Pilot study of a three‐step diagnostic pathway for young and old patients with Parkinson's disease dementia: screen, test and then diagnose
Identifieur interne : 002921 ( Main/Corpus ); précédent : 002920; suivant : 002922Pilot study of a three‐step diagnostic pathway for young and old patients with Parkinson's disease dementia: screen, test and then diagnose
Auteurs : Sarah H. M. Robben ; Monique J. M. Sleegers ; Paul L. J. Dautzenberg ; Floor S. Van Bergen ; Jan-Pieter Ter Bruggen ; Marcel G. M. Olde RikkertSource :
- International Journal of Geriatric Psychiatry [ 0885-6230 ] ; 2010-03.
English descriptors
Abstract
Objective: To pilot a three‐step diagnostic model for young and old patients with Parkinson's disease dementia (PDD). Methods: Prospective investigator‐blinded study. We developed a screening questionnaire for patients with Parkinson's disease (PD) and their caregivers. Further, patients were subjected to three screening instruments (Montreal Cognitive Assessment (MoCA), Frontal Assessment Battery (FAB), Addenbrooke's Cognitive Examination‐revised (ACE‐R) and a detailed neuropsychological examination (NPE). Based on the NPE, patients were divided in a PD (without dementia) and a PDD‐group. Results: Forty‐one PD patients, aged 37–94 years, participated in this study. Patients were divided in a young group, ≤65 (n = 22) and an old group >65 years (n = 19). In the young group (PDD, n = 5) the patient‐screening questionnaire predicted PDD with a sensitivity/specificity of 100.0%/94.1%; in the old group (PDD, n = 10) the proxy‐screening questionnaire predicted PDD with a sensitivity/specificity of 88.9%/66.7%. In the young group, ACE‐R had the largest Area Under the Curve (AUC) 0.88 (0.70–1.00), in the old group MoCA (AUC 1.00). However, the three instruments did not differ significantly. Conclusions: It seems feasible and efficient to use three consecutive diagnostic steps for PDD: (1) a screening questionnaire, (2) if positive: MoCA, FAB or ACE‐R as screening instrument and (3) if positive: a detailed NPE for diagnosing PDD. Copyright © 2009 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/gps.2331
Links to Exploration step
ISTEX:A69B6145B5F13DE196DE97FE9AA078BFDE03A8A8Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pilot study of a three‐step diagnostic pathway for young and old patients with Parkinson's disease dementia: screen, test and then diagnose</title><author><name sortKey="Robben, Sarah H M" sort="Robben, Sarah H M" uniqKey="Robben S" first="Sarah H. M." last="Robben">Sarah H. M. Robben</name><affiliation><mods:affiliation>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Sleegers, Monique J M" sort="Sleegers, Monique J M" uniqKey="Sleegers M" first="Monique J. M." last="Sleegers">Monique J. M. Sleegers</name><affiliation><mods:affiliation>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Dautzenberg, Paul L J" sort="Dautzenberg, Paul L J" uniqKey="Dautzenberg P" first="Paul L. J." last="Dautzenberg">Paul L. J. Dautzenberg</name><affiliation><mods:affiliation>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Van Bergen, Floor S" sort="Van Bergen, Floor S" uniqKey="Van Bergen F" first="Floor S." last="Van Bergen">Floor S. Van Bergen</name><affiliation><mods:affiliation>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Ter Bruggen, Jan Ieter" sort="Ter Bruggen, Jan Ieter" uniqKey="Ter Bruggen J" first="Jan-Pieter" last="Ter Bruggen">Jan-Pieter Ter Bruggen</name><affiliation><mods:affiliation>Department of Neurology, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Rikkert, Marcel G M Olde" sort="Rikkert, Marcel G M Olde" uniqKey="Rikkert M" first="Marcel G. M. Olde" last="Rikkert">Marcel G. M. Olde Rikkert</name><affiliation><mods:affiliation>Department of Geriatric Medicine, Alzheimer Centre Nijmegen, Radboud University Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A69B6145B5F13DE196DE97FE9AA078BFDE03A8A8</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/gps.2331</idno><idno type="url">https://api.istex.fr/document/A69B6145B5F13DE196DE97FE9AA078BFDE03A8A8/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002921</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Pilot study of a three‐step diagnostic pathway for young and old patients with Parkinson's disease dementia: screen, test and then diagnose</title><author><name sortKey="Robben, Sarah H M" sort="Robben, Sarah H M" uniqKey="Robben S" first="Sarah H. M." last="Robben">Sarah H. M. Robben</name><affiliation><mods:affiliation>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Sleegers, Monique