Functional connectivity of cortical motor areas in the resting state in Parkinson's disease
Identifieur interne : 002878 ( Main/Corpus ); précédent : 002877; suivant : 002879Functional connectivity of cortical motor areas in the resting state in Parkinson's disease
Auteurs : Tao Wu ; Xiangyu Long ; Liang Wang ; Mark Hallett ; Yufeng Zang ; Kuncheng Li ; Piu ChanSource :
- Human Brain Mapping [ 1065-9471 ] ; 2011-09.
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Abstract
Parkinson's disease (PD) patients have difficulty in initiating movements. Previous studies have suggested that the abnormal brain activity may happen not only during performance of self‐initiated movements but also in the before movement (baseline or resting) state. In the current study, we investigated the functional connectivity of brain networks in the resting state in PD. We chose the rostral supplementary motor area (pre‐SMA) and bilateral primary motor cortex (M1) as “seed” regions, because the pre‐SMA is important in motor preparation, whereas the M1 is critical in motor execution. FMRIs were acquired in 18 patients and 18 matched controls. We found that in the resting state, the pattern of connectivity with both the pre‐SMA or the M1 was changed in PD. Connectivity with the pre‐SMA in patients with PD compared to normal subjects was increased connectivity to the right M1 and decreased to the left putamen, right insula, right premotor cortex, and left inferior parietal lobule. We only found stronger connectivity in the M1 with its own local region in patients with PD compared to controls. Our findings demonstrate that the interactions of brain networks are abnormal in PD in the resting state. There are more connectivity changes of networks related to motor preparation and initiation than to networks of motor execution in PD. We postulate that these disrupted connections indicate a lack of readiness for movement and may be partly responsible for difficulty in initiating movements in PD. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
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DOI: 10.1002/hbm.21118
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Previous studies have suggested that the abnormal brain activity may happen not only during performance of self‐initiated movements but also in the before movement (baseline or resting) state. In the current study, we investigated the functional connectivity of brain networks in the resting state in PD. We chose the rostral supplementary motor area (pre‐SMA) and bilateral primary motor cortex (M1) as “seed” regions, because the pre‐SMA is important in motor preparation, whereas the M1 is critical in motor execution. FMRIs were acquired in 18 patients and 18 matched controls. We found that in the resting state, the pattern of connectivity with both the pre‐SMA or the M1 was changed in PD. Connectivity with the pre‐SMA in patients with PD compared to normal subjects was increased connectivity to the right M1 and decreased to the left putamen, right insula, right premotor cortex, and left inferior parietal lobule. We only found stronger connectivity in the M1 with its own local region in patients with PD compared to controls. Our findings demonstrate that the interactions of brain networks are abnormal in PD in the resting state. There are more connectivity changes of networks related to motor preparation and initiation than to networks of motor execution in PD. We postulate that these disrupted connections indicate a lack of readiness for movement and may be partly responsible for difficulty in initiating movements in PD. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Tao Wu</name><affiliations><json:string>Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Beijing, China</json:string></affiliations></json:item><json:item><name>Xiangyu Long</name><affiliations><json:string>State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China</json:string></affiliations></json:item><json:item><name>Liang Wang</name><affiliations><json:string>Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China</json:string></affiliations></json:item><json:item><name>Mark Hallett</name><affiliations><json:string>Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland</json:string></affiliations></json:item><json:item><name>Yufeng Zang</name><affiliations><json:string>State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China</json:string></affiliations></json:item><json:item><name>Kuncheng Li</name><affiliations><json:string>Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China</json:string></affiliations></json:item><json:item><name>Piu Chan</name><affiliations><json:string>Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Beijing, China</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>functional connectivity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>resting state</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>rostral supplementary motor area</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>primary motor cortex</value></json:item></subject><articleId><json:string>HBM21118</json:string></articleId><language><json:string>eng</json:string></language><abstract>Parkinson's disease (PD) patients have difficulty in initiating movements. Previous studies have suggested that the abnormal brain activity may happen not only during performance of self‐initiated movements but also in the before movement (baseline or resting) state. In the current study, we investigated the functional connectivity of brain networks in the resting state in PD. We chose the rostral supplementary motor area (pre‐SMA) and bilateral primary motor cortex (M1) as “seed” regions, because the pre‐SMA is important in motor preparation, whereas the M1 is critical in motor execution. FMRIs were acquired in 18 patients and 18 matched controls. We found that in the resting state, the pattern of connectivity with both the pre‐SMA or the M1 was changed in PD. Connectivity with the pre‐SMA in patients with PD compared to normal subjects was increased connectivity to the right M1 and decreased to the left putamen, right insula, right premotor cortex, and left inferior parietal lobule. We only found stronger connectivity in the M1 with its own local region in patients with PD compared to controls. Our findings demonstrate that the interactions of brain networks are abnormal in PD in the resting state. There are more connectivity changes of networks related to motor preparation and initiation than to networks of motor execution in PD. We postulate that these disrupted connections indicate a lack of readiness for movement and may be partly responsible for difficulty in initiating movements in PD. 