Coexistence of Creutzfeldt‐Jakob disease, Lewy body disease, and Alzheimer's disease pathology: An autopsy case showing typical clinical features of Creutzfeldt‐Jakob disease
Identifieur interne : 002963 ( Main/Corpus ); précédent : 002962; suivant : 002964Coexistence of Creutzfeldt‐Jakob disease, Lewy body disease, and Alzheimer's disease pathology: An autopsy case showing typical clinical features of Creutzfeldt‐Jakob disease
Auteurs : Takashi Haraguchi ; Seishi Terada ; Hideki Ishizu ; Kenichi Sakai ; Yasuyuki Tanabe ; Taiji Nagai ; Hiroshi Takata ; Keigo Nobukuni ; Yuetsu Ihara ; Tetsuyuki Kitamoto ; Shigetoshi KurodaSource :
- Neuropathology [ 0919-6544 ] ; 2009-08.
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Abstract
We report here an autopsy case of sporadic Creutzfeldt‐Jakob disease (CJD) without hereditary burden and with a clinical course typical of sporadic CJD. A 77‐year old man developed memory disturbance, followed by gait disturbance and myoclonus. He died of bronchopneumonia 5 months after the disease onset. Post‐mortem examination revealed neuronal loss, astrocytosis, and patchy spongiosis in the cerebral cortex and lenticular nuclei. Synaptic‐type deposits of prion protein were present in the cerebral cortex. Additionally, Lewy bodies were observed in the cerebral cortex and substantia nigra. Furthermore, senile plaques compatible with definite Alzheimer's disease according to Consortium to Establish a Registry for Alzheimer's disease criteria and neurofibrillary changes of the limbic system consistent with Braak stage IV were found. Based on a review of the published literature, this autopsy case is very rare, and we suppose that the incidence of CJD accompanied by Lewy body disease and Alzheimer's disease is very low.
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DOI: 10.1111/j.1440-1789.2008.00964.x
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Tsukubo‐gun, Okayama,</mods:affiliation></affiliation></author><author><name sortKey="Terada, Seishi" sort="Terada, Seishi" uniqKey="Terada S" first="Seishi" last="Terada">Seishi Terada</name><affiliation><mods:affiliation>Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata‐cho, Okayama,</mods:affiliation></affiliation></author><author><name sortKey="Ishizu, Hideki" sort="Ishizu, Hideki" uniqKey="Ishizu H" first="Hideki" last="Ishizu">Hideki Ishizu</name><affiliation><mods:affiliation>Department of Laboratory and Medicine, Zikei Institute, Urayasuhon‐cho, Okayama, and</mods:affiliation></affiliation></author><author><name sortKey="Sakai, Kenichi" sort="Sakai, Kenichi" uniqKey="Sakai K" first="Kenichi" last="Sakai">Kenichi Sakai</name><affiliation><mods:affiliation>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</mods:affiliation></affiliation></author><author><name sortKey="Tanabe, Yasuyuki" sort="Tanabe, Yasuyuki" uniqKey="Tanabe Y" first="Yasuyuki" last="Tanabe">Yasuyuki Tanabe</name><affiliation><mods:affiliation>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</mods:affiliation></affiliation></author><author><name sortKey="Nagai, Taiji" sort="Nagai, Taiji" uniqKey="Nagai T" first="Taiji" last="Nagai">Taiji Nagai</name><affiliation><mods:affiliation>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</mods:affiliation></affiliation></author><author><name sortKey="Takata, Hiroshi" sort="Takata, Hiroshi" uniqKey="Takata H" first="Hiroshi" last="Takata">Hiroshi Takata</name><affiliation><mods:affiliation>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</mods:affiliation></affiliation></author><author><name sortKey="Nobukuni, Keigo" sort="Nobukuni, Keigo" uniqKey="Nobukuni K" first="Keigo" last="Nobukuni">Keigo Nobukuni</name><affiliation><mods:affiliation>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</mods:affiliation></affiliation></author><author><name sortKey="Ihara, Yuetsu" sort="Ihara, Yuetsu" uniqKey="Ihara Y" first="Yuetsu" last="Ihara">Yuetsu Ihara</name><affiliation><mods:affiliation>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</mods:affiliation></affiliation></author><author><name sortKey="Kitamoto, Tetsuyuki" sort="Kitamoto, Tetsuyuki" uniqKey="Kitamoto T" first="Tetsuyuki" last="Kitamoto">Tetsuyuki Kitamoto</name><affiliation><mods:affiliation>Division of CJD Science and Technology, Department of Prion Research, Center for Translational and Advanced Animal Research on Human Diseases, Tohoku University Graduate School of Medicine, Seiryou‐cho, Sendai, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kuroda, Shigetoshi" sort="Kuroda, Shigetoshi" uniqKey="Kuroda S" first="Shigetoshi" last="Kuroda">Shigetoshi Kuroda</name><affiliation><mods:affiliation>Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata‐cho, Okayama,</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Neuropathology</title><idno type="ISSN">0919-6544</idno><idno type="eISSN">1440-1789</idno><imprint><publisher>Blackwell Publishing Asia</publisher><pubPlace>Melbourne, Australia</pubPlace><date type="published" when="2009-08">2009-08</date><biblScope unit="volume">29</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="454">454</biblScope><biblScope unit="page" to="459">459</biblScope></imprint><idno 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A 77‐year old man developed