J M" sort="Sleegers, Monique J M" uniqKey="Sleegers M" first="Monique J. M." last="Sleegers">Monique J. M. Sleegers</name><affiliation><mods:affiliation>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Dautzenberg, Paul L J" sort="Dautzenberg, Paul L J" uniqKey="Dautzenberg P" first="Paul L. J." last="Dautzenberg">Paul L. J. Dautzenberg</name><affiliation><mods:affiliation>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Van Bergen, Floor S" sort="Van Bergen, Floor S" uniqKey="Van Bergen F" first="Floor S." last="Van Bergen">Floor S. Van Bergen</name><affiliation><mods:affiliation>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Ter Bruggen, Jan Ieter" sort="Ter Bruggen, Jan Ieter" uniqKey="Ter Bruggen J" first="Jan-Pieter" last="Ter Bruggen">Jan-Pieter Ter Bruggen</name><affiliation><mods:affiliation>Department of Neurology, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Rikkert, Marcel G M Olde" sort="Rikkert, Marcel G M Olde" uniqKey="Rikkert M" first="Marcel G. M. Olde" last="Rikkert">Marcel G. M. Olde Rikkert</name><affiliation><mods:affiliation>Department of Geriatric Medicine, Alzheimer Centre Nijmegen, Radboud University Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Geriatric Psychiatry</title><title level="j" type="sub">A journal of the psychiatry of late life and allied sciences</title><title level="j" type="abbrev">Int. J. Geriat. Psychiatry</title><idno type="ISSN">0885-6230</idno><idno type="eISSN">1099-1166</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2010-03">2010-03</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="258">258</biblScope><biblScope unit="page" to="265">265</biblScope></imprint><idno type="ISSN">0885-6230</idno></series><idno type="istex">A69B6145B5F13DE196DE97FE9AA078BFDE03A8A8</idno><idno type="DOI">10.1002/gps.2331</idno><idno type="ArticleID">GPS2331</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-6230</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cognition</term><term>dementia</term><term>neuropsychology</term><term>screening tests</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To pilot a three‐step diagnostic model for young and old patients with Parkinson's disease dementia (PDD). Methods: Prospective investigator‐blinded study. We developed a screening questionnaire for patients with Parkinson's disease (PD) and their caregivers. Further, patients were subjected to three screening instruments (Montreal Cognitive Assessment (MoCA), Frontal Assessment Battery (FAB), Addenbrooke's Cognitive Examination‐revised (ACE‐R) and a detailed neuropsychological examination (NPE). Based on the NPE, patients were divided in a PD (without dementia) and a PDD‐group. Results: Forty‐one PD patients, aged 37–94 years, participated in this study. Patients were divided in a young group, ≤65 (n = 22) and an old group >65 years (n = 19). In the young group (PDD, n = 5) the patient‐screening questionnaire predicted PDD with a sensitivity/specificity of 100.0%/94.1%; in the old group (PDD, n = 10) the proxy‐screening questionnaire predicted PDD with a sensitivity/specificity of 88.9%/66.7%. In the young group, ACE‐R had the largest Area Under the Curve (AUC) 0.88 (0.70–1.00), in the old group MoCA (AUC 1.00). However, the three instruments did not differ significantly. Conclusions: It seems feasible and efficient to use three consecutive diagnostic steps for PDD: (1) a screening questionnaire, (2) if positive: MoCA, FAB or ACE‐R as screening instrument and (3) if positive: a detailed NPE for diagnosing PDD. Copyright © 2009 John Wiley & Sons, Ltd.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Sarah H. M. Robben</name><affiliations><json:string>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</json:string></affiliations></json:item><json:item><name>Monique J. M. Sleegers</name><affiliations><json:string>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</json:string></affiliations></json:item><json:item><name>Paul L. J. Dautzenberg</name><affiliations><json:string>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</json:string></affiliations></json:item><json:item><name>Floor S. van Bergen</name><affiliations><json:string>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</json:string></affiliations></json:item><json:item><name>Jan‐Pieter ter Bruggen</name><affiliations><json:string>Department of Neurology, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</json:string></affiliations></json:item><json:item><name>Marcel