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Previous studies have suggested that the abnormal brain activity may happen not only during performance of self‐initiated movements but also in the before movement (baseline or resting) state. In the current study, we investigated the functional connectivity of brain networks in the resting state in PD. We chose the rostral supplementary motor area (pre‐SMA) and bilateral primary motor cortex (M1) as “seed” regions, because the pre‐SMA is important in motor preparation, whereas the M1 is critical in motor execution. FMRIs were acquired in 18 patients and 18 matched controls. We found that in the resting state, the pattern of connectivity with both the pre‐SMA or the M1 was changed in PD. Connectivity with the pre‐SMA in patients with PD compared to normal subjects was increased connectivity to the right M1 and decreased to the left putamen, right insula, right premotor cortex, and left inferior parietal lobule. We only found stronger connectivity in the M1 with its own local region in patients with PD compared to controls. Our findings demonstrate that the interactions of brain networks are abnormal in PD in the resting state. There are more connectivity changes of networks related to motor preparation and initiation than to networks of motor execution in PD. We postulate that these disrupted connections indicate a lack of readiness for movement and may be partly responsible for difficulty in initiating movements in PD. 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xml:id="kwd4">rostral supplementary motor area</keyword><keyword xml:id="kwd5">primary motor cortex</keyword></keywordGroup><fundingInfo><fundingAgency>National Science Foundation of China</fundingAgency><fundingNumber>30870693</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Ministry of Science and Technology</fundingAgency><fundingNumber>2006AA02A408</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Parkinson's disease (PD) patients have difficulty in initiating movements. Previous studies have suggested that the abnormal brain activity may happen not only during performance of self‐initiated movements but also in the before movement (baseline or resting) state. In the current study, we investigated the functional connectivity of brain networks in the resting state in PD. We chose the rostral supplementary motor area (pre‐SMA) and bilateral primary motor cortex (M1) as “seed” regions, because the pre‐SMA is important in motor preparation, whereas the M1 is critical in motor execution. FMRIs were acquired in 18 patients and 18 matched controls. We found that in the resting state, the pattern of connectivity with both the pre‐SMA or the M1 was changed in PD. Connectivity with the pre‐SMA in patients with PD compared to normal subjects was increased connectivity to the right M1 and decreased to the left putamen, right insula, right premotor cortex, and left inferior parietal lobule. We only found stronger connectivity in the M1 with its own local region in patients with PD compared to controls. Our findings demonstrate that the interactions of brain networks are abnormal in PD in the resting state. There are more connectivity changes of networks related to motor preparation and initiation than to networks of motor execution in PD. We postulate that these disrupted connections indicate a lack of readiness for movement and may be partly responsible for difficulty in initiating movements in PD. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Functional connectivity of cortical motor areas in the resting state in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Functional Connectivity in Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Functional connectivity of cortical motor areas in the resting state in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Tao</namePart><namePart type="family">Wu</namePart><affiliation>Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Beijing, China</affiliation><description>Correspondence: Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Xiangyu</namePart><namePart type="family">Long</namePart><affiliation>State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Liang</namePart><namePart type="family">Wang</namePart><affiliation>Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mark</namePart><namePart type="family">Hallett</namePart><affiliation>Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yufeng</namePart><namePart type="family">Zang</namePart><affiliation>State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kuncheng</namePart><namePart type="family">Li</namePart><affiliation>Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Piu</namePart><namePart type="family">Chan</namePart><affiliation>Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Beijing, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-09</dateIssued><dateCaptured encoding="w3cdtf">2009-11-05</dateCaptured><dateValid encoding="w3cdtf">2010-06-07</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">4</extent><extent unit="tables">6</extent><extent unit="references">116</extent><extent unit="words">13501</extent></physicalDescription><abstract lang="en">Parkinson's disease (PD) patients have difficulty in initiating movements. Previous studies have suggested that the abnormal brain activity may happen not only during performance of self‐initiated movements but also in the before movement (baseline or resting) state. In the current study, we investigated the functional connectivity of brain networks in the resting state in PD. We chose the rostral supplementary motor area (pre‐SMA) and bilateral primary motor cortex (M1) as “seed” regions, because the pre‐SMA is important in motor preparation, whereas the M1 is critical in motor execution. FMRIs were acquired in 18 patients and 18 matched controls. We found that in the resting state, the pattern of connectivity with both the pre‐SMA or the M1 was changed in PD. Connectivity with the pre‐SMA in patients with PD compared to normal subjects was increased connectivity to the right M1 and decreased to the left putamen, right insula, right premotor cortex, and left inferior parietal lobule. We only found stronger connectivity in the M1 with its own local region in patients with PD compared to controls. Our findings demonstrate that the interactions of brain networks are abnormal in PD in the resting state. There are more connectivity changes of networks related to motor preparation and initiation than to networks of motor execution in PD. We postulate that these disrupted connections indicate a lack of readiness for movement and may be partly responsible for difficulty in initiating movements in PD. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.</abstract><note type="funding">National Science Foundation of China - No. 30870693; </note><note type="funding">Ministry of Science and Technology - No. 2006AA02A408; </note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>functional connectivity</topic><topic>resting state</topic><topic>rostral supplementary motor area</topic><topic>primary motor cortex</topic></subject><relatedItem type="host"><titleInfo><title>Human Brain Mapping</title></titleInfo><titleInfo type="abbreviated"><title>Hum. Brain Mapp.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">1065-9471</identifier><identifier type="eISSN">1097-0193</identifier><identifier type="DOI">10.1002/(ISSN)1097-0193</identifier><identifier type="PublisherID">HBM</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><detail type="issue"><caption>no.</caption><number>9</number></detail><extent unit="pages"><start>1443</start><end>1457</end><total>15</total></extent></part></relatedItem><identifier type="istex">FA9B85FC541373204B9B38C1AC4D7A17B749DCAE</identifier><identifier type="DOI">10.1002/hbm.21118</identifier><identifier type="ArticleID">HBM21118</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Wiley‐Liss, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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