memory disturbance, followed by gait disturbance and myoclonus. He died of bronchopneumonia 5 months after the disease onset. Post‐mortem examination revealed neuronal loss, astrocytosis, and patchy spongiosis in the cerebral cortex and lenticular nuclei. Synaptic‐type deposits of prion protein were present in the cerebral cortex. Additionally, Lewy bodies were observed in the cerebral cortex and substantia nigra. Furthermore, senile plaques compatible with definite Alzheimer's disease according to Consortium to Establish a Registry for Alzheimer's disease criteria and neurofibrillary changes of the limbic system consistent with Braak stage IV were found. Based on a review of the published literature, this autopsy case is very rare, and we suppose that the incidence of CJD accompanied by Lewy body disease and Alzheimer's disease is very low.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Takashi Haraguchi</name><affiliations><json:string>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</json:string></affiliations></json:item><json:item><name>Seishi Terada</name><affiliations><json:string>Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata‐cho, Okayama,</json:string></affiliations></json:item><json:item><name>Hideki Ishizu</name><affiliations><json:string>Department of Laboratory and Medicine, Zikei Institute, Urayasuhon‐cho, Okayama, and</json:string></affiliations></json:item><json:item><name>Kenichi Sakai</name><affiliations><json:string>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</json:string></affiliations></json:item><json:item><name>Yasuyuki Tanabe</name><affiliations><json:string>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</json:string></affiliations></json:item><json:item><name>Taiji Nagai</name><affiliations><json:string>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</json:string></affiliations></json:item><json:item><name>Hiroshi Takata</name><affiliations><json:string>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</json:string></affiliations></json:item><json:item><name>Keigo Nobukuni</name><affiliations><json:string>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</json:string></affiliations></json:item><json:item><name>Yuetsu Ihara</name><affiliations><json:string>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</json:string></affiliations></json:item><json:item><name>Tetsuyuki Kitamoto</name><affiliations><json:string>Division of CJD Science and Technology, Department of Prion Research, Center for Translational and Advanced Animal Research on Human Diseases, Tohoku University Graduate School of Medicine, Seiryou‐cho, Sendai, Japan</json:string></affiliations></json:item><json:item><name>Shigetoshi Kuroda</name><affiliations><json:string>Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata‐cho, Okayama,</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Alzheimer's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Creutzfeldt‐Jakob disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Lewy body disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>neurofibrillary change</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>senile plaque</value></json:item></subject><articleId><json:string>NEUP964</json:string></articleId><language><json:string>eng</json:string></language><abstract>We report here an autopsy case of sporadic Creutzfeldt‐Jakob disease (CJD) without hereditary burden and with a clinical course typical of sporadic CJD. 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A 77‐year old man developed memory disturbance, followed by gait disturbance and myoclonus. He died of bronchopneumonia 5 months after the disease onset. Post‐mortem examination revealed neuronal loss, astrocytosis, and patchy spongiosis in the cerebral cortex and lenticular nuclei. Synaptic‐type deposits of prion protein were present in the cerebral cortex. Additionally, Lewy bodies were observed in the cerebral cortex and substantia nigra. Furthermore, senile plaques compatible with definite Alzheimer's disease according to Consortium to Establish a Registry for Alzheimer's disease criteria and neurofibrillary changes of the limbic system consistent with Braak stage IV were found. Based on a review of the published literature, this autopsy case is very rare, and we suppose that the incidence of CJD accompanied by Lewy body disease and Alzheimer's disease is very low.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Alzheimer's disease</term></item><item><term>Creutzfeldt‐Jakob disease</term></item><item><term>Lewy body disease</term></item><item><term>neurofibrillary change</term></item><item><term>senile plaque</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-08">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/07387B8F1FECFF086718E0E1186E162164AF61FF/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Asia</publisherName><publisherLoc>Melbourne, Australia</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1440-1789</doi><issn type="print">0919-6544</issn><issn type="electronic">1440-1789</issn><idGroup><id type="product" value="NEUP"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="NEUROPATHOLOGY">Neuropathology</title></titleGroup></publicationMeta><publicationMeta level="part" position="08004"><doi