood cells as a valid biomarker in Friedreich ataxia. © 2011 Movement Disorder Society</abstract><qualityIndicators><score>6.896</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1147</abstractCharCount><pdfWordCount>10216</pdfWordCount><pdfCharCount>68734</pdfCharCount><pdfPageCount>17</pdfPageCount><abstractWordCount>158</abstractWordCount></qualityIndicators><title>Correlation of frataxin content in blood and skeletal muscle endorses frataxin as a biomarker in Friedreich ataxia</title><genre><json:string>article</json:string></genre><host><volume>26</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>4</total><last>1938</last><first>1935</first></pages><issn><json:string>0885-3185</json:string></issn><issue>10</issue><subject><json:item><value>Brief Report</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/mds.23789</json:string></doi><id>30F084F8B10A4EF3D905A61A9C09FFA58E8C1E9A</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/30F084F8B10A4EF3D905A61A9C09FFA58E8C1E9A/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/30F084F8B10A4EF3D905A61A9C09FFA58E8C1E9A/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/30F084F8B10A4EF3D905A61A9C09FFA58E8C1E9A/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Correlation of frataxin content in blood and skeletal muscle endorses frataxin as a biomarker in Friedreich ataxia</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2011</date></publicationStmt><notesStmt><note type="content">*Funding agencies: This study was funded by a grant from the Austrian National Bank (ÖNB Jubiläumsfond). Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Correlation of frataxin content in blood and skeletal muscle endorses frataxin as a biomarker in Friedreich ataxia</title><author><persName><forename type="first">Wolfgang</forename><surname>Nachbauer</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Julia</forename><surname>Wanschitz</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Hannes</forename><surname>Steinkellner</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Medical Chemistry, Medical University Vienna, Vienna, Austria</affiliation></author><author><persName><forename type="first">Andreas</forename><surname>Eigentler</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Brigitte</forename><surname>Sturm</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Medical Chemistry, Medical University Vienna, Vienna, Austria</affiliation></author><author><persName><forename type="first">Kurt</forename><surname>Hufler</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Barbara</forename><surname>Scheiber‐Mojdehkar</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Medical Chemistry, Medical University Vienna, Vienna, Austria</affiliation></author><author><persName><forename type="first">Werner</forename><surname>Poewe</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Markus</forename><surname>Reindl</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</affiliation></author><author><persName><forename type="first">Sylvia</forename><surname>Boesch</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Anichstr. 35, 6020 Innsbruck, Austria</p></note><affiliation>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. 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Assays to quantitatively measure frataxin in peripheral blood have been established. To determine the validity of frataxin as a biomarker for clinical trials, we assessed frataxin in clinically affected tissue. Methods:: In 7 patients with Friedreich ataxia, frataxin content was measured in blood and skeletal muscle before and after treatment with recombinant human erythropoietin, applying the electrochemiluminescence immunoassay. Results:: We found frataxin content to be correlated in peripheral blood mononuclear cells and skeletal muscle in drug‐naive patients with Friedreich ataxia. The correlation of frataxin content in both compartments remained significant after 8 weeks of treatment. Skeletal‐muscle frataxin values correlated with ataxia using the Scale for the Assessment and Rating of Ataxia score. 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number="1"></count><count type="referenceTotal" number="20"></count><count type="wordTotal" number="3313"></count></countGroup><titleGroup><title type="main" xml:lang="en">Correlation of frataxin content in blood and skeletal muscle endorses frataxin as a biomarker in Friedreich ataxia<link href="#fn1"></link></title><title type="short" xml:lang="en">Frataxin Content in Blood and Muscle</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Wolfgang</givenNames><familyName>Nachbauer</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Julia</givenNames><familyName>Wanschitz</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Hannes</givenNames><familyName>Steinkellner</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Andreas</givenNames><familyName>Eigentler</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Brigitte</givenNames><familyName>Sturm</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Kurt</givenNames><familyName>Hufler</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Barbara</givenNames><familyName>Scheiber‐Mojdehkar</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Werner</givenNames><familyName>Poewe</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Markus</givenNames><familyName>Reindl</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Sylvia</givenNames><familyName>Boesch</familyName><degrees>MD</degrees></personName><contactDetails><email normalForm="sylvia.boesch@i-med.ac.at">sylvia.boesch@i‐med.ac.at</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="AT" type="organization"><unparsedAffiliation>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="AT" type="organization"><unparsedAffiliation>Department of Medical Chemistry, Medical University Vienna, Vienna, Austria</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="AT" type="organization"><unparsedAffiliation>Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Friedreich ataxia</keyword><keyword xml:id="kwd2">frataxin</keyword><keyword xml:id="kwd3">skeletal muscle</keyword><keyword xml:id="kwd4">erythropoietin</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Background:</title><p>Friedreich ataxia is an autosomal recessive disorder caused by mutations in the <i>frataxin</i> gene, leading to reduced levels of the mitochondrial protein frataxin. Assays to quantitatively measure frataxin in peripheral blood have been established. To determine the validity of frataxin as a biomarker for clinical trials, we assessed frataxin in clinically affected tissue.