G. M. Olde Rikkert</name><affiliations><json:string>Department of Geriatric Medicine, Alzheimer Centre Nijmegen, Radboud University Medical Centre, Nijmegen, The Netherlands</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cognition</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>screening tests</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>neuropsychology</value></json:item></subject><articleId><json:string>GPS2331</json:string></articleId><language><json:string>eng</json:string></language><abstract>Objective: To pilot a three‐step diagnostic model for young and old patients with Parkinson's disease dementia (PDD). Methods: Prospective investigator‐blinded study. We developed a screening questionnaire for patients with Parkinson's disease (PD) and their caregivers. Further, patients were subjected to three screening instruments (Montreal Cognitive Assessment (MoCA), Frontal Assessment Battery (FAB), Addenbrooke's Cognitive Examination‐revised (ACE‐R) and a detailed neuropsychological examination (NPE). Based on the NPE, patients were divided in a PD (without dementia) and a PDD‐group. Results: Forty‐one PD patients, aged 37–94 years, participated in this study. Patients were divided in a young group, ≤65 (n = 22) and an old group >65 years (n = 19). In the young group (PDD, n = 5) the patient‐screening questionnaire predicted PDD with a sensitivity/specificity of 100.0%/94.1%; in the old group (PDD, n = 10) the proxy‐screening questionnaire predicted PDD with a sensitivity/specificity of 88.9%/66.7%. In the young group, ACE‐R had the largest Area Under the Curve (AUC) 0.88 (0.70–1.00), in the old group MoCA (AUC 1.00). However, the three instruments did not differ significantly. Conclusions: It seems feasible and efficient to use three consecutive diagnostic steps for PDD: (1) a screening questionnaire, (2) if positive: MoCA, FAB or ACE‐R as screening instrument and (3) if positive: a detailed NPE for diagnosing PDD. Copyright © 2009 John Wiley & Sons, Ltd.</abstract><qualityIndicators><score>6.169</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595 x 791 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1486</abstractCharCount><pdfWordCount>3661</pdfWordCount><pdfCharCount>23775</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>209</abstractWordCount></qualityIndicators><title>Pilot study of a three‐step diagnostic pathway for young and old patients with Parkinson's disease dementia: screen, test and then diagnose</title><genre><json:string>article</json:string></genre><host><volume>25</volume><publisherId><json:string>GPS</json:string></publisherId><pages><total>8</total><last>265</last><first>258</first></pages><issn><json:string>0885-6230</json:string></issn><issue>3</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1099-1166</json:string></eissn><title>International Journal of Geriatric Psychiatry</title><doi><json:string>10.1002/(ISSN)1099-1166</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1002/gps.2331</json:string></doi><id>A69B6145B5F13DE196DE97FE9AA078BFDE03A8A8</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/A69B6145B5F13DE196DE97FE9AA078BFDE03A8A8/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/A69B6145B5F13DE196DE97FE9AA078BFDE03A8A8/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/A69B6145B5F13DE196DE97FE9AA078BFDE03A8A8/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Pilot study of a three‐step diagnostic pathway for young and old patients with Parkinson's disease dementia: screen, test and then diagnose</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><availability><p>WILEY</p></availability><date>2010</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Pilot study of a three‐step diagnostic pathway for young and old patients with Parkinson's disease dementia: screen, test and then diagnose</title><author><persName><forename type="first">Sarah H. M.</forename><surname>Robben</surname></persName><affiliation>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</affiliation></author><author><persName><forename type="first">Monique J. M.</forename><surname>Sleegers</surname></persName><affiliation>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</affiliation></author><author><persName><forename type="first">Paul L. J.</forename><surname>Dautzenberg</surname></persName><note type="correspondence"><p>Correspondence: Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands.</p></note><affiliation>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</affiliation></author><author><persName><forename type="first">Floor S.