origin="wiley">10.1111/neu.2009.29.issue-4</doi><numberingGroup><numbering type="journalVolume" number="29">29</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2009-08">August 2009</coverDate></publicationMeta><publicationMeta level="unit" type="caseStudy" position="9" status="forIssue"><doi origin="wiley">10.1111/j.1440-1789.2008.00964.x</doi><idGroup><id type="unit" value="NEUP964"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">CASE REPORTS</title></titleGroup><copyright>© 2008 Japanese Society of Neuropathology</copyright><eventGroup><event type="firstOnline" date="2008-08-18"></event><event type="publishedOnlineFinalForm" date="2009-07-15"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.5 mode:FullText source:FullText result:FullText" date="2010-04-07"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-03"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="454">454</numbering><numbering type="pageLast" number="459">459</numbering></numberingGroup><correspondenceTo>Takashi Haraguchi, MD, PhD, Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, 4066 Hayashima‐cho, 701‐0304 Tsukubo‐gun Okayama, Japan. Email: <email normalForm="haraguchit@s-okayama.hosp.go.jp">haraguchit@s‐okayama.hosp.go.jp</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:NEUP.NEUP964.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 16 June 2008; revised and accepted 22 July 2008; published online 18 August 2008.</unparsedEditorialHistory><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="1"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="30"></count><count type="wordTotal" number="3540"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Coexistence of Creutzfeldt‐Jakob disease, Lewy body disease, and Alzheimer's disease pathology: An autopsy case showing typical clinical features of Creutzfeldt‐Jakob disease</title><title type="shortAuthors">T Haraguchi <i>et al.</i></title><title type="short">Coexistence of CJD, LBD, and AD pathology</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>Takashi</givenNames><familyName>Haraguchi</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>Seishi</givenNames><familyName>Terada</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>Hideki</givenNames><familyName>Ishizu</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Kenichi</givenNames><familyName>Sakai</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>Yasuyuki</givenNames><familyName>Tanabe</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>Taiji</givenNames><familyName>Nagai</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a1"><personName><givenNames>Hiroshi</givenNames><familyName>Takata</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a1"><personName><givenNames>Keigo</givenNames><familyName>Nobukuni</familyName></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a1"><personName><givenNames>Yuetsu</givenNames><familyName>Ihara</familyName></personName></creator><creator creatorRole="author" xml:id="cr10" affiliationRef="#a4"><personName><givenNames>Tetsuyuki</givenNames><familyName>Kitamoto</familyName></personName></creator><creator creatorRole="author" xml:id="cr11" affiliationRef="#a2"><personName><givenNames>Shigetoshi</givenNames><familyName>Kuroda</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata‐cho, Okayama,</unparsedAffiliation></affiliation><affiliation xml:id="a3"><unparsedAffiliation>Department of Laboratory and Medicine, Zikei Institute, Urayasuhon‐cho, Okayama, and</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="JP"><unparsedAffiliation>Division of CJD Science and Technology, Department of Prion Research, Center for Translational and Advanced Animal Research on Human Diseases, Tohoku University Graduate School of Medicine, Seiryou‐cho, Sendai, Japan</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Alzheimer's disease</keyword><keyword xml:id="k2">Creutzfeldt‐Jakob disease</keyword><keyword xml:id="k3">Lewy body disease</keyword><keyword xml:id="k4">neurofibrillary change</keyword><keyword xml:id="k5">senile plaque</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>We report here an autopsy case of sporadic Creutzfeldt‐Jakob disease (CJD) without hereditary burden and with a clinical course typical of sporadic CJD. A 77‐year old man developed memory disturbance, followed by gait disturbance and myoclonus. He died of bronchopneumonia 5 months after the disease onset. Post‐mortem examination revealed neuronal loss, astrocytosis, and patchy spongiosis in the cerebral cortex and lenticular nuclei. Synaptic‐type deposits of prion protein were present in the cerebral cortex. Additionally, Lewy bodies were observed in the cerebral cortex and substantia nigra. Furthermore, senile plaques compatible with definite Alzheimer's disease according to Consortium to Establish a Registry for Alzheimer's disease criteria and neurofibrillary changes of the limbic system consistent with Braak stage IV were found. Based on a review of the published literature, this autopsy case is very rare, and we suppose that the incidence of CJD accompanied by Lewy body disease and Alzheimer's disease is very low.