</p></section><section xml:id="abs1-2"><title type="main">Methods:</title><p>In 7 patients with Friedreich ataxia, frataxin content was measured in blood and skeletal muscle before and after treatment with recombinant human erythropoietin, applying the electrochemiluminescence immunoassay.</p></section><section xml:id="abs1-3"><title type="main">Results:</title><p>We found frataxin content to be correlated in peripheral blood mononuclear cells and skeletal muscle in drug‐naive patients with Friedreich ataxia. The correlation of frataxin content in both compartments remained significant after 8 weeks of treatment. Skeletal‐muscle frataxin values correlated with ataxia using the Scale for the Assessment and Rating of Ataxia score.</p></section><section xml:id="abs1-4"><title type="main">Conclusions:</title><p>Our results endorse frataxin measurements in peripheral blood cells as a valid biomarker in Friedreich ataxia. © 2011 Movement Disorder Society</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p><b>Funding agencies:</b> This study was funded by a grant from the Austrian National Bank (ÖNB Jubiläumsfond).</p><p><b>Relevant conflicts of interest/financial disclosures:</b> Nothing to report.</p><p>Full financial disclosures and author roles may be found in the online version of this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Correlation of frataxin content in blood and skeletal muscle endorses frataxin as a biomarker in Friedreich ataxia</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Frataxin Content in Blood and Muscle</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Correlation of frataxin content in blood and skeletal muscle endorses frataxin as a biomarker in Friedreich ataxia</title></titleInfo><name type="personal"><namePart type="given">Wolfgang</namePart><namePart type="family">Nachbauer</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Julia</namePart><namePart type="family">Wanschitz</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hannes</namePart><namePart type="family">Steinkellner</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Medical Chemistry, Medical University Vienna, Vienna, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andreas</namePart><namePart type="family">Eigentler</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Brigitte</namePart><namePart type="family">Sturm</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Medical Chemistry, Medical University Vienna, Vienna, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kurt</namePart><namePart type="family">Hufler</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Barbara</namePart><namePart type="family">Scheiber‐Mojdehkar</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Medical Chemistry, Medical University Vienna, Vienna, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Werner</namePart><namePart type="family">Poewe</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Markus</namePart><namePart type="family">Reindl</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sylvia</namePart><namePart type="family">Boesch</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Medical University Innsbruck, Innsbruck, Austria</affiliation><description>Correspondence: Anichstr. 35, 6020 Innsbruck, Austria</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-08-15</dateIssued><dateCaptured encoding="w3cdtf">2010-11-02</dateCaptured><dateValid encoding="w3cdtf">2011-04-17</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">20</extent><extent unit="words">3313</extent></physicalDescription><abstract lang="en">Background:: Friedreich ataxia is an autosomal recessive disorder caused by mutations in the frataxin gene, leading to reduced levels of the mitochondrial protein frataxin. Assays to quantitatively measure frataxin in peripheral blood have been established. To determine the validity of frataxin as a biomarker for clinical trials, we assessed frataxin in clinically affected tissue. Methods:: In 7 patients with Friedreich ataxia, frataxin content was measured in blood and skeletal muscle before and after treatment with recombinant human erythropoietin, applying the electrochemiluminescence immunoassay. Results:: We found frataxin content to be correlated in peripheral blood mononuclear cells and skeletal muscle in drug‐naive patients with Friedreich ataxia. The correlation of frataxin content in both compartments remained significant after 8 weeks of treatment. Skeletal‐muscle frataxin values correlated with ataxia using the Scale for the Assessment and Rating of Ataxia score. Conclusions:: Our results endorse frataxin measurements in peripheral blood cells as a valid biomarker in Friedreich ataxia. © 2011 Movement Disorder Society</abstract><note type="content">*Funding agencies: This study was funded by a grant from the Austrian National Bank (ÖNB Jubiläumsfond). Relevant conflicts of interest/financial disclosures: Nothing to report. Full financial disclosures and author roles may be found in the online version of this article.</note><subject lang="en"><genre>Keywords</genre><topic>Friedreich ataxia</topic><topic>frataxin</topic><topic>skeletal muscle</topic><topic>erythropoietin</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1935</start><end>1938</end><total>4</total></extent></part></relatedItem><identifier type="istex">30F084F8B10A4EF3D905A61A9C09FFA58E8C1E9A</identifier><identifier type="DOI">10.1002/mds.23789</identifier><identifier type="ArticleID">MDS23789</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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