</forename><surname>van Bergen</surname></persName><affiliation>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</affiliation></author><author><persName><forename type="first">Jan‐Pieter</forename><surname>ter Bruggen</surname></persName><affiliation>Department of Neurology, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</affiliation></author><author><persName><forename type="first">Marcel G. M. Olde</forename><surname>Rikkert</surname></persName><affiliation>Department of Geriatric Medicine, Alzheimer Centre Nijmegen, Radboud University Medical Centre, Nijmegen, The Netherlands</affiliation></author></analytic><monogr><title level="j">International Journal of Geriatric Psychiatry</title><title level="j" type="sub">A journal of the psychiatry of late life and allied sciences</title><title level="j" type="abbrev">Int. J. Geriat. Psychiatry</title><idno type="pISSN">0885-6230</idno><idno type="eISSN">1099-1166</idno><idno type="DOI">10.1002/(ISSN)1099-1166</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2010-03"></date><biblScope unit="volume">25</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="258">258</biblScope><biblScope unit="page" to="265">265</biblScope></imprint></monogr><idno type="istex">A69B6145B5F13DE196DE97FE9AA078BFDE03A8A8</idno><idno type="DOI">10.1002/gps.2331</idno><idno type="ArticleID">GPS2331</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Objective: To pilot a three‐step diagnostic model for young and old patients with Parkinson's disease dementia (PDD). Methods: Prospective investigator‐blinded study. We developed a screening questionnaire for patients with Parkinson's disease (PD) and their caregivers. Further, patients were subjected to three screening instruments (Montreal Cognitive Assessment (MoCA), Frontal Assessment Battery (FAB), Addenbrooke's Cognitive Examination‐revised (ACE‐R) and a detailed neuropsychological examination (NPE). Based on the NPE, patients were divided in a PD (without dementia) and a PDD‐group. Results: Forty‐one PD patients, aged 37–94 years, participated in this study. Patients were divided in a young group, ≤65 (n = 22) and an old group >65 years (n = 19). In the young group (PDD, n = 5) the patient‐screening questionnaire predicted PDD with a sensitivity/specificity of 100.0%/94.1%; in the old group (PDD, n = 10) the proxy‐screening questionnaire predicted PDD with a sensitivity/specificity of 88.9%/66.7%. In the young group, ACE‐R had the largest Area Under the Curve (AUC) 0.88 (0.70–1.00), in the old group MoCA (AUC 1.00). However, the three instruments did not differ significantly. Conclusions: It seems feasible and efficient to use three consecutive diagnostic steps for PDD: (1) a screening questionnaire, (2) if positive: MoCA, FAB or ACE‐R as screening instrument and (3) if positive: a detailed NPE for diagnosing PDD. Copyright © 2009 John Wiley & Sons, Ltd.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>dementia</term></item><item><term>cognition</term></item><item><term>screening tests</term></item><item><term>neuropsychology</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-11-20">Received</change><change when="2009-05-08">Registration</change><change when="2010-03">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/A69B6145B5F13DE196DE97FE9AA078BFDE03A8A8/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Ltd.</publisherName><publisherLoc>Chichester, UK</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1099-1166</doi><issn type="print">0885-6230</issn><issn type="electronic">1099-1166</issn><idGroup><id type="product" value="GPS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY">International Journal of Geriatric Psychiatry</title><title type="subtitle">A journal of the psychiatry of late life and allied sciences</title><title type="short">Int. J. Geriat. Psychiatry</title></titleGroup></publicationMeta><publicationMeta level="part" position="30"><doi origin="wiley" registered="yes">10.1002/gps.v25:3</doi><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="2010-03">March 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="60" status="forIssue"><doi origin="wiley" registered="yes">10.1002/gps.2331</doi><idGroup><id type="unit" value="GPS2331"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="publisher">Copyright © 2009 John Wiley & Sons, Ltd.