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Coexistence of Creutzfeldt‐Jakob disease, Lewy body disease, and Alzheimer's disease pathology: An autopsy case showing typical clinical features of Creutzfeldt‐Jakob disease</title></titleInfo><titleInfo type="abbreviated"><title>Coexistence of CJD, LBD, and AD pathology</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Coexistence of Creutzfeldt‐Jakob disease, Lewy body disease, and Alzheimer's disease pathology: An autopsy case showing typical clinical features of Creutzfeldt‐Jakob disease</title></titleInfo><name type="personal"><namePart type="given">Takashi</namePart><namePart type="family">Haraguchi</namePart><affiliation>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</affiliation><description>Correspondence: Takashi Haraguchi, MD, PhD, Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, 4066 Hayashima‐cho, 701‐0304 Tsukubo‐gun Okayama, Japan. Email: </description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Seishi</namePart><namePart type="family">Terada</namePart><affiliation>Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata‐cho, Okayama,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hideki</namePart><namePart type="family">Ishizu</namePart><affiliation>Department of Laboratory and Medicine, Zikei Institute, Urayasuhon‐cho, Okayama, and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kenichi</namePart><namePart type="family">Sakai</namePart><affiliation>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yasuyuki</namePart><namePart type="family">Tanabe</namePart><affiliation>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Taiji</namePart><namePart type="family">Nagai</namePart><affiliation>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hiroshi</namePart><namePart type="family">Takata</namePart><affiliation>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Keigo</namePart><namePart type="family">Nobukuni</namePart><affiliation>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yuetsu</namePart><namePart type="family">Ihara</namePart><affiliation>Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center, Hayashima‐cho, Tsukubo‐gun, Okayama,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tetsuyuki</namePart><namePart type="family">Kitamoto</namePart><affiliation>Division of CJD Science and Technology, Department of Prion Research, Center for Translational and Advanced Animal Research on Human Diseases, Tohoku University Graduate School of Medicine, Seiryou‐cho, Sendai, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Shigetoshi</namePart><namePart type="family">Kuroda</namePart><affiliation>Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata‐cho, Okayama,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="case report" displayLabel="caseStudy"></genre><originInfo><publisher>Blackwell Publishing Asia</publisher><place><placeTerm type="text">Melbourne, Australia</placeTerm></place><dateIssued encoding="w3cdtf">2009-08</dateIssued><edition>Received 16 June 2008; revised and accepted 22 July 2008; published online 18 August 2008.</edition><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">1</extent><extent unit="references">30</extent><extent unit="words">3540</extent></physicalDescription><abstract lang="en">We report here an autopsy case of sporadic Creutzfeldt‐Jakob disease (CJD) without hereditary burden and with a clinical course typical of sporadic CJD. A 77‐year old man developed memory disturbance, followed by gait disturbance and myoclonus. He died of bronchopneumonia 5 months after the disease onset. Post‐mortem examination revealed neuronal loss, astrocytosis, and patchy spongiosis in the cerebral cortex and lenticular nuclei. Synaptic‐type deposits of prion protein were present in the cerebral cortex. Additionally, Lewy bodies were observed in the cerebral cortex and substantia nigra. Furthermore, senile plaques compatible with definite Alzheimer's disease according to Consortium to Establish a Registry for Alzheimer's disease criteria and neurofibrillary changes of the limbic system consistent with Braak stage IV were found. Based on a review of the published literature, this autopsy case is very rare, and we suppose that the incidence of CJD accompanied by Lewy body disease and Alzheimer's disease is very low.</abstract><subject lang="en"><genre>Keywords</genre><topic>Alzheimer's disease</topic><topic>Creutzfeldt‐Jakob disease</topic><topic>Lewy body disease</topic><topic>neurofibrillary change</topic><topic>senile plaque</topic></subject><relatedItem type="host"><titleInfo><title>Neuropathology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0919-6544</identifier><identifier type="eISSN">1440-1789</identifier><identifier type="DOI">10.1111/(ISSN)1440-1789</identifier><identifier type="PublisherID">NEUP</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>454</start><end>459</end><total>6</total></extent></part></relatedItem><identifier type="istex">07387B8F1FECFF086718E0E1186E162164AF61FF</identifier><identifier type="DOI">10.1111/j.1440-1789.2008.00964.x</identifier><identifier type="ArticleID">NEUP964</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2008 Japanese Society of Neuropathology</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Asia</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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