</copyright><eventGroup><event type="manuscriptReceived" date="2008-11-20"></event><event type="manuscriptAccepted" date="2009-05-08"></event><event type="publishedOnlineEarlyUnpaginated" date="2009-07-06"></event><event type="firstOnline" date="2009-07-06"></event><event type="publishedOnlineFinalForm" date="2010-02-10"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-04"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-26"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-23"></event></eventGroup><numberingGroup><numbering type="pageFirst">258</numbering><numbering type="pageLast">265</numbering></numberingGroup><correspondenceTo>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:GPS.GPS2331.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="4"></count><count type="referenceTotal" number="28"></count></countGroup><titleGroup><title type="main" xml:lang="en">Pilot study of a three‐step diagnostic pathway for young and old patients with Parkinson's disease dementia: screen, test and then diagnose</title><title type="short" xml:lang="en">Pilot study of a three‐step diagnostic pathway for PDD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Sarah H. M.</givenNames><familyName>Robben</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Monique J. M.</givenNames><familyName>Sleegers</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Paul L. J.</givenNames><familyName>Dautzenberg</familyName></personName><contactDetails><email>p.dautzenberg@jbz.nl</email></contactDetails></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Floor S.</givenNames><familyName>van Bergen</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Jan‐Pieter</givenNames><familyName>ter Bruggen</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Marcel G. M. Olde</givenNames><familyName>Rikkert</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="NL" type="organization"><unparsedAffiliation>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="NL" type="organization"><unparsedAffiliation>Department of Neurology, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="NL" type="organization"><unparsedAffiliation>Department of Geriatric Medicine, Alzheimer Centre Nijmegen, Radboud University Medical Centre, Nijmegen, The Netherlands</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">dementia</keyword><keyword xml:id="kwd3">cognition</keyword><keyword xml:id="kwd4">screening tests</keyword><keyword xml:id="kwd5">neuropsychology</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Objective</title><p>To pilot a three‐step diagnostic model for young and old patients with Parkinson's disease dementia (PDD).</p></section><section xml:id="abs1-2"><title type="main">Methods</title><p>Prospective investigator‐blinded study. We developed a screening questionnaire for patients with Parkinson's disease (PD) and their caregivers. Further, patients were subjected to three screening instruments (Montreal Cognitive Assessment (MoCA), Frontal Assessment Battery (FAB), Addenbrooke's Cognitive Examination‐revised (ACE‐R) and a detailed neuropsychological examination (NPE). Based on the NPE, patients were divided in a PD (without dementia) and a PDD‐group.</p></section><section xml:id="abs1-3"><title type="main">Results</title><p>Forty‐one PD patients, aged 37–94 years, participated in this study. Patients were divided in a young group, ≤65 (<i>n</i> = 22) and an old group >65 years (<i>n</i> = 19). In the young group (PDD, <i>n</i> = 5) the patient‐screening questionnaire predicted PDD with a sensitivity/specificity of 100.0%/94.1%; in the old group (PDD, <i>n</i> = 10) the proxy‐screening questionnaire predicted PDD with a sensitivity/specificity of 88.9%/66.7%. In the young group, ACE‐R had the largest Area Under the Curve (AUC) 0.88 (0.70–1.00), in the old group MoCA (AUC 1.00). However, the three instruments did not differ significantly.</p></section><section xml:id="abs1-4"><title type="main">Conclusions</title><p>It seems feasible and efficient to use three consecutive diagnostic steps for PDD: (1) a screening questionnaire, (2) if positive: MoCA, FAB or ACE‐R as screening instrument and (3) if positive: a detailed NPE for diagnosing PDD. Copyright © 2009 John Wiley & Sons, Ltd.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Pilot study of a three‐step diagnostic pathway for young and old patients with Parkinson's disease dementia: screen, test and then diagnose</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Pilot study of a three‐step diagnostic pathway for PDD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Pilot study of a three‐step diagnostic pathway for young and old patients with Parkinson's disease dementia: screen, test and then diagnose</title></titleInfo><name type="personal"><namePart type="given">Sarah H. M.</namePart><namePart type="family">Robben</namePart><affiliation>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Monique J. M.</namePart><namePart type="family">Sleegers</namePart><affiliation>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul L. J.</namePart><namePart type="family">Dautzenberg</namePart><affiliation>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</affiliation><description>Correspondence: Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Floor S.</namePart><namePart type="family">van Bergen</namePart><affiliation>Department of Geriatric Medicine, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan‐Pieter</namePart><namePart type="family">ter Bruggen</namePart><affiliation>Department of Neurology, Jeroen Bosch Hospital, 's‐Hertogenbosch, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marcel G. M. Olde</namePart><namePart type="family">Rikkert</namePart><affiliation>Department of Geriatric Medicine, Alzheimer Centre Nijmegen, Radboud University Medical Centre, Nijmegen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Ltd.</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2010-03</dateIssued><dateCaptured encoding="w3cdtf">2008-11-20</dateCaptured><dateValid encoding="w3cdtf">2009-05-08</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">4</extent><extent unit="references">28</extent></physicalDescription><abstract lang="en">Objective: To pilot a three‐step diagnostic model for young and old patients with Parkinson's disease dementia (PDD). Methods: Prospective investigator‐blinded study. We developed a screening questionnaire for patients with Parkinson's disease (PD) and their caregivers. Further, patients were subjected to three screening instruments (Montreal Cognitive Assessment (MoCA), Frontal Assessment Battery (FAB), Addenbrooke's Cognitive Examination‐revised (ACE‐R) and a detailed neuropsychological examination (NPE). Based on the NPE, patients were divided in a PD (without dementia) and a PDD‐group. Results: Forty‐one PD patients, aged 37–94 years, participated in this study. Patients were divided in a young group, ≤65 (n = 22) and an old group >65 years (n = 19). In the young group (PDD, n = 5) the patient‐screening questionnaire predicted PDD with a sensitivity/specificity of 100.0%/94.1%; in the old group (PDD, n = 10) the proxy‐screening questionnaire predicted PDD with a sensitivity/specificity of 88.9%/66.7%. In the young group, ACE‐R had the largest Area Under the Curve (AUC) 0.88 (0.70–1.00), in the old group MoCA (AUC 1.00). However, the three instruments did not differ significantly. Conclusions: It seems feasible and efficient to use three consecutive diagnostic steps for PDD: (1) a screening questionnaire, (2) if positive: MoCA, FAB or ACE‐R as screening instrument and (3) if positive: a detailed NPE for diagnosing PDD. Copyright © 2009 John Wiley & Sons, Ltd.</abstract><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>dementia</topic><topic>cognition</topic><topic>screening tests</topic><topic>neuropsychology</topic></subject><relatedItem type="host"><titleInfo><title>International Journal of Geriatric Psychiatry</title><subTitle>A journal of the psychiatry of late life and allied sciences</subTitle></titleInfo><titleInfo type="abbreviated"><title>Int. J. Geriat. Psychiatry</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-6230</identifier><identifier type="eISSN">1099-1166</identifier><identifier type="DOI">10.1002/(ISSN)1099-1166</identifier><identifier type="PublisherID">GPS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>258</start><end>265</end><total>8</total></extent></part></relatedItem><identifier type="istex">A69B6145B5F13DE196DE97FE9AA078BFDE03A8A8</identifier><identifier type="DOI">10.1002/gps.2331</identifier><identifier type="ArticleID">GPS2331</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 John Wiley & Sons, Ltd.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Ltd.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002921 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 002921 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:A69B6145B5F13DE196DE97FE9AA078BFDE03A8A8
|texte= Pilot study of a three‐step diagnostic pathway for young and old patients with Parkinson's disease dementia: screen, test and then diagnose
}}
| This area was generated with Dilib version V0.6.23. |  |